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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3pjcPJCTyrosine-protein kinase JAK32.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3pjcPJCTyrosine-protein kinase JAK32.7.10.21.000
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.548
4hvh19RTyrosine-protein kinase JAK32.7.10.20.539
2i0ePDSProtein kinase C beta type2.7.11.130.535
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.529
4e4m0NHTyrosine-protein kinase JAK2/0.527
3iw4LW4Protein kinase C alpha type2.7.11.130.526
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.526
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.525
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.523
4gmy0X5Tyrosine-protein kinase JAK2/0.523
2ittAEEEpidermal growth factor receptor2.7.10.10.521
4c02TAKActivin receptor type-12.7.11.300.520
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.519
2jedLG8Protein kinase C theta type2.7.11.130.518
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.518
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.514
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.513
4jq8KJ8Epidermal growth factor receptor2.7.10.10.513
2itpAEEEpidermal growth factor receptor2.7.10.10.512
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.512
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.510
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.509
4jq7KJQEpidermal growth factor receptor2.7.10.10.509
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.509
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.508
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.507
4bchT7ZCyclin-dependent kinase 92.7.11.220.506
1f17NAIHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.501
3zep1NXTyrosine-protein kinase JAK32.7.10.20.501
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.500
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.500
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.499
4dymIYZActivin receptor type-12.7.11.300.499
4jrvKJVEpidermal growth factor receptor2.7.10.10.499
4hvg19QTyrosine-protein kinase JAK32.7.10.20.498
4hvi19STyrosine-protein kinase JAK32.7.10.20.498
3e5aVX6Aurora kinase A2.7.11.10.497
4qms1N1Serine/threonine-protein kinase 242.7.11.10.497
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.496
2y6o1N1Ephrin type-A receptor 42.7.10.10.496
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.495
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.495
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.495
5e8wSTUTGF-beta receptor type-12.7.11.300.494
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.493
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.493
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.493
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.492
3zze6XPHepatocyte growth factor receptor2.7.10.10.492
2vd5BI8Myotonin-protein kinase2.7.11.10.491
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.491
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.491
4gg70J8Hepatocyte growth factor receptor2.7.10.10.491
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.490
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.489
4jr3KJREpidermal growth factor receptor2.7.10.10.489
4othDRNSerine/threonine-protein kinase N1/0.489
2pzpACPFibroblast growth factor receptor 2/0.488
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.488
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.487
2yn8STUEphrin type-B receptor 42.7.10.10.487
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.487
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.487
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.487
4fnyI3KALK tyrosine kinase receptor2.7.10.10.487
4l9q9TPSerum albumin/0.487
4nka2K7Fibroblast growth factor receptor 1/0.487
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.486
2ev9NAPShikimate dehydrogenase (NADP(+))/0.486
2qo9ANPEphrin type-A receptor 32.7.10.10.486
4i22IREEpidermal growth factor receptor2.7.10.10.486
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.485
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.485
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.484
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.484
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.484
4f700STCyclin-dependent kinase 82.7.11.220.484
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.483
2vwx7X4Ephrin type-B receptor 42.7.10.10.483
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.483
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.483
4bgg844Activin receptor type-12.7.11.300.483
