sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.773 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.752 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.751 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.745 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.741 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.738 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.736 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.731 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.727 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.726 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.724 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.721 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.720 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.714 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.714 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.711 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.707 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.701 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.698 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.697 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.697 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.696 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.696 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.696 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.691 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.690 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.688 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.683 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.682 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.678 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.673 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.672 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.671 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.666 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.665 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.663 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.662 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.661 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.661 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.660 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.656 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.650 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.646 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.645 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.640 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.637 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.634 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.633 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.631 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.622 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.619 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.608 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.601 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.599 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.599 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.593 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.583 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.575 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.566 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.564 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.559 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.555 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.555 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.552 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.542 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.535 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.527 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.517 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.514 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.506 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.505 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.504 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.499 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.497 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.496 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.494 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.489 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.489 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.485 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.485 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.482 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.481 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.480 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.480 | |
| 2uuo | LK3 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.480 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.480 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.480 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.479 | |
| 2wqp | WQP | Polysialic acid capsule biosynthesis protein SiaC | / | 0.479 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.479 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.475 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.475 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.474 | |
| 4iae | 1DX | Alr2278 protein | / | 0.474 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.473 | |
| 4n1g | CEI | Obelin | / | 0.473 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.472 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.472 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.472 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.471 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.471 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.471 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.470 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.470 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.470 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.470 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.469 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.469 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4e2b | FMN | Dehydrogenase | / | 0.469 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.468 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.468 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.468 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.468 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.468 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.468 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.467 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.467 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.467 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.467 | |
| 3iex | GMP | Purine nucleoside phosphorylase | / | 0.466 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.466 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.466 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.465 | |
| 4iah | 1DX | Alr2278 protein | / | 0.465 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.465 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.464 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.464 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.464 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.464 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.463 | |
| 3fr4 | F8A | Fatty acid-binding protein, adipocyte | / | 0.463 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.463 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.462 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.462 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.461 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.461 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.460 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.460 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.459 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.459 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.459 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.459 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.459 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.459 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.459 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.458 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.458 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3fr2 | 8CA | Fatty acid-binding protein, adipocyte | / | 0.458 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.458 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.458 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.458 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.457 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.457 | |
| 3e6y | CW1 | 14-3-3-like protein C | / | 0.457 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.457 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.457 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.457 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.456 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.456 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.456 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.456 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.455 | |
| 2e1z | B4P | Propionate kinase | / | 0.455 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.455 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.455 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.454 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.454 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.454 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.454 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.454 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4ise | 1FW | Glucokinase | 2.7.1.2 | 0.454 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.453 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.453 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.453 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.453 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.453 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 1dtp | APU | Diphtheria toxin | / | 0.452 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.452 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.452 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.452 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.451 | |
| 1obb | NAD | Alpha-glucosidase | 3.2.1.20 | 0.451 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.451 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.451 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.451 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.451 | |
| 4h9t | HL4 | Phosphotriesterase | / | 0.451 | |
| 4jic | FMN | GTN Reductase | / | 0.451 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.451 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.450 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.450 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.450 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.449 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.449 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.449 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.449 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.448 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.448 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.448 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.448 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.448 | |
| 1cq8 | PY6 | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.447 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.447 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.447 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.447 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.447 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.446 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.446 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.446 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.446 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.446 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.446 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.445 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.445 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.445 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.445 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.445 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.445 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.444 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.444 | |
| 2iml | FMN | Uncharacterized protein | / | 0.444 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.444 | |
| 2vut | NAD | Nitrogen metabolite repression protein nmrA | / | 0.444 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.444 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.444 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.444 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.443 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.443 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 2ofi | ADK | 3-methyladenine DNA glycosylase I | / | 0.443 | |
| 2uup | LK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.443 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.443 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.443 | |
| 5cho | FAD | Flavin reductase | / | 0.443 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.443 | |
| 1bxs | NAD | Retinal dehydrogenase 1 | 1.2.1.36 | 0.442 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.442 | |
| 1lgt | BP3 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.442 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.442 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 3smk | CW7 | 14-3-3 protein sigma | / | 0.442 | |
| 3vsx | R32 | Renin | 3.4.23.15 | 0.442 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.442 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.442 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.442 | |
| 4y17 | LAE | Transcriptional regulator of ftsQAZ gene cluster | / | 0.442 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.441 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1kfb | IGP | Tryptophan synthase alpha chain | / | 0.441 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.441 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.441 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.441 | |
| 2qc8 | ADP | Glutamine synthetase | 6.3.1.2 | 0.441 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.441 | |
| 3eej | 53R | Uncharacterized protein | / | 0.441 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.441 | |
| 4u0z | APC | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.441 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.440 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.440 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.440 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3rbq | GLY_ALA_GLY_ALA_DAO | Protein unc-119 homolog A | / | 0.440 | |
| 3v2u | ATP | Protein GAL3 | / | 0.440 | |
| 3zrc | L8B | Von Hippel-Lindau disease tumor suppressor | / | 0.440 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.440 | |
| 4nvk | 2NY | Peroxidase | / | 0.440 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.440 |