sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2e5m | NAP | Isocitrate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2e5m | NAP | Isocitrate dehydrogenase | / | 1.000 | |
| 1n0u | SO1 | Elongation factor 2 | / | 0.518 | |
| 4iyg | 1HU | Strictosidine synthase | 4.3.3.2 | 0.516 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.508 | |
| 4ajb | TAP | Isocitrate dehydrogenase [NADP] | 1.1.1.42 | 0.504 | |
| 1kdm | DHT | Sex hormone-binding globulin | / | 0.499 | |
| 2pir | DHT | Androgen receptor | / | 0.497 | |
| 2q7k | TES | Androgen receptor | / | 0.492 | |
| 2c3c | NAP | 2-oxopropyl-CoM reductase, carboxylating | 1.8.1.5 | 0.491 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3evb | SAH | Genome polyprotein | 2.1.1.56 | 0.488 | |
| 3kb0 | A8S | Abscisic acid receptor PYL2 | / | 0.485 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.483 | |
| 2v2z | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.483 | |
| 3oji | PYV | Abscisic acid receptor PYL3 | / | 0.483 | |
| 1tou | B1V | Fatty acid-binding protein, adipocyte | / | 0.481 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 1hqu | HBY | Gag-Pol polyprotein | 2.7.7.49 | 0.477 | |
| 1xj7 | DHT | Androgen receptor | / | 0.477 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.477 | |
| 3zvu | A8S | Abscisic acid receptor PYR1 | / | 0.477 | |
| 2iyp | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.476 | |
| 4bqs | K2Q | Shikimate kinase | 2.7.1.71 | 0.476 | |
| 4l17 | DNQ | Glutamate receptor 2 | / | 0.476 | |
| 4oey | DHT | Androgen receptor | / | 0.476 | |
| 2d2i | NAP | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.475 | |
| 2fr0 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.475 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.475 | |
| 4oed | DHT | Androgen receptor | / | 0.475 | |
| 1t76 | DHT | Androgen receptor | / | 0.474 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.474 | |
| 2pio | DHT | Androgen receptor | / | 0.474 | |
| 5dto | SAH | Genome polyprotein | / | 0.474 | |
| 1t7f | DHT | Androgen receptor | / | 0.473 | |
| 4man | 1Y1 | Apoptosis regulator Bcl-2 | / | 0.473 | |
| 5cuq | NSC | Genome polyprotein | / | 0.473 | |
| 1t79 | DHT | Androgen receptor | / | 0.472 | |
| 1df7 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 2q2z | MKK | Kinesin-like protein KIF11 | / | 0.471 | |
| 4a51 | DQ8 | Kinesin-like protein KIF11 | / | 0.471 | |
| 1t7t | DHT | Androgen receptor | / | 0.470 | |
| 3dhb | C6L | N-acyl homoserine lactonase AiiA | 3.1.1.81 | 0.470 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.469 | |
| 3eva | SAH | Genome polyprotein | 2.1.1.56 | 0.469 | |
| 2fhl | BNI | Avidin-related protein 4/5 | / | 0.468 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.468 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.468 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.468 | |
| 1td2 | PXL | Pyridoxal kinase PdxY | / | 0.467 | |
| 2yiw | YIW | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 3ujl | A8S | Abscisic acid receptor PYL2 | / | 0.467 | |
| 3q2j | CKI | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.466 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.466 | |
| 4bcs | BTN | Avidin-related protein 4/5 | / | 0.466 | |
| 1eet | BFU | Gag-Pol polyprotein | 2.7.7.49 | 0.465 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.465 | |
| 2j9g | ADP | Biotin carboxylase | 6.3.4.14 | 0.465 | |
| 1nd5 | 2BF | Prostatic acid phosphatase | 3.1.3.2 | 0.464 | |
| 1t73 | DHT | Androgen receptor | / | 0.464 | |
| 1y52 | BTN | Avidin-related protein 4/5 | / | 0.464 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.464 | |
| 3m6r | BB2 | Peptide deformylase 1B, chloroplastic/mitochondrial | 3.5.1.88 | 0.464 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2bn4 | FAD | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 4p68 | MTX | Dihydrofolate reductase | / | 0.463 | |
| 1df8 | BTN | Streptavidin | / | 0.462 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.462 | |
| 2pit | DHT | Androgen receptor | / | 0.462 | |
| 2qxx | TTP | dCTP deaminase | 3.5.4.13 | 0.462 | |
| 3rhj | NAP | Cytosolic 10-formyltetrahydrofolate dehydrogenase | 1.5.1.6 | 0.462 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.461 | |
| 3kb3 | A8S | Abscisic acid receptor PYL2 | / | 0.461 | |
| 4fjz | 4FJ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.461 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.461 | |
| 1gpe | FAD | Glucose oxidase | 1.1.3.4 | 0.460 | |
| 1v0o | INR | Cell division control protein 2 homolog | 2.7.11.22 | 0.460 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2ibu | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.460 | |
| 2pkl | DHT | Androgen receptor | / | 0.460 | |
| 2ylp | TES | Androgen receptor | / | 0.460 | |
| 2ylq | TES | Androgen receptor | / | 0.460 | |
