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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cdu FAD NADH oxidase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cdu FADNADH oxidase / 1.222
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.910
1npx FADNADH peroxidase 1.11.1.1 0.840
3ish FADThioredoxin reductase 1.8.1.9 0.822
3cgb FADCoenzyme A disulfide reductase / 0.818
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.812
1trb FADThioredoxin reductase 1.8.1.9 0.807
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.807
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.805
1joa FADNADH peroxidase 1.11.1.1 0.798
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.798
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.797
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.797
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.796
1nhr FADNADH peroxidase 1.11.1.1 0.794
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.794
2hqm FADGlutathione reductase 1.8.1.7 0.792
2gqw FADFerredoxin reductase / 0.788
1nhq FADNADH peroxidase 1.11.1.1 0.786
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.786
1ger FADGlutathione reductase 1.8.1.7 0.784
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.782
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.781
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.781
4up3 FADThioredoxin reductase / 0.781
1tde FADThioredoxin reductase 1.8.1.9 0.778
2jk6 FADTrypanothione reductase / 0.768
4bjz FADProbable salicylate monooxygenase / 0.768
4bk3 FADProbable salicylate monooxygenase / 0.768
4ccq FADThioredoxin reductase / 0.768
4opg FDAConserved Archaeal protein / 0.768
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.767
4em3 FADCoenzyme A disulfide reductase / 0.767
3cgc FADCoenzyme A disulfide reductase / 0.766
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.764
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.763
3ics FADCoenzyme A disulfide reductase / 0.763
1ges FADGlutathione reductase 1.8.1.7 0.762
2wba FADTrypanothione reductase 1.8.1.12 0.762
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.762
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.762
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.762
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.761
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.761
1reo FADL-amino-acid oxidase 1.4.3.2 0.760
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.758
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.758
2tpr FADTrypanothione reductase 1.8.1.12 0.757
2whd FADThioredoxin reductase / 0.757
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.757
4opi FDAConserved Archaeal protein / 0.756
1f8w FADNADH peroxidase 1.11.1.1 0.755
1tdf FADThioredoxin reductase 1.8.1.9 0.755
1tdk FADL-amino-acid oxidase 1.4.3.2 0.754
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.754
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.754
4j33 FADKynurenine 3-monooxygenase / 0.754
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.754
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.753
3rp8 FADFAD-dependent urate hydroxylase / 0.752
4gcm FADThioredoxin reductase 1.8.1.9 0.748
2gr0 FADFerredoxin reductase / 0.746
1nhs FADNADH peroxidase 1.11.1.1 0.745
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.743
2q7v FADThioredoxin reductase / 0.743
2wow FADTrypanothione reductase / 0.743
2yvf FADFerredoxin reductase / 0.742
3atq FDAConserved Archaeal protein / 0.742
3atr FDAConserved Archaeal protein / 0.742
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.742
2q0k FADThioredoxin reductase 1.8.1.9 0.741
1fec FADTrypanothione reductase 1.8.1.12 0.740
4j34 FADKynurenine 3-monooxygenase / 0.739
4j36 FADKynurenine 3-monooxygenase / 0.739
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.738
1f3p FADFerredoxin reductase / 0.737
1feb FADTrypanothione reductase 1.8.1.12 0.737
4a5l FADThioredoxin reductase / 0.737
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.736
1tdo FADL-amino-acid oxidase 1.4.3.2 0.735
4opc FDAConserved Archaeal protein / 0.735
1k0j FADp-hydroxybenzoate hydroxylase / 0.734
1nhp FADNADH peroxidase 1.11.1.1 0.734
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.734
2r9z FADGlutathione amide reductase / 0.733
2gr3 FADFerredoxin reductase / 0.731
3r9u FADThioredoxin reductase / 0.731
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.730
2x8g FADThioredoxin glutathione reductase / 0.729
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
3cgd FADCoenzyme A disulfide reductase / 0.728
2jb1 FADL-amino acid oxidase / 0.727
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.726
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.726
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.726
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.724
