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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ech FAD Polyamine oxidase FMS1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4ech FADPolyamine oxidase FMS1 / 1.453
4gdp FADPolyamine oxidase FMS1 / 1.258
3bi2 FADPolyamine oxidase FMS1 / 1.240
1rsg FADPolyamine oxidase FMS1 / 1.209
3cnt FADPolyamine oxidase FMS1 / 1.200
3cn8 FADPolyamine oxidase FMS1 / 1.199
1yy5 FADPolyamine oxidase FMS1 / 1.141
4gut FADLysine-specific histone demethylase 1B 1 1.123
3cnd FADPolyamine oxidase FMS1 / 1.117
1z6l FADPolyamine oxidase FMS1 / 1.112
4gus FADLysine-specific histone demethylase 1B 1 1.099
2dw4 FADLysine-specific histone demethylase 1A 1 1.097
1h83 FADPolyamine oxidase 1.5.3.14 1.092
4fwf FADLysine-specific histone demethylase 1B 1 1.069
3bi5 FADPolyamine oxidase FMS1 / 1.067
2hko FADLysine-specific histone demethylase 1A 1 1.061
3kpf FADPolyamine oxidase 1.5.3.14 1.057
5l3d FADLysine-specific histone demethylase 1A 1 1.051
1xpq FADPolyamine oxidase FMS1 / 1.047
3k7m FAD6-hydroxy-L-nicotine oxidase / 1.047
2y48 FADLysine-specific histone demethylase 1A 1 1.037
4hsu FADLysine-specific histone demethylase 1B 1 1.034
2yg6 FADPutrescine oxidase / 1.024
4gur FADLysine-specific histone demethylase 1B 1 1.017
4fwe FADLysine-specific histone demethylase 1B 1 1.016
2iw5 FADLysine-specific histone demethylase 1A 1 1.012
2yg3 FADPutrescine oxidase / 1.012
4xbf FADLysine-specific histone demethylase 1A 1 0.999
2yg7 FADPutrescine oxidase / 0.996
3zdn FADMonoamine oxidase N 1.4.3.4 0.989
2yg4 FADPutrescine oxidase / 0.986
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.982
2e1m FADL-glutamate oxidase / 0.978
2uxx FAJLysine-specific histone demethylase 1A 1 0.977
4fwj FADLysine-specific histone demethylase 1B 1 0.975
2yg5 FADPutrescine oxidase / 0.967
1h81 FADPolyamine oxidase 1.5.3.14 0.963
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.962
4guu FA9Lysine-specific histone demethylase 1B 1 0.952
2jb1 FADL-amino acid oxidase / 0.927
2jb2 FADL-amino acid oxidase / 0.922
2vvl FADMonoamine oxidase N 1.4.3.4 0.903
2jae FADL-amino acid oxidase / 0.898
3kkj FADRenalase / 0.892
3we0 FADLysine 2-monooxygenase / 0.871
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.869
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.869
3qj4 FADRenalase / 0.866
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.864
4dsg FADUncharacterized protein / 0.857
2h94 FADLysine-specific histone demethylase 1A 1 0.849
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.849
4i58 FADCyclohexylamine Oxidase / 0.843
2q7v FADThioredoxin reductase / 0.841
2bab FADPutative aminooxidase / 0.836
3rha FDAPutrescine oxidase / 0.834
2iid FADL-amino-acid oxidase 1.4.3.2 0.833
4gcm FADThioredoxin reductase 1.8.1.9 0.812
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.810
3ad9 FADSubunit beta of sarcosine oxidase / 0.809
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.808
4mo2 FADUDP-galactopyranose mutase / 0.808
3cgc FADCoenzyme A disulfide reductase / 0.805
2b9x FADPutative aminooxidase / 0.802
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.801
3ukk FADUDP-galactopyranose mutase / 0.801
3ka7 FADPutative oxidoreductase / 0.797
4mih FADPyranose 2-oxidase 1.1.3.10 0.793
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.791
3he3 FADUDP-galactopyranose mutase / 0.791
4u8j FDAUDP-galactopyranose mutase / 0.790
4dsh FDAUncharacterized protein / 0.789
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.787
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.786
3cge FADCoenzyme A disulfide reductase / 0.785
2b9w FADPutative aminooxidase / 0.784
2bac FADPutative aminooxidase / 0.784
4wct FADFructosyl amine:oxygen oxidoreductase / 0.782
3cgb FADCoenzyme A disulfide reductase / 0.780
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.779
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.779
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.779
4z24 FADPutative GMC-type oxidoreductase R135 1 0.774
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.774
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.771
4ynt FDAGlucose oxidase, putative / 0.771
2b9y FADPutative aminooxidase / 0.770
4u8p FDAUDP-galactopyranose mutase / 0.770
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.764
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.763
3lov FADProtoporphyrinogen oxidase / 0.762
2ba9 FADPutative aminooxidase / 0.760
3nlc FADUncharacterized protein / 0.760
1f8s FADL-amino-acid oxidase 1.4.3.2 0.759
3t37 FADPyridoxine 4-oxidase / 0.758
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.756
4u8m FDAUDP-galactopyranose mutase / 0.756
3kve FADL-amino-acid oxidase / 0.751
3ukl FADUDP-galactopyranose mutase / 0.751
3r9u FADThioredoxin reductase / 0.750
1f8r FADL-amino-acid oxidase 1.4.3.2 0.746
1reo FADL-amino-acid oxidase 1.4.3.2 0.743
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.742
3pl8 FADPyranose 2-oxidase / 0.742
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.740
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.739
1f8w FADNADH peroxidase 1.11.1.1 0.738
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.737
