sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2rtm | IMI | Streptavidin |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2rtm | IMI | Streptavidin | / | 1.000 | |
| 2izk | GLL | Streptavidin | / | 0.715 | |
| 2rtl | IMI | Streptavidin | / | 0.671 | |
| 2rtk | GLL | Streptavidin | / | 0.639 | |
| 1srf | MTB | Streptavidin | / | 0.606 | |
| 2rtn | IMI | Streptavidin | / | 0.597 | |
| 1df8 | BTN | Streptavidin | / | 0.590 | |
| 3ry2 | BTN | Streptavidin | / | 0.577 | |
| 4bx7 | B4F | Streptavidin | / | 0.571 | |
| 2rtf | BTN | Streptavidin | / | 0.567 | |
| 2rtq | IMI | Streptavidin | / | 0.566 | |
| 2izj | BTN | Streptavidin | / | 0.563 | |
| 2izh | BTN | Streptavidin | / | 0.558 | |
| 1luq | BTN | Streptavidin | / | 0.555 | |
| 1sri | DMB | Streptavidin | / | 0.554 | |
| 1mk5 | BTN | Streptavidin | / | 0.547 | |
| 1srg | MHB | Streptavidin | / | 0.546 | |
| 2fhn | BNI | Avidin-related protein 4/5 | / | 0.541 | |
| 2rto | IMI | Streptavidin | / | 0.541 | |
| 3t2w | BTN | Avidin/streptavidin | / | 0.541 | |
| 1lcz | BH7 | Streptavidin | / | 0.540 | |
| 1stp | BTN | Streptavidin | / | 0.538 | |
| 2y3f | BTN | Streptavidin | / | 0.538 | |
| 2rte | BTN | Streptavidin | / | 0.535 | |
| 2rti | GLL | Streptavidin | / | 0.535 | |
| 1srj | NAB | Streptavidin | / | 0.532 | |
| 1swt | BTN | Streptavidin | / | 0.532 | |
| 2rtr | IMI | Streptavidin | / | 0.531 | |
| 1srh | MOB | Streptavidin | / | 0.530 | |
| 4dne | DTB | Streptavidin | / | 0.530 | |
| 2izg | BTN | Streptavidin | / | 0.529 | |
| 1sre | HAB | Streptavidin | / | 0.527 | |
| 3wyq | BTN | Streptavidin | / | 0.527 | |
| 4gda | BTN | Streptavidin | / | 0.525 | |
| 2izf | BTN | Streptavidin | / | 0.519 | |
| 1lcw | SHM | Streptavidin | / | 0.518 | |
| 3rdq | DTB | Streptavidin | / | 0.518 | |
| 3wzn | BTN | Streptavidin | / | 0.518 | |
| 2rtd | BTN | Streptavidin | / | 0.514 | |
| 2rtg | BTN | Streptavidin | / | 0.514 | |
| 1rxh | BNI | Streptavidin | / | 0.513 | |
| 1avd | BTN | Avidin | / | 0.512 | |
| 2izl | IMI | Streptavidin | / | 0.512 | |
| 1i9h | BNI | Streptavidin | / | 0.511 | |
| 2rtp | IMI | Streptavidin | / | 0.511 | |
| 2avi | BTN | Avidin | / | 0.510 | |
| 2c4i | BTN | Avidin | / | 0.505 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.505 | |
| 4z28 | BTN | Hoefavidin | / | 0.505 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.504 | |
| 2izi | BTN | Streptavidin | / | 0.500 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.494 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.493 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.493 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 2bl9 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.492 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.492 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.490 | |
| 2uyw | BTN | Avd protein | / | 0.489 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.488 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.487 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.486 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.486 | |
| 3up3 | XCA | aceDAF-12 | / | 0.484 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.483 | |
| 2a5c | 8DA | Avidin | / | 0.483 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.483 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.481 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.481 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.480 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 4je5 | PLP | Aromatic/aminoadipate aminotransferase 1 | 2.6.1.39 | 0.477 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.476 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.475 | |
| 4pd6 | URI | Nucleoside permease | / | 0.475 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 1rkg | VD1 | Vitamin D3 receptor | / | 0.474 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.474 | |
| 2wug | HPK | 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase | 3.7.1.17 | 0.474 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.474 | |
| 5iqd | GNP | Bifunctional AAC/APH | 2.3.1 | 0.473 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.472 | |
| 2npf | MOU | Elongation factor 2 | / | 0.472 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.472 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.472 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.471 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 3up0 | D7S | aceDAF-12 | / | 0.471 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.471 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.471 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.470 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.470 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.469 | |
| 2uz2 | BTN | Avd protein | / | 0.469 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 2o7o | DXT | Tetracycline repressor protein class D | / | 0.468 | |
| 4kxj | P34 | Nucleoprotein | / | 0.468 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.468 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.467 | |
| 3ew2 | BTN | Hypothetical conserved protein | / | 0.467 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.467 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.467 | |
| 1ndj | BTN | Streptavidin | / | 0.466 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.466 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.466 | |
| 3wyp | BSO | Streptavidin | / | 0.466 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4j7x | SAS | Sepiapterin reductase | 1.1.1.153 | 0.466 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.466 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.465 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.465 | |
| 2jfa | RAL | Estrogen receptor | / | 0.465 | |
| 3dg8 | RJ6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.465 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.464 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.464 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.464 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.464 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.464 | |
| 2zsc | BTN | Tamavidin2 | / | 0.464 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.464 | |
| 4n5n | NAP | Acetoacetyl-CoA reductase | 1.1.1.36 | 0.464 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.464 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.463 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.463 | |
| 4fog | C2F | Thymidylate synthase ThyA | / | 0.463 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1swp | BTQ | Streptavidin | / | 0.461 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.461 | |
