sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gts | D3M | DdmC |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3gts | D3M | DdmC | / | 1.000 | |
| 3gl2 | D3M | DdmC | / | 0.612 | |
| 3gb4 | D3M | DdmC | / | 0.546 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.514 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.507 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.501 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.494 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.493 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.492 | |
| 5dp2 | NAP | CurF | / | 0.487 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.486 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.484 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.484 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.484 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.484 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.484 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.482 | |
| 3gob | HXX | DdmC | / | 0.481 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.480 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.479 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.478 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.478 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.477 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.476 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.475 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.475 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.475 | |
| 1syn | F89 | Thymidylate synthase | / | 0.474 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.474 | |
| 3ndr | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.474 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.473 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.473 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.472 | |
| 4ckr | DI1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.472 | |
| 1zdw | FLV | Prenyltransferase | / | 0.471 | |
| 2xvv | 9DN | Serum albumin | / | 0.471 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.471 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.471 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.470 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.470 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.469 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.469 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.469 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.469 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.469 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 4kwh | NAP | Reductase homolog | / | 0.469 | |
| 5ej8 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.469 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 2zsc | BTN | Tamavidin2 | / | 0.468 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.468 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.468 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.467 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.467 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 3lu8 | IQX | Serum albumin | / | 0.467 | |
| 4l8u | 9AZ | Serum albumin | / | 0.467 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.466 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.466 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.465 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.465 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.465 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.465 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.464 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.464 | |
| 3o9h | K2E | Gag-Pol polyprotein | / | 0.464 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.464 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.464 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.464 | |
| 5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 | / | 0.464 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.463 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.463 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.463 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.462 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.462 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.462 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4iae | 1DX | Alr2278 protein | / | 0.462 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.462 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.462 | |
| 5ej9 | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.462 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.461 | |
| 2dek | SAH | Diphthine synthase | / | 0.461 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.461 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.461 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 1r2j | FAD | FkbI | / | 0.460 | |
| 1s20 | NAD | 2,3-diketo-L-gulonate reductase | 1.1.1.130 | 0.460 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.460 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.460 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.459 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.459 | |
| 2bxq | IMN | Serum albumin | / | 0.459 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.459 | |
| 3bx5 | 304 | Mitogen-activated protein kinase 14 | / | 0.459 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.459 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.459 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.459 | |
| 4yxm | 2BA | DNA integrity scanning protein DisA | / | 0.459 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.458 | |
| 1msn | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.458 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.458 | |
| 3up3 | XCA | aceDAF-12 | / | 0.458 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.458 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.458 | |
| 1c7o | PPG | Hemolysin | / | 0.457 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.457 | |
| 1mp0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.457 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.457 | |
| 2ejz | SAH | Diphthine synthase | / | 0.457 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.457 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.457 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.457 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.457 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.457 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.457 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.456 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1n5q | TNC | ActVA 6 protein | / | 0.456 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.456 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.456 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.456 | |
| 4fwf | FAD | Lysine-specific histone demethylase 1B | 1 | 0.456 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.456 | |
| 4l9k | EHF | Serum albumin | / | 0.456 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.455 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.455 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.455 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.455 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.455 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.455 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.454 | |
| 2e7r | SAH | Diphthine synthase | / | 0.454 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.454 | |
| 2gpj | FAD | Siderophore-interacting protein | / | 0.454 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.454 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.454 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.454 | |
| 3uqd | ADP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.454 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.454 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.454 | |
| 4gut | FAD | Lysine-specific histone demethylase 1B | 1 | 0.454 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.453 | |
| 1swp | BTN | Streptavidin | / | 0.453 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.453 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.453 | |
| 2vtb | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.453 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.453 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3anm | SYD | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.453 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.453 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.453 | |
| 4e2b | FMN | Dehydrogenase | / | 0.453 | |
| 4iah | 1DX | Alr2278 protein | / | 0.453 | |
| 4jv4 | 1OR | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.453 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.452 | |
| 2bun | FAD | AppA protein | / | 0.452 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.452 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.452 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.452 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.452 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.451 | |
| 2xvw | 9NR | Serum albumin | / | 0.451 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.451 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.451 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 4u07 | ATP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.451 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.451 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.450 | |
| 2bxm | IMN | Serum albumin | / | 0.450 | |
