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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ykvIK2Beta-transaminase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2ykvIK2Beta-transaminase/1.000
4aoaIK2Beta-phenylalanine transaminase2.6.10.609
4ao4PLKBeta-transaminase/0.589
4omaLCSMethionine gamma-lyase/0.504
1vbiNADMalate/L-lactate dehydrogenase family protein/0.493
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.492
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.492
1cq8PY6Aspartate aminotransferase2.6.1.10.487
4rh10TTSpore photoproduct lyase/0.487
1maqPGUAspartate aminotransferase, mitochondrial2.6.1.10.486
4zwmPLPOrnithine aminotransferase, mitochondrial, putative/0.484
4jeyPLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.483
3gncQQQGlutaryl-CoA dehydrogenase/0.481
2rqfJH3Hemolymph juvenile hormone binding protein/0.479
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.474
1b2lNDCAlcohol dehydrogenase1.1.1.10.473
1u1f183Uridine phosphorylase2.4.2.30.473
4bb3KKAIsopenicillin N synthase1.21.3.10.473
5irnADPNucleotide binding oligomerization domain containing 2/0.473
1pqc444Oxysterols receptor LXR-beta/0.472
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.472
1toiHCIAspartate aminotransferase2.6.1.10.472
3p0fBAUUridine phosphorylase 22.4.2.30.472
1hb1OCVIsopenicillin N synthase1.21.3.10.471
1hb3SCVIsopenicillin N synthase1.21.3.10.471
1xddAAYIntegrin alpha-L/0.471
3qpg3QPAspartate aminotransferase2.6.1.10.471
1u1d181Uridine phosphorylase2.4.2.30.470
3l6jZ90Alr2278 protein/0.470
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.469
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.468
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.468
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.468
4l9q9TPSerum albumin/0.468
1u1gBBBUridine phosphorylase2.4.2.30.467
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.467
4bfvZVVPantothenate kinase2.7.1.330.467
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.466
3af1GDPPantothenate kinase2.7.1.330.466
4u0mGTPCyclic GMP-AMP synthase/0.466
1mlzPLPAdenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.464
1obnASVIsopenicillin N synthase1.21.3.10.464
3qeoLLTDeoxycytidine kinase2.7.1.740.464
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.464
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.463
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.462
1u1cBAUUridine phosphorylase2.4.2.30.462
4iah1DXAlr2278 protein/0.462
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.461
3cgyRDCVirulence sensor histidine kinase PhoQ2.7.13.30.461
4e0u0MVCyclic dipeptide N-prenyltransferase/0.461
4ocvANPAminoglycoside phosphotransferase/0.461
1towCRZFatty acid-binding protein, adipocyte/0.460
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.460
2x7hPFNProstaglandin reductase 310.460
4jxrACOAcetyltransferase/0.460
1bk0ACVIsopenicillin N synthase1.21.3.10.459
1qiqACCIsopenicillin N synthase1.21.3.10.459
2a9y26AAdenosine kinase2.7.1.200.459
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.459
5d3fFSC14-3-3 protein zeta/delta/0.459
1i5cADPChemotaxis protein CheA2.7.13.30.458
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.458
3p9tTCLRepressor/0.458
4fhf0TTSpore photoproduct lyase/0.458
1u0wSTLChalcone synthase 22.3.1.740.457
5c80URIUridine phosphorylase/0.457
1dggNDPCatalase1.11.1.60.456
1rc4DDFDihydrofolate reductase1.5.1.30.456
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.456
3phjDHKShikimate dehydrogenase (NADP(+))/0.456
3zkyWT4Isopenicillin N synthase1.21.3.10.456
4qij1HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.456
4xoqF42Coenzyme F420:L-glutamate ligase/0.456
7stdCRPScytalone dehydratase4.2.1.940.456
2oatPFMOrnithine aminotransferase, mitochondrial2.6.1.130.455
4bfuZVUPantothenate kinase2.7.1.330.455
4zm3PLPAminotransferase/0.455
1dghNDPCatalase1.11.1.60.454
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.454
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3fhxPXLPyridoxal kinase2.7.1.350.454
3fufBESLeukotriene A-4 hydrolase3.3.2.60.454
3gb4D3MDdmC/0.454
3vf60H6Glucokinase2.7.1.20.454
3wv9FEGHmd co-occurring protein HcgE/0.454
