sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2qbr | 910 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2qbr | 910 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 1.000 | |
| 2h4k | 509 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.745 | |
| 2b07 | 598 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.624 | |
| 2qbs | 024 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.598 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.529 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.510 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.507 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.501 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.499 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.498 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.498 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.491 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.487 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.486 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.484 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.483 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.483 | |
| 1rxj | BNI | Streptavidin | / | 0.481 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.480 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.480 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.480 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.479 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.479 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.479 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.479 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.477 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.476 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.476 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.475 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.475 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.473 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.473 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.473 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.472 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.472 | |
| 4y1b | NAP | AntE | / | 0.471 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.470 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.470 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.470 | |
| 4zas | TYD | CalS13 | / | 0.470 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.469 | |
| 2j7d | GI1 | Beta-glucosidase A | 3.2.1.21 | 0.469 | |
| 3b04 | OOP | Isopentenyl-diphosphate delta-isomerase | / | 0.469 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.469 | |
| 1w1v | ALJ | Chitinase | / | 0.468 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.468 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.468 | |
| 3p5s | AVU | CD38 molecule | / | 0.468 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.467 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.467 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.467 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.467 | |
| 1qv0 | CZH | Obelin | / | 0.466 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.466 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 3e6e | DCS | Alanine racemase | / | 0.466 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.466 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.465 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.465 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.464 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.464 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.464 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.463 | |
| 2qe2 | 452 | Polyprotein | / | 0.463 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.463 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.463 | |
| 4j7g | TRH | PCZA361.3 | / | 0.463 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.462 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.462 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.462 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4eua | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.462 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.462 | |
| 1a26 | CNA | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.461 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 2bzs | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.461 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.461 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.461 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.461 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 4iae | 1DX | Alr2278 protein | / | 0.461 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1y6r | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | 3.2.2.9 | 0.460 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.460 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.460 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.460 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.460 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.460 | |
| 1a4l | DCF | Adenosine deaminase | 3.5.4.4 | 0.459 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.459 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.459 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.459 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.459 | |
| 5dp2 | NAP | CurF | / | 0.459 | |
| 1s36 | CEI | Obelin | / | 0.458 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.458 | |
| 2ejz | SAH | Diphthine synthase | / | 0.458 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.458 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.458 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.457 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.457 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.457 | |
| 3beo | UD1 | UDP-N-acetylglucosamine 2-epimerase | / | 0.457 | |
| 3w5u | FAD | Ferredoxin | / | 0.457 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.457 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.457 | |
| 1dtp | APU | Diphtheria toxin | / | 0.456 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.456 | |
| 1pxg | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.456 | |
| 2bxo | OPB | Serum albumin | / | 0.456 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.456 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.456 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 4gm4 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.456 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 4j7h | TRH | PCZA361.3 | / | 0.456 | |
| 4jey | PLP | Acetylornithine/succinyldiaminopimelate aminotransferase | 2.6.1.11 | 0.456 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2q0g | UPU | Poly(A) polymerase, putative | / | 0.455 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.455 | |
| 2zry | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.455 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.455 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.455 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.455 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.454 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 1wuu | ANP | Galactokinase | 2.7.1.6 | 0.454 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.454 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3l3r | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.454 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.454 | |
| 4jxr | ACO | Acetyltransferase | / | 0.454 | |
| 1i05 | LTL | Major urinary protein 6 | / | 0.453 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.453 | |
| 1syn | F89 | Thymidylate synthase | / | 0.453 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.453 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 3tl1 | JRO | Putative polyketide cyclase | / | 0.453 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.453 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 1gaq | FAD | Ferredoxin | / | 0.452 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.452 | |
| 1s7l | COA | Acetyl transferase | / | 0.452 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.452 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.452 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.452 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.452 | |
| 2zrv | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.452 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.452 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.452 | |
| 4gg1 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 4wbd | ADP | Putative cysteine ligase BshC | / | 0.452 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.452 | |
| 1dpm | EBP | Parathion hydrolase | 3.1.8.1 | 0.451 | |
| 1fml | RTL | Retinol dehydratase | / | 0.451 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.451 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.451 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.451 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.451 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.451 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.451 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.451 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.451 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.451 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 4phl | PIL | Phosphodiesterase | / | 0.451 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.450 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.450 | |
| 3b03 | VNR | Isopentenyl-diphosphate delta-isomerase | / | 0.450 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.450 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.450 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.449 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.449 | |
| 2q15 | 3MR | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.449 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.449 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.449 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.449 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.448 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.448 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.448 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.447 | |
| 1asc | NPL | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 1qsn | COA | HAT A1 | / | 0.447 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.447 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 4br0 | AU1 | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.447 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4iah | 1DX | Alr2278 protein | / | 0.447 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.447 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.447 | |
| 1dqa | COA | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.34 | 0.446 | |
| 1u0h | ONM | Adenylate cyclase type 2 | / | 0.446 | |
| 1u0h | ONM | Adenylate cyclase type 5 | / | 0.446 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1zos | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.446 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.446 | |
| 2p1o | NLA | Protein TRANSPORT INHIBITOR RESPONSE 1 | / | 0.446 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 2zrx | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4kxj | P34 | Nucleoprotein | / | 0.446 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.445 | |
| 1eyy | NAP | NADP-dependent fatty aldehyde dehydrogenase | 1.2.1.4 | 0.445 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1til | ATP | Anti-sigma F factor | / | 0.445 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.445 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.445 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.445 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 4afe | GGY | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.445 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.445 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.445 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.445 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.445 | |
| 4xul | GTP | Uncharacterized protein mg662 | / | 0.445 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.444 | |
| 1clq | GDP | DNA-directed DNA polymerase | / | 0.444 | |
| 1ftl | DNQ | Glutamate receptor 2 | / | 0.444 | |
| 1n3s | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.444 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.444 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.444 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3bm1 | FMN | Putative NAD(P)H nitroreductase YdjA | / | 0.444 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.444 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 4da7 | AC2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.444 | |
| 4dxl | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.444 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.444 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.444 | |
| 4zob | LGC | Lin1840 protein | / | 0.444 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1u1c | BAU | Uridine phosphorylase | 2.4.2.3 | 0.443 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.443 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.443 | |
| 2rtf | BTN | Streptavidin | / | 0.443 | |
| 2w6m | OA1 | Biotin carboxylase | 6.3.4.14 | 0.443 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.443 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4oaq | NDP | R-specific carbonyl reductase | / | 0.443 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.443 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1k4g | AIQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.442 | |
| 2i9p | NAD | 3-hydroxyisobutyrate dehydrogenase, mitochondrial | 1.1.1.31 | 0.442 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3nhu | M42 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.442 | |
| 4dan | 2FA | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.442 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.442 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.441 | |
| 1aj2 | 2PH | Dihydropteroate synthase | / | 0.441 | |
| 1dmw | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.441 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 1k2s | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.441 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.441 | |
| 2vss | ACO | Hydroxycinnamoyl-CoA hydratase-lyase | 4.1.2.41 | 0.441 | |
| 2z52 | H23 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.441 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.441 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.440 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1sre | HAB | Streptavidin | / | 0.440 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.440 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.440 | |
| 2ov2 | GCP | Ras-related C3 botulinum toxin substrate 3 | / | 0.440 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.440 | |
| 3h03 | UBP | Glutamate receptor 2 | / | 0.440 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.440 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.440 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4h6r | FDA | Proline dehydrogenase | / | 0.440 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.440 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.440 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.440 |