sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1n5s | ADL | ActVA 6 protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1n5s | ADL | ActVA 6 protein | / | 1.000 | |
| 1n5t | OAL | ActVA 6 protein | / | 0.821 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.631 | |
| 1n5v | NOM | ActVA 6 protein | / | 0.511 | |
| 3zy3 | GDP | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.511 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.501 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.500 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.492 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.490 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.490 | |
| 1n0h | CIE | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.489 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.488 | |
| 1ryw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.487 | |
| 2rl1 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.487 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.487 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.483 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.482 | |
| 2bxo | OPB | Serum albumin | / | 0.479 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.479 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.479 | |
| 4h03 | LAR | Actin, alpha skeletal muscle | / | 0.479 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.479 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.477 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.477 | |
| 5doz | NDP | JamJ | / | 0.477 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.476 | |
| 5iqh | GNP | Bifunctional AAC/APH | 2.3.1 | 0.476 | |
| 1i7l | ATP | Synapsin-2 | / | 0.475 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.475 | |
| 3swq | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.475 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.475 | |
| 3ceh | AVE | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.474 | |
| 3zy5 | GFB | GDP-fucose protein O-fucosyltransferase 1 | 2.4.1.221 | 0.474 | |
| 4nzo | ANP | Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 | / | 0.474 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.473 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.473 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.472 | |
| 2imk | GTX | AGAP009194-PA | / | 0.472 | |
| 4ifn | 12O | Kelch-like ECH-associated protein 1 | / | 0.472 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.472 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.471 | |
| 1t9a | 1TB | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.470 | |
| 1wkl | ATP | Nucleoside diphosphate kinase | / | 0.470 | |
| 2qf2 | GDP | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] | 4.1.1.32 | 0.470 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.470 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.470 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.470 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.469 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.469 | |
| 2ya3 | J7V | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.469 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.469 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.469 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.469 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.468 | |
| 3dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4eyb | 0WO | Metallo-beta-lactamase type 2 | / | 0.468 | |
| 4f48 | C2E | Uncharacterized protein | / | 0.468 | |
| 3bm4 | ADV | ADP-sugar pyrophosphatase | 3.6.1.13 | 0.467 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.467 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.466 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.466 | |
| 2vpy | MGD | Thiosulfate reductase | / | 0.466 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.466 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.465 | |
| 2fkn | NAD | Urocanate hydratase | 4.2.1.49 | 0.465 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.465 | |
| 4ovi | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.465 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.464 | |
| 1sep | BIO | Sepiapterin reductase | 1.1.1.153 | 0.464 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.464 | |
| 3te4 | ACO | Dopamine N-acetyltransferase | / | 0.464 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.463 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.463 | |
| 1qrt | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.463 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.463 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.463 | |
| 3nbz | GTP | GTP-binding nuclear protein Ran | / | 0.463 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.463 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.462 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 4bqu | CLR | Japanin | / | 0.462 | |
| 4hr2 | ADP | Nucleoside diphosphate kinase | / | 0.462 | |
| 5agy | GTB | Tau class glutathione S-transferase | / | 0.462 | |
| 5iw5 | NMN | NADH pyrophosphatase | / | 0.462 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.461 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.461 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.461 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 1ig1 | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.460 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.460 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.460 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.460 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.460 | |
| 4wct | FAD | Fructosyl amine:oxygen oxidoreductase | / | 0.460 | |
| 5a02 | NAP | Glucose-fructose oxidoreductase | / | 0.460 | |
| 5iqe | GNP | Bifunctional AAC/APH | 2.3.1 | 0.460 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.460 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.460 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.460 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2lbv | EB4 | Extracellular fatty acid-binding protein | / | 0.459 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.459 | |
| 3w0c | 6DS | Vitamin D3 receptor | / | 0.459 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.459 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.458 | |
| 1oyc | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.458 | |
