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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdq47DAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
2pdq47DAldose reductase1.1.1.211.000
2pdfZSTAldose reductase1.1.1.210.744
2pdu393Aldose reductase1.1.1.210.739
1ieiZESAldose reductase1.1.1.210.644
2dv0ZSTAldose reductase1.1.1.210.639
3t423T4Aldose reductase1.1.1.210.634
1us0LDTAldose reductase1.1.1.210.631
2duxZSTAldose reductase1.1.1.210.623
1pwlBFIAldose reductase1.1.1.210.622
3ghrLDTAldose reductase1.1.1.210.622
3ghsLDTAldose reductase1.1.1.210.622
3lboLDTAldose reductase1.1.1.210.621
3lz5LDTAldose reductase1.1.1.210.620
2pdn47DAldose reductase1.1.1.210.615
3ghtLDTAldose reductase1.1.1.210.614
3lqlLDTAldose reductase1.1.1.210.614
4gca2X9Aldose reductase1.1.1.210.612
2i16LDTAldose reductase1.1.1.210.610
1t40ID5Aldose reductase1.1.1.210.606
3ghuLDTAldose reductase1.1.1.210.604
2fz9ZSTAldose reductase1.1.1.210.603
2iki388Aldose reductase1.1.1.210.603
2i17LDTAldose reductase1.1.1.210.602
1z8962PAldose reductase1.1.1.210.600
1z3n3NAAldose reductase1.1.1.210.599
2hvoZSTAldose reductase1.1.1.210.597
2qxwLDTAldose reductase1.1.1.210.595
3mb9ZSTAldose reductase1.1.1.210.594
2ikj393Aldose reductase1.1.1.210.593
3m4h388Aldose reductase1.1.1.210.591
2pdc393Aldose reductase1.1.1.210.589
2pzn393Aldose reductase1.1.1.210.589
3ld5LDTAldose reductase1.1.1.210.588
3m64393Aldose reductase1.1.1.210.588
2hv5ZSTAldose reductase1.1.1.210.587
3g5eQ74Aldose reductase1.1.1.210.587
2duzZSTAldose reductase1.1.1.210.584
2pdh47DAldose reductase1.1.1.210.578
2pdxZSTAldose reductase1.1.1.210.576
2pdlTOLAldose reductase1.1.1.210.570
4yu153NAldose reductase1.1.1.210.570
1frbZSTAldose reductase-related protein 2/0.569
2fz8ZSTAldose reductase1.1.1.210.569
3lenZSTAldose reductase1.1.1.210.568
2pdg47DAldose reductase1.1.1.210.567
2fzbTOLAldose reductase1.1.1.210.565
2pdj393Aldose reductase1.1.1.210.559
2pdbZSTAldose reductase1.1.1.210.558
1t41ID5Aldose reductase1.1.1.210.557
2fzdTOLAldose reductase1.1.1.210.555
2pd5ZSTAldose reductase1.1.1.210.542
3mc5393Aldose reductase1.1.1.210.537
1ah3TOLAldose reductase1.1.1.210.535
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.529
5liu388Aldo-keto reductase family 1 member B101.1.10.529
2agtFIDAldose reductase1.1.1.210.528
1el3I84Aldose reductase1.1.1.210.526
2pdp393Aldose reductase1.1.1.210.523
2ikhLITAldose reductase1.1.1.210.522
4wevSUZAldo-keto reductase family 1 member B101.1.10.514
1rxjBNIStreptavidin/0.513
3v94WYQPhosphodiesterase/0.506
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.505
2pdwFIDAldose reductase1.1.1.210.505
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.504
2nvcITAAldose reductase1.1.1.210.501
1ekoI84Aldose reductase1.1.1.210.495
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.495
4phlPILPhosphodiesterase/0.495
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.493
3vo2FADFerredoxin--NADP reductase/0.492
1h42FADFerredoxin--NADP reductase1.18.1.20.491
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.491
2vrjNCWBeta-glucosidase A3.2.1.210.491
2zsbADPPantothenate kinase2.7.1.330.491
4i5xFLFAldo-keto reductase family 1 member B101.1.10.491
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.490
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.489
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.489
1ah0SBIAldose reductase1.1.1.210.488
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.488
3v35NTIAldose reductase1.1.1.210.488
2xufTZ4Acetylcholinesterase3.1.1.70.487
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.487
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.487
1adsNAPAldose reductase1.1.1.210.484
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.484
4dbw511Aldo-keto reductase family 1 member C3/0.484
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.483
4u163C0Muscarinic acetylcholine receptor M3/0.483
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
1queFADFerredoxin--NADP reductase1.18.1.20.481
2f2kTGGAldose reductase1.1.1.210.481
3af4GCPPantothenate kinase2.7.1.330.481
3uweVJJAldo-keto reductase family 1 member C3/0.481
2cbqTH2Neocarzinostatin/0.480
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.480
