sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3eei | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3eei | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 1.000 | |
| 1zos | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.644 | |
| 4x24 | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.609 | |
| 1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.605 | |
| 3dp9 | BIG | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.597 | |
| 1y6q | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.593 | |
| 1nc1 | MTH | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.578 | |
| 4wkb | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.578 | |
| 4bmz | MTA | Aminodeoxyfutalosine nucleosidase | / | 0.557 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.509 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.501 | |
| 4iwv | 1J9 | Glucokinase | 2.7.1.2 | 0.497 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.493 | |
| 2c3o | TPP | Pyruvate synthase | / | 0.490 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 3e6y | CW1 | 14-3-3-like protein C | / | 0.486 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.486 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.485 | |
| 3hll | I46 | Mitogen-activated protein kinase 14 | / | 0.485 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 2yis | I46 | Mitogen-activated protein kinase 14 | / | 0.484 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.483 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.482 | |
| 4gcx | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.482 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.481 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.480 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.479 | |
| 1efz | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.478 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.478 | |
| 1ozq | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.477 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.477 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 2hzq | STR | Apolipoprotein D | / | 0.476 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.476 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.474 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.474 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.473 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.472 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.472 | |
| 4hqv | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.472 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.471 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.471 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.471 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.471 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3qp6 | HL6 | Transcriptional activator, LuxR/UhpA family of regulators | / | 0.470 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.469 | |
| 1nqm | BTN | Streptavidin | / | 0.469 | |
| 2ji9 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.469 | |
| 4pzt | SOP | Histone acetyltransferase p300 | / | 0.469 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.468 | |
| 1fkw | PUR | Adenosine deaminase | 3.5.4.4 | 0.467 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1srf | MTB | Streptavidin | / | 0.467 | |
| 1syn | F89 | Thymidylate synthase | / | 0.467 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.467 | |
| 4pl9 | ADP | Ethylene receptor 1 | / | 0.467 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.466 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.466 | |
| 4rtr | SAM | DNA adenine methylase | 2.1.1.72 | 0.466 | |
| 5i39 | FAD | L-amino acid deaminase | / | 0.466 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.466 | |
| 1rzy | 5AS | Histidine triad nucleotide-binding protein 1 | 3 | 0.465 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.465 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.465 | |
| 1mbz | IOT | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.464 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 2x20 | PID | Peridinin-chlorophyll a-binding protein 1, chloroplastic | / | 0.462 | |
| 2xk3 | XK3 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.462 | |
| 3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.462 | |
| 3wzn | BTN | Streptavidin | / | 0.462 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.461 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.461 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.461 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.461 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.461 | |
| 3tl1 | JRO | Putative polyketide cyclase | / | 0.461 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.460 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 1kek | HTL | Pyruvate synthase | / | 0.459 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.459 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.459 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.459 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.459 | |
| 2zd1 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.459 | |
| 3hxc | BD6 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.459 | |
| 4n1g | CEI | Obelin | / | 0.459 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.459 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.458 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.458 | |
| 2c3p | 1TP | Pyruvate synthase | / | 0.458 | |
| 2ji7 | ADP | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.458 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.458 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.458 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.458 | |
| 1f3e | DPZ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 1it7 | GUN | tRNA-guanine(15) transglycosylase | 2.4.2.48 | 0.457 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.457 | |
| 4zth | GG5 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.457 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.457 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.456 | |
| 2pda | TPP | Pyruvate synthase | / | 0.456 | |
| 2z1w | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.456 | |
| 3gkj | HC3 | Niemann-Pick C1 protein | / | 0.456 | |
| 3rix | 923 | Luciferin 4-monooxygenase | 1.13.12.7 | 0.456 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.456 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.456 | |
| 4gh3 | 0EV | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.455 | |
| 1prc | UQ1 | Reaction center protein L chain | / | 0.455 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.455 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3fnh | JPJ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 3ndj | JHZ | Methyltransferase | / | 0.455 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.455 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.455 | |
| 4az0 | S61 | Lysosomal protective protein | 3.4.16.5 | 0.455 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4eh5 | IRG | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.455 | |
| 4h7z | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.455 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.454 | |
| 1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.454 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3seq | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.454 | |
| 4y0k | NAP | AntE | / | 0.454 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.453 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.453 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.453 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.453 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.453 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.453 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.453 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.453 | |
| 4ivy | 1GT | Estrogen receptor | / | 0.453 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.453 | |
| 1equ | EQI | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1juj | LYA | Thymidylate synthase | 2.1.1.45 | 0.452 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.452 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.452 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.452 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3up3 | XCA | aceDAF-12 | / | 0.452 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.452 | |
| 4c2w | ANP | Aurora kinase B-A | 2.7.11.1 | 0.452 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.451 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.451 | |
| 1ove | 358 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 2b35 | TCL | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.451 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.451 | |
| 3dzl | 3OC | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3hl7 | I46 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3k3i | I46 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3mcy | ZH1 | FimH | / | 0.451 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.451 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.451 | |