| 4mry | CEI | Obelin | / | 0.461 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 5iqb | GNP | Bifunctional AAC/APH | 2.3.1 | 0.461 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.460 | |
| 1drb | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1eg2 | MTA | Modification methylase RsrI | 2.1.1.72 | 0.460 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.460 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.460 | |
| 2fsz | OHT | Estrogen receptor beta | / | 0.460 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.460 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.460 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 3vrv | YSD | Vitamin D3 receptor | / | 0.460 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.460 | |
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 0.460 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.460 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.460 | |
| 1mep | BTN | Streptavidin | / | 0.459 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.459 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.459 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3p8j | FMN | Pentaerythritol tetranitrate reductase | / | 0.459 | |
| 3qgt | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.459 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 4g8z | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 4u9y | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.459 | |
| 5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.458 | |
| 3g7j | GTX | Glutathione transferase GST1-4 | / | 0.458 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4a2a | ATP | Cell division protein FtsA | / | 0.458 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.458 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.457 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.457 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.457 | |
| 2o1x | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.457 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.457 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.457 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.457 | |
| 3glu | LYS_VAL_MET | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.457 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.457 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.457 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 1dr5 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.456 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2oeg | UPG | UDP-glucose pyrophosphorylase | / | 0.456 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 3gxf | IFM | Glucosylceramidase | 3.2.1.45 | 0.456 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.456 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4b5n | FMN | NAD(P)H:flavin oxidoreductase Sye4 | / | 0.456 | |
| 5gcn | COA | HAT A1 | / | 0.456 | |
| 5kf9 | COA | Predicted acetyltransferase | / | 0.456 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.455 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.455 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.455 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.455 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.454 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.454 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.454 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.454 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3sqx | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.454 | |
| 4b5o | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.454 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.453 | |
| 2g8a | UMP | Thymidylate synthase | / | 0.453 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.453 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.453 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.453 | |
| 4kak | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.453 | |
| 5dib | NAD | Betaine-aldehyde dehydrogenase | / | 0.453 | |
| 1nc9 | IMI | Streptavidin | / | 0.452 | |
| 1sbr | VIB | Putative HMP/thiamine-binding protein YkoF | / | 0.452 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.452 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.452 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.452 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.452 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.452 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.452 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.452 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.451 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.451 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.451 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.451 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.451 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.451 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
| 4ap3 | FAD | Steroid monooxygenase | / | 0.451 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.451 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.451 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.450 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.450 | |
| 1rx7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.450 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.450 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.450 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.450 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.450 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.450 | |
| 3w0h | W12 | Vitamin D3 receptor | / | 0.450 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.450 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.450 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.450 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.449 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.449 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.449 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.449 | |
| 2hc4 | VDX | Vitamin D3 receptor A | / | 0.449 | |
| 2kce | D16 | Thymidylate synthase | / | 0.449 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.449 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.449 | |
| 3w0i | O11 | Vitamin D3 receptor | / | 0.449 | |
| 4cry | ACO | PanD regulatory factor | / | 0.449 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.449 | |
| 4l8u | 9AZ | Serum albumin | / | 0.449 | |
| 4wxg | 2BO | Serine hydroxymethyltransferase | / | 0.449 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.449 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.448 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.448 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.448 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.448 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.448 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.448 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.448 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.448 | |
