Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 1.000 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.511 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.507 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.502 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.501 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.499 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.496 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.496 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.494 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.494 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.492 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.491 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.490 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.488 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.488 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.488 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.487 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.487 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.486 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.486 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.484 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.484 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.483 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.483 | |
| 4e2d | FMN | Dehydrogenase | / | 0.481 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.479 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.478 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.478 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.478 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.478 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.478 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.478 | |
| 1z41 | FMN | NADPH dehydrogenase | / | 0.477 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.477 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.477 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.475 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.475 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.475 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.474 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.474 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.474 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.473 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.473 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.473 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.472 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.472 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.472 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.471 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.471 | |
| 2wp9 | CBE | Succinate dehydrogenase iron-sulfur subunit | 1.3.5.1 | 0.471 | |
| 2wp9 | CBE | Succinate dehydrogenase cytochrome b556 subunit | / | 0.471 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.471 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.471 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.470 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.470 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.470 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.470 | |
| 2aba | STR | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.470 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.470 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.469 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.469 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.469 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.468 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.468 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.468 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.467 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.467 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.467 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.467 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.467 | |
| 3ful | 52D | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.467 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.467 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.467 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.467 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.467 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.467 | |
| 5a4v | QUE | Glutathione S-transferase F2 | 2.5.1.18 | 0.467 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.466 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.466 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.466 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.465 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.464 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.464 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.464 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.463 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.463 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.462 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.462 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.462 | |
| 4rsy | B3N | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.462 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.462 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.461 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.461 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.461 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.461 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.460 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3e6e | DCS | Alanine racemase | / | 0.460 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.460 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.460 | |
| 5ao1 | DG3 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.460 | |
| 1lke | DOG | Bilin-binding protein | / | 0.459 | |
| 1t3z | CAO | Formyl-CoA:oxalate CoA-transferase | / | 0.459 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.459 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.459 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.459 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.459 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.459 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.459 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.459 | |
| 4nes | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.459 | |
| 4tnz | TTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.459 | |
| 1c7o | PPG | Hemolysin | / | 0.458 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.458 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.458 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.458 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.458 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.458 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.457 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.457 | |
| 2r5n | TPP | Transketolase 1 | / | 0.457 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.457 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.457 | |
| 4k36 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.457 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.456 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.456 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.456 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.455 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.455 | |
| 2r8p | T6F | Transketolase 1 | / | 0.455 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.455 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.455 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.455 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.455 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.454 | |
| 1w19 | T1P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.454 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.453 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1ja1 | FMN | NADPH--cytochrome P450 reductase | / | 0.453 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.453 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.453 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.453 | |
| 2p9g | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.453 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.453 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.453 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.453 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.452 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.452 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 2e1z | B4P | Propionate kinase | / | 0.452 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.452 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.452 | |
| 2xgo | ZKD | Uncharacterized protein | / | 0.452 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.452 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.452 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.452 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.452 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.452 | |
| 4h6p | FMN | Chromate reductase | / | 0.452 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.452 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.451 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.451 | |
| 3eks | CY9 | Actin-5C | / | 0.451 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.451 | |
| 3ndj | JHZ | Methyltransferase | / | 0.451 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.451 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.451 | |
| 4to4 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.451 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.450 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.450 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.450 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.450 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.450 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.450 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.450 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.450 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.450 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.450 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.450 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.450 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.450 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.450 | |
| 4nv1 | TYD | Formyl transferase | / | 0.450 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.449 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.449 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.449 | |
| 2y1w | 849 | Histone-arginine methyltransferase CARM1 | / | 0.449 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.449 | |
| 2zs8 | ADP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3eku | CY9 | Actin-5C | / | 0.449 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.449 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.449 | |
| 3fuj | 00G | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.449 | |
| 4nvk | 2NY | Peroxidase | / | 0.449 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.449 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.449 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.448 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.448 | |
| 1z44 | FMN | NADPH dehydrogenase | / | 0.448 | |
| 2cda | NAP | Glucose 1-dehydrogenase | / | 0.448 | |
| 2e20 | B4P | Propionate kinase | / | 0.448 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.448 | |
| 2r8o | T5X | Transketolase 1 | / | 0.448 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2z3l | PHE_ARG_TYR_LEU_GLY | Leucyl/phenylalanyl-tRNA--protein transferase | 2.3.2.6 | 0.448 | |
| 3c1o | NAP | Eugenol synthase | / | 0.448 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.448 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.448 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.447 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.447 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.447 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.447 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.447 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.447 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.447 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.447 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.447 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.447 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1ngs | TPP | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.446 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.446 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 1wam | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.446 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.446 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.446 | |
| 3frk | TQP | QdtB | / | 0.446 | |
| 3ftx | RE2 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.446 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.446 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.446 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.446 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.445 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.445 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.445 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.445 | |
| 2x91 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.445 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3fuf | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.445 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.445 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.445 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.445 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.445 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.445 | |
| 4pmj | NAP | Putative oxidoreductase | / | 0.445 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.445 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.444 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1p4a | PCP | Pur operon repressor | / | 0.444 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.444 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.444 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.444 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.444 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.444 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.444 | |
| 4b69 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4bxk | 1IU | Angiotensin-converting enzyme | 3.2.1 | 0.444 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.444 | |
| 4j7h | TRH | PCZA361.3 | / | 0.444 | |
| 4to1 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.443 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.443 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.443 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xyt | TC9 | Soluble acetylcholine receptor | / | 0.443 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.443 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.443 | |
| 3tjl | FMN | NADPH dehydrogenase | / | 0.443 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4b1c | 1B1 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.443 | |
| 4qg1 | DTP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.443 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
| 1az2 | NAP | Aldose reductase | 1.1.1.21 | 0.442 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 1h61 | PDN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1tiq | COA | Spermidine/spermine N(1)-acetyltransferase | / | 0.442 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1ye6 | NAD | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.442 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.442 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.442 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.442 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.442 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 3chs | 4BU | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.442 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.442 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.442 | |
| 3v2u | ATP | Protein GAL3 | / | 0.442 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.442 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.442 | |
| 4dld | TZG | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4l4x | NDP | AmphI | / | 0.442 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4usr | FAD | Monooxygenase | / | 0.442 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.442 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.442 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.442 | |
| 5p2p | DHG | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.441 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.441 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.441 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.441 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.441 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.441 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.441 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.441 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 3e4v | FMN | Uncharacterized protein | / | 0.441 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.441 | |
| 4e32 | DWN | Methyltransferase | / | 0.441 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.441 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.441 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.441 | |
| 5dp2 | NAP | CurF | / | 0.441 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.441 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 2e8w | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.440 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.440 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.440 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.440 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.440 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.440 |