| 4iae | 1DX | Alr2278 protein | / | 0.451 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.450 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.450 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.450 | |
| 2izk | GLL | Streptavidin | / | 0.450 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.450 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.450 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 3gya | COA | GCN5-related N-acetyltransferase | / | 0.450 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.450 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.450 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4eh3 | IRG | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4if5 | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.450 | |
| 1ia9 | ANP | Transient receptor potential cation channel subfamily M member 7 | 2.7.11.1 | 0.449 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.449 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.449 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.449 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.449 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.449 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.449 | |
| 3n1t | 5GP | Purine nucleoside phosphoramidase | / | 0.449 | |
| 3roc | 29B | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.449 | |
| 3wtk | TH4 | Acetylcholine-binding protein | / | 0.449 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.449 | |
| 4b5n | FMN | NAD(P)H:flavin oxidoreductase Sye4 | / | 0.449 | |
| 4cby | KEE | Histone deacetylase 4 | 3.5.1.98 | 0.449 | |
| 4eh4 | IRG | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 4hsh | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.449 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.449 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.448 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.448 | |
| 3bgv | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.448 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.448 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.448 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.448 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.448 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.448 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.448 | |
| 1bq1 | CB3 | Thymidylate synthase | / | 0.447 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.447 | |
| 1fcy | 564 | Retinoic acid receptor gamma | / | 0.447 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.447 | |
| 1q4w | DQU | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.447 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 1z5u | CMP | Class B acid phosphatase | / | 0.447 | |
| 2gzl | 2AA | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | 4.6.1.12 | 0.447 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3qri | 919 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 3t5i | SER_SER_CMT_FAR | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.447 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4b6u | M7G | Eukaryotic translation initiation factor 4E type 3 | / | 0.447 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4do0 | DZA | Histone lysine demethylase PHF8 | 1.14.11.27 | 0.447 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.447 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.447 | |
| 4y1b | NAP | AntE | / | 0.447 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.446 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1jje | BYS | Beta-lactamase | / | 0.446 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 2bxq | IMN | Serum albumin | / | 0.446 | |
| 2cjf | RP4 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.446 | |
| 2d2g | DZZ | Phosphotriesterase | / | 0.446 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.446 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.446 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.446 | |
| 4fps | 0UX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.446 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.445 | |
| 1fcx | 184 | Retinoic acid receptor gamma | / | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.445 | |
| 1q63 | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.445 | |
| 2c3y | HTL | Pyruvate synthase | / | 0.445 | |
| 2xkc | 4VQ | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.445 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.445 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4gh1 | 0WX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.445 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1k9s | FM2 | Purine nucleoside phosphorylase DeoD-type | / | 0.444 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.444 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.444 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.444 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 2jbl | SMA | Reaction center protein L chain | / | 0.444 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.444 | |
| 2nsd | 4PI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2xb8 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.444 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.444 | |
| 3hf6 | LX0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.444 | |
| 4hvx | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.444 | |
| 1b87 | ACO | Aac(6')-Ii protein | / | 0.443 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.443 | |
| 1p16 | GTP | mRNA-capping enzyme subunit alpha | 2.7.7.50 | 0.443 | |
| 1yqj | 6NP | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2bbf | 344 | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 2c94 | TSF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.443 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.443 | |
| 2z1x | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.443 | |
| 3ge7 | AFQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 3gg2 | UGA | Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family | / | 0.443 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.443 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.443 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.443 | |
| 4u2l | SFD | Cholesterol oxidase | 1.1.3.6 | 0.443 | |
| 4ykl | GMP | Aprataxin-like protein | 3 | 0.443 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.443 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.442 | |
| 1qv0 | CZH | Obelin | / | 0.442 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2bif | ANP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.442 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.442 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.442 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.442 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.442 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4az3 | S35 | Lysosomal protective protein | 3.4.16.5 | 0.442 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.442 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.442 | |
| 4eh2 | IRG | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4phl | PIL | Phosphodiesterase | / | 0.442 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.442 | |
| 4y6u | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.442 | |
| 1ci7 | CB3 | Thymidylate synthase | 2.1.1.45 | 0.441 | |
| 1piw | NAP | NADP-dependent alcohol dehydrogenase 6 | 1.1.1.2 | 0.441 | |
| 2bxo | OPB | Serum albumin | / | 0.441 | |
| 2fjb | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.441 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.441 | |
| 2og8 | 1N8 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 2ol4 | JPN | Enoyl-ACP reductase | / | 0.441 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.441 | |
| 2rtq | IMI | Streptavidin | / | 0.441 | |
| 2y3f | BTN | Streptavidin | / | 0.441 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.441 | |
| 3ar6 | 12D | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.441 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.441 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4rto | SFG | DNA adenine methylase | 2.1.1.72 | 0.441 | |
| 4y7c | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1fkx | PRH | Adenosine deaminase | 3.5.4.4 | 0.440 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.440 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.440 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.440 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.440 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.440 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.440 | |
| 2g1a | 5HG | Class B acid phosphatase | 3.1.3.2 | 0.440 | |
| 2ibw | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.440 | |
| 2op0 | 7PC | Enoyl-ACP reductase | / | 0.440 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2rti | GLL | Streptavidin | / | 0.440 | |
| 2yat | EEU | Estrogen receptor | / | 0.440 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.440 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.440 | |
| 4y6n | UPG | Glucosyl-3-phosphoglycerate synthase | 2.4.1.266 | 0.440 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.440 |