Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
2pdq | 47D | Aldose reductase | 1.1.1.21 |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
2pdq | 47D | Aldose reductase | 1.1.1.21 | 1.000 | |
2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.744 | |
2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.739 | |
1iei | ZES | Aldose reductase | 1.1.1.21 | 0.644 | |
2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.639 | |
3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.634 | |
1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.631 | |
2dux | ZST | Aldose reductase | 1.1.1.21 | 0.623 | |
1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.622 | |
3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.622 | |
3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.622 | |
3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.621 | |
3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.620 | |
2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.615 | |
3ght | LDT | Aldose reductase | 1.1.1.21 | 0.614 | |
3lql | LDT | Aldose reductase | 1.1.1.21 | 0.614 | |
4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.612 | |
2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.610 | |
1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.606 | |
3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.604 | |
2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
2iki | 388 | Aldose reductase | 1.1.1.21 | 0.603 | |
2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.602 | |
1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.600 | |
1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.599 | |
2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.597 | |
2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.595 | |
3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.594 | |
2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.593 | |
3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.591 | |
2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.589 | |
2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.589 | |
3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.588 | |
3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.588 | |
2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.587 | |
3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.587 | |
2duz | ZST | Aldose reductase | 1.1.1.21 | 0.584 | |
2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.578 | |
2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.576 | |
2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.570 | |
4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.570 | |
1frb | ZST | Aldose reductase-related protein 2 | / | 0.569 | |
2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.569 | |
3len | ZST | Aldose reductase | 1.1.1.21 | 0.568 | |
2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.567 | |
2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.565 | |
2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.559 | |
2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.558 | |
1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.557 | |
2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.555 | |
2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.542 | |
3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.537 | |
1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.535 | |
1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.529 | |
5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.529 | |
2agt | FID | Aldose reductase | 1.1.1.21 | 0.528 | |
1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.526 | |
2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.523 | |
2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.522 | |
4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.514 | |
1rxj | BNI | Streptavidin | / | 0.513 | |
3v94 | WYQ | Phosphodiesterase | / | 0.506 | |
1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.505 | |
2pdw | FID | Aldose reductase | 1.1.1.21 | 0.505 | |
1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.504 | |
2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.501 | |
1eko | I84 | Aldose reductase | 1.1.1.21 | 0.495 | |
4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
4phl | PIL | Phosphodiesterase | / | 0.495 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.493 | |
3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.492 | |
1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.491 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.491 | |
2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.491 | |
2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.491 | |
4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.491 | |
1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.490 | |
1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.489 | |
4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.489 | |
1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.488 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.488 | |
2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
1ads | NAP | Aldose reductase | 1.1.1.21 | 0.484 | |
1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.484 | |
1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.483 | |
4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.483 | |
3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.481 | |
2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.481 | |
3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.481 | |
3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.481 | |
2cbq | TH2 | Neocarzinostatin | / | 0.480 | |
3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.480 | |
1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.479 | |
2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.479 | |
1s36 | CEI | Obelin | / | 0.478 | |
1sm4 | FAD | Ferredoxin--NADP reductase | / | 0.478 | |
3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.478 | |
3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.477 | |
1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.477 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.477 | |
4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.477 | |
1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.476 | |
1e62 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.475 | |
1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.475 | |
2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.474 | |
1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.474 | |
3vjk | M51 | Dipeptidyl peptidase 4 | / | 0.474 | |
3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.474 | |
4lcn | GNG | Cytidine and deoxycytidylate deaminase zinc-binding region | / | 0.474 | |
1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.473 | |
2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.473 | |
2inz | OHP | Aldose reductase | 1.1.1.21 | 0.473 | |
2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.473 | |
3b9g | IMH | IAG-nucleoside hydrolase | / | 0.473 | |
4j7h | TRH | PCZA361.3 | / | 0.473 | |
1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.472 | |
1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.472 | |
2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.472 | |
3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.472 | |
