sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.826 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.816 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.806 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.802 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.789 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.780 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.779 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.773 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.760 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.749 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.747 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.746 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.745 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.744 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.737 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.729 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.727 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.726 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.725 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.724 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.709 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.708 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.707 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.705 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.698 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.698 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.695 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.691 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.687 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.685 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.685 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.679 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.676 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.674 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.653 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.647 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.644 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.638 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.635 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.602 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.602 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.590 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.584 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.580 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.578 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.578 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.565 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.559 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.555 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.554 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.552 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.550 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.549 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.548 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.537 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.532 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.529 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.523 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.515 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.506 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.503 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.499 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.496 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.494 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.493 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.488 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.488 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.487 | |
| 1gw2 | FER | Peroxidase C1A | 1.11.1.7 | 0.483 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.480 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.480 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.478 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.477 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.476 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.476 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.476 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.475 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4iae | 1DX | Alr2278 protein | / | 0.475 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.474 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.474 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.474 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.474 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.473 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.472 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 4iah | 1DX | Alr2278 protein | / | 0.471 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.469 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.469 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.469 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.469 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.468 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.468 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.468 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.467 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.466 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.466 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.465 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.465 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.464 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.464 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.464 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.464 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.463 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.463 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.463 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.463 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.462 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.462 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.462 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.462 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.462 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.461 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.461 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 4n1g | CEI | Obelin | / | 0.461 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.461 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.459 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.459 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.459 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.459 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.459 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.459 | |
| 4jic | FMN | GTN Reductase | / | 0.459 | |
| 4rel | KMP | Glycosyltransferase | / | 0.459 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.458 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.457 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.457 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.457 | |
| 4js1 | CTN | Beta-galactoside alpha-2,6-sialyltransferase 1 | 2.4.99.1 | 0.457 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.457 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.457 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.456 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3eku | CY9 | Actin-5C | / | 0.456 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.456 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.455 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.455 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.455 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.455 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.455 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.454 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.454 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.454 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.454 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.454 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.454 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.454 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.453 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.453 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.453 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.453 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.453 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.453 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.452 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.452 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.452 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.452 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.452 | |
| 1kw0 | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.451 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.451 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.451 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.451 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.451 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.450 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.450 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.450 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.450 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.450 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.450 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4ca8 | 3ES | Angiotensin-converting enzyme | 3.4.15.1 | 0.450 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.450 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.449 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.449 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.449 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.449 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.448 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.448 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.448 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.448 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.448 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.448 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.448 | |
| 4hn1 | TYD | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.448 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.447 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.447 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 2cv2 | GSU | Glutamate--tRNA ligase | 6.1.1.17 | 0.447 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.447 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.447 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.447 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.447 | |
| 3c1o | NAP | Eugenol synthase | / | 0.447 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.447 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.447 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.446 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.446 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.446 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.446 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.446 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.446 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 3ld6 | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.446 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.446 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.446 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.446 | |
| 1e81 | M91 | Endothiapepsin | 3.4.23.22 | 0.445 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.445 | |
| 1xzq | FON | tRNA modification GTPase MnmE | 3.6.5 | 0.445 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.445 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 3kmx | G00 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.445 | |
| 4j7h | TRH | PCZA361.3 | / | 0.445 | |
| 4jv3 | N32 | Beta-ketoacyl synthase | / | 0.445 | |
| 4pzs | ACO | Histone acetyltransferase p300 | / | 0.445 | |
| 4xrb | NDP | Possible bifunctional enzyme riboflavin biosynthesis protein RibD: diaminohydroxyphosphoribosylaminopyrimidine deaminase (Riboflavin-specific deaminase) + 5-amino-6-(5-phosphoribosylamino)uracil reduc | / | 0.445 | |
| 4yp6 | NAP | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.445 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.445 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.444 | |
| 3e39 | FMN | Nitroreductase | / | 0.444 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.444 | |
| 4loc | BTN | Pyruvate carboxylase | / | 0.444 | |
| 5er0 | FAD | Uncharacterized NAD(FAD)-dependent dehydrogenase | / | 0.444 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.443 | |
| 1zdw | FLV | Prenyltransferase | / | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.443 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.443 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.443 | |
| 3eks | CY9 | Actin-5C | / | 0.443 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.443 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.443 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.443 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.442 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.442 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.442 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.442 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.442 | |
| 4rtb | SAM | Putative thiazole biosynthesis protein ThiH | / | 0.442 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.442 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.441 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.441 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1q6i | FK5 | FKBP-type peptidyl-prolyl cis-trans isomerase FkpA | 5.2.1.8 | 0.441 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.441 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.441 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.441 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.441 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.441 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.441 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.441 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.440 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.440 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.440 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.440 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.440 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.440 | |
| 3ck7 | ACX | Starch-binding protein SusD | / | 0.440 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.440 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.440 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.440 | |
| 3w3l | RX8 | Toll-like receptor 8 | / | 0.440 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 |