sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3sfd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3sfd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 1.000 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.725 | |
| 3aeb | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.611 | |
| 4yxd | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.608 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.512 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.509 | |
| 4o5u | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.493 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3iaa | TYD | CalG2 | / | 0.491 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.490 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.489 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.484 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 5dbj | FAD | FADH2-dependent halogenase PltA | / | 0.482 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.480 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2aqj | FAD | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.479 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.478 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.478 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 1iy8 | NAD | Levodione reductase | / | 0.476 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.476 | |
| 2q0l | FAD | Thioredoxin reductase | 1.8.1.9 | 0.476 | |
| 4jin | 1L7 | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.476 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.474 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.473 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.473 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.473 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.472 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 4i02 | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.472 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.471 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.471 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.471 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.470 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.470 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.469 | |
| 1ad3 | NAD | Aldehyde dehydrogenase, dimeric NADP-preferring | / | 0.468 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1zmd | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.468 | |
| 2cdu | FAD | NADH oxidase | / | 0.468 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.468 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.468 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.468 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.467 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.467 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.467 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.467 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.467 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.467 | |
| 1pvg | ANP | DNA topoisomerase 2 | 5.99.1.3 | 0.466 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.466 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.465 | |
| 1onf | FAD | Glutathione reductase | 1.8.1.7 | 0.465 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.465 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.465 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.465 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.464 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.464 | |
| 1c0l | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.463 | |
| 1j3j | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.463 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.463 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.463 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 2onm | ADP | Aldehyde dehydrogenase, mitochondrial | 1.2.1.3 | 0.462 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.462 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.462 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.461 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.461 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.461 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.461 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.461 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.461 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.460 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.460 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.460 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.459 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.459 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2ard | FDA | Flavin-dependent tryptophan halogenase PrnA | 1.14.19.9 | 0.459 | |
| 2b4y | APR | NAD-dependent protein deacylase sirtuin-5, mitochondrial | / | 0.459 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.459 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.459 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.458 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.458 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.458 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.458 | |
| 2wes | FAD | Tryptophan 5-halogenase | / | 0.458 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.458 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.458 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.457 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.457 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.457 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.457 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.457 | |
| 2yvj | NAI | Ferredoxin reductase | / | 0.457 | |
| 3w8f | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 5a3b | APR | SIR2 family protein | / | 0.457 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.456 | |
| 1bof | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.456 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.456 | |
| 1q1w | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.456 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.456 | |
| 1vbn | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.456 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.456 | |
| 3bbr | BHY | Glutamate receptor 2 | / | 0.456 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.456 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2dsg | SAH | Diphthine synthase | / | 0.455 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.455 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.455 | |
| 4wji | NAP | Putative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase | / | 0.455 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.455 | |
| 5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.455 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.454 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 1u1i | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.454 | |
| 2gr1 | FAD | Ferredoxin reductase | / | 0.454 | |
| 2gtb | AZP | Orf1ab polyprotein | / | 0.454 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.454 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.454 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.454 | |
| 3ilt | TRU | Glutamate receptor 2 | / | 0.454 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.454 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.454 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.454 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2dki | FAD | 3-hydroxybenzoate 4-monooxygenase | 1.14.13.23 | 0.453 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.453 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.453 | |
| 3q70 | RIT | Candidapepsin-2 | 3.4.23.24 | 0.453 | |
| 3r3s | NAD | Putative oxidoreductase | / | 0.453 | |
| 4btj | ATP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.453 | |
| 4goj | GNP | ADP-ribosylation factor-like protein 3 | / | 0.453 | |
| 4jwf | SAH | tRNA (guanine(9)-N1)-methyltransferase | / | 0.453 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.453 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.453 | |
| 4xd1 | T3Q | Qdtf | / | 0.453 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.453 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.452 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.452 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.452 | |
| 3cge | FAD | Coenzyme A disulfide reductase | / | 0.452 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3w23 | 3RO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.452 | |
| 4cvl | ACP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.452 | |
| 4gap | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.452 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.452 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.451 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.451 | |
| 2emu | SAH | Diphthine synthase | / | 0.451 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 3nlc | FAD | Uncharacterized protein | / | 0.451 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.451 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.451 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.450 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.450 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.450 | |
| 3iwj | NAD | Aminoaldehyde dehydrogenase | / | 0.450 | |
| 3kbz | 2T4 | Fructose-1,6-bisphosphatase 1 | 3.1.3.11 | 0.450 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.450 | |
| 3w3o | ROE | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.450 | |
| 3wds | NAD | NADH-dependent quinuclidinone reductase | / | 0.450 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.450 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.450 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.450 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.449 | |