1ogjFADFerredoxin--NADP reductase1.18.1.20.479
2iqdLPAAldose reductase1.1.1.210.479
1s36CEIObelin/0.478
1sm4FADFerredoxin--NADP reductase/0.478
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.478
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
1gjrFADFerredoxin--NADP reductase1.18.1.20.477
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.477
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.477
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.477
4stdBFSScytalone dehydratase4.2.1.940.477
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.476
3zc3FADFerredoxin--NADP reductase1.18.1.20.476
1e62FADFerredoxin--NADP reductase1.18.1.20.475
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.475
2cekN8TAcetylcholinesterase3.1.1.70.475
1esmCOAPantothenate kinase2.7.1.330.474
1yw7A41Methionine aminopeptidase 2/0.474
3vjkM51Dipeptidyl peptidase 4/0.474
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.474
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.474
1qtiGNTAcetylcholinesterase3.1.1.70.473
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.473
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.473
2inzOHPAldose reductase1.1.1.210.473
2xupTZ5Acetylcholinesterase3.1.1.70.473
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.473
3b9gIMHIAG-nucleoside hydrolase/0.473
4j7hTRHPCZA361.3/0.473
1tkcM6TTransketolase 12.2.1.10.472
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.472
2geuCOKPantothenate kinase2.7.1.330.472
3dz7O8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.472
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.472
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.472
1bjkFADFerredoxin--NADP reductase1.18.1.20.471
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1acjTHAAcetylcholinesterase3.1.1.70.470
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.470
2gg0U11Methionine aminopeptidase/0.470
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.470
4bfxZVXPantothenate kinase2.7.1.330.470
5cxv0HKMuscarinic acetylcholine receptor M1/0.470
1dx6GNTAcetylcholinesterase3.1.1.70.469
2vt4P32Beta-1 adrenergic receptor/0.469
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.469
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.469
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
3r8hZOMAldo-keto reductase family 1 member C3/0.469
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.469
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.469
4u95MIYMultidrug efflux pump subunit AcrB/0.469
2aot2PMHistamine N-methyltransferase2.1.1.80.468
3cv6HXSAldo-keto reductase family 1 member C21/0.468
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
2bjsACVIsopenicillin N synthase1.21.3.10.467
2xi4AFTAcetylcholinesterase3.1.1.70.467
2y1x845Histone-arginine methyltransferase CARM1/0.467
4fam0SZAldo-keto reductase family 1 member C3/0.467
5dsg0HKMuscarinic acetylcholine receptor M4/0.467
1gpnHUBAcetylcholinesterase3.1.1.70.466
1u65CP0Acetylcholinesterase3.1.1.70.466
2c1zU2FAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.466
3h7rNAPAldo-keto reductase family 4 member C8/0.466
3nu03TUDihydrofolate reductase1.5.1.30.466
4ga8SBIAldo-keto reductase family 1 member B101.1.10.466
4n3l2FNProthrombin3.4.21.50.466
1lnmDTXBilin-binding protein/0.465
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2c2bSAMThreonine synthase 1, chloroplastic4.2.3.10.465
2gmvUN8Phosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.465
2xuhTZ4Acetylcholinesterase3.1.1.70.465
3u2cSUZAldose reductase1.1.1.210.465
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.465
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.465
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.465
1h22E10Acetylcholinesterase3.1.1.70.464
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.464
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
2zevIPEGeranylgeranyl pyrophosphate synthase/0.464
1ihiIU5Aldo-keto reductase family 1 member C2/0.463
1kieAD3IAG-nucleoside hydrolase/0.463
1w87FADFerredoxin--NADP reductase1.18.1.20.463
2hzqSTRApolipoprotein D/0.463
3e4vFMNUncharacterized protein/0.463
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.463
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
