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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fg2 FAD Putative rubredoxin reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fg2 FADPutative rubredoxin reductase / 1.396
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 1.053
4em4 FADCoenzyme A disulfide reductase / 0.996
4eqx FADCoenzyme A disulfide reductase / 0.972
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.968
4eqw FADCoenzyme A disulfide reductase / 0.961
4eqs FADCoenzyme A disulfide reductase / 0.957
1yqz FADCoenzyme A disulfide reductase / 0.954
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.947
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.944
4em3 FADCoenzyme A disulfide reductase / 0.938
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.933
4eqr FADCoenzyme A disulfide reductase / 0.928
1d7y FADFerredoxin reductase / 0.925
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.924
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.922
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.916
2gqw FADFerredoxin reductase / 0.903
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.901
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.898
3icr FADCoenzyme A disulfide reductase / 0.893
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.888
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.886
4emw FADCoenzyme A disulfide reductase / 0.884
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.882
2gr3 FADFerredoxin reductase / 0.881
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.862
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.856
2gr0 FADFerredoxin reductase / 0.856
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.851
3ics FADCoenzyme A disulfide reductase / 0.842
3cgc FADCoenzyme A disulfide reductase / 0.839
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.836
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.829
1f3p FADFerredoxin reductase / 0.823
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.823
3cgb FADCoenzyme A disulfide reductase / 0.823
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.821
1q1r FADPutidaredoxin reductase 1.18.1.5 0.816
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.816
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.815
4yry FADGlutamate synthase, beta subunit / 0.815
1q1w FADPutidaredoxin reductase 1.18.1.5 0.808
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.796
1nhr FADNADH peroxidase 1.11.1.1 0.793
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.792
4z24 FADPutative GMC-type oxidoreductase R135 1 0.788
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.787
4hb9 FADUncharacterized protein / 0.784
1joa FADNADH peroxidase 1.11.1.1 0.783
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.782
2npx FADNADH peroxidase 1.11.1.1 0.779
1nhp FADNADH peroxidase 1.11.1.1 0.777
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.776
3cgd FADCoenzyme A disulfide reductase / 0.773
3atq FDAConserved Archaeal protein / 0.770
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.770
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.769
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.768
3f8d FADNADH oxidase/thioredoxin reductase / 0.767
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.767
1f8w FADNADH peroxidase 1.11.1.1 0.762
4bk3 FADProbable salicylate monooxygenase / 0.762
3t37 FADPyridoxine 4-oxidase / 0.757
4opg FDAConserved Archaeal protein / 0.757
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.755
3ict FADCoenzyme A disulfide reductase / 0.755
3nlc FADUncharacterized protein / 0.755
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.754
4bjz FADProbable salicylate monooxygenase / 0.753
1nhq FADNADH peroxidase 1.11.1.1 0.748
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.748
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.747
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.747
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.747
4opt FDAConserved Archaeal protein / 0.747
2zbw FADFerredoxin--NADP reductase / 0.746
4jn9 FADDepH / 0.743
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.739
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.739
2yvj FADFerredoxin reductase / 0.739
4nte FADDepH / 0.736
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.732
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.730
2xdo FADTetX family tetracycline inactivation enzyme / 0.728
4a5l FADThioredoxin reductase / 0.728
4la1 FADThioredoxin glutathione reductase / 0.727
1tde FADThioredoxin reductase 1.8.1.9 0.726
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.726
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.725