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.736
1tdk FADL-amino-acid oxidase 1.4.3.2 0.736
3f8d FADNADH oxidase/thioredoxin reductase / 0.736
2ign FADPyranose 2-oxidase / 0.735
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.734
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.733
3lsh FADPyranose 2-oxidase / 0.732
4mo2 FDAUDP-galactopyranose mutase / 0.732
3k4c FADPyranose 2-oxidase / 0.731
3utf FDAUDP-galactopyranose mutase / 0.730
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.730
4nzh FADL-ornithine N(5)-monooxygenase / 0.730
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.729
4z26 FADPutative GMC-type oxidoreductase R135 1 0.729
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.727
2gr1 FADFerredoxin reductase / 0.727
1k0l FADp-hydroxybenzoate hydroxylase / 0.725
3q9t FAYUncharacterized protein / 0.725
1tdf FADThioredoxin reductase 1.8.1.9 0.722
2yvj FADFerredoxin reductase / 0.722
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
4opd FDAConserved Archaeal protein / 0.721
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.720
3hdy FDAUDP-galactopyranose mutase / 0.720
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.720
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.719
4u8i FDAUDP-galactopyranose mutase / 0.719
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.718
3icr FADCoenzyme A disulfide reductase / 0.718
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.717
1tde FADThioredoxin reductase 1.8.1.9 0.717
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.717
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.717
4rsl FADFructosyl peptide oxidase / 0.716
3ukk FDAUDP-galactopyranose mutase / 0.715
4x9m FADUncharacterized protein MG039 homolog / 0.715
2npx FADNADH peroxidase 1.11.1.1 0.713
3uka FADUDP-galactopyranose mutase / 0.713
4opc FDAConserved Archaeal protein / 0.713
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.713
3gsi FADDimethylglycine oxidase 1.5.3.10 0.712
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.711
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.710
3lsm SFDPyranose 2-oxidase / 0.710
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.710
1qo8 FADFumarate reductase flavoprotein subunit / 0.709
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.708
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.707
3uth FDAUDP-galactopyranose mutase / 0.707
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.706
3lsi FADPyranose 2-oxidase / 0.706
1gal FADGlucose oxidase 1.1.3.4 0.705
1tdn FADL-amino-acid oxidase 1.4.3.2 0.705
2ywl FADThioredoxin reductase related protein / 0.705
3ukf FDAUDP-galactopyranose mutase / 0.705
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.704
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.704
5br7 FADUDP-galactopyranose mutase / 0.703
5j60 FADThioredoxin reductase / 0.703
2cdu FADNADH oxidase / 0.702
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.702
4wx1 FDAUDP-galactopyranose mutase / 0.702
4ysh FADGlycine oxidase / 0.702
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.701
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.701
3qvr FADGlucose oxidase 1.1.3.4 0.700
3rp8 FADFAD-dependent urate hydroxylase / 0.700
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.700
4x9n FADUncharacterized protein MG039 homolog / 0.700
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
4a5l FADThioredoxin reductase / 0.699
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.697
4jq9 FADDihydrolipoyl dehydrogenase / 0.696
4nev FADTrypanothione reductase / 0.696
3mj4 FADUDP-galactopyranose mutase / 0.694
3dme FADPutative conserved exported protein / 0.693
1gpe FADGlucose oxidase 1.1.3.4 0.692
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.692
3ics FADCoenzyme A disulfide reductase / 0.692
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.691
2rgh FADAlpha-Glycerophosphate Oxidase / 0.691
1ffu FADCarbon monoxide dehydrogenase medium chain / 0.690
1joa FADNADH peroxidase 1.11.1.1 0.690
3v76 FDAUncharacterized protein / 0.690
4at0 FADPossible succinate dehydrogenase / 0.690
4k5r FADOxygenase / 0.690
4u8l FDAUDP-galactopyranose mutase / 0.690
5hsa FASAlcohol oxidase 1 1.1.3.13 0.690
3gyj FADCholesterol oxidase 1.1.3.6 0.689
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.687
3cgd FADCoenzyme A disulfide reductase / 0.687
4yry FADGlutamate synthase, beta subunit / 0.687
1ng4 FADGlycine oxidase 1.4.3.19 0.686
4bjz FADProbable salicylate monooxygenase / 0.686
4u8k FDAUDP-galactopyranose mutase / 0.685
2xvf FADPutative flavin-containing monooxygenase / 0.684
3ict FADCoenzyme A disulfide reductase / 0.683
4opg FDAConserved Archaeal protein / 0.683
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.681
3atq FDAConserved Archaeal protein / 0.681
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.681
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.680
3s5w FADL-ornithine N(5)-monooxygenase / 0.680
1pdh FASp-hydroxybenzoate hydroxylase / 0.678
3gyi FADCholesterol oxidase 1.1.3.6 0.677
4u2s FDACholesterol oxidase 1.1.3.6 0.677
1b8s FADCholesterol oxidase 1.1.3.6 0.676
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.676
