sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1ib6 | NAD | Malate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1ib6 | NAD | Malate dehydrogenase | / | 1.000 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.597 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.582 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.575 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.565 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.545 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.538 | |
| 4ros | APR | Malate dehydrogenase | / | 0.534 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.522 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.522 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.521 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.514 | |
| 3h3f | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.514 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.511 | |
| 1b8v | NAD | Malate dehydrogenase | / | 0.509 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.507 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.503 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.503 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.500 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.500 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.499 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.498 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.498 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.496 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.495 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.495 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.495 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.495 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.494 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.494 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.493 | |
| 3rud | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.493 | |
| 4ajn | 88V | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.493 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.492 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.492 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.490 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.490 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.490 | |
| 1ur5 | NAD | Malate dehydrogenase | / | 0.489 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.489 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.488 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.487 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.486 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.485 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.484 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.483 | |
| 1gv0 | NAD | Malate dehydrogenase | / | 0.482 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.481 | |
| 3rn8 | RN8 | Glutamate receptor 2 | / | 0.480 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.479 | |
| 4dja | FAD | (6-4) photolyase | / | 0.479 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.479 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.477 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.477 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.477 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.476 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.475 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.475 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.474 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.473 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.473 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.472 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.472 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.472 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.471 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.471 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.470 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.470 | |
| 1y7t | NDP | Malate dehydrogenase | / | 0.469 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.469 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.469 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.469 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.469 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.469 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.468 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.468 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.468 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.468 | |
| 4dd8 | BAT | Disintegrin and metalloproteinase domain-containing protein 8 | 3.4.24 | 0.468 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.467 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.467 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.467 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.466 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.466 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.465 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.465 | |
| 4g74 | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.465 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.465 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.464 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.464 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.464 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.463 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.463 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.463 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.463 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.463 | |
| 3wsw | NAD | L-lactate dehydrogenase | / | 0.463 | |
| 5fs7 | FAD | Apoptosis-inducing factor 1, mitochondrial | 1.1.1 | 0.463 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.462 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.462 | |
| 3nbv | ANP | Ketohexokinase | / | 0.462 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.462 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.461 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.461 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.460 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.460 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.460 | |
| 3c21 | 2BA | DNA integrity scanning protein DisA | / | 0.460 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.460 | |
| 3ms4 | 21N | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.460 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.459 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.459 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.459 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.459 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.459 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 4fj0 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.459 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.459 | |
| 4gl4 | NAI | Alcohol dehydrogenase class-3 | / | 0.459 | |
| 5a3b | APR | SIR2 family protein | / | 0.459 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.458 | |
| 2d1c | NAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.458 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.458 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.458 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.458 | |
| 3c1y | 2BA | DNA integrity scanning protein DisA | / | 0.458 | |
| 3sfe | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.458 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.458 | |
| 1b8u | NAD | Malate dehydrogenase | / | 0.457 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.457 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.457 | |
| 1iy8 | NAD | Levodione reductase | / | 0.457 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.457 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.457 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.457 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.457 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.456 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.456 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3cos | NAD | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.456 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.456 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.456 | |
| 4blr | UTP | NTPase P4 | / | 0.456 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.456 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.456 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.455 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.455 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 3tsc | NAD | Uncharacterized protein | / | 0.455 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.455 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.455 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.454 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.454 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.454 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.454 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.454 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.454 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.453 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.453 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.453 | |
| 2qn7 | HBZ | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.453 | |
| 2w06 | FRV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 3eku | CY9 | Actin-5C | / | 0.453 | |
| 3etd | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.453 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.453 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.452 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.452 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.452 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3u4c | NDP | NADPH-dependent reductase BacG | / | 0.452 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.452 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.452 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.451 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.451 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.451 | |
| 3mgd | ACO | Predicted acetyltransferase | / | 0.451 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 5ahs | FAD | Acyl-CoA dehydrogenase | / | 0.451 | |
| 1egd | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.450 | |
| 1lwi | NAP | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.450 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.450 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 1yqd | NAP | Sinapyl alcohol dehydrogenase | / | 0.450 | |
| 2a87 | FAD | Thioredoxin reductase | 1.8.1.9 | 0.450 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.450 | |
| 2ohv | NHL | Glutamate racemase | / | 0.450 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.450 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.450 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.450 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.450 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.450 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.450 | |
| 4jji | NAD | Alcohol dehydrogenase class-3 | / | 0.450 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1dr3 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.449 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.449 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2f17 | PYI | Thiamin pyrophosphokinase 1 | 2.7.6.2 | 0.449 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 2x6t | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.449 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.449 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.449 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.449 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.449 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.449 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.448 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.448 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.448 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 2q7v | FAD | Thioredoxin reductase | / | 0.448 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.448 | |
| 2ylr | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.448 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.448 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.448 | |
| 3r96 | ACO | MccE protein | / | 0.448 | |
| 3sgl | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.448 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.448 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.448 | |
| 5f8e | SAH | Possible transcriptional regulatory protein | / | 0.448 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.448 | |
| 1bmd | NAD | Malate dehydrogenase | / | 0.447 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.447 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.447 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.447 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 1ykf | NAP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.447 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.447 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.447 | |
| 3e8x | NAP | BH1520 protein | / | 0.447 | |
| 3ru7 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.447 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.447 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.447 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.447 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.447 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.446 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.446 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.446 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.446 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.446 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.446 | |
| 4jal | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.446 | |
| 4l8u | 9AZ | Serum albumin | / | 0.446 | |
| 4nwz | FAD | FAD-dependent pyridine nucleotide-disulfide oxidoreductase | / | 0.446 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.446 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.446 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.445 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.445 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.445 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.445 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.445 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3t2v | KKJ | Peptidoglycan recognition protein 1 | / | 0.445 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.445 | |
| 5a3c | NAD | SIR2 family protein | / | 0.445 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.445 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.444 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.444 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.444 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.444 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 4eu8 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.444 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.444 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.443 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.443 | |
| 1yqx | NAP | Sinapyl alcohol dehydrogenase | / | 0.443 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.443 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.443 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.443 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.443 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.443 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.443 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.443 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.443 | |
| 4h8a | NAI | Ureidoglycolate dehydrogenase (NAD(+)) | 1.1.1.350 | 0.443 | |
| 5jla | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.442 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.442 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.442 | |
| 1xq6 | NAP | Uncharacterized protein At5g02240 | / | 0.442 | |
| 2hrb | NAP | Carbonyl reductase [NADPH] 3 | 1.1.1.184 | 0.442 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.442 | |
| 2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.442 | |
| 3cty | FAD | Probable thioredoxin reductase | / | 0.442 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.442 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.442 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.442 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.442 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.442 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.442 | |
| 4d86 | ADP | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.442 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4qec | NAP | ElxO | / | 0.442 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.442 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.442 | |
| 4yry | FAD | Glutamate synthase, beta subunit | / | 0.442 | |
| 5js6 | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.442 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1dli | UDX | UDP-glucose 6-dehydrogenase | / | 0.441 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.441 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.441 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 3itj | FAD | Thioredoxin reductase 1 | 1.8.1.9 | 0.441 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.441 | |
| 3pm9 | FAD | Putative oxidoreductase | / | 0.441 | |
| 3wle | NAD | (R)-specific carbonyl reductase | / | 0.441 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.441 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.441 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.441 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1jmh | UMP | Thymidylate synthase | / | 0.440 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.440 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.440 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.440 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.440 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.440 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.440 | |
| 3sx2 | NAD | Uncharacterized protein | / | 0.440 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.440 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.440 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.440 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 |