4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.472 | |
4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
1bjk | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.471 | |
1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.470 | |
2gg0 | U11 | Methionine aminopeptidase | / | 0.470 | |
3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
4af6 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.470 | |
4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.470 | |
5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.470 | |
1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.469 | |
3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.469 | |
3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.469 | |
3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
4u95 | MIY | Multidrug efflux pump subunit AcrB | / | 0.469 | |
2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.468 | |
3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.468 | |
3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
2y1x | 845 | Histone-arginine methyltransferase CARM1 | / | 0.467 | |
4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.467 | |
1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.466 | |
3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.466 | |
3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.466 | |
4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.466 | |
1lnm | DTX | Bilin-binding protein | / | 0.465 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
2c2b | SAM | Threonine synthase 1, chloroplastic | 4.2.3.1 | 0.465 | |
2gmv | UN8 | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.465 | |
2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.465 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.465 | |
1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.464 | |
2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.464 | |
1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.463 | |
1kie | AD3 | IAG-nucleoside hydrolase | / | 0.463 | |
1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.463 | |
2hzq | STR | Apolipoprotein D | / | 0.463 | |
3e4v | FMN | Uncharacterized protein | / | 0.463 | |
3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.463 | |
4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
4kn2 | LYA | Folate receptor beta | / | 0.463 | |
1e63 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.462 | |
1qv0 | CZH | Obelin | / | 0.462 | |
1s07 | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.462 | |
2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.462 | |
4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.462 | |
1gaq | FAD | Ferredoxin | / | 0.461 | |
1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.461 | |
1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
2pdy | FID | Aldose reductase | 1.1.1.21 | 0.461 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
4kn1 | 04J | Folate receptor beta | / | 0.461 | |
4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
1gm8 | SOX | Penicillin G acylase | 3.5.1.11 | 0.460 | |
2bd0 | BIO | Sepiapterin reductase | / | 0.460 | |
3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.460 | |
3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.460 | |
3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.460 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.460 | |
4kfj | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.460 | |
1mlz | PLP | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.459 | |
1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.459 | |
2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.459 | |
3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.459 | |
3t0k | DCQ | Sulfide-quinone reductase | / | 0.459 | |
4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
4mrx | CZH | Obelin | / | 0.459 | |
2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.458 | |
3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.458 | |
4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
1vp5 | NAP | Oxidoreductase, aldo/keto reductase family | / | 0.457 | |
2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
2get | COK | Pantothenate kinase | 2.7.1.33 | 0.457 | |
2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.457 | |
3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.457 | |
1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
1qgz | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
2qx7 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.456 | |
2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.456 | |
3dz6 | M8E | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.456 | |
4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.456 | |
4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
1z5u | CMP | Class B acid phosphatase | / | 0.455 | |
2f59 | INI | 6,7-dimethyl-8-ribityllumazine synthase 1 | / | 0.455 | |
2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.455 | |
2pf8 | NDP | Aldose reductase | 1.1.1.21 | 0.455 | |
4a7y | NHF | Aldos-2-ulose dehydratase | / | 0.455 | |
4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.455 | |
4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.455 | |
1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.454 | |
1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.454 | |
1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.454 | |
1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.454 | |
2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.454 | |
3bw4 | FMN | Putative 2-nitropropane dioxygenase | / | 0.454 | |
3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.454 | |
4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.454 | |
4d2d | ALA_ALA_ALA | Di-or tripeptide:H+ symporter | / | 0.454 | |
4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.454 | |
4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.454 | |
4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.454 | |
2y04 | 68H | Beta-1 adrenergic receptor | / | 0.454 | |
1go2 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.453 | |
1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.453 | |
2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.453 | |
3k31 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
2evm | FC2 | Methionine aminopeptidase | / | 0.452 | |
2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.452 | |
2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.452 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.452 | |
3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.452 | |
3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.452 | |
4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.452 | |
4kmz | FOL | Folate receptor beta | / | 0.452 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.452 | |
1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.451 | |
2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.451 | |
4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.451 | |
4bpr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.451 | |
5epe | SAH | Uncharacterized protein | / | 0.451 | |
1gt5 | BZQ | Odorant-binding protein | / | 0.450 | |
1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.450 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.450 | |
1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.450 | |
2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.450 | |