2r9z FADGlutathione amide reductase / 0.724
2x8h FADThioredoxin glutathione reductase / 0.724
1ger FADGlutathione reductase 1.8.1.7 0.723
2x8g FADThioredoxin glutathione reductase / 0.723
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.723
1fec FADTrypanothione reductase 1.8.1.12 0.722
2wp5 FADTrypanothione reductase / 0.722
5dbj FADFADH2-dependent halogenase PltA / 0.722
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.719
4opl FDAConserved Archaeal protein / 0.718
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.717
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.716
2qa1 FADPgaE / 0.716
2wba FADTrypanothione reductase 1.8.1.12 0.716
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.715
4x4j FADPutative oxygenase / 0.715
1get FADGlutathione reductase 1.8.1.7 0.714
3cge FADCoenzyme A disulfide reductase / 0.714
4up3 FADThioredoxin reductase / 0.714
1nhs FADNADH peroxidase 1.11.1.1 0.713
2gr1 FADFerredoxin reductase / 0.712
2gv8 FADThiol-specific monooxygenase 1.14.13 0.712
2v6o FADThioredoxin glutathione reductase / 0.712
4k2x FADPolyketide oxygenase/hydroxylase / 0.712
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.711
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.710
2jk6 FADTrypanothione reductase / 0.710
2hqm FADGlutathione reductase 1.8.1.7 0.709
4bk2 FADProbable salicylate monooxygenase / 0.709
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.708
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.708
4qi7 FADCellobiose dehydrogenase / 0.708
3ish FADThioredoxin reductase 1.8.1.9 0.706
1zk7 FADMercuric reductase 1.16.1.1 0.704
2q0k FADThioredoxin reductase 1.8.1.9 0.703
4j2w FADKynurenine 3-monooxygenase / 0.701
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.701
1trb FADThioredoxin reductase 1.8.1.9 0.700
3t2k FADSulfide-quinone reductase / 0.700
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.699
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.699
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.698
4opu FDAConserved Archaeal protein / 0.698
2eq7 FADDihydrolipoyl dehydrogenase / 0.697
2w0h FADTrypanothione reductase / 0.697
1k0l FADp-hydroxybenzoate hydroxylase / 0.696
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.696
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.695
1gxf FADTrypanothione reductase 1.8.1.12 0.694
1pdh FASp-hydroxybenzoate hydroxylase / 0.694
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.694
2yvf FADFerredoxin reductase / 0.694
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.694
4ysh FADGlycine oxidase / 0.694
1geu FADGlutathione reductase 1.8.1.7 0.693
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.693
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.692
3t2z FADSulfide-quinone reductase / 0.692
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.692
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.692
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.691
4cnk FADL-amino acid oxidase / 0.691
4z26 FADPutative GMC-type oxidoreductase R135 1 0.690
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.689
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.689
1feb FADTrypanothione reductase 1.8.1.12 0.688
4opi FDAConserved Archaeal protein / 0.688
1fea FADTrypanothione reductase 1.8.1.12 0.687
2rab FADGlutathione amide reductase / 0.687
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.687
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.686
1b4v FADCholesterol oxidase 1.1.3.6 0.685
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.685
2eq8 FADDihydrolipoyl dehydrogenase / 0.685
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.684
3e4v FMNUncharacterized protein / 0.684
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.684
4a99 FADTetX family tetracycline inactivation enzyme / 0.684
2wow FADTrypanothione reductase / 0.683
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.683
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
4j57 FADThioredoxin reductase 2 1.8.1.9 0.682
1eje FMNProtein MTH_152 / 0.681
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.681
2jb2 FADL-amino acid oxidase / 0.681
4qi4 FADCellobiose dehydrogenase / 0.681
1zx9 FADMercuric reductase 1.16.1.1 0.680
2e1m FADL-glutamate oxidase / 0.679
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.679
4j31 FADKynurenine 3-monooxygenase / 0.679
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.678
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.678
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.678
1reo FADL-amino-acid oxidase 1.4.3.2 0.677
3bg7 FADPyranose 2-oxidase / 0.677
4qi5 FADCellobiose dehydrogenase / 0.677
4xoo FMNCoenzyme F420:L-glutamate ligase / 0.677
2eq9 FADDihydrolipoyl dehydrogenase / 0.676