4adcPLPSuccinylornithine transaminase2.6.1.810.454
4ba5PXGProbable aminotransferase/0.454
4iae1DXAlr2278 protein/0.454
1el4CTZObelin/0.453
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.453
4eb5PLPCysteine desulfurase IscS 2/0.453
1odjGMPPurine nucleoside phosphorylase/0.452
1qv0CZHObelin/0.452
2cjfRP43-dehydroquinate dehydratase4.2.1.100.452
2jb4A14Isopenicillin N synthase1.21.3.10.452
3hl0NADMaleylacetate reductase/0.452
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.452
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.452
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.451
1x2hLPALipoate-protein ligase A6.3.1.200.451
2bu9HFVIsopenicillin N synthase1.21.3.10.451
2pl0STITyrosine-protein kinase Lck2.7.10.20.451
3h3qH13Collagen type IV alpha-3-binding protein/0.451
3lfeZ84Mitogen-activated protein kinase 14/0.451
4bfzZVZPantothenate kinase2.7.1.330.451
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.450
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
2geuCOKPantothenate kinase2.7.1.330.450
4a87NARMajor pollen allergen Bet v 1-A/0.450
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.450
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.450
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.449
1hfqMOTDihydrofolate reductase1.5.1.30.449
1rftPXMPyridoxal kinase2.7.1.350.449
1tilATPAnti-sigma F factor/0.449
1zprCB3Thymidylate synthase/0.449
2w6qOA5Biotin carboxylase6.3.4.140.449
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3p0eBAUUridine phosphorylase 22.4.2.30.449
3p2oNADBifunctional protein FolD/0.449
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.449
4y9uNAPNADPH--cytochrome P450 reductase/0.449
4zgsNADPutative D-lactate dehydrogenase/0.449
1fmjRTLRetinol dehydratase/0.448
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.448
1mu6CDAProthrombin3.4.21.50.448
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.448
1u2gAPRNAD(P) transhydrogenase subunit alpha part 11.6.1.20.448
2yac937Serine/threonine-protein kinase PLK12.7.11.210.448
3b1dPLSBetaC-S lyase/0.448
3fr5I4AFatty acid-binding protein, adipocyte/0.448
3fvqATPFe(3+) ions import ATP-binding protein FbpC/0.448
3gtsD3MDdmC/0.448
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
3tvqDQHMultifunctional cyclase-dehydratase-3-O-methyl transferase TcmN2.1.10.448
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.448
4jlj1NMDeoxycytidine kinase2.7.1.740.448
4jqh1MFAlr2278 protein/0.448
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.448
1touB1VFatty acid-binding protein, adipocyte/0.447
2iviACWIsopenicillin N synthase1.21.3.10.447
2v5aLZLBiotin carboxylase6.3.4.140.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
3to3ATPPetrobactin biosynthesis protein AsbB/0.447
4boeCLRJapanin/0.447
4cdmFO1Deoxyribodipyrimidine photolyase/0.447
4lzwTHMUridine phosphorylase/0.447
4qii2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.447
4tx9AMZPhosphoribosyl isomerase A/0.447
1ml6GBXGlutathione S-transferase A22.5.1.180.446
1qjfACSIsopenicillin N synthase1.21.3.10.446
1uymPU3Heat shock protein HSP 90-beta/0.446
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2qimZEAClass 10 plant pathogenesis-related protein/0.446
2zevIPEGeranylgeranyl pyrophosphate synthase/0.446
2zsbADPPantothenate kinase2.7.1.330.446
3dcsMZMCarbonic anhydrase 24.2.1.10.446
3nyrMLCPutative fatty acid synthase/0.446
4a802ANMajor pollen allergen Bet v 1-A/0.446
4jauADPSensor histidine kinase/0.446
4jf1PLPAcetylornithine/succinyldiaminopimelate aminotransferase2.6.1.110.446
1fw0KAIGlutamate receptor 2/0.445
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
1x8lOXRRetinol dehydratase/0.445
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2ed3SAHDiphthine synthase/0.445
2ejzSAHDiphthine synthase/0.445
2gesCOKPantothenate kinase2.7.1.330.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
3dgeADPSensor histidine kinase/0.445
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
3znsNU7Histone deacetylase 73.5.1.980.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
4dk70KSOxysterols receptor LXR-beta/0.445
4nbjD3YD-tyrosyl-tRNA(Tyr) deacylase/0.445