4gk2L66Ephrin type-A receptor 32.7.10.10.483
4kugNAD3-hydroxybutyryl-CoA dehydrogenase/0.483
4oztP1AEcdysone receptor, putative/0.483
3l0lHC3Nuclear receptor ROR-gamma/0.482
2itqITQEpidermal growth factor receptor2.7.10.10.481
3zh8C58Protein kinase C iota type2.7.11.130.481
2of2547Tyrosine-protein kinase Lck2.7.10.20.480
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.480
4jia1K3Tyrosine-protein kinase JAK2/0.480
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.479
2pz5ACPFibroblast growth factor receptor 2/0.479
3uyt0CKCasein kinase I isoform delta2.7.11.10.479
4k9oTPPBenzoylformate decarboxylase4.1.1.70.479
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.478
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.478
2wkmPFYHepatocyte growth factor receptor2.7.10.10.478
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.478
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.478
4qmzB49Serine/threonine-protein kinase 242.7.11.10.478
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.477
3l8p0CEAngiopoietin-1 receptor2.7.10.10.477
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.477
1ykdCMPAdenylate cyclase/0.476
2itnANPEpidermal growth factor receptor2.7.10.10.476
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.476
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.476
3qf9NM8Serine/threonine-protein kinase pim-12.7.11.10.476
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.476
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.476
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.475
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.475
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.475
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.475
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.475
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.475
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.475
2ojg19AMitogen-activated protein kinase 12.7.11.240.474
2wotZZGTGF-beta receptor type-12.7.11.300.474
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.474
3gwfFADCyclohexanone monooxygenase/0.474
3mdvCL6Cholesterol 24-hydroxylase/0.474
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.474
3vo30KFVascular endothelial growth factor receptor 22.7.10.10.474
1bygSTUTyrosine-protein kinase CSK/0.473
1kzjCB3Thymidylate synthase/0.473
1xddAAYIntegrin alpha-L/0.473
2py3ACPFibroblast growth factor receptor 2/0.473
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.473
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.472
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.472
3tucFPWTyrosine-protein kinase SYK2.7.10.20.472
4b99R4LMitogen-activated protein kinase 72.7.11.240.472
4wboANWRhodopsin kinase/0.472
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.471
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.471
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.471
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.471
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.471
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.471
1py5PY1TGF-beta receptor type-12.7.11.300.470
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.470
3idsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.470
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.470
3s1dZIRCytokinin dehydrogenase 11.5.99.120.470
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.469
1vjy460TGF-beta receptor type-12.7.11.300.469
1x8lOXRRetinol dehydratase/0.469
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.469
3w32W32Epidermal growth factor receptor2.7.10.10.469
4fod0UVALK tyrosine kinase receptor2.7.10.10.469
4gg50J3Hepatocyte growth factor receptor2.7.10.10.469
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.469
6cp4CAMCamphor 5-monooxygenase1.14.15.10.469
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.468
2po7CHDFerrochelatase, mitochondrial4.99.1.10.468
2zjwREFCasein kinase II subunit alpha2.7.11.10.468
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.468
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.468
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.468
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.468
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.468
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
3c50ADPRhodopsin kinase/0.467
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.467
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.467
4f650S9Fibroblast growth factor receptor 1/0.467
4hjoAQ4Epidermal growth factor receptor2.7.10.10.467
4j97ACPFibroblast growth factor receptor 2/0.467
2x1nX1NCyclin-dependent kinase 22.7.11.220.466
