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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qziX72Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3qziX72Cyclin-dependent kinase 22.7.11.221.000
3qwjX6ACyclin-dependent kinase 22.7.11.220.610
3r7iX9ICyclin-dependent kinase 22.7.11.220.608
3rm618ZCyclin-dependent kinase 22.7.11.220.608
3r1sX73Cyclin-dependent kinase 22.7.11.220.607
3qqfX07Cyclin-dependent kinase 22.7.11.220.605
3r28XA0Cyclin-dependent kinase 22.7.11.220.603
4fki09KCyclin-dependent kinase 22.7.11.220.599
3r7eX88Cyclin-dependent kinase 22.7.11.220.594
3roy22ZCyclin-dependent kinase 22.7.11.220.594
4ez30S0Cyclin-dependent kinase 22.7.11.220.593
3r1qX75Cyclin-dependent kinase 22.7.11.220.592
3r7yZ04Cyclin-dependent kinase 22.7.11.220.588
3ql8X01Cyclin-dependent kinase 22.7.11.220.586
3qtzX42Cyclin-dependent kinase 22.7.11.220.586
2r3gSC9Cyclin-dependent kinase 22.7.11.220.584
3r73X87Cyclin-dependent kinase 22.7.11.220.581
3r7vZ02Cyclin-dependent kinase 22.7.11.220.581
1vyzN5BCyclin-dependent kinase 22.7.11.220.578
3fz1B98Cyclin-dependent kinase 22.7.11.220.573
3r1yX76Cyclin-dependent kinase 22.7.11.220.573
3rk909ZCyclin-dependent kinase 22.7.11.220.573
3r8lZ30Cyclin-dependent kinase 22.7.11.220.571
3ddqRRCCyclin-dependent kinase 22.7.11.220.570
3r9hZ67Cyclin-dependent kinase 22.7.11.220.570
3qwkX62Cyclin-dependent kinase 22.7.11.220.569
3rpo24ZCyclin-dependent kinase 22.7.11.220.569
3r7uX96Cyclin-dependent kinase 22.7.11.220.568
3qx4X4BCyclin-dependent kinase 22.7.11.220.567
1di8DTQCyclin-dependent kinase 22.7.11.220.565
3ezrEZRCyclin-dependent kinase 22.7.11.220.564
3iggEFQCyclin-dependent kinase 22.7.11.220.564
2exmZIPCyclin-dependent kinase 22.7.11.220.563
2btrU73Cyclin-dependent kinase 22.7.11.220.562
3qzhX69Cyclin-dependent kinase 22.7.11.220.562
3r6xX84Cyclin-dependent kinase 22.7.11.220.562
3rkb12ZCyclin-dependent kinase 22.7.11.220.562
4fkj11KCyclin-dependent kinase 22.7.11.220.562
2r64740Cyclin-dependent kinase 22.7.11.220.560
1b39ATPCyclin-dependent kinase 22.7.11.220.558
2btsU32Cyclin-dependent kinase 22.7.11.220.555
1w0xOLOCyclin-dependent kinase 22.7.11.220.554
2iw84SPCyclin-dependent kinase 22.7.11.220.554
3sqq99ZCyclin-dependent kinase 22.7.11.220.554
4fkq42KCyclin-dependent kinase 22.7.11.220.554
1h1s4SPCyclin-dependent kinase 22.7.11.220.552
2vu3LZECyclin-dependent kinase 22.7.11.220.552
4fkr45KCyclin-dependent kinase 22.7.11.220.552
2w06FRVCyclin-dependent kinase 22.7.11.220.551
4nj32KDCyclin-dependent kinase 22.7.11.220.551
3lfsA07Cyclin-dependent kinase 22.7.11.220.550
1ke6LS2Cyclin-dependent kinase 22.7.11.220.549
2iw94SPCyclin-dependent kinase 22.7.11.220.548
3qqkX02Cyclin-dependent kinase 22.7.11.220.548
3raiX85Cyclin-dependent kinase 22.7.11.220.547
3rni21ZCyclin-dependent kinase 22.7.11.220.547
1h1r6CPCyclin-dependent kinase 22.7.11.220.546
2c6o4SPCyclin-dependent kinase 22.7.11.220.546
3r8zZ63Cyclin-dependent kinase 22.7.11.220.546
3s2pPMUCyclin-dependent kinase 22.7.11.220.546
2a0cCK9Cyclin-dependent kinase 22.7.11.220.545
3lfnA27Cyclin-dependent kinase 22.7.11.220.545
3qzgX67Cyclin-dependent kinase 22.7.11.220.545
3rpv26ZCyclin-dependent kinase 22.7.11.220.545
3s0o50ZCyclin-dependent kinase 22.7.11.220.545