| 1nht | PGS | Adenylosuccinate synthetase | / | 0.449 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.449 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1rx4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.449 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.449 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.449 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.449 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.449 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.449 | |
| 4uir | FAD | Oleate hydratase | 4.2.1.53 | 0.449 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.448 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1m76 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.448 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.448 | |
| 2dsh | SAH | Diphthine synthase | / | 0.448 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.448 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.448 | |
| 2zzc | FAD | Thioredoxin reductase 1, cytoplasmic | 1.8.1.9 | 0.448 | |
| 3d8x | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.448 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.448 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.448 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.448 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.448 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.448 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.448 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.448 | |
| 4rqu | NAD | Alcohol dehydrogenase class-P | / | 0.448 | |
| 4xbo | SAH | tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ | 2.1.1.200 | 0.448 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.448 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.447 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.447 | |
| 1qyv | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.447 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.447 | |
| 2hut | SAH | Diphthine synthase | / | 0.447 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.447 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.447 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 4iac | ACP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 4xgx | ADP | FAD:protein FMN transferase | / | 0.447 | |
| 1f0y | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.446 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.446 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.446 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.446 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.446 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.446 | |
| 2p5c | SAH | Diphthine synthase | / | 0.446 | |
| 2qir | COA | Aminoglycoside 6-N-acetyltransferase type Ib11 | / | 0.446 | |
| 2r9z | FAD | Glutathione amide reductase | / | 0.446 | |
| 2rab | FAD | Glutathione amide reductase | / | 0.446 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.446 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.446 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.446 | |
| 4f97 | VDO | Putative glycosyltransferase | / | 0.446 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.446 | |
| 1flm | FMN | FMN-binding protein | / | 0.445 | |
| 1gqt | ACP | Ribokinase | / | 0.445 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 2egs | SAH | Diphthine synthase | / | 0.445 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.445 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.445 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.445 | |
| 3pju | C2E | Diguanylate cyclase/phosphodiesterase | / | 0.445 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.445 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.445 | |
| 4xzm | NAP | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.445 | |
| 4ysj | ADP | Calmodulin-like domain protein kinase | / | 0.445 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA2 | 3.6.3 | 0.445 | |
| 4zir | ANP | Energy-coupling factor transporter ATP-binding protein EcfA1 | / | 0.445 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1bdb | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | / | 0.444 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.444 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 1nff | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.444 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.444 | |
| 2dgn | DOI | Adenylosuccinate synthetase isozyme 1 | / | 0.444 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.444 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.444 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.444 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.444 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 3lpg | Z78 | Beta-glucuronidase | 3.2.1.31 | 0.444 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.444 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.444 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.444 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.443 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 1szj | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.443 | |
| 1t2a | NDP | GDP-mannose 4,6 dehydratase | 4.2.1.47 | 0.443 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.443 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2uyi | ADP | Kinesin-like protein KIF11 | / | 0.443 | |
| 2xpv | MIY | Tetracycline repressor protein class D | / | 0.443 | |
| 3a6q | FMN | FMN-binding protein | / | 0.443 | |
| 3cgd | FAD | Coenzyme A disulfide reductase | / | 0.443 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.443 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.443 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.443 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3ppo | DCK | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.443 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.443 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4k6m | SAH | Genome polyprotein | / | 0.443 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4l4x | NDP | AmphI | / | 0.443 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.443 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.443 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.443 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.443 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.442 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.442 | |
| 1x7d | NAD | Putative ornithine cyclodeaminase | / | 0.442 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.442 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.442 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.442 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 2v3a | FAD | Rubredoxin-NAD(+) reductase | 1.18.1.1 | 0.442 | |
| 2xrl | DXT | Tetracycline repressor protein class D | / | 0.442 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.442 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.442 | |
| 3eld | SFG | Methyltransferase | / | 0.442 | |
| 3fg2 | FAD | Putative rubredoxin reductase | / | 0.442 | |
| 3geg | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.442 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.442 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.442 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.442 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.442 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.442 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.442 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4qxp | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1dss | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.441 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.441 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.441 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.441 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 1zrc | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.441 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.441 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.441 | |
| 2gd6 | ACO | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.441 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.441 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.441 | |
| 3dgh | FAD | Thioredoxin reductase 1, mitochondrial | 1.8.1.9 | 0.441 | |
| 3dzv | ADP | Hydroxyethylthiazole kinase | / | 0.441 | |
| 3elu | SAM | Methyltransferase | / | 0.441 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 3s87 | ADP | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.441 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.441 | |
| 4gkm | 683 | Anthranilate phosphoribosyltransferase | / | 0.441 | |
| 4hmx | FMN | Pyridoxamine 5'-phosphate oxidase | / | 0.441 | |
| 4nvk | 2NY | Peroxidase | / | 0.441 | |
| 4tvb | NAD | Homospermidine synthase | 2.5.1.44 | 0.441 | |
| 4udr | FAD | 5-(hydroxymethyl)furfural oxidase | / | 0.441 | |
| 4yer | ADP | Antibiotic ABC transporter, ATP-binding protein, putative | / | 0.441 | |
| 4ykg | FAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.441 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.441 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.441 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.441 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.440 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.440 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.440 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.440 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.440 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.440 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.440 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.440 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.440 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.440 | |
| 3r1r | ATP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.440 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.440 | |
| 4elh | 53I | Dihydrofolate reductase | / | 0.440 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.440 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.440 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.440 | |
| 4qed | NAP | ElxO | / | 0.440 | |
| 4u2t | FAD | Cholesterol oxidase | 1.1.3.6 | 0.440 | |
| 5cyo | GDP | Septin-9 | / | 0.440 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.440 |