sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4j8p | FMN | Flavodoxin |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4j8p | FMN | Flavodoxin | / | 1.000 | |
| 3klb | FMN | Uncharacterized protein | / | 0.638 | |
| 3rua | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.498 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.496 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.496 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.495 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.495 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.495 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.493 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.490 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.490 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.488 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.487 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.486 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.485 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.484 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.484 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.481 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.480 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.480 | |
| 4gi5 | FAD | Putative NAD(P)H dehydrogenase (Quinone) | / | 0.479 | |
| 1nuu | NAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.478 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.478 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.478 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.477 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.477 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 3ru9 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.476 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.475 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.475 | |
| 3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.475 | |
| 3ruf | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.475 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.475 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.475 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.474 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.473 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.473 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.473 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.473 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.473 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.472 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.472 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.471 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3wag | TYD | Glycosyltransferase | / | 0.471 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.470 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.469 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.469 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.469 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.468 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.468 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.468 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.468 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.467 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.467 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.467 | |
| 4rvf | TYD | D-mycarose 3-C-methyltransferase | / | 0.467 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.466 | |
| 2xy3 | DUP | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.466 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.466 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2ejz | SAH | Diphthine synthase | / | 0.465 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.465 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.464 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.464 | |
| 4b64 | FAD | L-ornithine N(5)-monooxygenase | / | 0.464 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.464 | |
| 3ov7 | ATP | CCA-adding enzyme | 2.7.7.72 | 0.463 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.463 | |
| 2fre | FMN | NAD(P)H-flavin oxidoreductase | / | 0.462 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.462 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.462 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 2qzl | IXS | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3zho | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.461 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.461 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.460 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.460 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.460 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.460 | |
| 3d28 | B34 | Genome polyprotein | 2.7.7.48 | 0.460 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.460 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.460 | |
| 1ri1 | GTG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.459 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.459 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.459 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.459 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.459 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.458 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.458 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.458 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.458 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.458 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.458 | |
| 1k4m | NAD | Nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.457 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.457 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.457 | |
| 3cow | 52H | Pantothenate synthetase | 6.3.2.1 | 0.457 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.457 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.457 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4die | C5P | Cytidylate kinase | / | 0.457 | |
| 4qof | FMN | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.457 | |
| 1vso | AT1 | Glutamate receptor ionotropic, kainate 1 | / | 0.456 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.456 | |
| 2zja | ACP | ATP-dependent DNA helicase Hel308 | / | 0.456 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.456 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 3ieu | GDP | GTPase Era | / | 0.456 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4e2y | JHZ | Methyltransferase | / | 0.456 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.456 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.455 | |
| 2qs4 | LY5 | Glutamate receptor ionotropic, kainate 1 | / | 0.455 | |
| 3ahn | 3A1 | Oligopeptidase | / | 0.455 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.455 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 3r96 | ACO | MccE protein | / | 0.455 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 5cku | FAD | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.455 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.454 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.454 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.454 | |
| 2qmy | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 3a3g | DLZ | Lumazine protein | / | 0.454 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.454 | |
| 3r7k | FDA | Probable acyl CoA dehydrogenase | / | 0.454 | |
| 5f12 | FMN | NAD(P)H dehydrogenase (quinone) | / | 0.454 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.453 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.453 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.453 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.453 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.453 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.453 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.453 | |
| 1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.452 | |
| 1n2i | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.452 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.452 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.452 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.452 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.451 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.451 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.451 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.451 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.451 | |
| 3cls | FAD | Electron transfer flavoprotein subunit alpha | / | 0.451 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.451 | |
| 3pmy | 41L | Endothiapepsin | 3.4.23.22 | 0.451 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.450 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.450 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.450 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.450 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 4dja | FAD | (6-4) photolyase | / | 0.450 | |
| 4hxy | NDP | Plm1 | / | 0.450 | |
| 5a3b | APR | SIR2 family protein | / | 0.450 | |
| 5dp2 | NAP | CurF | / | 0.450 | |
| 4s0v | SUV | Orexin receptor type 2 | / | 0.450 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.449 | |
| 2hux | SAH | Diphthine synthase | / | 0.449 | |
| 2pci | SAH | Diphthine synthase | / | 0.449 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.449 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.449 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.449 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.449 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3r95 | ACO | MccE protein | / | 0.449 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.449 | |
| 4j7h | TRH | PCZA361.3 | / | 0.449 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.449 | |
| 1ohh | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.448 | |
| 1ohh | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.448 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.448 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.448 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 3ivg | FG5 | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3m4p | 4AD | Asparaginyl-tRNA synthetase, putative | / | 0.448 | |
| 3wqu | ATP | Cell division protein FtsA | / | 0.448 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.448 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.448 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.448 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.448 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.448 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.447 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.447 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.447 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.447 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.447 | |
| 3u9e | COA | Lmo1369 protein | / | 0.447 | |
| 4b0q | GMF | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 4qly | FMN | Enone reductase CLA-ER | / | 0.447 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.446 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.446 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.446 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.446 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4b72 | 2FB | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.446 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.446 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.446 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.446 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.445 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.445 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.445 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.445 | |
| 3clu | FAD | Electron transfer flavoprotein subunit alpha | / | 0.445 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.445 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.445 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.445 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.444 | |
| 2eeq | SAH | Diphthine synthase | / | 0.444 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.444 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.444 | |
| 3cvu | FAD | RE11660p | / | 0.444 | |
| 3hlw | CE3 | Beta-lactamase | / | 0.444 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.444 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.444 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.444 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.444 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.444 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.444 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.443 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.443 | |
| 2pca | SAH | Diphthine synthase | / | 0.443 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3eld | SFG | Methyltransferase | / | 0.443 | |
| 3f6s | FMN | Flavodoxin | / | 0.443 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.443 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.443 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 1amo | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.442 | |
| 1qrs | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.442 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.442 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.442 | |
| 2e17 | SAH | Diphthine synthase | / | 0.442 | |
| 2el3 | SAH | Diphthine synthase | / | 0.442 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.442 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.442 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.442 | |
| 3gye | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.442 | |
| 3keu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.442 | |
| 4jic | FMN | GTN Reductase | / | 0.442 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.442 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.442 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.442 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.441 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.441 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.441 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.441 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.441 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3c1o | NAP | Eugenol synthase | / | 0.441 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.441 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.441 | |
| 3gob | HXX | DdmC | / | 0.441 | |
| 3i25 | MV7 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.441 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.441 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.441 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4j75 | TYM | Tryptophan--tRNA ligase | / | 0.441 | |
| 4p63 | NAD | Probable deoxyhypusine synthase | 2.5.1.46 | 0.441 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.441 | |
| 1c7o | PPG | Hemolysin | / | 0.440 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.440 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.440 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3ge6 | FMN | Nitroreductase | / | 0.440 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 3koy | Z97 | D-ornithine 4,5-aminomutase subunit beta | / | 0.440 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.440 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.440 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.440 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.440 |