2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.450 | |
2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.450 | |
2zoz | ET | Transcriptional regulator | / | 0.450 | |
3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.450 | |
4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.449 | |
2ch2 | KY1 | Serine--pyruvate aminotransferase | / | 0.449 | |
2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.449 | |
3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
4lrh | FOL | Folate receptor alpha | / | 0.449 | |
4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.449 | |
1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
1el4 | CTZ | Obelin | / | 0.448 | |
1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.448 | |
1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.448 | |
1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.448 | |
1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.448 | |
2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.448 | |
2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.448 | |
2vcz | VC3 | Hematopoietic prostaglandin D synthase | / | 0.448 | |
3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.448 | |
5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
1fwy | UD1 | Bifunctional protein GlmU | / | 0.447 | |
2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.447 | |
2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.447 | |
2x1l | ADN | Methionine--tRNA ligase | / | 0.447 | |
3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.447 | |
4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.447 | |
2ycx | P32 | Beta-1 adrenergic receptor | / | 0.447 | |
1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.446 | |
1gaw | FAD | Ferredoxin | / | 0.446 | |
1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.446 | |
1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
3c1k | T15 | Prothrombin | 3.4.21.5 | 0.446 | |
3dr7 | GPD | GDP-perosamine synthase | / | 0.446 | |
3g5i | DNB | Pyrimidine-specific ribonucleoside hydrolase RihA | / | 0.446 | |
3hgg | CHD | CmeR | / | 0.446 | |
3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
3szf | DCQ | Sulfide-quinone reductase | / | 0.446 | |
4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.446 | |
4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.446 | |
4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.446 | |
1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.445 | |
1pwm | FID | Aldose reductase | 1.1.1.21 | 0.445 | |
1uhh | CZP | Aequorin-2 | / | 0.445 | |
1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.445 | |
2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.445 | |
2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.445 | |
2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.445 | |
2puc | GUN | HTH-type transcriptional repressor PurR | / | 0.445 | |
2vdy | HCY | Corticosteroid-binding globulin | / | 0.445 | |
3c1o | NAP | Eugenol synthase | / | 0.445 | |
3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
3lzz | GDP | Uncharacterized protein | / | 0.445 | |
3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.445 | |
5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.445 | |
1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.444 | |
2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.444 | |
2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
3esz | FMN | Flavodoxin | / | 0.444 | |
3h0w | N8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.444 | |
4a7z | AY9 | Aldos-2-ulose dehydratase | / | 0.444 | |
4jtp | ASC | Ribosome inactivating protein | / | 0.444 | |
4wbd | ADP | Putative cysteine ligase BshC | / | 0.444 | |
5c1g | GDU | Histo-blood group ABO system transferase | / | 0.444 | |
1bx0 | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.443 | |
1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
1vfs | DCS | Alanine racemase | / | 0.443 | |
2b82 | ADN | Class B acid phosphatase | 3.1.3.2 | 0.443 | |
2gpv | OHT | Estrogen-related receptor gamma | / | 0.443 | |
2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
2qjp | ANJ | Cytochrome b | / | 0.443 | |
3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
3epx | IMQ | IAG-nucleoside hydrolase | / | 0.443 | |
3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
3ntq | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.443 | |
3p9t | TCL | Repressor | / | 0.443 | |
3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.443 | |
4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.443 | |
4es5 | MGT | Polymerase basic protein 2 | / | 0.443 | |
4kn0 | MTX | Folate receptor beta | / | 0.443 | |
1bh5 | GTX | Lactoylglutathione lyase | 4.4.1.5 | 0.442 | |
1rsg | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.442 | |
1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.442 | |
2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.442 | |
2gg2 | U12 | Methionine aminopeptidase | / | 0.442 | |
2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.442 | |
3c27 | DKK | Prothrombin | 3.4.21.5 | 0.442 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3fx4 | FX4 | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.442 | |
3ihz | FK5 | Peptidylprolyl isomerase | / | 0.442 | |
3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.442 | |
1fnb | FAD | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.441 | |
1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.441 | |
1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.441 | |
1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.441 | |
1t5b | FMN | FMN-dependent NADH-azoreductase | / | 0.441 | |
2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
2bxm | IMN | Serum albumin | / | 0.441 | |
2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
2hej | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.441 | |
2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
3dzi | RGT | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.441 | |
3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.441 | |
3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.441 | |
4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.441 | |
4jhi | EMU | Nodulin-13 | / | 0.441 | |
4nhy | PD2 | Prolyl 3-hydroxylase OGFOD1 | 1.14.11 | 0.441 | |
4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.441 | |
5flj | QUE | Quercetinase QueD | / | 0.441 | |
1dib | L34 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.440 | |
1s9d | AFB | Cytohesin-2 | / | 0.440 | |
1s9d | AFB | ADP-ribosylation factor 1 | / | 0.440 | |
1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.440 | |
1x1c | SAH | C-20 methyltransferase | / | 0.440 | |
2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.440 | |
2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.440 | |
2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
2vz0 | D64 | Pteridine reductase | / | 0.440 | |
2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
3gx9 | TXD | Morphinone reductase | / | 0.440 | |
3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.440 | |
3voi | RCB | Glucanase | / | 0.440 | |
3zdn | FAD | Monoamine oxidase N | 1.4.3.4 | 0.440 | |
4j7g | TRH | PCZA361.3 | / | 0.440 | |
4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.440 | |
5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.440 | |
3d4s | TIM | Beta-2 adrenergic receptor | / | 0.440 |