4kn2LYAFolate receptor beta/0.463
1e63FADFerredoxin--NADP reductase1.18.1.20.462
1qv0CZHObelin/0.462
1s07PLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.462
2xujTZ5Acetylcholinesterase3.1.1.70.462
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.462
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.462
1gaqFADFerredoxin/0.461
1odnAPVIsopenicillin N synthase1.21.3.10.461
1pj6FOLDimethylglycine oxidase1.5.3.100.461
1xf0ASDAldo-keto reductase family 1 member C3/0.461
2pdyFIDAldose reductase1.1.1.210.461
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4kn104JFolate receptor beta/0.461
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.461
1gm8SOXPenicillin G acylase3.5.1.110.460
2bd0BIOSepiapterin reductase/0.460
3p2vDOYAldose reductase1.1.1.210.460
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.460
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.460
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.460
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.460
4jpg1OXPyruvate kinase PKM2.7.1.400.460
4kfjFOLDihydrofolate reductase1.5.1.30.460
5a4wQCTGlutathione S-transferase F22.5.1.180.460
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.459
1w4lGL8Acetylcholinesterase3.1.1.70.459
1zgcA2EAcetylcholinesterase3.1.1.70.459
2rqfJH3Hemolymph juvenile hormone binding protein/0.459
2wmdZZ0NmrA-like family domain-containing protein 1/0.459
3af2ACPPantothenate kinase2.7.1.330.459
3t0kDCQSulfide-quinone reductase/0.459
4ey7E20Acetylcholinesterase3.1.1.70.459
4mrxCZHObelin/0.459
2f3815MAldo-keto reductase family 1 member C3/0.458
2w6cBM4Acetylcholinesterase3.1.1.70.458
3af3GCPPantothenate kinase2.7.1.330.458
3zj7C1KStrictosidine-O-beta-D-glucosidase3.2.1.1050.458
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4dbuBT9Aldo-keto reductase family 1 member C3/0.458
4jtqFLPAldo-keto reductase family 1 member C2/0.458
1vp5NAPOxidoreductase, aldo/keto reductase family/0.457
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
2getCOKPantothenate kinase2.7.1.330.457
2y1w849Histone-arginine methyltransferase CARM1/0.457
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
3zv7NHGAcetylcholinesterase3.1.1.70.457
4daj0HKMuscarinic acetylcholine receptor M3/0.457
1e66HUXAcetylcholinesterase3.1.1.70.456
1qgzFADFerredoxin--NADP reductase1.18.1.20.456
2qx7NAPEugenol synthase 11.1.1.3180.456
2zsaADPPantothenate kinase2.7.1.330.456
3biz61EWee1-like protein kinase2.7.10.20.456
3dz6M8ES-adenosylmethionine decarboxylase proenzyme4.1.1.500.456
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.456
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4xo7ASDAldo-keto reductase family 1 member C2/0.456
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
1votHUPAcetylcholinesterase3.1.1.70.455
1z5uCMPClass B acid phosphatase/0.455
2f59INI6,7-dimethyl-8-ribityllumazine synthase 1/0.455
2hxzH7JCathepsin S3.4.22.270.455
2pf8NDPAldose reductase1.1.1.210.455
4a7yNHFAldos-2-ulose dehydratase/0.455
4jtrIZPAldo-keto reductase family 1 member C2/0.455
4n3r2GUTankyrase-12.4.2.300.455
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.454
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.454
1ogiFADFerredoxin--NADP reductase1.18.1.20.454
1yw8A75Methionine aminopeptidase 2/0.454
2d06ESTSulfotransferase 1A12.8.2.10.454
3bw4FMNPutative 2-nitropropane dioxygenase/0.454
3bxoUPPdTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose/0.454
4bfsZVSPantothenate kinase2.7.1.330.454
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.454
4e0u0MVCyclic dipeptide N-prenyltransferase/0.454
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4li61XOTankyrase-12.4.2.300.454
4pnmNU1Tankyrase-22.4.2.300.454
2y0468HBeta-1 adrenergic receptor/0.454
1go2FADFerredoxin--NADP reductase1.18.1.20.453
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
2rc6FADFerredoxin--NADP reductase/0.453
3k31NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.453
3r43ID8Aldo-keto reductase family 1 member C3/0.453
4hmn16JAldo-keto reductase family 1 member C3/0.453
1ry8RUTAldo-keto reductase family 1 member C3/0.452
1zq5E04Aldo-keto reductase family 1 member C3/0.452
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.452
2evmFC2Methionine aminopeptidase/0.452
