sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2xtn | GTP | GTPase IMAP family member 2 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2xtn | GTP | GTPase IMAP family member 2 | / | 1.000 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.495 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.488 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.483 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.482 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.482 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.481 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.480 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.480 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.479 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.478 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.477 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.475 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.474 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.474 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.474 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.474 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.472 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.472 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.472 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.471 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.471 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.471 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.471 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.471 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.471 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.470 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.470 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.469 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.469 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.469 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.469 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.468 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.468 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 1vce | SAH | Diphthine synthase | / | 0.466 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.466 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.466 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.466 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.465 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.465 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.465 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.465 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.465 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.464 | |
| 1c9k | 5GP | Bifunctional adenosylcobalamin biosynthesis protein CobU | / | 0.463 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.463 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.463 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.462 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.462 | |
| 5e7o | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.462 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.461 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.461 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.461 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.461 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.460 | |
| 1fcb | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.460 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.460 | |
| 2y3r | TRK | TamL | / | 0.460 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.460 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.460 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.460 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.460 | |
| 2b4r | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.459 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.459 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.459 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.459 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.459 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.458 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.458 | |
| 4a31 | MYA | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.458 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.457 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.457 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.457 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.457 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.457 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 4l4x | NDP | AmphI | / | 0.457 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.457 | |
| 4opt | FDA | Conserved Archaeal protein | / | 0.457 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.456 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.456 | |
| 2y3s | TIR | TamL | / | 0.456 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.456 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.456 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 4qxp | 1YE | Stimulator of interferon genes protein | / | 0.456 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.456 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.455 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.455 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.455 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.455 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3t7x | 4SH | Endothiapepsin | 3.4.23.22 | 0.455 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.455 | |
| 1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.454 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.454 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.454 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.454 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.454 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.454 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.454 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.453 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.453 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.453 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.453 | |
| 2xfy | ACX | Beta-amylase | 3.2.1.2 | 0.453 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.453 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.453 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.453 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.452 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.452 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.452 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.452 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.452 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4x5i | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.451 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.451 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.451 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.451 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.451 | |
| 3pft | FMN | Flavin reductase | / | 0.451 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.451 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.451 | |
| 4loi | 1YC | Stimulator of interferon genes protein | / | 0.451 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.450 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.450 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.450 | |
| 1zio | AP5 | Adenylate kinase | / | 0.450 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2v2q | NVG | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.450 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.450 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.450 | |
| 3kpb | SAM | Uncharacterized protein MJ0100 | / | 0.450 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.450 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.450 | |
| 3slz | 3TL | Putative gag-pro-pol polyprotein | / | 0.450 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.450 | |
| 3ziu | LSS | Leucyl-tRNA synthetase | / | 0.450 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 1bmd | NAD | Malate dehydrogenase | / | 0.449 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.449 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.449 | |
| 1qy8 | RDI | Endoplasmin | / | 0.449 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2e07 | SAH | Diphthine synthase | / | 0.449 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.449 | |
| 2owu | SAH | Diphthine synthase | / | 0.449 | |
| 2pck | SAH | Diphthine synthase | / | 0.449 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.449 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.449 | |
| 2web | PP4 | Penicillopepsin-1 | 3.4.23.20 | 0.449 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.449 | |
| 3axk | NDP | Ribulose bisphosphate carboxylase large chain | 4.1.1.39 | 0.449 | |
| 3ukf | GDU | UDP-galactopyranose mutase | / | 0.449 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.449 | |
| 1m75 | CAA | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.448 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.448 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.448 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.448 | |
| 3atq | FDA | Conserved Archaeal protein | / | 0.448 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.448 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.448 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.448 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.448 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.448 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.448 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 4tm4 | FDA | KtzI | / | 0.448 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.447 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.447 | |
| 2e4n | SAH | Diphthine synthase | / | 0.447 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.447 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.447 | |
| 3bnk | FMN | Flavoredoxin | / | 0.447 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3ieu | GDP | GTPase Era | / | 0.447 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.447 | |
| 4blr | UTP | NTPase P4 | / | 0.447 | |
| 4e2d | FMN | Dehydrogenase | / | 0.447 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.447 | |
| 4iv6 | FDA | Isovaleryl-CoA dehydrogenase | / | 0.447 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.447 | |
| 1m8k | NAD | Nicotinamide-nucleotide adenylyltransferase | 2.7.7.1 | 0.446 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.446 | |
| 2dxx | SAH | Diphthine synthase | / | 0.446 | |
| 2e15 | SAH | Diphthine synthase | / | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.446 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.446 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.446 | |
| 4ien | COA | Putative acyl-CoA hydrolase | / | 0.446 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.446 | |
| 1iy8 | NAD | Levodione reductase | / | 0.445 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.445 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.445 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.445 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2h12 | CMX | Citrate synthase | / | 0.445 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.445 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.445 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.445 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.445 | |
| 4e2x | TYD | Methyltransferase | / | 0.445 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.445 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4rww | 2BA | Lmo2692 protein | / | 0.445 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.445 | |
| 5fsi | 8DG | 7,8-dihydro-8-oxoguanine triphosphatase | 3.6.1.55 | 0.445 | |
| 1cdo | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.444 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.444 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.444 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.444 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.444 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.444 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.444 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.444 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3tdj | 3TJ | Glutamate receptor 2 | / | 0.444 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.444 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.444 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 4oad | CLM | Uncharacterized protein | / | 0.444 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.444 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.444 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 1e82 | M90 | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.443 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.443 | |
| 3pww | ROC | Endothiapepsin | 3.4.23.22 | 0.443 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.443 | |
| 4gtp | 7TP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.442 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.442 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1wng | SAH | Diphthine synthase | / | 0.442 | |
| 1zdw | FLV | Prenyltransferase | / | 0.442 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2dek | SAH | Diphthine synthase | / | 0.442 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.442 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 3a3g | DLZ | Lumazine protein | / | 0.442 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3eld | SFG | Methyltransferase | / | 0.442 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.442 | |
| 3wid | NAP | Glucose 1-dehydrogenase | / | 0.442 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.442 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.442 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 4qec | NAP | ElxO | / | 0.442 | |
| 4qly | FMN | Enone reductase CLA-ER | / | 0.442 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1nah | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.441 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2hux | SAH | Diphthine synthase | / | 0.441 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.441 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.441 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2owk | SAH | Diphthine synthase | / | 0.441 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.441 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.441 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3eks | CY9 | Actin-5C | / | 0.441 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.441 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.441 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.441 | |
| 3toh | 079 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.441 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.440 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.440 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.440 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.440 | |
| 2e17 | SAH | Diphthine synthase | / | 0.440 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.440 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.440 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.440 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.440 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.440 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.440 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.440 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.440 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.440 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.440 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.440 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.440 |