sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 1.000 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.654 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.638 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.636 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.629 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.628 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.627 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.626 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.625 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.624 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.620 | |
| 1a42 | BZU | Carbonic anhydrase 2 | 4.2.1.1 | 0.618 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.617 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.616 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.615 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.614 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.613 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.611 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.610 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.609 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.608 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.607 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.606 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.601 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.599 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.598 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.597 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.596 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.594 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.590 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.589 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.588 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.572 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.571 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.563 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.554 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.554 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.549 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 0.543 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.541 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.540 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.537 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.536 | |
| 1eou | SMS | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.535 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.534 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.532 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.532 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.531 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.530 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.527 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.526 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.525 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.523 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.522 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.520 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.518 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.517 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.515 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.514 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.513 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.512 | |
| 3p5l | IT5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.509 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.507 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.504 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.502 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.499 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.498 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.498 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.495 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.495 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.492 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.492 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.491 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.490 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.489 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.489 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.489 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.488 | |
| 4dz7 | D02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.488 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.487 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.487 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.486 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.486 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.484 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.484 | |
| 1bdm | NAX | Malate dehydrogenase | / | 0.482 | |
| 4jic | FMN | GTN Reductase | / | 0.479 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.479 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.478 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.478 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.478 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.478 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.477 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.477 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.476 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.476 | |
| 1b8u | NAD | Malate dehydrogenase | / | 0.475 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.475 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.475 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.475 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.470 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.470 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.470 | |
| 4iae | 1DX | Alr2278 protein | / | 0.470 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.470 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.470 | |
| 1q51 | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.469 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 1lc3 | NAD | Biliverdin reductase A | 1.3.1.24 | 0.468 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.468 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.468 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.468 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.468 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.468 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.467 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.466 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.465 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.465 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.465 | |
| 4knn | E1F | Carbonic anhydrase 13 | 4.2.1.1 | 0.465 | |
| 1foa | UD1 | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase | 2.4.1.101 | 0.464 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.464 | |
| 2v2v | V12 | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.464 | |
| 3aw9 | GDU | NAD-dependent epimerase/dehydratase | / | 0.464 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.464 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.464 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.464 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.463 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.463 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.463 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.463 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.463 | |
| 4e2y | JHZ | Methyltransferase | / | 0.463 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.463 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.463 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.462 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.462 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.462 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.462 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.461 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.461 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.461 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 1c9w | NAP | Aldose reductase-related protein 2 | / | 0.460 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.460 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.460 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.460 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.460 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.460 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.460 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.459 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.459 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.458 | |
| 1v2h | GUN | Purine nucleoside phosphorylase | 2.4.2.1 | 0.458 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.458 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.458 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.458 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.458 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.458 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.457 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.457 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.457 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.457 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.457 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.457 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.457 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.457 | |
| 4bri | UNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.457 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1qpf | 858 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.456 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 2b8t | THM | Thymidine kinase | / | 0.456 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.456 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.456 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.456 | |
| 1ivs | VAA | Valine--tRNA ligase | 6.1.1.9 | 0.455 | |
| 3pft | FMN | Flavin reductase | / | 0.455 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.455 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.455 | |
| 4iah | 1DX | Alr2278 protein | / | 0.455 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.454 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.454 | |
| 3jyo | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.454 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.454 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.454 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.454 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.453 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.453 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.453 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.453 | |
| 4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.453 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.453 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.452 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.452 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.452 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.452 | |
| 3bgs | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.452 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.452 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4e2b | FMN | Dehydrogenase | / | 0.452 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.452 | |
| 4tmb | FMN | Old yellow enzyme | / | 0.452 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.451 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.451 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.451 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.451 | |
| 4giu | 636 | Anthranilate phosphoribosyltransferase | / | 0.451 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.451 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.450 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.450 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.450 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.450 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4h6p | FMN | Chromate reductase | / | 0.450 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.450 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.449 | |
| 1vjt | NAD | Alpha-glucosidase, putative | / | 0.449 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.449 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.449 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.449 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.449 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.449 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.449 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.448 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.448 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.448 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.448 | |
| 2oa1 | FAD | Flavin-dependent tryptophan halogenase RebH | 1.14.19.9 | 0.448 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.448 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.448 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.448 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.448 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.448 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4x7w | MVI | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.448 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.447 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.447 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.447 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.447 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.447 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.447 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.447 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.447 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.447 | |
| 4x7v | MIV | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.447 | |
| 4xr9 | NAD | CalS8 | / | 0.447 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.446 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.446 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.446 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.445 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.445 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.445 | |
| 3apw | DP0 | Alpha-1-acid glycoprotein 2 | / | 0.445 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.445 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.445 | |
| 3jyq | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.445 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.445 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.445 | |
| 1fki | SB1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.444 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.444 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.444 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.444 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.444 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.444 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.444 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.443 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.443 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.443 | |
| 3keq | NAD | Redox-sensing transcriptional repressor Rex | / | 0.443 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.443 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.443 | |
| 3zhq | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.443 | |
| 4j7h | TRH | PCZA361.3 | / | 0.443 | |
| 4pne | SAH | Methyltransferase-like protein | / | 0.443 | |
| 5bnw | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.443 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.442 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.442 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.442 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.442 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.442 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.442 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 3vp6 | HLD | Glutamate decarboxylase 1 | 4.1.1.15 | 0.442 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.442 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.441 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.441 | |
| 2b4d | COA | Diamine acetyltransferase 1 | / | 0.441 | |
| 2dxd | ANP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.441 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.441 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.441 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.441 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.441 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.441 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.441 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.441 | |
| 1b5e | DCM | Deoxycytidylate 5-hydroxymethyltransferase | 2.1.2.8 | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.440 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.440 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.440 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.440 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.440 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.440 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.440 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.440 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.440 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4rnw | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.440 |