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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ept FDA Putative FAD-monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3ept FDAPutative FAD-monooxygenase / 1.363
4k5r FADOxygenase / 0.893
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.839
4bjz FADProbable salicylate monooxygenase / 0.822
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.820
4opg FDAConserved Archaeal protein / 0.816
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.806
4opc FDAConserved Archaeal protein / 0.805
2qa1 FADPgaE / 0.801
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.801
4icy FADPgaE / 0.795
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.794
4j34 FADKynurenine 3-monooxygenase / 0.789
3atq FDAConserved Archaeal protein / 0.787
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.786
3atr FDAConserved Archaeal protein / 0.785
2eq8 FADDihydrolipoyl dehydrogenase / 0.783
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.780
1nhr FADNADH peroxidase 1.11.1.1 0.779
2eq6 FADDihydrolipoyl dehydrogenase / 0.777
2xyo FADTetX family tetracycline inactivation enzyme / 0.776
2xdo FADTetX family tetracycline inactivation enzyme / 0.775
4bk3 FADProbable salicylate monooxygenase / 0.769
3rp8 FADFAD-dependent urate hydroxylase / 0.768
4a6n FADTetX family tetracycline inactivation enzyme / 0.767
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.766
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.763
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.763
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.761
2wp5 FADTrypanothione reductase / 0.760
2zbw FADFerredoxin--NADP reductase / 0.760
5buk FADFADH2-dependent halogenase / 0.760
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.758
4bk2 FADProbable salicylate monooxygenase / 0.758
4k2x FADPolyketide oxygenase/hydroxylase / 0.758
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.757
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.756
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.756
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.755
4nte FADDepH / 0.751
3lad FADDihydrolipoyl dehydrogenase / 0.750
1d7l RFLp-hydroxybenzoate hydroxylase / 0.746
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.746
4ntc FADThioredoxin reductase gliT / 0.746
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.745
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.744
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.741
4opu FDAConserved Archaeal protein / 0.740
1k0j FADp-hydroxybenzoate hydroxylase / 0.738
3fmw FADOxygenase / 0.736
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.736
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.735
2yqu FADDihydrolipoyl dehydrogenase / 0.735
2eq9 FADDihydrolipoyl dehydrogenase / 0.734
3nix FADFlavoprotein/dehydrogenase / 0.734
3p9u FADTetX family tetracycline inactivation enzyme / 0.733
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.733
1zk7 FADMercuric reductase 1.16.1.1 0.732
1feb FADTrypanothione reductase 1.8.1.12 0.727
2tpr FADTrypanothione reductase 1.8.1.12 0.727
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.727
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.727
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.726
2eq7 FADDihydrolipoyl dehydrogenase / 0.725
2hqm FADGlutathione reductase 1.8.1.7 0.724
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.721
2jk6 FADTrypanothione reductase / 0.721
2yg4 FADPutrescine oxidase / 0.719
4mok FADPyranose 2-oxidase / 0.719
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.718
3cgb FADCoenzyme A disulfide reductase / 0.718
4fwf FADLysine-specific histone demethylase 1B 1 0.718
5dbj FADFADH2-dependent halogenase PltA / 0.717
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.716
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.715
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.715
1c0k FADD-amino-acid oxidase 1.4.3.3 0.714
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.714
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.714
4opi FDAConserved Archaeal protein / 0.714
1geu FADGlutathione reductase 1.8.1.7 0.713
2q0k FADThioredoxin reductase 1.8.1.9 0.709
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.708
3v76 FDAUncharacterized protein / 0.708
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.708
4j33 FADKynurenine 3-monooxygenase / 0.707
4j57 FADThioredoxin reductase 2 1.8.1.9 0.707
4jnq FDAThioredoxin reductase / 0.707
4opl FDAConserved Archaeal protein / 0.707
1z6l FADPolyamine oxidase FMS1 / 0.706
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.706
4hb9 FADUncharacterized protein / 0.706
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.706
2qa2 FADPolyketide oxygenase CabE / 0.705
1pkv RBFRiboflavin synthase 2.5.1.9 0.704