| 2cwf | NDP | Delta(1)-pyrroline-2-carboxylate/Delta(1)-piperideine-2-carboxylate reductase | / | 0.450 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.450 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.450 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.450 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.450 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.450 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.450 | |
| 4e2d | FMN | Dehydrogenase | / | 0.450 | |
| 4g21 | 0VP | Vitamin D3 receptor A | / | 0.450 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.450 | |
| 4u7w | NDP | MxaA | / | 0.450 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.450 | |
| 5doz | NDP | JamJ | / | 0.450 | |
| 5e92 | ANP | TGF-beta receptor type-2 | 2.7.11.30 | 0.450 | |
| 1i2l | DCS | Aminodeoxychorismate lyase | 4.1.3.38 | 0.449 | |
| 1kqf | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.449 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.449 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.449 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 2p2x | SAH | Diphthine synthase | / | 0.449 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.449 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.449 | |
| 3uko | NAD | Alcohol dehydrogenase class-3 | / | 0.449 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.449 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.449 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.448 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.448 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.448 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.448 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.448 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.448 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.448 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.448 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.448 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.448 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.448 | |
| 3up0 | D7S | aceDAF-12 | / | 0.448 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.448 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.448 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 3cqe | P91 | Wee1-like protein kinase | 2.7.10.2 | 0.447 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.447 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.447 | |
| 4hsu | FAD | Lysine-specific histone demethylase 1B | 1 | 0.447 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.447 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.447 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.447 | |
| 4rpj | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.447 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.447 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.447 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.446 | |
| 1ijh | FAD | Cholesterol oxidase | 1.1.3.6 | 0.446 | |
| 1mrw | K57 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1pua | COA | HAT A1 | / | 0.446 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.446 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.446 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.446 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2iyp | A2P | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.446 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.446 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.446 | |
| 3mzh | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.446 | |
| 3ql6 | NIM | Lactoperoxidase | 1.11.1.7 | 0.446 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.446 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.446 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.446 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.446 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.446 | |
| 5bv3 | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.446 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.445 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.445 | |
| 2wuf | KEM | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.445 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.445 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 3gnw | XNC | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 3he3 | FAD | UDP-galactopyranose mutase | / | 0.445 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.445 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.445 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1ols | TDP | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.444 | |
| 1swd | BTN | Streptavidin | / | 0.444 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.444 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.444 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.444 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.444 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.444 | |
| 2zrf | DTP | Protein RecA | / | 0.444 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.444 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.444 | |
| 3up4 | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.444 | |
| 3vwd | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.444 | |
| 3wag | TYD | Glycosyltransferase | / | 0.444 | |
| 4aos | NAP | Steroid monooxygenase | / | 0.444 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.444 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.444 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.444 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.444 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.444 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.444 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.443 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.443 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.443 | |
| 1qv1 | CZH | Obelin | / | 0.443 | |
| 2gfs | PQB | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.443 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 2owu | SAH | Diphthine synthase | / | 0.443 | |
| 2qta | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.443 | |
| 2wks | CB6 | 3-dehydroquinate dehydratase | 4.2.1.10 | 0.443 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.443 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 3qv1 | NAD | Glyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic | 1.2.1.13 | 0.443 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.443 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.443 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.443 | |
| 4l4x | NDP | AmphI | / | 0.443 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.443 | |
| 5j60 | FAD | Thioredoxin reductase | / | 0.443 | |
| 1cbo | FAD | Cholesterol oxidase | 1.1.3.6 | 0.442 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2jgs | BTN | Avidin | / | 0.442 | |
| 2pui | ADP | Methylthioribose kinase | 2.7.1.100 | 0.442 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.442 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.442 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.442 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 3zgl | 10E | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase | / | 0.442 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.442 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.442 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.442 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.442 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 5djt | FMN | NPH1-2 | / | 0.442 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.442 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.442 | |
| 1ghe | ACO | Acetyltransferase | 2.3.1 | 0.441 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.441 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.441 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.441 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3d8b | ADP | Fidgetin-like protein 1 | 3.6.4 | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.441 | |
| 3rqh | B6P | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.441 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.441 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.441 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.441 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.441 | |
| 4mk9 | 28R | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.441 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.440 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.440 | |
| 1rl3 | PCG | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.440 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.440 | |
| 2dsh | SAH | Diphthine synthase | / | 0.440 | |
| 2dv3 | SAH | Diphthine synthase | / | 0.440 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.440 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.440 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 2zts | ADP | Uncharacterized protein | / | 0.440 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.440 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.440 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3owj | 1EL | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase alpha chain | 1.13.11.3 | 0.440 | |
| 3pce | 3HP | Protocatechuate 3,4-dioxygenase beta chain | 1.13.11.3 | 0.440 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.440 | |
| 3vth | AP2 | Carbamoyltransferase | / | 0.440 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4fwe | FAD | Lysine-specific histone demethylase 1B | 1 | 0.440 | |
| 4l9q | 9TP | Serum albumin | / | 0.440 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.440 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.440 | |
| 5esd | TDP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 | |
| 5f2r | ACP | 78 kDa glucose-regulated protein | / | 0.440 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.440 |