sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2ihu | TP9 | N(2)-(2-carboxyethyl)arginine synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2ihu | TP9 | N(2)-(2-carboxyethyl)arginine synthase | / | 1.000 | |
| 1upa | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.681 | |
| 1upb | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.677 | |
| 2iht | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.662 | |
| 2ihv | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.597 | |
| 1upc | TPP | N(2)-(2-carboxyethyl)arginine synthase | / | 0.596 | |
| 2q5o | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.537 | |
| 4zp1 | TPP | Pyruvate decarboxylase | 4.1.1.1 | 0.515 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.496 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 1kek | HTL | Pyruvate synthase | / | 0.487 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.487 | |
| 2c3y | HTL | Pyruvate synthase | / | 0.485 | |
| 5ahk | TPP | Acetolactate synthase II, large subunit | / | 0.484 | |
| 2pvj | P44 | Casein kinase II subunit alpha | 2.7.11.1 | 0.483 | |
| 4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.481 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.480 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.480 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.480 | |
| 2pan | TDP | Glyoxylate carboligase | 4.1.1.47 | 0.479 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.478 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.477 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.477 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.477 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.476 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.476 | |
| 4l8u | 9AZ | Serum albumin | / | 0.476 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.475 | |
| 1ozh | HE3 | Acetolactate synthase, catabolic | 2.2.1.6 | 0.475 | |
| 2c3o | TPP | Pyruvate synthase | / | 0.475 | |
| 3r95 | ACO | MccE protein | / | 0.475 | |
| 1mcz | TDP | Benzoylformate decarboxylase | 4.1.1.7 | 0.474 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.474 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.473 | |
| 2uz1 | TPP | Benzaldehyde lyase | / | 0.473 | |
| 3zuy | TCH | Transporter | / | 0.473 | |
| 2c42 | TPP | Pyruvate synthase | / | 0.472 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.472 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.471 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.469 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.469 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.468 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.468 | |
| 3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.468 | |
| 4qmt | H1N | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.468 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.467 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.467 | |
| 2jlc | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.467 | |
| 2uza | HTL | Pyruvate synthase | / | 0.467 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.465 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.465 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.464 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.464 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.464 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.464 | |
| 2ag0 | TPP | Benzaldehyde lyase | / | 0.463 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.462 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.462 | |
| 3ih0 | ANP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.462 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.462 | |
| 4oal | 245 | Cytokinin dehydrogenase 4 | / | 0.462 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.461 | |
| 3r96 | ACO | MccE protein | / | 0.461 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.460 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.460 | |
| 4im0 | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.460 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.459 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.459 | |
| 1r2j | FAD | FkbI | / | 0.458 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.458 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.458 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.458 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1dlj | UGA | UDP-glucose 6-dehydrogenase | / | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.457 | |
| 2zsi | GA4 | Gibberellin receptor GID1A | 3 | 0.457 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.457 | |
| 3pe2 | E1B | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
| 4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.457 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.457 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.457 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.456 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.456 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.456 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3hl7 | I46 | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 3uqd | ATP | ATP-dependent 6-phosphofructokinase isozyme 2 | 2.7.1.11 | 0.456 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.456 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.456 | |
| 4eh3 | IRG | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.455 | |
| 1cx2 | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.455 | |
| 1l4m | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.455 | |
| 2c31 | TZD | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.455 | |
| 2ji6 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.455 | |
| 2wgj | VGH | Hepatocyte growth factor receptor | 2.7.10.1 | 0.455 | |
| 3p2o | NAD | Bifunctional protein FolD | / | 0.455 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.455 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 1kqg | MGD | Formate dehydrogenase, nitrate-inducible, major subunit | 1.1.5.6 | 0.454 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.454 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.454 | |
| 1s6q | TPB | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.454 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3k3i | I46 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.454 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.454 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.454 | |
| 4l4x | NDP | AmphI | / | 0.454 | |
| 4tla | ADP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.454 | |
| 5eso | TDP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.454 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.453 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.453 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.453 | |
| 2pda | TPP | Pyruvate synthase | / | 0.453 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.453 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.453 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.453 | |
| 4gu6 | 10N | Focal adhesion kinase 1 | 2.7.10.2 | 0.453 | |
| 5ify | TRH | Glucose-1-phosphate thymidylyltransferase | / | 0.453 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1ezv | UQ6 | Cytochrome b | / | 0.452 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2c3p | 1TP | Pyruvate synthase | / | 0.452 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.452 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.452 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.452 | |
| 3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.452 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.452 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.452 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.452 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1eh4 | IC1 | Casein kinase I homolog 1 | 2.7.11.1 | 0.451 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.451 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.451 | |
| 3a4p | DFQ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.451 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.451 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.451 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.451 | |
| 4c3x | FAD | 3-ketosteroid dehydrogenase | / | 0.451 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.451 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.450 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 1vjy | 460 | TGF-beta receptor type-1 | 2.7.11.30 | 0.450 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.450 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.450 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 1a9z | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.449 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.449 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.449 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.449 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.449 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.449 | |