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.704
3ka7 FADPutative oxidoreductase / 0.704
1c0l FADD-amino-acid oxidase 1.4.3.3 0.703
3cty FADProbable thioredoxin reductase / 0.703
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.702
2wow FADTrypanothione reductase / 0.701
2xvf FADPutative flavin-containing monooxygenase / 0.700
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.700
3urh FADDihydrolipoyl dehydrogenase / 0.700
1zx9 FADMercuric reductase 1.16.1.1 0.699
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.699
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
4gut FADLysine-specific histone demethylase 1B 1 0.699
1ng3 FADGlycine oxidase 1.4.3.19 0.698
2wba FADTrypanothione reductase 1.8.1.12 0.698
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.698
4eo3 FMNBacterioferritin comigratory protein/NADH dehydrogenase / 0.698
4opt FDAConserved Archaeal protein / 0.698
4em3 FADCoenzyme A disulfide reductase / 0.697
4r38 RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.697
1joa FADNADH peroxidase 1.11.1.1 0.696
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
2r9z FADGlutathione amide reductase / 0.694
3ad9 FADSubunit beta of sarcosine oxidase / 0.694
4fk1 FADPutative thioredoxin reductase / 0.694
3cgc FADCoenzyme A disulfide reductase / 0.693
3hji FADVivid PAS protein VVD / 0.691
2x3n FADProbable FAD-dependent monooxygenase / 0.690
4j31 FADKynurenine 3-monooxygenase / 0.690
2w0h FADTrypanothione reductase / 0.689
1tde FADThioredoxin reductase 1.8.1.9 0.688
1k0l FADp-hydroxybenzoate hydroxylase / 0.687
2dw4 FADLysine-specific histone demethylase 1A 1 0.687
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
4guv FADTetX family tetracycline inactivation enzyme / 0.687
1ib0 FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.685
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.685
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.685
1nhp FADNADH peroxidase 1.11.1.1 0.684
3rha FDAPutrescine oxidase / 0.684
4cnk FADL-amino acid oxidase / 0.684
4em4 FADCoenzyme A disulfide reductase / 0.684
4fwe FADLysine-specific histone demethylase 1B 1 0.684
4j36 FADKynurenine 3-monooxygenase / 0.684
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.683
3a3b RBFLumazine protein / 0.683
4a65 FADThioredoxin reductase / 0.683
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.683
2q7v FADThioredoxin reductase / 0.682
3hdy FADUDP-galactopyranose mutase / 0.682
4jq9 FADDihydrolipoyl dehydrogenase / 0.682
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
3ish FADThioredoxin reductase 1.8.1.9 0.680
4gus FADLysine-specific histone demethylase 1B 1 0.680
4hsu FADLysine-specific histone demethylase 1B 1 0.680
1rsg FADPolyamine oxidase FMS1 / 0.679
4hj3 FMNLOV protein / 0.679
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.678
1npx FADNADH peroxidase 1.11.1.1 0.678
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.678
3k30 ADPHistamine dehydrogenase / 0.678
4nev FADTrypanothione reductase / 0.678
4tm4 FDAKtzI / 0.678
1rq1 FADEndoplasmic oxidoreductin-1 1.8.4 0.677
2vq7 FADPutative flavin-containing monooxygenase / 0.677
2gqf FADUncharacterized protein HI_0933 / 0.676
3if9 FADGlycine oxidase 1.4.3.19 0.676
4f07 FADStyrene monooxygenase component 2 / 0.676
4fwj FADLysine-specific histone demethylase 1B 1 0.676
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.675
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.674
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.674
2h94 FADLysine-specific histone demethylase 1A 1 0.674
3in6 FMNUncharacterized protein / 0.674
3qvr FADGlucose oxidase 1.1.3.4 0.674
1n9n FMNPutative blue light receptor / 0.673
2xve FADPutative flavin-containing monooxygenase / 0.673
3k4n FADPyranose 2-oxidase / 0.673
4c3y FAD3-ketosteroid dehydrogenase / 0.673
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.673
4gcm FADThioredoxin reductase 1.8.1.9 0.673
1ng4 FADGlycine oxidase 1.4.3.19 0.672
4eet FMNPhototropin-2 2.7.11.1 0.672
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.672
1cqx FADFlavohemoprotein / 0.671
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.671
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.671
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.671
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.671
1pdh FASp-hydroxybenzoate hydroxylase / 0.670
3a3g DLZLumazine protein / 0.670
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.670
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.670
2gr3 FADFerredoxin reductase / 0.669
2v6o FADThioredoxin glutathione reductase / 0.669
4i58 FADCyclohexylamine Oxidase / 0.669
1gal FADGlucose oxidase 1.1.3.4 0.668
1nhq FADNADH peroxidase 1.11.1.1 0.668
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.668
4kuk RBFPutative blue-light photoreceptor / 0.668