3k30 ADPHistamine dehydrogenase / 0.676
4c3x FAD3-ketosteroid dehydrogenase / 0.676
1knr FADL-aspartate oxidase 1.4.3.16 0.675
2gr3 FADFerredoxin reductase / 0.675
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.675
4eqx FADCoenzyme A disulfide reductase / 0.675
1cf3 FADGlucose oxidase 1.1.3.4 0.674
1ojt FADDihydrolipoyl dehydrogenase / 0.674
2xve FADPutative flavin-containing monooxygenase / 0.674
1nhr FADNADH peroxidase 1.11.1.1 0.673
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.673
3ada NADSubunit alpha of sarocosine oxidase / 0.673
4bk2 FADProbable salicylate monooxygenase / 0.673
4cbq FADThioredoxin reductase / 0.673
4uir FADOleate hydratase 4.2.1.53 0.673
1ek5 NADUDP-glucose 4-epimerase / 0.672
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.672
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.672
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
3atr FDAConserved Archaeal protein / 0.671
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.671
4tlz FADKtzI / 0.671
1c0l FADD-amino-acid oxidase 1.4.3.3 0.670
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.670
1nhq FADNADH peroxidase 1.11.1.1 0.670
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.670
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.670
4gde FDAUDP-galactopyranose mutase / 0.670
1nhp FADNADH peroxidase 1.11.1.1 0.669
1nhs FADNADH peroxidase 1.11.1.1 0.669
2q0k FADThioredoxin reductase 1.8.1.9 0.669
4opt FDAConserved Archaeal protein / 0.669
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.668
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.668
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.667
4opl FDAConserved Archaeal protein / 0.667
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.666
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.665
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.665
4j31 FADKynurenine 3-monooxygenase / 0.665
5hhf FDAUDP-galactopyranose mutase / 0.665
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.664
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.664
3utg FDAUDP-galactopyranose mutase / 0.664
4u8o FDAUDP-galactopyranose mutase / 0.664
1c0k FADD-amino-acid oxidase 1.4.3.3 0.663
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
4tm3 FADKtzI / 0.663
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.662
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.662
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.662
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.662
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.661
1n4u FAECholesterol oxidase 1.1.3.6 0.661
2hqm FADGlutathione reductase 1.8.1.7 0.661
4ttc FMNIodotyrosine deiodinase 1 / 0.661
4xwr FADCholesterol oxidase 1.1.3.6 0.661
1yqz FADCoenzyme A disulfide reductase / 0.660
2eq7 FADDihydrolipoyl dehydrogenase / 0.660
2r9z FADGlutathione amide reductase / 0.660
3cnj FADCholesterol oxidase 1.1.3.6 0.660
4u2l SFDCholesterol oxidase 1.1.3.6 0.660
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.660
1k0j FADp-hydroxybenzoate hydroxylase / 0.659
1tdo FADL-amino-acid oxidase 1.4.3.2 0.659
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.659
3urh FADDihydrolipoyl dehydrogenase / 0.659
4j36 FADKynurenine 3-monooxygenase / 0.659
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.658
4j2w FADKynurenine 3-monooxygenase / 0.658
4yac NAIC alpha-dehydrogenase / 0.658
5hxw FADL-amino acid deaminase / 0.658
2cvj FADThioredoxin reductase related protein / 0.657
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.657
2rgo FADAlpha-Glycerophosphate Oxidase / 0.657
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.657
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.657
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.657
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.656
3bg7 FADPyranose 2-oxidase / 0.656
3ou6 SAMSAM-dependent methyltransferase / 0.656
4j34 FADKynurenine 3-monooxygenase / 0.656
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.656
1b4v FADCholesterol oxidase 1.1.3.6 0.655
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.655
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.655
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.654
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.654
4u8n FDAUDP-galactopyranose mutase / 0.654
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.654
1ijh FADCholesterol oxidase 1.1.3.6 0.653
1q1r FADPutidaredoxin reductase 1.18.1.5 0.653
2du8 FADD-amino-acid oxidase 1.4.3.3 0.652
2pd7 FADVivid PAS protein VVD / 0.652
2v6o FADThioredoxin glutathione reductase / 0.652
2wow FADTrypanothione reductase / 0.652
3sx2 NADUncharacterized protein / 0.652
4bk3 FADProbable salicylate monooxygenase / 0.651
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.651
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.651
5j3w FMNSensory box protein / 0.651
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.650
2gqf FADUncharacterized protein HI_0933 / 0.650
3ad9 NADSubunit alpha of sarocosine oxidase / 0.650
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.650
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.650
4eeu FMNPhototropin-2 2.7.11.1 0.650