| 3iaf | TPP | Benzaldehyde lyase | / | 0.449 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.449 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3ruh | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.449 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.449 | |
| 4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.449 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.449 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.449 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.448 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.448 | |
| 1oky | STU | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.448 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.448 | |
| 2cgp | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.448 | |
| 2cx8 | SAH | Ribosomal RNA small subunit methyltransferase E | / | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.448 | |
| 2j4z | 626 | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 2q5q | TPW | Indole-3-pyruvate decarboxylase | 4.1.1.74 | 0.448 | |
| 2xvv | 9DN | Serum albumin | / | 0.448 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3pj8 | 404 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.448 | |
| 1gqt | ACP | Ribokinase | / | 0.447 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.447 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.447 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.447 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.447 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.447 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 2yis | I46 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3gb4 | D3M | DdmC | / | 0.447 | |
| 4eh5 | IRG | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.447 | |
| 4pk4 | ADP | Unconventional myosin-VI | / | 0.447 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.447 | |
| 1fml | RTL | Retinol dehydratase | / | 0.446 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1pjk | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.446 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.446 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.446 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.446 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3ac1 | KZI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.446 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.446 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.446 | |
| 3lcd | BDY | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.446 | |
| 3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.446 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.446 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.446 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.446 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 1um0 | FMN | Chorismate synthase | / | 0.445 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.445 | |
| 2huq | SAH | Diphthine synthase | / | 0.445 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.445 | |
| 2xvw | 9NR | Serum albumin | / | 0.445 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.445 | |
| 3hko | ANP | Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands | / | 0.445 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.445 | |
| 3new | 3NE | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.445 | |
| 3vwe | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.445 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.444 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.444 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.444 | |
| 1zdw | FLV | Prenyltransferase | / | 0.444 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.444 | |
| 2x7j | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.444 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.444 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3eku | CY9 | Actin-5C | / | 0.444 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.444 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.444 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.444 | |
| 4x5j | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.444 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.443 | |
| 1mew | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.443 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.443 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.443 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.443 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.443 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3eej | 53R | Uncharacterized protein | / | 0.443 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.443 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3qd3 | 3Q5 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3rpr | 25Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.443 | |
| 3vrt | YS2 | Vitamin D3 receptor | / | 0.443 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.443 | |
| 3zxz | KRW | Hepatocyte growth factor receptor | 2.7.10.1 | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.443 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 4ijp | 1EH | Serine/threonine-protein kinase PRP4 homolog | 2.7.11.1 | 0.443 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4jxr | ACO | Acetyltransferase | / | 0.443 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.443 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.443 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 1qy5 | NEC | Endoplasmin | / | 0.442 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.442 | |
| 1ykr | 628 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.442 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.442 | |
| 3dha | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.442 | |
| 3dok | GWJ | Pol protein | / | 0.442 | |
| 3med | 65B | Gag-Pol polyprotein | 2.7.7.49 | 0.442 | |
| 3oev | 3OE | Proteasome subunit beta type-5 | 3.4.25.1 | 0.442 | |
| 3oev | 3OE | Proteasome subunit beta type-6 | 3.4.25.1 | 0.442 | |
| 3qpv | ADP | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 | 2.7.1.105 | 0.442 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.442 | |
| 4zth | GG5 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 5ej9 | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.442 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.442 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.441 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1rc1 | KT3 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.441 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.441 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.441 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2zlc | VDX | Vitamin D3 receptor | / | 0.441 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.441 | |
| 3dr1 | C5D | Vitamin D3 receptor A | / | 0.441 | |
| 3gob | HXX | DdmC | / | 0.441 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.441 | |
| 3k9u | ACO | Spermidine N(1)-acetyltransferase | / | 0.441 | |
| 3kn5 | ANP | Ribosomal protein S6 kinase alpha-5 | 2.7.11.1 | 0.441 | |
| 3lu8 | IQX | Serum albumin | / | 0.441 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.441 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.441 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.441 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.441 | |
| 4kl9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.441 | |
| 4o95 | 245 | Cytokinin dehydrogenase 4 | / | 0.441 | |
| 4ork | GDP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 4xx9 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.441 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1jsc | TPP | Acetolactate synthase catalytic subunit, mitochondrial | 2.2.1.6 | 0.440 | |
| 1l4h | NCN | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | 2.4.2.21 | 0.440 | |
| 2bxf | DZP | Serum albumin | / | 0.440 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.440 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 2oo5 | TXD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.440 | |
| 2xrw | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.440 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 3ag9 | A02 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.440 | |
| 3eya | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.440 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 3hwx | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 | |
| 3k0f | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.440 | |
| 3qfv | NM7 | Serine/threonine-protein kinase MRCK beta | 2.7.11.1 | 0.440 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 4dym | IYZ | Activin receptor type-1 | 2.7.11.30 | 0.440 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.440 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.440 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.440 | |
| 4kwi | 1TJ | Reductase homolog | / | 0.440 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.440 | |
| 4r81 | FMN | Predicted NADH dehydrogenase | / | 0.440 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.440 | |
| 4ros | APR | Malate dehydrogenase | / | 0.440 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.440 |