sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2du2 | FMN | Lactate oxidase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2du2 | FMN | Lactate oxidase | / | 1.000 | |
| 4rje | FNR | Lactate oxidase | / | 0.608 | |
| 5ebu | FMN | Lactate oxidase | / | 0.601 | |
| 2e77 | FMN | Lactate oxidase | / | 0.595 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.570 | |
| 4yl2 | FMN | Lactate oxidase | / | 0.570 | |
| 2j6x | FMN | Lactate oxidase | / | 0.552 | |
| 1gox | FMN | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.551 | |
| 3giy | FMN | (S)-mandelate dehydrogenase | 1.1.99.31 | 0.544 | |
| 2nli | FMN | Lactate oxidase | / | 0.537 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.520 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.512 | |
| 2zfa | FMN | Lactate oxidase | / | 0.512 | |
| 3hgr | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.511 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.507 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.502 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.501 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.497 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.495 | |
| 2oz0 | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.495 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.495 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.492 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.491 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.489 | |
| 1uu9 | BI3 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.488 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.487 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.487 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.486 | |
| 4awt | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.486 | |
| 1lm1 | FMN | Ferredoxin-dependent glutamate synthase 2 | 1.4.7.1 | 0.485 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.484 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.482 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.481 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.481 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.480 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.480 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.479 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.478 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.478 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.477 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.477 | |
| 4h6k | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.477 | |
| 4rnw | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.477 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.476 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.476 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.475 | |
| 1ofe | FMN | Ferredoxin-dependent glutamate synthase 2 | 1.4.7.1 | 0.474 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.473 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.472 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.472 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.472 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.471 | |
| 1vji | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.471 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.471 | |
| 4aws | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.471 | |
| 4axa | RKD | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.471 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.470 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 4ocp | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.470 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.469 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.469 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.469 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
| 1llz | FMN | Ferredoxin-dependent glutamate synthase 2 | 1.4.7.1 | 0.468 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.468 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.467 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.467 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.467 | |
| 1j4j | ACO | Acetyltransferase | 2.3.1 | 0.466 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.466 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.466 | |
| 3gr8 | FMN | NADPH dehydrogenase | / | 0.466 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.466 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.466 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.466 | |
| 5ccy | TMP | Polymerase acidic protein | / | 0.466 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.465 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.465 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.464 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.464 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.464 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.463 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.463 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.463 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.463 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.463 | |
| 4e2b | FMN | Dehydrogenase | / | 0.463 | |
| 4gd4 | 0WS | Lysine-specific demethylase 4A | 1.14.11 | 0.463 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.463 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.463 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.462 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.462 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.462 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.462 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.462 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.462 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.461 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.461 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.461 | |
| 4g1d | 0VK | Vitamin D3 receptor A | / | 0.461 | |
| 4rnv | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.461 | |
| 4wuc | ANP | DNA gyrase subunit B | / | 0.461 | |
| 1ofd | FMN | Ferredoxin-dependent glutamate synthase 2 | 1.4.7.1 | 0.460 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.460 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.460 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.460 | |
| 4iae | 1DX | Alr2278 protein | / | 0.460 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.460 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.459 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.459 | |
| 1orr | NAD | CDP-paratose 2-epimerase | / | 0.459 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.459 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.459 | |
| 4l8u | 9AZ | Serum albumin | / | 0.459 | |
| 4rnu | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.459 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.459 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.458 | |
| 2q3k | MUW | Gag-Pol polyprotein | / | 0.458 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.457 | |
| 2g0n | GDP | Ras-related C3 botulinum toxin substrate 3 | / | 0.457 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.457 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4tmc | FMN | Old yellow enzyme | / | 0.457 | |
| 1xnj | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.456 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.456 | |
