Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 |
PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
---|---|---|---|---|---|
4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 1.000 | |
2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.528 | |
3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.517 | |
4anm | WUL | Casein kinase II subunit alpha | 2.7.11.1 | 0.517 | |
4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.516 | |
5cvh | ADP | Casein kinase II subunit alpha | 2.7.11.1 | 0.509 | |
3a99 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.505 | |
2v7a | 627 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.500 | |
4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
3at3 | ATK | Casein kinase II subunit alpha | 2.7.11.1 | 0.496 | |
4jr7 | GNP | Casein kinase II subunit alpha | 2.7.11.1 | 0.496 | |
2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.495 | |
4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.495 | |
4gub | 0Y4 | Casein kinase II subunit alpha | 2.7.11.1 | 0.492 | |
2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.491 | |
2pvl | P55 | Casein kinase II subunit alpha | 2.7.11.1 | 0.489 | |
3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.489 | |
4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.487 | |
2j0k | 4ST | Focal adhesion kinase 1 | 2.7.10.2 | 0.486 | |
3oom | 507 | Activin receptor type-1 | 2.7.11.30 | 0.485 | |
4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.485 | |
2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.484 | |
1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.483 | |
2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.481 | |
3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.479 | |
3mtf | A3F | Activin receptor type-1 | 2.7.11.30 | 0.479 | |
1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.478 | |
2izs | BRQ | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.478 | |
1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.477 | |
3axw | TID | Casein kinase II subunit alpha | 2.7.11.1 | 0.477 | |
3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.477 | |
4q71 | FAD | Bifunctional protein PutA | / | 0.477 | |
2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.476 | |
3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.476 | |
1daw | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.475 | |
2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.475 | |
4hgs | 15G | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.475 | |
4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.475 | |
4xiw | AZM | Carbonic anhydrase, alpha type | / | 0.475 | |
4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.474 | |
5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.474 | |
4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.473 | |
1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.472 | |
2gcd | STU | Serine/threonine-protein kinase TAO2 | 2.7.11.1 | 0.472 | |
3vt7 | VDX | Vitamin D3 receptor | / | 0.472 | |
4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.472 | |
4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.472 | |
2x6d | X6D | Aurora kinase A | 2.7.11.1 | 0.471 | |
3v3v | MYU | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.471 | |
4a7c | E46 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.471 | |
4dgm | AGI | Casein kinase II subunit alpha | 2.7.11.1 | 0.471 | |
4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.471 | |
2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.470 | |
3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.470 | |
4bkz | 1WS | Maternal embryonic leucine zipper kinase | 2.7.11.1 | 0.470 | |
4k33 | ACP | Fibroblast growth factor receptor 3 | 2.7.10.1 | 0.470 | |
5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.470 | |
1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.469 | |
2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.469 | |
2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.469 | |
3at4 | CCK | Casein kinase II subunit alpha | 2.7.11.1 | 0.469 | |
4k18 | 1OB | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.469 | |
1m2r | MNY | Casein kinase II subunit alpha | 2.7.11.1 | 0.468 | |
4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.468 | |
1m2q | MNX | Casein kinase II subunit alpha | 2.7.11.1 | 0.467 | |
1om1 | IQA | Casein kinase II subunit alpha | 2.7.11.1 | 0.467 | |
2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.467 | |
2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.467 | |
3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.467 | |
3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.467 | |
4e4m | 0NH | Tyrosine-protein kinase JAK2 | / | 0.467 | |
4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.467 | |
4kzo | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.467 | |
2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.466 | |
3r3b | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.465 | |
4g17 | 0VN | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.465 | |
4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.465 | |
1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.464 | |
1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
1oky | STU | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.464 | |
2izu | P01 | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.464 | |
3owk | 18E | Casein kinase II subunit alpha | 2.7.11.1 | 0.464 | |
3vrw | YS5 | Vitamin D3 receptor | / | 0.464 | |
4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.464 | |
5itz | LOC | Tubulin beta-2B chain | / | 0.464 | |
1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.463 | |
2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.463 | |
2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.463 | |
3cy2 | MB9 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.463 | |
3ofm | 4B0 | Casein kinase II subunit alpha' | 2.7.11.1 | 0.463 | |
3r32 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.463 | |
3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.463 | |
4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.463 | |
4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
2xuu | ADP | Death-associated protein kinase 1 | 2.7.11.1 | 0.462 | |
3ama | SKE | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.462 | |
4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.462 | |
4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.462 | |
1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
2x7g | PVB | SRSF protein kinase 2 | 2.7.11.1 | 0.461 | |
2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.461 | |
2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.460 | |
2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.460 | |
4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.460 | |
4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.460 | |
4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.460 | |
4ux9 | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.460 | |
1q5k | TMU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.459 | |
1uu3 | LY4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.459 | |
3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.459 | |