4bcoT6QCyclin-dependent kinase 22.7.11.220.545
1oguST8Cyclin-dependent kinase 22.7.11.220.544
3r8uZ31Cyclin-dependent kinase 22.7.11.220.544
4bcpT3CCyclin-dependent kinase 22.7.11.220.544
2vttLZDCyclin-dependent kinase 22.7.11.220.543
3qqlX03Cyclin-dependent kinase 22.7.11.220.543
1ke7LS3Cyclin-dependent kinase 22.7.11.220.542
1v1k3FPCyclin-dependent kinase 22.7.11.220.542
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.542
3ig7EFPCyclin-dependent kinase 22.7.11.220.542
3qxoX65Cyclin-dependent kinase 22.7.11.220.542
4fkpLS5Cyclin-dependent kinase 22.7.11.220.542
4fkt48KCyclin-dependent kinase 22.7.11.220.542
3r8pZ46Cyclin-dependent kinase 22.7.11.220.541
3sw418KCyclin-dependent kinase 22.7.11.220.541
4lyn1YGCyclin-dependent kinase 22.7.11.220.541
1ke9LS5Cyclin-dependent kinase 22.7.11.220.540
2b55D31Cyclin-dependent kinase 22.7.11.220.540
1oi9N20Cyclin-dependent kinase 22.7.11.220.539
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.539
3qtuX44Cyclin-dependent kinase 22.7.11.220.538
3rk507ZCyclin-dependent kinase 22.7.11.220.538
1ckpPVBCyclin-dependent kinase 22.7.11.220.537
1ke8LS4Cyclin-dependent kinase 22.7.11.220.537
2uzoC62Cyclin-dependent kinase 22.7.11.220.537
4bcnT9NCyclin-dependent kinase 22.7.11.220.537
3r71X86Cyclin-dependent kinase 22.7.11.220.536
4eor4SPCyclin-dependent kinase 22.7.11.220.536
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.535
3qtqX35Cyclin-dependent kinase 22.7.11.220.535
3rm719ZCyclin-dependent kinase 22.7.11.220.535
1oitHDTCyclin-dependent kinase 22.7.11.220.534
1w8cN69Cyclin-dependent kinase 22.7.11.220.534
1g5sI17Cyclin-dependent kinase 22.7.11.220.533
1vyw292Cyclin-dependent kinase 22.7.11.220.533
2c4g514Cyclin-dependent kinase 22.7.11.220.533
3qruX19Cyclin-dependent kinase 22.7.11.220.533
1ykr628Cyclin-dependent kinase 22.7.11.220.532
2duv371Cyclin-dependent kinase 22.7.11.220.532
3ddpRC8Cyclin-dependent kinase 22.7.11.220.532
1pxkCK3Cyclin-dependent kinase 22.7.11.220.531
4cfnJYMCyclin-dependent kinase 22.7.11.220.531
3qu0X40Cyclin-dependent kinase 22.7.11.220.530
1b38ATPCyclin-dependent kinase 22.7.11.220.529
1p2a5BNCyclin-dependent kinase 22.7.11.220.529
3qqhX0ACyclin-dependent kinase 22.7.11.220.529
2r3iSCFCyclin-dependent kinase 22.7.11.220.528
2wpa889Cyclin-dependent kinase 22.7.11.220.528
4ek610KCyclin-dependent kinase 22.7.11.220.528
2r3p3SCCyclin-dependent kinase 22.7.11.220.527
3lfqA28Cyclin-dependent kinase 22.7.11.220.527
3rk708ZCyclin-dependent kinase 22.7.11.220.527
1gih1PUCyclin-dependent kinase 22.7.11.220.526
4eok4SPCyclin-dependent kinase 22.7.11.220.526
3rahO1ZCyclin-dependent kinase 22.7.11.220.525
3s1h56ZCyclin-dependent kinase 22.7.11.220.525
1oiqHDUCyclin-dependent kinase 22.7.11.220.524
1oiyN41Cyclin-dependent kinase 22.7.11.220.524
1pxoCK7Cyclin-dependent kinase 22.7.11.220.524
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.524
2wxvWXVCyclin-dependent kinase 22.7.11.220.524
3qx2X63Cyclin-dependent kinase 22.7.11.220.524
4bgh3I6Cyclin-dependent kinase 22.7.11.220.524
1e9hINRCyclin-dependent kinase 22.7.11.220.523
1oiuN76Cyclin-dependent kinase 22.7.11.220.523
2wihP48Cyclin-dependent kinase 22.7.11.220.523
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.522
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.522