| 2gqa | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.456 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.456 | |
| 2yer | TQ1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.456 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.456 | |
| 3mje | NDP | AmphB | / | 0.456 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.456 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.456 | |
| 4rnx | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.456 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.456 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.456 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 2lfo | GCH | Fatty acid-binding protein, liver | / | 0.455 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.455 | |
| 2y8q | ADP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.455 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.455 | |
| 3l5l | FMN | Xenobiotic reductase | / | 0.455 | |
| 4bzo | 676 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 4xq6 | FMN | Dihydroorotate dehydrogenase (quinone) | / | 0.455 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.455 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.454 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.454 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.454 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.454 | |
| 4uoc | NCN | CinA-like protein | / | 0.454 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.453 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.453 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.453 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.453 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.453 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.453 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 2a84 | ATP | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.452 | |
| 2q3o | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.452 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.452 | |
| 2wue | KEK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.452 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.452 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.452 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.452 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.452 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 4bzn | UGX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.452 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1sb8 | UD2 | WbpP | / | 0.451 | |
| 2anb | 5GP | Guanylate kinase | 2.7.4.8 | 0.451 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.451 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.451 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.451 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 2x0r | NAD | Malate dehydrogenase | / | 0.451 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.451 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.451 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 5dp2 | NAP | CurF | / | 0.451 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.450 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.450 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.450 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.450 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.450 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.450 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.450 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 4fuy | EK2 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.450 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.450 | |
| 4yao | 2AM | NADPH--cytochrome P450 reductase | / | 0.450 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 1oyc | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.449 | |
| 1qcw | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.449 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.449 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.449 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.449 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
| 2e16 | SAH | Diphthine synthase | / | 0.449 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.449 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.449 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.449 | |
| 4iah | 1DX | Alr2278 protein | / | 0.449 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.449 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.448 | |
| 1bwk | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.448 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.448 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.448 | |
| 1sqk | LAR | Actin, alpha skeletal muscle | / | 0.448 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3kru | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.448 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4ivb | 1J5 | Tyrosine-protein kinase JAK1 | / | 0.448 | |
| 4l4x | NDP | AmphI | / | 0.448 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.448 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 1bv9 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.447 | |
| 1jdz | FMB | Purine nucleoside phosphorylase | / | 0.447 | |
| 1jq5 | NAD | Glycerol dehydrogenase | 1.1.1.6 | 0.447 | |
| 1rd7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 2e4n | SAH | Diphthine synthase | / | 0.447 | |
| 2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.447 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.447 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.447 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.447 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.447 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.447 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 3qiz | QI2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.447 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.447 | |
| 3zhs | TD6 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.447 | |
| 4d5g | FAD | Cyclohexane-1,2-dione hydrolase | 3.7.1.11 | 0.447 | |
| 4ef9 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.447 | |
| 4kwh | NAP | Reductase homolog | / | 0.447 | |
| 5bsf | NAD | Pyrroline-5-carboxylate reductase | / | 0.447 | |
| 1c2t | NHS | Phosphoribosylglycinamide formyltransferase | / | 0.446 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.446 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.446 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.446 | |
| 1ny5 | ADP | Transcriptional regulator (NtrC family) | / | 0.446 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.446 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.446 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.446 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.446 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.446 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.446 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.446 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.446 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.446 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.446 | |
| 4b5n | FMN | NAD(P)H:flavin oxidoreductase Sye4 | / | 0.446 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.446 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 4uth | FMN | Xenobiotic reductase | / | 0.446 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.446 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2ehl | SAH | Diphthine synthase | / | 0.445 | |