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.452
2zsdCOAPantothenate kinase2.7.1.330.452
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.452
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.452
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.452
4bfwZVWPantothenate kinase2.7.1.330.452
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.452
4kmzFOLFolate receptor beta/0.452
4u140HKMuscarinic acetylcholine receptor M3/0.452
1yw9A84Methionine aminopeptidase 2/0.451
2ct8MSPMethionine--tRNA ligase6.1.1.100.451
4bjcRPBTankyrase-22.4.2.300.451
4bprFADFerredoxin--NADP reductase1.18.1.20.451
4jq2SUZAldo-keto reductase family 1 member C2/0.451
5epeSAHUncharacterized protein/0.451
1gt5BZQOdorant-binding protein/0.450
1mabADPATP synthase subunit beta, mitochondrial3.6.3.140.450
1ni4TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
1ni4TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.450
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.450
2pdiZSTAldose reductase1.1.1.210.450
2zozETTranscriptional regulator/0.450
3burTES3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3o76GTBGlutathione S-transferase P 12.5.1.180.450
4jq4IMNAldo-keto reductase family 1 member C2/0.450
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
1pj7FFODimethylglycine oxidase1.5.3.100.449
2ch2KY1Serine--pyruvate aminotransferase/0.449
2r86ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase/0.449
3aezGDPPantothenate kinase2.7.1.330.449
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.449
4lrhFOLFolate receptor alpha/0.449
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
1a26CNAPoly [ADP-ribose] polymerase 12.4.2.300.448
1el4CTZObelin/0.448
1mrqSTRAldo-keto reductase family 1 member C1/0.448
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.448
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.448
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.448
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.448
2is72CLAldose reductase1.1.1.210.448
2vczVC3Hematopoietic prostaglandin D synthase/0.448
3f3y4OABile salt sulfotransferase2.8.2.140.448
5cc9DDFDihydrofolate reductase1.5.1.30.448
1fwyUD1Bifunctional protein GlmU/0.447
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.447
2ea4F79Methionine aminopeptidase 2/0.447
2x1lADNMethionine--tRNA ligase/0.447
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.447
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.447
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.447
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
5cmx0G6Prothrombin3.4.21.50.447
2ycxP32Beta-1 adrenergic receptor/0.447
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.446
1gawFADFerredoxin/0.446
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.446
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1zgbA1EAcetylcholinesterase3.1.1.70.446
2w3mFOLDihydrofolate reductase1.5.1.30.446
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3c1kT15Prothrombin3.4.21.50.446
3dr7GPDGDP-perosamine synthase/0.446
3g5iDNBPyrimidine-specific ribonucleoside hydrolase RihA/0.446
3hggCHDCmeR/0.446
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3szfDCQSulfide-quinone reductase/0.446
4dbs0HVAldo-keto reductase family 1 member C3/0.446
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.446
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.446
4mt92D6Tankyrase-12.4.2.300.446
1eveE20Acetylcholinesterase3.1.1.70.445
1p0pBCHCholinesterase3.1.1.80.445
1pwmFIDAldose reductase1.1.1.210.445
1uhhCZPAequorin-2/0.445
1w6jR71Lanosterol synthase5.4.99.70.445
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.445
2ga2A19Methionine aminopeptidase 2/0.445
2gmsP0PPutative pyridoxamine 5-phosphate-dependent dehydrase/0.445
2pdmZSTAldose reductase1.1.1.210.445
2pucGUNHTH-type transcriptional repressor PurR/0.445
2vdyHCYCorticosteroid-binding globulin/0.445
3c1oNAPEugenol synthase/0.445
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3fsjD7KBenzoylformate decarboxylase4.1.1.70.445
3lzzGDPUncharacterized protein/0.445
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3zhoFMNNAD(P)H dehydrogenase (quinone)/0.445
5a4vQUEGlutathione S-transferase F22.5.1.180.445
