sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.848 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.846 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.839 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.831 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.828 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.828 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.828 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.820 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.820 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.811 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.805 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.804 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.803 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.802 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.800 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.797 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.794 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.790 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.782 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.777 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.775 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.771 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.769 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.765 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.765 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.764 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.762 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.761 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.760 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.759 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.759 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.754 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.754 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.751 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.750 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.750 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.749 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.748 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.746 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.745 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.744 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.742 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.740 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.739 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.738 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.731 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.727 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.726 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.722 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.719 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.716 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.716 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.715 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.712 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.710 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.706 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.703 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.702 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.700 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.696 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.694 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.692 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.691 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.686 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.685 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.684 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.681 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.678 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.675 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.672 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.672 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.669 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.668 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.667 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.666 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.659 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.657 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.655 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.652 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.651 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.650 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.648 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.643 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.642 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.641 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.639 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.632 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.630 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.625 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.613 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.602 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.594 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.586 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.585 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.580 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.578 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.577 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.576 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.570 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.560 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.556 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.556 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.552 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.551 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.550 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.543 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.528 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.527 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.523 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.522 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.517 | |
| 4iae | 1DX | Alr2278 protein | / | 0.503 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.500 | |
| 4iah | 1DX | Alr2278 protein | / | 0.498 | |
| 5fl4 | 9FK | Carbonic anhydrase 9 | 4.2.1.1 | 0.495 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.491 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.489 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.488 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.486 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.485 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.483 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.482 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.479 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.478 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.478 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.478 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.476 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.476 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.475 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.471 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.469 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.468 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.468 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.467 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.467 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.466 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.466 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.465 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.465 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.465 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.465 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.463 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.462 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.462 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.462 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.461 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.461 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.461 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.461 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.461 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.461 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.460 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.460 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.460 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.459 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.459 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 4j7h | TRH | PCZA361.3 | / | 0.459 | |
| 4wdg | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.459 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.458 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.458 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.457 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.457 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.457 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.456 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.456 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.456 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 2z3n | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.456 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.456 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.455 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.455 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.455 | |
| 2yj4 | ATP | Copper-transporting ATPase | / | 0.455 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.455 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.455 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.453 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.453 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.453 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.453 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.453 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.453 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 3p0e | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.453 | |
| 3qvp | FAD | Glucose oxidase | 1.1.3.4 | 0.453 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.452 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.452 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.452 | |
| 3b9x | NOS | Pyrimidine-specific ribonucleoside hydrolase RihB | 3.2.2.8 | 0.452 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 4n1g | CEI | Obelin | / | 0.452 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.451 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.451 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.451 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.451 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.451 | |
| 3tvq | DQH | Multifunctional cyclase-dehydratase-3-O-methyl transferase TcmN | 2.1.1 | 0.451 | |
| 4jic | FMN | GTN Reductase | / | 0.451 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.450 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3v2u | ATP | Protein GAL3 | / | 0.450 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.450 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.449 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.448 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.448 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.448 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.448 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.448 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4xr9 | NAD | CalS8 | / | 0.448 | |
| 4y1b | NAP | AntE | / | 0.448 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.447 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.447 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.447 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.446 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.446 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.446 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.446 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.446 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.445 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.445 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.445 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.445 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.445 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.444 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.444 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.444 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.444 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.444 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3bnk | FMN | Flavoredoxin | / | 0.444 | |
| 3hdq | GDU | UDP-galactopyranose mutase | / | 0.444 | |
| 3ioc | A5D | Pantothenate synthetase | 6.3.2.1 | 0.444 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.444 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.444 | |
| 1kap | GLY_SER_ASN_SER | Serralysin | 3.4.24.40 | 0.443 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.443 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.443 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.443 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.443 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4e32 | DWN | Methyltransferase | / | 0.443 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.443 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.443 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.443 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.442 | |
| 2a2s | GSN | Glutathione S-transferase P | 2.5.1.18 | 0.442 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.442 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.442 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.442 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.442 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.442 | |
| 4ein | NOH | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.442 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 1jf2 | CZH | Obelin | / | 0.441 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.441 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.441 | |
| 2dg4 | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.441 | |
| 2gqa | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.441 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.441 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.441 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.441 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.441 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.441 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.441 | |
| 4oi4 | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.441 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.441 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.441 | |
| 1bzm | MZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.440 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.440 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.440 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.440 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.440 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.440 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.440 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.440 | |
| 5doz | NDP | JamJ | / | 0.440 |