5aniES4Cyclin-dependent kinase 22.7.11.220.522
2b52D42Cyclin-dependent kinase 22.7.11.220.521
4fklCK2Cyclin-dependent kinase 22.7.11.220.521
1h0vUN4Cyclin-dependent kinase 22.7.11.220.520
1h0w207Cyclin-dependent kinase 22.7.11.220.520
1r78FMDCyclin-dependent kinase 22.7.11.220.520
2a4lRRCCyclin-dependent kinase 22.7.11.220.520
2uznC96Cyclin-dependent kinase 22.7.11.220.519
2cchATPCyclin-dependent kinase 22.7.11.220.518
3rak03ZCyclin-dependent kinase 22.7.11.220.518
2r3fSC8Cyclin-dependent kinase 22.7.11.220.517
2c6iDT1Cyclin-dependent kinase 22.7.11.220.516
3wblPDYCyclin-dependent kinase 22.7.11.220.515
3dogNNNCyclin-dependent kinase 22.7.11.220.514
1e1vCMGCyclin-dependent kinase 22.7.11.220.513
2vthLZ2Cyclin-dependent kinase 22.7.11.220.513
1pxmCK5Cyclin-dependent kinase 22.7.11.220.512
3ral04ZCyclin-dependent kinase 22.7.11.220.512
3rjc06ZCyclin-dependent kinase 22.7.11.220.512
3pj8404Cyclin-dependent kinase 22.7.11.220.511
4fkg4CKCyclin-dependent kinase 22.7.11.220.511
2r3r6SCCyclin-dependent kinase 22.7.11.220.510
3ezvEZVCyclin-dependent kinase 22.7.11.220.510
1oirHDYCyclin-dependent kinase 22.7.11.220.508
1pxlCK4Cyclin-dependent kinase 22.7.11.220.507
3tnwF18Cyclin-dependent kinase 22.7.11.220.507
4eol1ROCyclin-dependent kinase 22.7.11.220.506
1fvt106Cyclin-dependent kinase 22.7.11.220.505
1pyePM1Cyclin-dependent kinase 22.7.11.220.505
2c5yMTWCyclin-dependent kinase 22.7.11.220.505
2vtqLZACyclin-dependent kinase 22.7.11.220.505
3my5RFZCyclin-dependent kinase 22.7.11.220.505
3r9dX6BCyclin-dependent kinase 22.7.11.220.505
4fkw62KCyclin-dependent kinase 22.7.11.220.505
1gij2PUCyclin-dependent kinase 22.7.11.220.504
1h1q2A6Cyclin-dependent kinase 22.7.11.220.503
1ke5LS1Cyclin-dependent kinase 22.7.11.220.503
2r3mSCXCyclin-dependent kinase 22.7.11.220.503
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.503
3qtxX43Cyclin-dependent kinase 22.7.11.220.502
2r3o2SCCyclin-dependent kinase 22.7.11.220.501
1dm2HMDCyclin-dependent kinase 22.7.11.220.500
2xnbY8LCyclin-dependent kinase 22.7.11.220.500
3tiz3TICyclin-dependent kinase 22.7.11.220.500
4acm7YGCyclin-dependent kinase 22.7.11.220.500
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.500
3qrtX14Cyclin-dependent kinase 22.7.11.220.499
3unj0BXCyclin-dependent kinase 22.7.11.220.499
1e1xNW1Cyclin-dependent kinase 22.7.11.220.498
2bhhRYUCyclin-dependent kinase 22.7.11.220.498
3rmf20ZCyclin-dependent kinase 22.7.11.220.498
4fko20KCyclin-dependent kinase 22.7.11.220.498
2c6mDT5Cyclin-dependent kinase 22.7.11.220.497
3py0SU9Cyclin-dependent kinase 22.7.11.220.497
3qxpX64Cyclin-dependent kinase 22.7.11.220.497
3s00Z60Cyclin-dependent kinase 22.7.11.220.496
2c69CT8Cyclin-dependent kinase 22.7.11.220.495
3ti1B49Cyclin-dependent kinase 22.7.11.220.495
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.494
3qtrX36Cyclin-dependent kinase 22.7.11.220.494
4fkv61KCyclin-dependent kinase 22.7.11.220.494
1aq1STUCyclin-dependent kinase 22.7.11.220.493
1y91CT9Cyclin-dependent kinase 22.7.11.220.493
2r3lSCWCyclin-dependent kinase 22.7.11.220.493
3unk0BYCyclin-dependent kinase 22.7.11.220.493
2c6kDT2Cyclin-dependent kinase 22.7.11.220.492
2uzlC94Cyclin-dependent kinase 22.7.11.220.492
1gz8MBPCyclin-dependent kinase 22.7.11.220.491