4h0x | NAD | Iota toxin component Ia | / | 0.459 | |
5dpv | SKE | Aurora kinase A | 2.7.11.1 | 0.459 | |
1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.458 | |
1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.458 | |
3ics | COA | Coenzyme A disulfide reductase | / | 0.458 | |
3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.458 | |
3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.458 | |
4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.458 | |
4c58 | 824 | Cyclin-G-associated kinase | 2.7.11.1 | 0.458 | |
4i6g | FAD | Cryptochrome-2 | / | 0.458 | |
4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.458 | |
5dr6 | SKE | Aurora kinase A | 2.7.11.1 | 0.458 | |
1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.457 | |
1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.457 | |
1osv | CHC | Bile acid receptor | / | 0.457 | |
1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
2etm | 7PY | Focal adhesion kinase 1 | 2.7.10.2 | 0.457 | |
2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.457 | |
2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.457 | |
3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.457 | |
3vt4 | 5YI | Vitamin D3 receptor | / | 0.457 | |
4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.457 | |
4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.457 | |
1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.456 | |
1og5 | SWF | Cytochrome P450 2C9 | / | 0.456 | |
1ykd | CMP | Adenylate cyclase | / | 0.456 | |
2py3 | ACP | Fibroblast growth factor receptor 2 | / | 0.456 | |
2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.456 | |
3uim | ANP | BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 | 2.7.10.1 | 0.456 | |
4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.456 | |
1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
2g24 | 7IG | Renin | 3.4.23.15 | 0.455 | |
2j2i | LY4 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
2pvy | ACP | Fibroblast growth factor receptor 2 | / | 0.455 | |
2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.455 | |
3ict | FAD | Coenzyme A disulfide reductase | / | 0.455 | |
5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.455 | |
1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
2ghl | LIB | Mitogen-activated protein kinase 14 | / | 0.454 | |
2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.454 | |
2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.454 | |
3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.454 | |
3r34 | COA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.454 | |
3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.454 | |
3tqh | NDP | Quinone oxidoreductase | / | 0.454 | |
4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.454 | |
4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.454 | |
4n70 | 2HX | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.454 | |
4wkq | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.454 | |
5dr9 | SKE | Aurora kinase A | 2.7.11.1 | 0.454 | |
5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.454 | |
1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.453 | |
1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
2h96 | 893 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.453 | |
2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.453 | |
3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
3jy0 | LYG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.453 | |
4mq1 | 2C3 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 2.7.12.1 | 0.453 | |
4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.453 | |
1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
1mb9 | ATP | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.452 | |
1uyr | D1L | Acetyl-CoA carboxylase | / | 0.452 | |
2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
3cgo | JNO | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.452 | |
3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.452 | |
3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
3r35 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.452 | |
3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
4hnc | 0UT | Mandelate racemase | / | 0.452 | |
4ieb | ANP | Calmodulin-domain protein kinase 1 | / | 0.452 | |
5csh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.452 | |
5dt4 | ATP | Aurora kinase A | 2.7.11.1 | 0.452 | |
1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.451 | |
2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.451 | |
3rwp | ABQ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
3vt8 | YI3 | Vitamin D3 receptor | / | 0.451 | |
4c4j | X21 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.451 | |
4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.451 | |
4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.451 | |
4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
4ocg | FAD | FAD-dependent pyridine nucleotide-disulphide oxidoreductase | / | 0.451 | |
4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.451 | |
1ol5 | ADP | Aurora kinase A | 2.7.11.1 | 0.450 | |
1q4u | 4CA | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.450 | |
1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.450 | |
1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.450 | |
1s0z | EB1 | Vitamin D3 receptor | / | 0.450 | |
1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.450 | |
3icr | COA | Coenzyme A disulfide reductase | / | 0.450 | |
3nga | 3NG | Casein kinase II subunit alpha | 2.7.11.1 | 0.450 | |
3r37 | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.450 | |
3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
4btj | ADP | Tau-tubulin kinase 1 | 2.7.11.1 | 0.450 | |
4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.450 | |
4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
4q73 | FAD | Bifunctional protein PutA | / | 0.450 | |
1g5s | I17 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.449 | |
1h1w | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
1ie8 | KH1 | Vitamin D3 receptor | / | 0.449 | |
1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
1q3w | ATU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.449 | |
2obj | VRV | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.449 | |
3gwf | FAD | Cyclohexanone monooxygenase | / | 0.449 | |
4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.449 | |
4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
4gk4 | L90 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.449 | |
4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.449 | |
1byg | STU | Tyrosine-protein kinase CSK | / | 0.448 | |
1nzd | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.448 | |
2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.448 | |
2pe2 | 464 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
2y37 | A54 | Nitric oxide synthase, inducible | 1.14.13.39 | 0.448 | |
3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
3c4x | ATP | Rhodopsin kinase | / | 0.448 | |
3orm | AGS | Serine/threonine protein kinase | / | 0.448 | |
3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.448 | |
3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.448 | |
4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.448 | |