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.466
3iqzH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.466
3mtlFEFCyclin-dependent kinase 162.7.11.220.466
1rw8580TGF-beta receptor type-12.7.11.300.465
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.465
2ftoCB3Thymidylate synthase/0.465
3dt1P40Mitogen-activated protein kinase 14/0.465
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.465
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.465
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.465
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.465
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.464
2pwlACPFibroblast growth factor receptor 2/0.464
3fln3FNMitogen-activated protein kinase 14/0.464
3t2zFADSulfide-quinone reductase/0.464
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.464
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.464
4l8u9AZSerum albumin/0.464
4nks2M2Fibroblast growth factor receptor 1/0.464
1di8DTQCyclin-dependent kinase 22.7.11.220.463
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.463
3oom507Activin receptor type-12.7.11.300.463
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.463
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.463
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.463
1lp4ANPCasein kinase II subunit alpha2.7.11.10.462
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.462
1m17AQ4Epidermal growth factor receptor2.7.10.10.462
1oi9N20Cyclin-dependent kinase 22.7.11.220.462
1yvj4STTyrosine-protein kinase JAK32.7.10.20.462
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.462
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.462
2v7a627Tyrosine-protein kinase ABL12.7.10.20.462
2wxvWXVCyclin-dependent kinase 22.7.11.220.462
3blrCPBCyclin-dependent kinase 92.7.11.220.462
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.462
4grb0XGCasein kinase II subunit alpha2.7.11.10.462
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.462
5auuLU2Death-associated protein kinase 12.7.11.10.462
1aj22PHDihydropteroate synthase/0.461
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.461
2xikJ60Serine/threonine-protein kinase 252.7.11.10.461
3a4pDFQHepatocyte growth factor receptor2.7.10.10.461
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.461
3vf9477Tyrosine-protein kinase SYK2.7.10.20.461
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.461
4g160VMCasein kinase I isoform gamma-32.7.11.10.461
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.461
4oavACP2-5A-dependent ribonuclease3.1.260.461
1dz8CAMCamphor 5-monooxygenase1.14.15.10.460
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.460
1yrdCAMCamphor 5-monooxygenase1.14.15.10.460
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.460
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.460
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.460
3ttjJBIMitogen-activated protein kinase 102.7.11.240.460
4c62XWWTyrosine-protein kinase JAK2/0.460
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.460
4hni16WCasein kinase I isoform epsilon2.7.11.10.460
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.460
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.460
1zrzBI1Protein kinase C iota type2.7.11.130.459
2pvnP63Casein kinase II subunit alpha2.7.11.10.459
2vwy7X5Ephrin type-B receptor 42.7.10.10.459
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.459
2yxuATPPyridoxal kinase2.7.1.350.459
3vjoANPEpidermal growth factor receptor2.7.10.10.459
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.459
1cbfSAHCobalt-precorrin-4 C(11)-methyltransferase2.1.1.2710.458
1t85CAMCamphor 5-monooxygenase1.14.15.10.458
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.458
2vbpVB1Isopenicillin N synthase1.21.3.10.458
3ac2KSETyrosine-protein kinase Lck2.7.10.20.458
3dcv55ESerine/threonine-protein kinase pim-12.7.11.10.458
3hl0NADMaleylacetate reductase/0.458
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.458
4lopSB4Mitogen-activated protein kinase 14/0.458
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.458
4wkqIREEpidermal growth factor receptor2.7.10.10.458
2fhnBNIAvidin-related protein 4/5/0.457
2hcdBIVVitamin D3 receptor A/0.457
2io6330Wee1-like protein kinase2.7.10.20.457
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2ym8YM8Serine/threonine-protein kinase Chk12.7.11.10.457
2zb45OPProstaglandin reductase 21.3.1.480.457
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3phjDHKShikimate dehydrogenase (NADP(+))/0.457
4bfxZVXPantothenate kinase2.7.1.330.457
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.457
4ix6ADPUncharacterized protein/0.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