| 1xh7 | R96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 2xpw | OTC | Tetracycline repressor protein class D | / | 0.458 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.458 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.457 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3kbo | NDP | Glyoxylate/hydroxypyruvate reductase A | / | 0.457 | |
| 4ejg | NCT | Cytochrome P450 2A13 | 1.14.14.1 | 0.457 | |
| 4fok | C2E | Uncharacterized protein | / | 0.457 | |
| 4kxj | P34 | Nucleoprotein | / | 0.457 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.457 | |
| 1q4x | G24 | Thyroid hormone receptor beta | / | 0.456 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.456 | |
| 2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.456 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.456 | |
| 4c1f | X8Z | Metallo-beta-lactamase type 2 | / | 0.456 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.456 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.456 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.455 | |
| 3wec | AUI | Cytochrome P450 | / | 0.455 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.455 | |
| 1cm0 | COA | Histone acetyltransferase KAT2B | 2.3.1.48 | 0.454 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2y8l | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.454 | |
| 4dw6 | 0MN | HTH-type transcriptional regulator EthR | / | 0.454 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.454 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1ppj | ANY | Cytochrome b | / | 0.453 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.453 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.453 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.453 | |
| 3jq3 | ADP | Lombricine kinase | / | 0.453 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.453 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.453 | |
| 4ewv | APC | 4-substituted benzoates-glutamate ligase GH3.12 | 6.3.2 | 0.453 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.453 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.453 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.453 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.452 | |
| 1fml | RTL | Retinol dehydratase | / | 0.452 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.452 | |
| 3e6e | DCS | Alanine racemase | / | 0.452 | |
| 3ue4 | DB8 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.452 | |
| 4co4 | ATP | Nitrogen regulatory protein P-II 1 | / | 0.452 | |
| 1tvr | TB9 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 1wc1 | TAT | Adenylate cyclase | / | 0.451 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.451 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.451 | |
| 2ym1 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.451 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.451 | |
| 3iss | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.451 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4cnz | ADP | Nitrogen regulatory protein P-II 1 | / | 0.451 | |
| 4eiq | KCT | Putative FAD-monooxygenase | / | 0.451 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.451 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.451 | |
| 4kxn | 6K6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.451 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.451 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.450 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.450 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 1svh | I08 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.450 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.450 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.450 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.450 | |
| 2yg5 | FAD | Putrescine oxidase | / | 0.450 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3dqr | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.450 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.450 | |
| 3lcm | FAD | Putative oxidoreductase | / | 0.450 | |
| 3w3z | GTP | GTP-binding nuclear protein Ran | / | 0.450 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.450 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.450 | |
| 4z0p | NDP | NAD-dependent dehydrogenase | / | 0.450 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.450 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.449 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.449 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.449 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.449 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.449 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.449 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.449 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.449 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.449 | |
| 4ceo | G0T | Integrase | / | 0.449 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.449 | |
| 4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 4rje | FNR | Lactate oxidase | / | 0.449 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1egc | CO8 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.448 | |
| 1klm | SPP | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2cdu | FAD | NADH oxidase | / | 0.448 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.448 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 3c1o | NAP | Eugenol synthase | / | 0.448 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.448 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.448 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.447 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.447 | |
| 1hpz | AAP | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.447 | |
| 1t9b | 1CS | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.447 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.447 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.447 | |
| 3iaa | TYD | CalG2 | / | 0.447 | |
| 3ix3 | OHN | Transcriptional activator protein LasR | / | 0.447 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.447 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.447 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.447 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.447 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.447 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.447 | |
| 5c7h | NDP | Putative oxidoreductase | / | 0.447 | |
| 1z0a | GDP | Ras-related protein Rab-2A | / | 0.446 | |
| 2cah | NDP | Catalase | 1.11.1.6 | 0.446 | |
| 2fgj | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.446 | |