4eos1ROCyclin-dependent kinase 22.7.11.220.491
3pxyJWSCyclin-dependent kinase 22.7.11.220.490
1pxpCK8Cyclin-dependent kinase 22.7.11.220.488
3r8vZ62Cyclin-dependent kinase 22.7.11.220.488
4eop1ROCyclin-dependent kinase 22.7.11.220.488
1urwI1PCyclin-dependent kinase 22.7.11.220.487
2b53D23Cyclin-dependent kinase 22.7.11.220.487
2j9mPY8Cyclin-dependent kinase 22.7.11.220.486
2r3kSCQCyclin-dependent kinase 22.7.11.220.486
3r9nZ68Cyclin-dependent kinase 22.7.11.220.486
4eon1ROCyclin-dependent kinase 22.7.11.220.486
1v0pPVBCell division control protein 2 homolog2.7.11.220.484
3uli1N3Cyclin-dependent kinase 22.7.11.220.484
4bcqTJFCyclin-dependent kinase 22.7.11.220.482
1h1pCMGCyclin-dependent kinase 22.7.11.220.481
2c5nCK8Cyclin-dependent kinase 22.7.11.220.481
2x1nX1NCyclin-dependent kinase 22.7.11.220.480
3bhtMFRCyclin-dependent kinase 22.7.11.220.480
2bheBRYCyclin-dependent kinase 22.7.11.220.479
2xmyCDKCyclin-dependent kinase 22.7.11.220.479
2uzbC75Cyclin-dependent kinase 22.7.11.220.478
2vtsLZCCyclin-dependent kinase 22.7.11.220.477
2wotZZGTGF-beta receptor type-12.7.11.300.477
2w17I19Cyclin-dependent kinase 22.7.11.220.476
1unlRRCCyclin-dependent-like kinase 52.7.11.10.475
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.474
3rpr25ZCyclin-dependent kinase 22.7.11.220.474
3sheI85MAP kinase-activated protein kinase 32.7.11.10.474
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.473
2c6lDT4Cyclin-dependent kinase 22.7.11.220.472
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.472
3rpy27ZCyclin-dependent kinase 22.7.11.220.472
4kd11QKCyclin-dependent kinase 22.7.11.220.472
3sw719KCyclin-dependent kinase 22.7.11.220.471
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.470
1gy3ATPCyclin-dependent kinase 22.7.11.220.469
1ungALHCyclin-dependent-like kinase 52.7.11.10.468
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
2vv9IM9Cyclin-dependent kinase 22.7.11.220.468
2zdt46CMitogen-activated protein kinase 102.7.11.240.468
4fks46KCyclin-dependent kinase 22.7.11.220.468
4fx360KCyclin-dependent kinase 22.7.11.220.468
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.468
2uzeC95Cyclin-dependent kinase 22.7.11.220.467
2fvdLIACyclin-dependent kinase 22.7.11.220.466
4qmpDKISerine/threonine-protein kinase 242.7.11.10.466
4ek816KCyclin-dependent kinase 22.7.11.220.464
4eomATPCyclin-dependent kinase 22.7.11.220.464
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.463
2zjwREFCasein kinase II subunit alpha2.7.11.10.462
3c4xATPRhodopsin kinase/0.462
1hckATPCyclin-dependent kinase 22.7.11.220.461
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
4i3zADPCyclin-dependent kinase 22.7.11.220.461
1y8yCT7Cyclin-dependent kinase 22.7.11.220.460
4eoi1ROCyclin-dependent kinase 22.7.11.220.460
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.460
4q73FADBifunctional protein PutA/0.460
1eh4IC1Casein kinase I homolog 12.7.11.10.459
2wipP49Cyclin-dependent kinase 22.7.11.220.459
3gobHXXDdmC/0.459
3qtwX3ACyclin-dependent kinase 22.7.11.220.459
3axwTIDCasein kinase II subunit alpha2.7.11.10.458
4iva1J5Tyrosine-protein kinase JAK2/0.457
2bkzSBCCyclin-dependent kinase 22.7.11.220.456
2i40BLZCyclin-dependent kinase 22.7.11.220.456
3be9P04Casein kinase II subunit alpha2.7.11.10.456