4l4fCAMCamphor 5-monooxygenase1.14.15.10.457
4pleCPSNuclear receptor subfamily 5 group A member 2/0.457
1bdlIM1Gag-Pol polyprotein3.4.23.160.456
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
2feuCAMCamphor 5-monooxygenase1.14.15.10.456
2hk9NAPShikimate dehydrogenase (NADP(+))/0.456
2hw2RFPRifampin ADP-ribosyl transferase/0.456
2vx07X7Ephrin type-B receptor 42.7.10.10.456
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.456
3cgcCOACoenzyme A disulfide reductase/0.456
3iok1P6Tyrosine-protein kinase JAK2/0.456
3iqeH4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.456
3ljtLA3A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.456
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.456
3p8jFMNPentaerythritol tetranitrate reductase/0.456
3poz03PEpidermal growth factor receptor2.7.10.10.456
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.456
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.456
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.456
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.456
4kb81QOCasein kinase I isoform delta2.7.11.10.456
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.456
5dp2NAPCurF/0.456
5e8xSTUTGF-beta receptor type-12.7.11.300.456
2j4z626Aurora kinase A2.7.11.10.455
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.455
2y3rTIRTamL/0.455
3a783EVVitamin D3 receptor/0.455
3ac1KZITyrosine-protein kinase Lck2.7.10.20.455
3bgxMEFThymidylate synthase/0.455
3p84FMNPentaerythritol tetranitrate reductase/0.455
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.455
4aotGW8Serine/threonine-protein kinase 102.7.11.10.455
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.455
4ix4ADPUncharacterized protein/0.455
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.455
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.455
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.454
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.454
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.454
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.454
2z97CAMCamphor 5-monooxygenase1.14.15.10.454
3biz61EWee1-like protein kinase2.7.10.20.454
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.454
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.454
3zkuHCVIsopenicillin N synthase1.21.3.10.454
4aa5NQBMitogen-activated protein kinase 14/0.454
4c61LMMTyrosine-protein kinase JAK2/0.454
4g2fC07Ephrin type-A receptor 32.7.10.10.454
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.454
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.454
4qmpDKISerine/threonine-protein kinase 242.7.11.10.454
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.454
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.453
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
2ghlLIBMitogen-activated protein kinase 14/0.453
2j0j4STFocal adhesion kinase 12.7.10.20.453
2ovhAS0Progesterone receptor/0.453
2vx17X8Ephrin type-B receptor 42.7.10.10.453
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.453
2zybKSLTyrosine-protein kinase Lck2.7.10.20.453
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.453
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.453
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.453
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.453
3w33W19Epidermal growth factor receptor2.7.10.10.453
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.453
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.453
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.453
4g48PZBMycocyclosin synthase1.14.21.90.453
4gh5NADShort-chain dehydrogenase/reductase SDR/0.453
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.453
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.453
4u7wNDPMxaA/0.453
4uyaAGSMitogen-activated protein kinase kinase kinase 212.7.11.250.453
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
1fmjRTLRetinol dehydratase/0.452
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
1o76CAMCamphor 5-monooxygenase1.14.15.10.452
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.452
2a1oCAMCamphor 5-monooxygenase1.14.15.10.452
2izrBRKCasein kinase I isoform gamma-32.7.11.10.452
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.452
2uzlC94Cyclin-dependent kinase 22.7.11.220.452
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.452
2ze2T27Gag-Pol polyprotein2.7.7.490.452
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.452
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.452
3ggfGVDSerine/threonine-protein kinase 26/0.452
3hmm855TGF-beta receptor type-12.7.11.300.452
3ielU5PRibonuclease TTHA02523.10.452