| 2ilt | NN1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 2rc3 | NAD | CBS domain | / | 0.446 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.446 | |
| 3gts | D3M | DdmC | / | 0.446 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.446 | |
| 3r3f | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.446 | |
| 3up3 | XCA | aceDAF-12 | / | 0.446 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.446 | |
| 4cx3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.446 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.446 | |
| 4hl2 | ZZ7 | Metallo-beta-lactamase type 2 | / | 0.446 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.446 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.446 | |
| 5byl | GCP | Bifunctional AAC/APH | 2.3.1 | 0.446 | |
| 5dif | GNP | GTP-binding nuclear protein Ran | / | 0.446 | |
| 1nas | ASE | Sepiapterin reductase | 1.1.1.153 | 0.445 | |
| 1o1v | TCH | Gastrotropin | / | 0.445 | |
| 1r2j | FAD | FkbI | / | 0.445 | |
| 2bue | COA | AAC(6')-Ib | / | 0.445 | |
| 2j09 | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.445 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.445 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.445 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.445 | |
| 2xzw | ATP | Nitrogen regulatory protein P-II | / | 0.445 | |
| 3cvu | FAD | RE11660p | / | 0.445 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.445 | |
| 3lv1 | NAP | NAD(P)-dependent benzaldehyde dehydrogenase | 1.2.1.28 | 0.445 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.445 | |
| 3sjz | GNP | Translation initiation factor 2 subunit gamma | / | 0.445 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.445 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.445 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.445 | |
| 4q7h | GTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.445 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.445 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.445 | |
| 1swt | BTN | Streptavidin | / | 0.444 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.444 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.444 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.444 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.444 | |
| 2wd4 | TBV | Ascorbate peroxidase | / | 0.444 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3pit | GNP | Ras-related protein M-Ras | / | 0.444 | |
| 3tp0 | FO5 | HTH-type transcriptional regulator EthR | / | 0.444 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 4b66 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4bqy | FNT | Egl nine homolog 1 | / | 0.444 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.444 | |
| 4kq2 | U5P | Glycogen [starch] synthase isoform 2 | 2.4.1.11 | 0.444 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.444 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.444 | |
| 4zo3 | C6L | Acylhomoserine lactonase | / | 0.444 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.443 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.443 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.443 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.443 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.443 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.443 | |
| 3wo0 | ADP | Alanine--anticapsin ligase | / | 0.443 | |
| 3zm6 | 2GN | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.443 | |
| 4at9 | UTP | Interleukin enhancer-binding factor 2 | / | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.443 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.443 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.443 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.443 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.443 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.442 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.442 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.442 | |
| 2w71 | L23 | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 3hdy | FAD | UDP-galactopyranose mutase | / | 0.442 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3tl1 | JRO | Putative polyketide cyclase | / | 0.442 | |
| 4ng2 | OHN | Transcriptional activator protein LasR | / | 0.442 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.442 | |
| 4xwt | U5P | Ribonuclease J | / | 0.442 | |
| 5kf1 | COA | Predicted acetyltransferase | / | 0.442 | |
| 4ntj | AZJ | P2Y purinoceptor 12 | / | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1tl7 | ONM | Adenylate cyclase type 2 | / | 0.441 | |
| 1tl7 | ONM | Adenylate cyclase type 5 | / | 0.441 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.441 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.441 | |
| 2pak | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.441 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.441 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.441 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3e5h | GNP | Ras-related protein Rab-28 | / | 0.441 | |
| 3gb4 | D3M | DdmC | / | 0.441 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.441 | |
| 3sfi | 3SF | HTH-type transcriptional regulator EthR | / | 0.441 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4bva | T3 | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.441 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4ekk | ANP | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.441 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 4y9u | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 5a04 | NDP | Glucose-fructose oxidoreductase | / | 0.441 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.440 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.440 | |
| 1pnq | NDP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.440 | |
| 1t9c | 1SM | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.440 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.440 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.440 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.440 | |
| 2rgj | FAD | Flavin-containing monooxygenase | / | 0.440 | |
| 2uvy | GVI | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.440 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 3hub | 469 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.440 | |
| 4eqw | COA | Coenzyme A disulfide reductase | / | 0.440 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.440 | |
| 4n9w | GDP | Phosphatidyl-myo-inositol mannosyltransferase | 2.4.1.57 | 0.440 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.440 | |
| 4zbr | NPS | Serum albumin | / | 0.440 |