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
1odcA8BAcetylcholinesterase3.1.1.70.444
1tfz8694-hydroxyphenylpyruvate dioxygenase1.13.11.270.444
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.444
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
2z2w770Wee1-like protein kinase2.7.10.20.444
3cr0809Wee1-like protein kinase2.7.10.20.444
3eszFMNFlavodoxin/0.444
3h0wN8MS-adenosylmethionine decarboxylase proenzyme4.1.1.500.444
4a7zAY9Aldos-2-ulose dehydratase/0.444
4jtpASCRibosome inactivating protein/0.444
4wbdADPPutative cysteine ligase BshC/0.444
5c1gGDUHisto-blood group ABO system transferase/0.444
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.443
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.443
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1vfsDCSAlanine racemase/0.443
2b82ADNClass B acid phosphatase3.1.3.20.443
2gpvOHTEstrogen-related receptor gamma/0.443
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2qjpANJCytochrome b/0.443
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3epxIMQIAG-nucleoside hydrolase/0.443
3ghvGHCDihydrofolate reductase1.5.1.30.443
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.443
3ntqNADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.443
3p9tTCLRepressor/0.443
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.443
4arbC57Acetylcholinesterase3.1.1.70.443
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.443
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4c717RD3-oxoacyl-ACP synthase/0.443
4es5MGTPolymerase basic protein 2/0.443
4kn0MTXFolate receptor beta/0.443
1bh5GTXLactoylglutathione lyase4.4.1.50.442
1rsgFADPolyamine oxidase FMS1/0.442
1t7o152Carnitine O-acetyltransferase2.3.1.70.442
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.442
2aovC2MHistamine N-methyltransferase2.1.1.80.442
2gg2U12Methionine aminopeptidase/0.442
2ipw2CLAldose reductase1.1.1.210.442
3c27DKKProthrombin3.4.21.50.442
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3fx4FX4Alcohol dehydrogenase [NADP(+)]1.1.1.20.442
3ihzFK5Peptidylprolyl isomerase/0.442
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3qftFADNADPH--cytochrome P450 reductase/0.442
3ug8IMNAldo-keto reductase family 1 member C3/0.442
4n9qFMNFMN-dependent NADH-azoreductase 1/0.442
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.441
1m2xMCOMetallo-beta-lactamase type 2/0.441
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.441
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.441
1t5bFMNFMN-dependent NADH-azoreductase/0.441
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.441
2bxmIMNSerum albumin/0.441
2gywOBIAcetylcholinesterase3.1.1.70.441
2hejNDPAldo-keto reductase family 1 member C211.1.10.441
2xugTZ4Acetylcholinesterase3.1.1.70.441
3dziRGTADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.441
3ho9N3A3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.441
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
3vf60H6Glucokinase2.7.1.20.441
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4ey6GNTAcetylcholinesterase3.1.1.70.441
4fllYZ6Methionine aminopeptidase 1/0.441
4jhiEMUNodulin-13/0.441
4nhyPD2Prolyl 3-hydroxylase OGFOD11.14.110.441
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.441
5fljQUEQuercetinase QueD/0.441
1dibL34C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.440
1s9dAFBCytohesin-2/0.440
1s9dAFBADP-ribosylation factor 1/0.440
1sjwNGVNogalonic acid methyl ester cyclase/0.440
1x1cSAHC-20 methyltransferase/0.440
2io6330Wee1-like protein kinase2.7.10.20.440
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.440
2ok8FADFerredoxin--NADP reductase, apicoplast/0.440
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2vz0D64Pteridine reductase/0.440
2w3aTOPDihydrofolate reductase1.5.1.30.440
2xuoTZ4Acetylcholinesterase3.1.1.70.440
2xuqTZ4Acetylcholinesterase3.1.1.70.440
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.440
3gx9TXDMorphinone reductase/0.440
3h3qH13Collagen type IV alpha-3-binding protein/0.440
3qgi33FGenome polyprotein2.7.7.480.440
3voiRCBGlucanase/0.440
3zdnFADMonoamine oxidase N1.4.3.40.440
4j7gTRHPCZA361.3/0.440
4twnB96Ephrin type-A receptor 32.7.10.10.440
5fd8A5APutative carboxypeptidase yocD/0.440
3d4sTIMBeta-2 adrenergic receptor/0.440