sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 1.000 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.684 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.674 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.669 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.555 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.544 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.535 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.528 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.524 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.524 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.523 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.523 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.523 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.521 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.520 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.519 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.516 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.514 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.511 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.511 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.511 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.508 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.506 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.506 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.506 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.506 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.505 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.504 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.503 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.502 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.501 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.500 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.499 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.499 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.498 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.498 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.497 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.495 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.494 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.494 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.493 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.492 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.491 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.491 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.490 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.489 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.489 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.489 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.488 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.488 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.487 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.486 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.486 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.485 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.484 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.484 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.483 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.482 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.481 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.480 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.480 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.480 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.479 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.479 | |
| 3gob | HXX | DdmC | / | 0.479 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.479 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.479 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.479 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 2jcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.478 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.478 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.478 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.477 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.477 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.477 | |
| 4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.477 | |
| 1llq | NAD | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.476 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.476 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.476 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.476 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.475 | |
| 2q66 | ATP | Poly(A) polymerase | 2.7.7.19 | 0.475 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.475 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.474 | |
| 3ras | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.474 | |
| 4b42 | 942 | Glucose-1-phosphate thymidylyltransferase | / | 0.474 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.474 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.472 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.472 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.472 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.472 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.471 | |
| 2y3r | TRK | TamL | / | 0.471 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.471 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.471 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.470 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.470 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.470 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.470 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.470 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.470 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.470 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.470 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.469 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.469 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.468 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.468 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.468 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.468 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.468 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.467 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.467 | |
| 4oqy | NDP | (S)-imine reductase | / | 0.467 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.467 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 3kp4 | MII | Transcriptional regulator TcaR | / | 0.466 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.466 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.466 | |
| 5a3c | NAD | SIR2 family protein | / | 0.466 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.465 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.464 | |
| 2zgy | GDP | Plasmid segregation protein ParM | / | 0.464 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.464 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.464 | |
| 4nmd | FDA | Bifunctional protein PutA | / | 0.464 | |
| 4o3m | ADP | Bloom syndrome protein | 3.6.4.12 | 0.464 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.464 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.463 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.463 | |
| 3d8v | UD1 | Bifunctional protein GlmU | / | 0.463 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.463 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.463 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.463 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.463 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.463 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.462 | |
| 2y4g | TIR | TamL | / | 0.462 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.462 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.462 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.461 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.461 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.461 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.461 | |
| 2z0y | SAM | Ribosomal RNA small subunit methyltransferase E | / | 0.461 | |
| 3cge | NDP | Coenzyme A disulfide reductase | / | 0.461 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.461 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1o0s | NAI | NAD-dependent malic enzyme, mitochondrial | 1.1.1.38 | 0.460 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.460 | |
| 2wpx | ACO | Orf14 | / | 0.460 | |
| 2y3s | TIR | TamL | / | 0.460 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.460 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.460 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4n6h | EJ4 | Delta-type opioid receptor | / | 0.460 | |
| 4yao | FMN | NADPH--cytochrome P450 reductase | / | 0.460 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.459 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.459 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.459 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.459 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.459 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.459 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.459 | |
| 5a3b | APR | SIR2 family protein | / | 0.459 | |
| 1aj8 | COA | Citrate synthase | / | 0.458 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.458 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.458 | |
| 3cgd | NAD | Coenzyme A disulfide reductase | / | 0.458 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 3u8l | 09Q | Acetylcholine-binding protein | / | 0.458 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4ejv | LCL | Transcriptional regulator TcaR | / | 0.458 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.457 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.457 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.457 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 1sus | SAH | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.457 | |