3nmpPYVAbscisic acid receptor PYL2/0.452
3qlsNDPDihydrofolate reductase1.5.1.30.452
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.452
4e2bFMNDehydrogenase/0.452
4ic7ANPMitogen-activated protein kinase 72.7.11.240.452
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.452
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.452
4ktkKTKCytochrome P450/0.452
4looSB4Mitogen-activated protein kinase 14/0.452
1f4eTPRThymidylate synthase/0.451
1gih1PUCyclin-dependent kinase 22.7.11.220.451
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1nooCAHCamphor 5-monooxygenase1.14.15.10.451
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.451
1xkkFMMEpidermal growth factor receptor2.7.10.10.451
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.451
2hk51BMTyrosine-protein kinase HCK2.7.10.20.451
2of4979Tyrosine-protein kinase Lck2.7.10.20.451
2pmnK51Protein kinase 7/0.451
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.451
3l63CAMCamphor 5-monooxygenase1.14.15.10.451
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.451
3w2sW2REpidermal growth factor receptor2.7.10.10.451
4fob0USALK tyrosine kinase receptor2.7.10.10.451
4jlj1NMDeoxycytidine kinase2.7.1.740.451
4wqmFADToluene-4-monooxygenase electron transfer component1.18.1.30.451
1i58ACPChemotaxis protein CheA2.7.13.30.450
1pjcNADAlanine dehydrogenase/0.450
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.450
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.450
2fgiPD1Fibroblast growth factor receptor 1/0.450
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.450
3nglNAPBifunctional protein FolD/0.450
4dc0NDPPutative ketoacyl reductase1.3.10.450
4knzCB3Thymidylate synthase/0.450
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
1jpaANPEphrin type-B receptor 22.7.10.10.449
1ouk084Mitogen-activated protein kinase 14/0.449
2acxANPG protein-coupled receptor kinase 62.7.11.160.449
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.449
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.449
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.449
2rhrEMOPutative ketoacyl reductase1.3.10.449
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.449
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.449
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.449
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.449
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.449
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.449
3fklFKLMitogen-activated protein kinase 14/0.449
3flyFLYMitogen-activated protein kinase 14/0.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.449
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.449
4mwhATPCasein kinase II subunit alpha2.7.11.10.449
4prvADPDNA gyrase subunit B/0.449
1aq1STUCyclin-dependent kinase 22.7.11.220.448
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1eioGCHGastrotropin/0.448
1g63FMNEpidermin decarboxylase4.1.10.448
1oiyN41Cyclin-dependent kinase 22.7.11.220.448
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.448
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.448
1tduDURThymidylate synthase/0.448
1u54ACPActivated CDC42 kinase 1/0.448
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.448
2ejzSAHDiphthine synthase/0.448
2hziJINTyrosine-protein kinase ABL12.7.10.20.448
2i40BLZCyclin-dependent kinase 22.7.11.220.448
2itvANPEpidermal growth factor receptor2.7.10.10.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.448
2vf0F89Thymidylate synthase/0.448
2x6dX6DAurora kinase A2.7.11.10.448
3hx4ANPCalmodulin-domain protein kinase 1/0.448
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.448
3vetADPnebramycin 5' synthase6.1.2.20.448
4bb432WEphrin type-B receptor 42.7.10.10.448
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.448
4gk4L90Ephrin type-A receptor 32.7.10.10.448
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.448
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4nc3ERM5-hydroxytryptamine receptor 2B/0.448
4nk92K5Fibroblast growth factor receptor 1/0.448
4uxxACPDiacylglycerol kinase2.7.1.1070.448
1dz4CAMCamphor 5-monooxygenase1.14.15.10.447
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
1k6pXN3Gag-Pol polyprotein3.4.23.160.447
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
1qrpHH0Pepsin A-43.4.23.10.447
1yw2PGJMitogen-activated protein kinase 14/0.447
1zemNADXylitol dehydrogenase/0.447
1zz2B11Mitogen-activated protein kinase 14/0.447
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.447
2o7pNAPRiboflavin biosynthesis protein RibD/0.447
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.447
2xa4AZ5Tyrosine-protein kinase JAK2/0.447