| 2en5 | SAH | Diphthine synthase | / | 0.445 | |
| 2gfd | RDA | Endoplasmin | / | 0.445 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.445 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.445 | |
| 2yex | YEX | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3dog | NNN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.445 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.445 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.445 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.445 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.445 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.445 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.445 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.445 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 4ho4 | THM | Glucose-1-phosphate thymidylyltransferase | / | 0.445 | |
| 4ihl | 1F5 | 14-3-3 protein zeta/delta | / | 0.445 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.445 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.444 | |
| 1r2j | FAD | FkbI | / | 0.444 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.444 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.444 | |
| 2e15 | SAH | Diphthine synthase | / | 0.444 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.444 | |
| 2hux | SAH | Diphthine synthase | / | 0.444 | |
| 2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 2pch | SAH | Diphthine synthase | / | 0.444 | |
| 2q46 | NAP | Uncharacterized protein At5g02240 | / | 0.444 | |
| 2udp | UPP | UDP-glucose 4-epimerase | 5.1.3.2 | 0.444 | |
| 2uyi | ADP | Kinesin-like protein KIF11 | / | 0.444 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.444 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.444 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.444 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.444 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.444 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.444 | |
| 4q4k | FMN | Uncharacterized protein | / | 0.444 | |
| 4rwt | ANP | Actin-5C | / | 0.444 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.443 | |
| 1c2t | GAR | Phosphoribosylglycinamide formyltransferase | / | 0.443 | |
| 1c70 | L75 | Protease | / | 0.443 | |
| 2el0 | SAH | Diphthine synthase | / | 0.443 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.443 | |
| 2op9 | WR1 | Orf1ab polyprotein | / | 0.443 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 2vtt | LZD | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2xk9 | XK9 | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.443 | |
| 2yxl | SFG | 450aa long hypothetical fmu protein | / | 0.443 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.443 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.443 | |
| 3o3j | BB4 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.443 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.443 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.443 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.443 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.443 | |
| 4h4q | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.443 | |
| 4k7y | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.443 | |
| 4l9q | 9TP | Serum albumin | / | 0.443 | |
| 4nmc | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4otp | ADP | Serine/threonine-protein kinase RIO1 | 2.7.11.1 | 0.443 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.443 | |
| 4yqf | GDP | Septin-9 | / | 0.443 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 1orr | CDP | CDP-paratose 2-epimerase | / | 0.442 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.442 | |
| 3alm | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.442 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.442 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.442 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3w2e | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.442 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.442 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4hyh | 1AM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 4n57 | ADP | APH(2'')-Id | / | 0.442 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.442 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.442 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.442 | |
| 1eyq | NAR | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.441 | |
| 1h8h | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 1h8h | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 1iay | AVG | 1-aminocyclopropane-1-carboxylate synthase 2 | 4.4.1.14 | 0.441 | |
| 1j7l | ADP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.441 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.441 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.441 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.441 | |
| 2v7q | ATP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 2v7q | ATP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 2xb9 | XNW | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.441 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.441 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.441 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.441 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.441 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.441 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.441 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4eo3 | FMN | Bacterioferritin comigratory protein/NADH dehydrogenase | / | 0.441 | |
| 4fdu | IHS | Putative multiple inositol polyphosphate histidine phosphatase 1 | / | 0.441 | |
| 4u0z | APC | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.441 | |
| 5kgh | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1c0l | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.440 | |
| 1ea0 | FMN | Glutamate synthase [NADPH] large chain | 1.4.1.13 | 0.440 | |
| 2dxv | SAH | Diphthine synthase | / | 0.440 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2qtv | GNP | Small COPII coat GTPase SAR1 | 3.6.5 | 0.440 | |
| 2r26 | CMC | Citrate synthase | 2.3.3.16 | 0.440 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3anx | MTA | Polyamine aminopropyltransferase | / | 0.440 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 3haz | FAD | Bifunctional protein PutA | / | 0.440 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.440 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.440 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.440 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.440 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.440 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4i6a | HMG | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 1.1.1.88 | 0.440 | |
| 4idt | T28 | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.440 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.440 | |
| 4z9r | FMN | Omega-3 polyunsaturated fatty acid synthase subunit PfaD | / | 0.440 | |
| 4zla | BES | Cytosol aminopeptidase | 3.4.11.1 | 0.440 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 5a0y | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.440 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.440 |