5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.448 | |
5dt3 | ATP | Aurora kinase A | 2.7.11.1 | 0.448 | |
1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
1g67 | TZP | Thiamine-phosphate synthase | / | 0.447 | |
1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.447 | |
2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.447 | |
3b6z | CO7 | Enoyl reductase LovC | 1 | 0.447 | |
3u8n | 09S | Acetylcholine-binding protein | / | 0.447 | |
4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.447 | |
5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
5fm7 | ADP | RuvB-like helicase | / | 0.447 | |
5kgp | ACO | Predicted acetyltransferase | / | 0.447 | |
1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.446 | |
1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.446 | |
2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.446 | |
2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.446 | |
3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.446 | |
3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.446 | |
4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.446 | |
4iwq | 1FV | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.446 | |
4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.446 | |
1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
1eny | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
1j39 | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
1pn3 | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.445 | |
1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.445 | |
1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
2ijm | ATP | Focal adhesion kinase 1 | 2.7.10.2 | 0.445 | |
2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.445 | |
2vwq | NAP | Glucose 1-dehydrogenase | / | 0.445 | |
2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
3h0s | B38 | Acetyl-CoA carboxylase | / | 0.445 | |
3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.445 | |
3opd | HIE | Heat shock protein 83 | / | 0.445 | |
3vt9 | YI4 | Vitamin D3 receptor | / | 0.445 | |
4eom | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
4l52 | 1UL | Mitogen-activated protein kinase kinase kinase 7 | 2.7.11.25 | 0.445 | |
5e8y | STU | TGF-beta receptor type-2 | 2.7.11.30 | 0.445 | |
1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.444 | |
1jgt | APC | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.444 | |
1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
1yhs | STU | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.444 | |
2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.444 | |
2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.444 | |
4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.444 | |
4ek8 | 16K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.444 | |
4hvi | 19S | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.444 | |
4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.444 | |
4o0s | ADN | Aurora kinase A | 2.7.11.1 | 0.444 | |
4xf7 | ACP | Carbohydrate/pyrimidine kinase, PfkB family | / | 0.444 | |
1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
1bxo | PP7 | Penicillopepsin-1 | 3.4.23.20 | 0.443 | |
1xny | 191 | Propionyl-CoA carboxylase complex B subunit | / | 0.443 | |
2i40 | BLZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.443 | |
2pzp | ACP | Fibroblast growth factor receptor 2 | / | 0.443 | |
2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
3a7j | ADP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.443 | |
4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.443 | |
4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.443 | |
4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.443 | |
4qna | X11 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.443 | |
1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.442 | |
1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.442 | |
1q97 | ATP | Serine/threonine-protein kinase SKY1 | 2.7.11.1 | 0.442 | |
2a0c | CK9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.442 | |
2q0b | ACP | Fibroblast growth factor receptor 2 | / | 0.442 | |
2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.442 | |
2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
3b89 | 5GP | 16S rRNA methylase | / | 0.442 | |
3c50 | ADP | Rhodopsin kinase | / | 0.442 | |
3cbl | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.442 | |
3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.442 | |
3mb6 | 01I | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.442 | |
3q4z | ANP | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
3vt6 | 5YI | Vitamin D3 receptor | / | 0.442 | |
4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.442 | |
4fr4 | STU | Serine/threonine-protein kinase 32A | 2.7.11.1 | 0.442 | |
4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.442 | |
4ia7 | BIV | Vitamin D3 receptor A | / | 0.442 | |
4ktf | 1TM | Cytochrome P450 | / | 0.442 | |
4y12 | AGS | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.442 | |
5cu6 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.442 | |
1ke9 | LS5 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.441 | |
2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
2vtj | LZ4 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.441 | |
2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.441 | |
3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.441 | |
3kvx | FMY | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.441 | |
3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.441 | |
3uyt | 0CK | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
4fko | 20K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.441 | |
4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
4g1z | 0VP | Vitamin D3 receptor A | / | 0.441 | |
4hgl | 0YO | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.441 | |
4hnf | 16W | Casein kinase I isoform delta | 2.7.11.1 | 0.441 | |
4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.441 | |
4ktk | KTK | Cytochrome P450 | / | 0.441 | |
4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.441 | |
4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.441 | |
5dt0 | SKE | Aurora kinase A | 2.7.11.1 | 0.441 | |
1bxq | PP8 | Penicillopepsin-1 | 3.4.23.20 | 0.440 | |
1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
2buj | STU | Serine/threonine-protein kinase 16 | / | 0.440 | |
2pe1 | 517 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.440 | |
3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.440 | |
3kf7 | L9G | Mitogen-activated protein kinase 14 | / | 0.440 | |
3lqf | NAD | Galactitol dehydrogenase | / | 0.440 | |
3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
3w0s | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.440 | |
3w16 | P9J | Aurora kinase A | 2.7.11.1 | 0.440 | |
4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.440 | |
4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
4hvg | 19Q | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.440 | |
4kbk | 1QG | Casein kinase I isoform delta | 2.7.11.1 | 0.440 | |
4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
4ryv | ZEA | Protein LlR18A | / | 0.440 | |
4yt5 | H4M | H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338 | / | 0.440 |