2ok7 FADFerredoxin--NADP reductase, apicoplast / 0.676
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.676
2tpr FADTrypanothione reductase 1.8.1.12 0.675
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.675
5a8a FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.675
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.674
2q7v FADThioredoxin reductase / 0.674
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.674
4j34 FADKynurenine 3-monooxygenase / 0.674
4tm1 FDAKtzI / 0.674
3atr FDAConserved Archaeal protein / 0.673
3t14 FADSulfide-quinone reductase / 0.673
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.672
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.672
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.672
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.672
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
2cdu FADNADH oxidase / 0.671
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.671
1h42 FADFerredoxin--NADP reductase 1.18.1.2 0.670
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.670
1ges FADGlutathione reductase 1.8.1.7 0.669
2yqu FADDihydrolipoyl dehydrogenase / 0.669
5a89 FMNRiboflavin biosynthesis protein RibF 2.7.1.26 0.669
4i58 FADCyclohexylamine Oxidase / 0.668
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.667
2eq6 FADDihydrolipoyl dehydrogenase / 0.667
3gwd FADCyclohexanone monooxygenase / 0.667
4a6n FADTetX family tetracycline inactivation enzyme / 0.667
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.667
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.666
3syi FADSulfide-quinone reductase / 0.666
1k0j FADp-hydroxybenzoate hydroxylase / 0.665
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.665
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.665
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.664
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.664
4j33 FADKynurenine 3-monooxygenase / 0.663
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.662
2b9x FADPutative aminooxidase / 0.662
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.662
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.661
2gpj FADSiderophore-interacting protein / 0.661
2x3n FADProbable FAD-dependent monooxygenase / 0.661
1fnc FDAFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.660
1qlt FADVanillyl-alcohol oxidase 1.1.3.38 0.660
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.660
5j4e FMNSensory box protein / 0.660
1cbo FADCholesterol oxidase 1.1.3.6 0.659
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.659
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.659
4guv FADTetX family tetracycline inactivation enzyme / 0.659
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.659
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
1tdf FADThioredoxin reductase 1.8.1.9 0.658
3cox FADCholesterol oxidase 1.1.3.6 0.658
4b67 FADL-ornithine N(5)-monooxygenase / 0.658
4jq9 FADDihydrolipoyl dehydrogenase / 0.658
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.658
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.657
1phh FADp-hydroxybenzoate hydroxylase / 0.657
2qa2 FADPolyketide oxygenase CabE / 0.657
1qh0 FADFerredoxin--NADP reductase 1.18.1.2 0.656
3r9u FADThioredoxin reductase / 0.656
3sz0 FADSulfide-quinone reductase / 0.656
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.656
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.655
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.655
4mo2 FADUDP-galactopyranose mutase / 0.655
1mxt FAECholesterol oxidase 1.1.3.6 0.654
3ept FDAPutative FAD-monooxygenase / 0.654
3pl8 FADPyranose 2-oxidase / 0.654
4b69 FADL-ornithine N(5)-monooxygenase / 0.654
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.654
1n4v FADCholesterol oxidase 1.1.3.6 0.653
4gcm FADThioredoxin reductase 1.8.1.9 0.653
4rek FADCholesterol oxidase 1.1.3.6 0.653
2jae FADL-amino acid oxidase / 0.652
2jb1 FADL-amino acid oxidase / 0.652
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.652
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.652
4dsg FADUncharacterized protein / 0.652
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.652
4wct FADFructosyl amine:oxygen oxidoreductase / 0.652
2nli FMNLactate oxidase / 0.651
3hdy FADUDP-galactopyranose mutase / 0.651
3urh FADDihydrolipoyl dehydrogenase / 0.651
1bx1 FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.650
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.650
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.650
3k4c FADPyranose 2-oxidase / 0.650
3qfr FADNADPH--cytochrome P450 reductase / 0.650
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.650
4y7c FADNADPH--cytochrome P450 reductase / 0.650