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.724
4rsl FADFructosyl peptide oxidase / 0.724
1yqz FADCoenzyme A disulfide reductase / 0.723
3cge FADCoenzyme A disulfide reductase / 0.722
3icr FADCoenzyme A disulfide reductase / 0.722
4opu FDAConserved Archaeal protein / 0.722
4bk2 FADProbable salicylate monooxygenase / 0.720
4emw FADCoenzyme A disulfide reductase / 0.720
3cnd FADPolyamine oxidase FMS1 / 0.719
3ict FADCoenzyme A disulfide reductase / 0.719
1bzl FADTrypanothione reductase 1.8.1.12 0.718
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.718
3lad FADDihydrolipoyl dehydrogenase / 0.718
3urh FADDihydrolipoyl dehydrogenase / 0.718
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.718
3kve FADL-amino-acid oxidase / 0.717
4nte FADDepH / 0.717
4opt FDAConserved Archaeal protein / 0.717
2e77 FMNLactate oxidase / 0.716
3lov FADProtoporphyrinogen oxidase / 0.716
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.715
2x8h FADThioredoxin glutathione reductase / 0.715
4ntc FADThioredoxin reductase gliT / 0.715
1d7y FADFerredoxin reductase / 0.714
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.714
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.714
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.714
3fmw FADOxygenase / 0.713
5j60 FADThioredoxin reductase / 0.713
2eq6 FADDihydrolipoyl dehydrogenase / 0.712
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.712
4j2w FADKynurenine 3-monooxygenase / 0.712
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.711
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.711
1zk7 FADMercuric reductase 1.16.1.1 0.710
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.710
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.709
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.709
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.709
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.708
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.708
4cbq FADThioredoxin reductase / 0.706
4gdp FADPolyamine oxidase FMS1 / 0.706
4yry FADGlutamate synthase, beta subunit / 0.706
1rsg FADPolyamine oxidase FMS1 / 0.704
3cnt FADPolyamine oxidase FMS1 / 0.704
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.703
5l3d FADLysine-specific histone demethylase 1A 1 0.703
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.702
4ech FADPolyamine oxidase FMS1 / 0.702
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.701
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.701
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.701
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.701
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.700
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.699
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.699
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.698
4dna FADProbable glutathione reductase / 0.698
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.698
2zbw FADFerredoxin--NADP reductase / 0.697
1fea FADTrypanothione reductase 1.8.1.12 0.696
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.696
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.696
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.695
5i39 FADL-amino acid deaminase / 0.695
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.694
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.694
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.693
3cn8 FADPolyamine oxidase FMS1 / 0.692
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.692
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.691
4opd FDAConserved Archaeal protein / 0.691
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.691
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.690
2b9x FADPutative aminooxidase / 0.690
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.690
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.689
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.688
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.688
4hb9 FADUncharacterized protein / 0.688
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.688
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.687
1qo8 FADFumarate reductase flavoprotein subunit / 0.686
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.686
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.685
4x4j FADPutative oxygenase / 0.685
1h81 FADPolyamine oxidase 1.5.3.14 0.684
2v6o FADThioredoxin glutathione reductase / 0.684
3d8x FADThioredoxin reductase 1 1.8.1.9 0.684
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.683
2gr1 FADFerredoxin reductase / 0.683
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.683
3haz FADBifunctional protein PutA / 0.683
4eqs FADCoenzyme A disulfide reductase / 0.683
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.683
4j31 FADKynurenine 3-monooxygenase / 0.683
1typ FADTrypanothione reductase 1.8.1.12 0.682