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.447
3bfb9ODPheromone-binding protein ASP1/0.447
3c1kT15Prothrombin3.4.21.50.447
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.447
3vrwYS5Vitamin D3 receptor/0.447
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.447
4b4vL34Bifunctional protein FolD/0.447
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.447
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.447
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.447
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.447
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4ktf1TMCytochrome P450/0.447
4loqSB4Mitogen-activated protein kinase 14/0.447
5cu6ATPCasein kinase II subunit alpha2.7.11.10.447
5cvhADPCasein kinase II subunit alpha2.7.11.10.447
1rfuADPPyridoxal kinase2.7.1.350.446
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.446
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.446
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.446
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.446
2gr1FADFerredoxin reductase/0.446
2j0m4STFocal adhesion kinase 12.7.10.20.446
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.446
3du8553Glycogen synthase kinase-3 beta2.7.11.260.446
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.446
3ujlA8SAbscisic acid receptor PYL2/0.446
3zkyWT4Isopenicillin N synthase1.21.3.10.446
4gu94GUFocal adhesion kinase 12.7.10.20.446
4tuvCPZCytochrome P450 1191.140.446
4twpAXITyrosine-protein kinase ABL12.7.10.20.446
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.445
1fm7DFVChalcone--flavonone isomerase 15.5.1.60.445
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.445
2zaxCAMCamphor 5-monooxygenase1.14.15.10.445
3bfa9ODOdorant binding protein ASP1/0.445
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.445
3ns2PYVAbscisic acid receptor PYL2/0.445
3nwxKVSGag-Pol polyprotein3.4.23.160.445
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.445
3vt7VDXVitamin D3 receptor/0.445
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4ckcSAHmRNA-capping enzyme catalytic subunit2.1.1.560.445
4ckrDI1Epithelial discoidin domain-containing receptor 12.7.10.10.445
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.445
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.445
4kl9NDPDihydrofolate reductase1.5.1.30.445
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.445
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.445
5k2bZMAAdenosine receptor A2a/0.445
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1klkPMDDihydrofolate reductase1.5.1.30.444
1w2xRCPAcetyl-CoA carboxylase/0.444
2bxmIMNSerum albumin/0.444
2hamC33Vitamin D3 receptor/0.444
2vmyFFOSerine hydroxymethyltransferase/0.444
2vwz7X6Ephrin type-B receptor 42.7.10.10.444
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.444
2zbaZBATrichothecene 3-O-acetyltransferase/0.444
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3da24MDCarbonic anhydrase 134.2.1.10.444
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3nww3NWMitogen-activated protein kinase 14/0.444
4a6nFADTetX family tetracycline inactivation enzyme/0.444
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4g2gTDHMycocyclosin synthase1.14.21.90.444
4jqeANPCasein kinase II subunit alpha2.7.11.10.444
4lfiGNPCasein kinase II subunit alpha2.7.11.10.444
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.444
4qmySTUSerine/threonine-protein kinase 242.7.11.10.444
1cjuFOKAdenylate cyclase type 2/0.443
1cjuFOKAdenylate cyclase type 5/0.443
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.443
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
1qiqACCIsopenicillin N synthase1.21.3.10.443
2c6eHPMAurora kinase A2.7.11.10.443
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.443
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.443
3a4vNADNDP-sugar epimerase/0.443
3a60STURibosomal protein S6 kinase beta-12.7.11.10.443
3au8NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.443
3be9P04Casein kinase II subunit alpha2.7.11.10.443
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.443
3c4xATPRhodopsin kinase/0.443
3clyACPFibroblast growth factor receptor 2/0.443
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.443
3iphG11Mitogen-activated protein kinase 14/0.443
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.443
3uxyNADShort-chain dehydrogenase/reductase SDR/0.443
3v3vMYUMitogen-activated protein kinase 82.7.11.240.443
4g1y0VOVitamin D3 receptor A/0.443
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.443
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.443
4iteTEYVitamin D3 receptor/0.443
4mihFADPyranose 2-oxidase1.1.3.100.443