| 5iub | CLR | Adenosine receptor A2a | / | 0.448 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.447 | |
| 1nzy | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.447 | |
| 1s0z | EB1 | Vitamin D3 receptor | / | 0.447 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.447 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.447 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.446 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1swd | BTN | Streptavidin | / | 0.446 | |
| 2blc | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.446 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.446 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.446 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.446 | |
| 3gts | D3M | DdmC | / | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.446 | |
| 4dpd | UMP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.446 | |
| 4lb9 | EVP | Serum albumin | / | 0.446 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.445 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.445 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.445 | |
| 1j8u | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.445 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.445 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.445 | |
| 2bxo | OPB | Serum albumin | / | 0.445 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2j9g | ADP | Biotin carboxylase | 6.3.4.14 | 0.445 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2z4s | ADP | Chromosomal replication initiator protein DnaA | / | 0.445 | |
| 2z9d | FMN | FMN-dependent NADH-azoreductase | / | 0.445 | |
| 3gon | ANP | Phosphomevalonate kinase | / | 0.445 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.445 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.445 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.445 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4deg | 0JJ | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.445 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 1n43 | BTN | Streptavidin | / | 0.444 | |
| 1n9m | BTN | Streptavidin | / | 0.444 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3anl | SYC | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.444 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 3gy9 | COA | GCN5-related N-acetyltransferase | / | 0.444 | |
| 3w0j | T08 | Vitamin D3 receptor | / | 0.444 | |
| 4rrf | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.444 | |
| 1ci7 | CB3 | Thymidylate synthase | 2.1.1.45 | 0.443 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1i24 | UPG | UDP-sulfoquinovose synthase, chloroplastic | 3.13.1.1 | 0.443 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.443 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.443 | |
| 1u0h | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1u0h | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.443 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.443 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.443 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.443 | |
| 2qqf | A1R | NAD-dependent protein deacetylase HST2 | 3.5.1 | 0.443 | |
| 2zla | VDB | Vitamin D3 receptor | / | 0.443 | |
| 3arv | SAU | Chitinase A | / | 0.443 | |
| 3bej | MUF | Bile acid receptor | / | 0.443 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.443 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.443 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3v1u | HXC | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.443 | |
| 4ag9 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.443 | |
| 4aux | XTC | Tetracycline repressor protein class D | / | 0.443 | |
| 4hmb | PZZ | Phospholipase A2 VRV-PL-VIIIa | / | 0.443 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.443 | |
| 4wxf | PLG | Serine hydroxymethyltransferase | / | 0.443 | |
| 4x5g | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4yfy | 1YJ | VioF | / | 0.443 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.442 | |
| 1n4h | REA | Nuclear receptor ROR-beta | / | 0.442 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.442 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.442 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 1xp8 | AGS | Protein RecA | / | 0.442 | |
| 2bxm | IMN | Serum albumin | / | 0.442 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ehj | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.442 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.442 | |
| 3zhr | TPP | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.442 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.442 | |
| 5dp2 | NAP | CurF | / | 0.442 | |
| 1dyj | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.441 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1lke | DOG | Bilin-binding protein | / | 0.441 | |
| 1m79 | MQ1 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1n0u | SO1 | Elongation factor 2 | / | 0.441 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.441 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2ze2 | T27 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.441 | |
| 3dtt | NAP | NADP oxidoreductase, coenzyme F420-dependent | / | 0.441 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.441 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.441 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 4h6u | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.441 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.441 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.441 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.441 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.441 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.441 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.441 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.440 | |
| 1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1kzi | THG | Thymidylate synthase | / | 0.440 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1tsx | UMP | Thymidylate synthase | / | 0.440 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 3bhl | THG | Thymidylate synthase | / | 0.440 | |
| 3el7 | PD3 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.440 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.440 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.440 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.440 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.440 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.440 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.440 |