4hnb FMNLOV protein / 0.682
4u8m FDAUDP-galactopyranose mutase / 0.682
1phh FADp-hydroxybenzoate hydroxylase / 0.681
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.680
2yqu FADDihydrolipoyl dehydrogenase / 0.679
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.679
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.678
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.677
1ryi FADGlycine oxidase 1.4.3.19 0.677
1zx9 FADMercuric reductase 1.16.1.1 0.677
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.677
1q1r FADPutidaredoxin reductase 1.18.1.5 0.676
1tj2 FADBifunctional protein PutA 1.5.5.2 0.676
4fwj FADLysine-specific histone demethylase 1B 1 0.675
2g37 FADProline dehydrogenase / 0.674
3bi2 FADPolyamine oxidase FMS1 / 0.674
4opl FDAConserved Archaeal protein / 0.674
2eq7 FADDihydrolipoyl dehydrogenase / 0.672
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.671
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.671
3fg2 FADPutative rubredoxin reductase / 0.671
1q1w FADPutidaredoxin reductase 1.18.1.5 0.670
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.670
1yy5 FADPolyamine oxidase FMS1 / 0.670
2e1m FADL-glutamate oxidase / 0.670
3ka7 FADPutative oxidoreductase / 0.670
2xdo FADTetX family tetracycline inactivation enzyme / 0.669
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.669
4em4 FADCoenzyme A disulfide reductase / 0.669
1d7l RFLp-hydroxybenzoate hydroxylase / 0.668
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.668
2rgh FADAlpha-Glycerophosphate Oxidase / 0.668
3cty FADProbable thioredoxin reductase / 0.668
3we0 FADLysine 2-monooxygenase / 0.668
1f8r FADL-amino-acid oxidase 1.4.3.2 0.667
2npx FADNADH peroxidase 1.11.1.1 0.667
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.667
2dvl FADAcyl-CoA dehydrogenase / 0.666
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.666
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.666
2iid FADL-amino-acid oxidase 1.4.3.2 0.665
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.665
3bi5 FADPolyamine oxidase FMS1 / 0.664
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.664
4gde FDAUDP-galactopyranose mutase / 0.664
4jn9 FADDepH / 0.664
1cqx FADFlavohemoprotein / 0.663
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.663
3u2l FADFAD-linked sulfhydryl oxidase ALR 1.8.3.2 0.663
4jq9 FADDihydrolipoyl dehydrogenase / 0.663
1umk FADNADH-cytochrome b5 reductase 3 1.6.2.2 0.662
4eep FMNPhototropin-2 2.7.11.1 0.662
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
2pr5 FMNBlue-light photoreceptor / 0.661
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.661
4ccr FADThioredoxin reductase / 0.661
4u8n FDAUDP-galactopyranose mutase / 0.661
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.660
4b1b FADThioredoxin reductase 1.8.1.9 0.660
2iw5 FADLysine-specific histone demethylase 1A 1 0.659
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.659
5buk FADFADH2-dependent halogenase / 0.659
1ege FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.658
1onf FADGlutathione reductase 1.8.1.7 0.658
1tyt FADTrypanothione reductase 1.8.1.12 0.658
2w0h FADTrypanothione reductase / 0.658
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.658
4k5r FADOxygenase / 0.658
4u8o FDAUDP-galactopyranose mutase / 0.658
1geu FADGlutathione reductase 1.8.1.7 0.657
2qa1 FADPgaE / 0.656
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.656
4eqw FADCoenzyme A disulfide reductase / 0.656
2wp5 FADTrypanothione reductase / 0.655
3zdn FADMonoamine oxidase N 1.4.3.4 0.655
4dsh FDAUncharacterized protein / 0.655
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.654
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.654
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.654
1tj0 FADBifunctional protein PutA 1.5.5.2 0.654
4m5p FMNNADPH dehydrogenase / 0.654
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.654
4eqx FADCoenzyme A disulfide reductase / 0.653
4x9m FADUncharacterized protein MG039 homolog / 0.653
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.652
1ojt FADDihydrolipoyl dehydrogenase / 0.652
2eq8 FADDihydrolipoyl dehydrogenase / 0.652
3fbs FADOxidoreductase / 0.652
3gwd FADCyclohexanone monooxygenase / 0.652
3p8j FMNPentaerythritol tetranitrate reductase / 0.652
3uth FDAUDP-galactopyranose mutase / 0.652
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.651
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.651
2cvj FADThioredoxin reductase related protein / 0.651
3klb FMNUncharacterized protein / 0.651
3ukk FDAUDP-galactopyranose mutase / 0.651
4k2x FADPolyketide oxygenase/hydroxylase / 0.651
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.650
2ohj FMNType A flavoprotein FprA 1 0.650
2yg4 FADPutrescine oxidase / 0.650
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.650
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.650