3qqgX06Cyclin-dependent kinase 22.7.11.220.456
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.456
2b54D05Cyclin-dependent kinase 22.7.11.220.455
2c6tDT5Cyclin-dependent kinase 22.7.11.220.455
2dwbANPAurora kinase A2.7.11.10.455
2eufLQQCyclin-dependent kinase 62.7.11.220.455
3qzfX66Cyclin-dependent kinase 22.7.11.220.455
3ukuC69Actin-related protein 3/0.455
2c68CT6Cyclin-dependent kinase 22.7.11.220.454
2g1n1IGRenin3.4.23.150.454
2qkrIXMCdc2-like CDK2/CDC28 like protein kinase/0.454
3i60E86Mitogen-activated protein kinase 12.7.11.240.454
1fvv107Cyclin-dependent kinase 22.7.11.220.453
1nooCAHCamphor 5-monooxygenase1.14.15.10.453
2r3q5SCCyclin-dependent kinase 22.7.11.220.452
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.452
3lq5SLQCyclin-dependent kinase 92.7.11.220.452
4btjATPTau-tubulin kinase 12.7.11.10.452
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.451
5dr6SKEAurora kinase A2.7.11.10.451
2uzdC85Cyclin-dependent kinase 22.7.11.220.450
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.450
1t85CAMCamphor 5-monooxygenase1.14.15.10.449
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2f2cAP9Cyclin-dependent kinase 62.7.11.220.448
2g2zCOZMalonyl CoA-acyl carrier protein transacylase2.3.1.390.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.448
3wowANPCasein kinase II subunit alpha2.7.11.10.448
4l49CAMCamphor 5-monooxygenase1.14.15.10.448
1nzdUPGDNA beta-glucosyltransferase/0.447
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.447
5drdATPAurora kinase A2.7.11.10.447
1qmzATPCyclin-dependent kinase 22.7.11.220.446
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.446
1finATPCyclin-dependent kinase 22.7.11.220.445
2qbmCAMCamphor 5-monooxygenase1.14.15.10.445
2w1hL0FCyclin-dependent kinase 22.7.11.220.445
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.445
3u4uLNHCasein kinase II subunit alpha2.7.11.10.445
4fob0USALK tyrosine kinase receptor2.7.10.10.445
4fv6E57Mitogen-activated protein kinase 12.7.11.240.445
4jqeANPCasein kinase II subunit alpha2.7.11.10.445
1rx8NAPDihydrofolate reductase1.5.1.30.444
1unhIXMCyclin-dependent-like kinase 52.7.11.10.444
1v0oINRCell division control protein 2 homolog2.7.11.220.444
2a1nCAMCamphor 5-monooxygenase1.14.15.10.444
2qblCAMCamphor 5-monooxygenase1.14.15.10.444
2w1fL0FAurora kinase A2.7.11.10.444
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.444
6cp4CAMCamphor 5-monooxygenase1.14.15.10.444
2qboCAMCamphor 5-monooxygenase1.14.15.10.443
2xb7GUIALK tyrosine kinase receptor2.7.10.10.443
2zaxCAMCamphor 5-monooxygenase1.14.15.10.443
4gub0Y4Casein kinase II subunit alpha2.7.11.10.443
3rzb02ZCyclin-dependent kinase 22.7.11.220.442
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.442
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.442
2np8CC3Aurora kinase A2.7.11.10.441
3qyw6PBMitogen-activated protein kinase 12.7.11.240.441
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.441
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.441
4k8aK8AFocal adhesion kinase 12.7.10.20.441
2o0uC0MMitogen-activated protein kinase 102.7.11.240.440
4aqc88ATyrosine-protein kinase JAK2/0.440
4qmlANPSerine/threonine-protein kinase 242.7.11.10.440
5eccNAPDehydrofolate reductase type I/0.440