4nieNBHNuclear receptor ROR-gamma/0.445
1synF89Thymidylate synthase/0.444
1tgv5UDUridine phosphorylase2.4.2.30.444
2h94FADLysine-specific histone demethylase 1A10.444
2uuk897Prothrombin3.4.21.50.444
2zi53L1Deoxycytidine kinase2.7.1.740.444
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3jzfJZKBiotin carboxylase6.3.4.140.444
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.444
4bfyZVYPantothenate kinase2.7.1.330.444
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.444
4yaw2AMNADPH--cytochrome P450 reductase/0.444
1g63FMNEpidermin decarboxylase4.1.10.443
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.443
1ygkRRCPyridoxal kinase2.7.1.350.443
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
2zs9ADPPantothenate kinase2.7.1.330.443
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.443
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3qvrFADGlucose oxidase1.1.3.40.443
3sl2ATPSensor histidine kinase WalK/0.443
4bfwZVWPantothenate kinase2.7.1.330.443
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4l8u9AZSerum albumin/0.443
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.443
4xymCOAAcyl-CoA synthetase (NDP forming)/0.443
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.443
5k2aZMAAdenosine receptor A2a/0.443
1dliUDXUDP-glucose 6-dehydrogenase/0.442
1o9bNAIQuinate/shikimate dehydrogenase/0.442
1qk35GPHypoxanthine-guanine-xanthine phosphoribosyltransferase2.4.2.220.442
1ygjRMCPyridoxal kinase2.7.1.350.442
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.442
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.442
2g8yNADHydroxycarboxylate dehydrogenase B/0.442
2jj2ADPATP synthase subunit alpha, mitochondrial/0.442
2jj2ADPATP synthase subunit beta, mitochondrial3.6.3.140.442
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2parTMP5'-deoxynucleotidase YfbR/0.442
2w6zL21Biotin carboxylase6.3.4.140.442
3gcq1BUMitogen-activated protein kinase 14/0.442
3h3t16HCollagen type IV alpha-3-binding protein/0.442
3ixp834Ecdysone receptor/0.442
3p62FMNPentaerythritol tetranitrate reductase/0.442
3pm1ETHTH-type transcriptional regulator QacR/0.442
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.442
3t8xT8XT-cell surface glycoprotein CD1b/0.442
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4rvgTYDD-mycarose 3-C-methyltransferase/0.442
4xbjIN5Alanine racemase, biosynthetic/0.442
5c1gGDUHisto-blood group ABO system transferase/0.442
6stdMS2Scytalone dehydratase4.2.1.940.442
1fmlRTLRetinol dehydratase/0.441
1je1GMPPurine nucleoside phosphorylase/0.441
1me6IVSPlasmepsin-23.4.23.390.441
1nceCB3Thymidylate synthase/0.441
1qoqIGPTryptophan synthase alpha chain/0.441
1qv1CZHObelin/0.441
2ab8MTPAdenosine kinase2.7.1.200.441
2y60M8FIsopenicillin N synthase1.21.3.10.441
3hv3R49Mitogen-activated protein kinase 14/0.441
3mnrSD1Heat shock protein HSP 90-alpha/0.441
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3rbaCODPhosphopantetheine adenylyltransferase/0.441
3zeiAWHO-acetylserine sulfhydrylase/0.441
4b2gV1NUncharacterized protein/0.441
4b4vL34Bifunctional protein FolD/0.441
4e2xTYDMethyltransferase/0.441
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4jx1CAHCamphor 5-monooxygenase1.14.15.10.441
4m2bUPGUDP-glucose pyrophosphorylase/0.441
1aiqCB3Thymidylate synthase/0.440
1dljUGAUDP-glucose 6-dehydrogenase/0.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.440
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.440
2rehFADNitroalkane oxidase1.7.3.10.440
2v58LZJBiotin carboxylase6.3.4.140.440
2y6fM9FIsopenicillin N synthase1.21.3.10.440
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3cw901A4-chlorobenzoyl CoA ligase/0.440
3fpbATPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.440
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.440
3zrrPXGSerine-pyruvate aminotransferase (AgxT)/0.440
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.440
4dbc3QPAspartate aminotransferase2.6.1.10.440
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.440
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.440
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.440
4yao2AMNADPH--cytochrome P450 reductase/0.440