4qysPLRTryptophan synthase beta chain 24.2.1.200.443
5aaaVGHALK tyrosine kinase receptor2.7.10.10.443
5drdATPAurora kinase A2.7.11.10.443
1dkfBMSRetinoic acid receptor alpha/0.442
1ojtFADDihydrolipoyl dehydrogenase/0.442
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.442
1zx1CB1Ribosyldihydronicotinamide dehydrogenase [quinone]/0.442
2chlDKICasein kinase I isoform gamma-32.7.11.10.442
2hqpNDPDihydrofolate reductase1.5.1.30.442
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.442
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.442
2q61SF1Peroxisome proliferator-activated receptor gamma/0.442
2zlaVDBVitamin D3 receptor/0.442
3c14FOKAdenylate cyclase type 2/0.442
3c14FOKAdenylate cyclase type 5/0.442
3emg685Tyrosine-protein kinase SYK2.7.10.20.442
3iqfE4MF420-dependent methylenetetrahydromethanopterin dehydrogenase1.5.98.10.442
3up3XCAaceDAF-12/0.442
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.442
3vt45YIVitamin D3 receptor/0.442
3zoiM2WIsopenicillin N synthase1.21.3.10.442
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.442
4f630S7Fibroblast growth factor receptor 1/0.442
4ia1BIVVitamin D3 receptor A/0.442
4kwi1TJReductase homolog/0.442
4l4eCAMCamphor 5-monooxygenase1.14.15.10.442
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.442
4qnaX11Serine/threonine-protein kinase 242.7.11.10.442
4xgxADPFAD:protein FMN transferase/0.442
5eccNAPDehydrofolate reductase type I/0.442
7catNDPCatalase1.11.1.60.442
1crbRTLRetinol-binding protein 1/0.441
1f28UMPThymidylate synthase2.1.1.450.441
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.441
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1rfvADPPyridoxal kinase2.7.1.350.441
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.441
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.441
2bhhRYUCyclin-dependent kinase 22.7.11.220.441
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.441
2ejvNADL-threonine 3-dehydrogenase/0.441
2gs7ANPEpidermal growth factor receptor2.7.10.10.441
2ignFADPyranose 2-oxidase/0.441
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
2q9fC3SCholesterol 24-hydroxylase/0.441
2vwu7X1Ephrin type-B receptor 42.7.10.10.441
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.441
2znpK55Peroxisome proliferator-activated receptor delta/0.441
3arvSAUChitinase A/0.441
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.441
3gc8B45Mitogen-activated protein kinase 112.7.11.240.441
3gggNADPrephenate dehydrogenase/0.441
3l8sBFFMitogen-activated protein kinase 14/0.441
3nj0PYVAbscisic acid receptor PYL2/0.441
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
3rdqDTBStreptavidin/0.441
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.441
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.441
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4gub0Y4Casein kinase II subunit alpha2.7.11.10.441
4guvFADTetX family tetracycline inactivation enzyme/0.441
4ia7BIVVitamin D3 receptor A/0.441
4jlk1NODeoxycytidine kinase2.7.1.740.441
4kba1QMCasein kinase I isoform delta2.7.11.10.441
4zohFADPutative oxidoreductase FAD-binding subunit/0.441
1dduDDUThymidylate synthase/0.440
1p0pBCHCholinesterase3.1.1.80.440
1t2cNAIL-lactate dehydrogenase1.1.1.270.440
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2bbqPFGThymidylate synthase/0.440
2harOCCVitamin D3 receptor/0.440
2j9lATPH(+)/Cl(-) exchange transporter 5/0.440
2r43G3GGag-Pol polyprotein3.4.23.160.440
2xyuQ9GEphrin type-A receptor 42.7.10.10.440
3a1nNADNDP-sugar epimerase/0.440
3cppCAMCamphor 5-monooxygenase1.14.15.10.440
3ddqRRCCyclin-dependent kinase 22.7.11.220.440
3fwfCAMCamphor 5-monooxygenase1.14.15.10.440
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.440
3i6qNDPPutative leucoanthocyanidin reductase 1/0.440
3jynNDPQuinone oxidoreductase/0.440
3lqfNADGalactitol dehydrogenase/0.440
3p7nFMNLight-activated DNA-binding protein EL222/0.440
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
3sx2NADUncharacterized protein/0.440
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.440
4appN53Serine/threonine-protein kinase PAK 42.7.11.10.440
4c58824Cyclin-G-associated kinase2.7.11.10.440
4ead0NPThymidine phosphorylase2.4.2.40.440
4gevCB3Thymidylate synthase/0.440
4ie5MD6Alpha-ketoglutarate-dependent dioxygenase FTO/0.440
4ipw1G7Mycocyclosin synthase1.14.21.90.440
4ktl1CQCytochrome P450/0.440
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.440
4oaeCLMUncharacterized protein/0.440
4pd6URINucleoside permease/0.440
4qo9627Serine/threonine-protein kinase 242.7.11.10.440
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.440
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.440