| 1yon | A2R | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.457 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.457 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.457 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.456 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.456 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.456 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.456 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.455 | |
| 1eio | GCH | Gastrotropin | / | 0.455 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.455 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta | / | 0.455 | |
| 3eql | MXP | DNA-directed RNA polymerase subunit beta' | / | 0.455 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.455 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.454 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.454 | |
| 2ves | GVR | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.454 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.454 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.454 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.454 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1ozv | SAH | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.453 | |
| 1v59 | FAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.453 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.453 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.453 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.452 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2h12 | CMX | Citrate synthase | / | 0.452 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.452 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.452 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 2f1k | NAP | Prephenate dehydrogenase | / | 0.451 | |
| 2hsd | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.451 | |
| 2uzf | CAA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.451 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.451 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.451 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.451 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.451 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.451 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.451 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.451 | |
| 4iae | 1DX | Alr2278 protein | / | 0.451 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.451 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.451 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.450 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.450 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.450 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.450 | |
| 3h3c | P1E | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.450 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.450 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.450 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.449 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.449 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2fy4 | COA | Choline O-acetyltransferase | 2.3.1.6 | 0.449 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.449 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.449 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.449 | |
| 3p84 | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.449 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 4e5y | NDP | GDP-L-fucose synthase | 1.1.1.271 | 0.449 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.449 | |
| 4i5v | B4P | Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 2 | / | 0.449 | |
| 5a9s | NAP | Putative dehydrogenase | / | 0.449 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.449 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.448 | |
| 1sq5 | ADP | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.448 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.448 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 2yyi | FAD | 4-hydroxyphenylacetate 3-monooxygenase oxygenase component | 1.14.14.9 | 0.448 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.448 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.448 | |
| 3zuy | TCH | Transporter | / | 0.448 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.448 | |
| 4o67 | 1SY | Cyclic GMP-AMP synthase | / | 0.448 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.448 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.447 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.447 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.447 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.447 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 3fhy | ATP | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 3h4l | ANP | DNA mismatch repair protein PMS1 | / | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3ibq | ATP | Pyridoxal kinase | / | 0.447 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.447 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.447 | |
| 4xr9 | NAD | CalS8 | / | 0.447 | |
| 1ep3 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.446 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.446 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.446 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.446 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.446 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
| 3a4v | NAD | NDP-sugar epimerase | / | 0.446 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.446 | |
| 3mk6 | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.446 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.446 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.446 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.446 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.446 | |
| 4o2b | LOC | Tubulin beta-2B chain | / | 0.446 | |
| 1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.445 | |
| 2cx8 | SAH | Ribosomal RNA small subunit methyltransferase E | / | 0.445 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.445 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.445 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.445 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.445 | |
| 3zs7 | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.445 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.445 | |
| 4lcg | 1WM | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.445 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1np7 | FAD | Cryptochrome DASH | / | 0.444 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.444 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.444 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2bxo | OPB | Serum albumin | / | 0.444 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2eq7 | NAD | Dihydrolipoyl dehydrogenase | / | 0.444 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.444 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.444 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.444 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.444 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.444 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.444 | |
| 3v1y | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1, cytosolic | 1.2.1.12 | 0.444 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.444 | |
| 4v12 | POG | MaoC like domain protein | / | 0.444 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.444 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.443 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.443 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.443 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.443 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.443 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.443 | |
| 3lsh | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.443 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.443 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.443 | |
| 4j49 | NAI | Uncharacterized protein | / | 0.443 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.443 | |
| 4tqg | NDP | Putative dTDP-d-glucose 4 6-dehydratase | / | 0.443 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.442 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.442 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.442 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.442 | |
| 4h3c | 0YZ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4nm9 | FAD | Bifunctional protein PutA | / | 0.442 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.441 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.441 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.441 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.441 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.441 | |
| 3h3f | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.441 | |
| 3ijd | C2F | Methylenetetrahydrofolate reductase | / | 0.441 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.441 | |
| 3uoz | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.441 | |
| 4b13 | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4jic | FMN | GTN Reductase | / | 0.441 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.441 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.441 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.440 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.440 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.440 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.440 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 2xfs | J01 | Uncharacterized protein | / | 0.440 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.440 | |
| 3tri | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.440 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4d7e | FAD | Putative lysine-N-oxygenase | / | 0.440 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.440 | |
| 4obu | PLP | Pyridoxal-dependent decarboxylase domain protein | / | 0.440 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 5cts | CMC | Citrate synthase, mitochondrial | 2.3.3.1 | 0.440 |