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.668
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.668
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.668
2bab FADPutative aminooxidase / 0.667
2gjn FMNNitronate monooxygenase 1.13.12.16 0.667
2hko FADLysine-specific histone demethylase 1A 1 0.667
2ywl FADThioredoxin reductase related protein / 0.667
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.667
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.666
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.666
1rx0 FADIsobutyryl-CoA dehydrogenase, mitochondrial 1.3.99 0.666
2yg7 FADPutrescine oxidase / 0.666
3bi5 FADPolyamine oxidase FMS1 / 0.666
4jn9 FADDepH / 0.666
4up3 FADThioredoxin reductase / 0.666
1cl0 FADThioredoxin reductase 1.8.1.9 0.665
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.665
2ed4 FAD4-hydroxyphenylacetate 3-monooxygenase reductase component 1.5.1.36 0.665
3kve FADL-amino-acid oxidase / 0.665
4gdp FADPolyamine oxidase FMS1 / 0.665
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.664
1tdf FADThioredoxin reductase 1.8.1.9 0.664
2jae FADL-amino acid oxidase / 0.664
3djl FADPutative acyl-CoA dehydrogenase AidB 1.3.99 0.664
3he3 FADUDP-galactopyranose mutase / 0.664
3t50 FMNBlue-light-activated histidine kinase 2.7.13.3 0.664
4dja FAD(6-4) photolyase / 0.664
4p2l FADSulfhydryl oxidase 1 1.8.3.2 0.664
1mxt FAECholesterol oxidase 1.1.3.6 0.663
2a87 FADThioredoxin reductase 1.8.1.9 0.663
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.663
4h6r FDAProline dehydrogenase / 0.663
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.662
3r5z F42Uncharacterized protein / 0.662
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.661
1rz1 FADPhenol 2-hydroxylase component B / 0.661
2hfo FMNActivator of photopigment and puc expression / 0.661
2npx FADNADH peroxidase 1.11.1.1 0.661
2rab FADGlutathione amide reductase / 0.661
3mzi FMNActivator of photopigment and puc expression / 0.661
4d5g FADCyclohexane-1,2-dione hydrolase 3.7.1.11 0.661
4x4j FADPutative oxygenase / 0.661
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.660
2a1t FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.660
3d72 FADVivid PAS protein VVD / 0.660
2bn4 FADNADPH--cytochrome P450 reductase / 0.659
4zoh FADPutative oxidoreductase FAD-binding subunit / 0.659
1fec FADTrypanothione reductase 1.8.1.12 0.658
1ryi FADGlycine oxidase 1.4.3.19 0.658
2e77 FMNLactate oxidase / 0.658
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.658
3ict FADCoenzyme A disulfide reductase / 0.658
4ynt FDAGlucose oxidase, putative / 0.658
1ger FADGlutathione reductase 1.8.1.7 0.657
1lvl FADDihydrolipoyl dehydrogenase 1.8.1.4 0.657
2r0c FADPutative FAD-monooxygenase / 0.657
3cgd FADCoenzyme A disulfide reductase / 0.657
3we0 FADLysine 2-monooxygenase / 0.657
4kto FADPutative isovaleryl-CoA dehydrogenase protein / 0.657
4mo2 FDAUDP-galactopyranose mutase / 0.657
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.656
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.656
1reo FADL-amino-acid oxidase 1.4.3.2 0.656
4b1b FADThioredoxin reductase 1.8.1.9 0.656
4c3x FAD3-ketosteroid dehydrogenase / 0.656
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.656
1gaw FADFerredoxin / 0.655
1tdn FADL-amino-acid oxidase 1.4.3.2 0.655
2wzw FMNNitroreductase NfnB / 0.655
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.655
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.654
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 0.654
3fg2 FADPutative rubredoxin reductase / 0.654
3w5h FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.654
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.654
1amo FADNADPH--cytochrome P450 reductase / 0.653
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.653
1ja1 FADNADPH--cytochrome P450 reductase / 0.653
1owl FADDeoxyribodipyrimidine photo-lyase 4.1.99.3 0.653
2b9y FADPutative aminooxidase / 0.653
2vqb FADPutative flavin-containing monooxygenase / 0.653
4eqx FADCoenzyme A disulfide reductase / 0.653
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.653
1kbi FMNCytochrome b2, mitochondrial 1.1.2.3 0.652
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.652
3w4y FADMitochondrial FAD-linked sulfhydryl oxidase ERV1 1.8.3.2 0.652
1b4v FADCholesterol oxidase 1.1.3.6 0.651
1f3p FADFerredoxin reductase / 0.651
1knr FADL-aspartate oxidase 1.4.3.16 0.651
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.651
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.651
1fnb FADFerredoxin--NADP reductase, chloroplastic 1.18.1.2 0.650
2bac FADPutative aminooxidase / 0.650
3icr FADCoenzyme A disulfide reductase / 0.650
4ccr FADThioredoxin reductase / 0.650
4cnj FADL-amino acid oxidase / 0.650
4z24 FADPutative GMC-type oxidoreductase R135 1 0.650
5i39 FADL-amino acid deaminase / 0.650