| 3bhh | 5CP | Calcium/calmodulin-dependent protein kinase type II subunit beta | 2.7.11.17 | 0.460 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4jda | A9S | Abscisic acid receptor PYL3 | / | 0.460 | |
| 4pb2 | 5UD | Nucleoside permease | / | 0.460 | |
| 2rtl | IMI | Streptavidin | / | 0.459 | |
| 2x2r | X2O | Kinesin-like protein KIF11 | / | 0.459 | |
| 2x7e | X7E | Kinesin-like protein KIF11 | / | 0.459 | |
| 2z4j | DHT | Androgen receptor | / | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.459 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.459 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.459 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 4ds8 | A8S | Abscisic acid receptor PYL3 | / | 0.459 | |
| 4oea | DHT | Androgen receptor | / | 0.459 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.458 | |
| 2vb8 | TLM | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.458 | |
| 3fnu | 006 | HAP protein | / | 0.458 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.458 | |
| 4k7a | DHT | Androgen receptor | / | 0.458 | |
| 4pd5 | GEO | Nucleoside permease | / | 0.458 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.458 | |
| 2pot | GUN | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.457 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3kdi | A8S | Abscisic acid receptor PYL2 | / | 0.457 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3nxt | D2E | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3qvr | FAD | Glucose oxidase | 1.1.3.4 | 0.457 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.457 | |
| 4agu | D15 | Cyclin-dependent kinase-like 1 | / | 0.457 | |
| 4ju4 | 1O3 | Genome polyprotein | 2.7.7.48 | 0.457 | |
| 4u0s | ADP | Adenosine monophosphate-protein transferase FICD | 2.7.7.n1 | 0.457 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.457 | |
| 2fme | 3QC | Kinesin-like protein KIF11 | / | 0.456 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3v8t | 477 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.456 | |
| 4aql | TXC | Guanine deaminase | 3.5.4.3 | 0.456 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.456 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.455 | |
| 1vyq | DUX | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.455 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2c3k | ABO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2jla | TPP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.455 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.455 | |
| 4hlw | TES | Androgen receptor | / | 0.455 | |
| 1k4h | APQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.454 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.454 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.454 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.454 | |
| 1xxj | UNC | Uricase | 1.7.3.3 | 0.454 | |
| 2ama | DHT | Androgen receptor | / | 0.454 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.454 | |
| 3s0o | 50Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3w9r | A8S | Abscisic acid receptor PYL9 | / | 0.454 | |
| 4oic | A8S | Bet v I allergen-like | / | 0.454 | |
| 4q5j | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.454 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.453 | |
| 1e7a | PFL | Serum albumin | / | 0.453 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.453 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.453 | |
| 3pd2 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.453 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.452 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1t7m | DHT | Androgen receptor | / | 0.452 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.452 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.452 | |
| 2vqj | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.452 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.452 | |
| 3ebl | GA4 | Gibberellin receptor GID1 | / | 0.452 | |
| 3gwu | SRE | Na(+):neurotransmitter symporter (Snf family) | / | 0.452 | |
| 4ho6 | UTP | Glucose-1-phosphate thymidylyltransferase | / | 0.452 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 5ikt | TLF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1mc1 | PCX | Carboxyethyl-arginine beta-lactam-synthase | 6.3.3.4 | 0.451 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.451 | |
| 1srf | MTB | Streptavidin | / | 0.451 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.451 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.451 | |
| 2ew5 | Y12 | Peptide deformylase | / | 0.451 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.451 | |
| 2pwy | SAH | tRNA (adenine(58)-N(1))-methyltransferase TrmI | 2.1.1.220 | 0.451 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.451 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.451 | |
| 4at2 | ASD | Possible succinate dehydrogenase | / | 0.451 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.451 | |
| 4lga | A2O | Abscisic acid receptor PYL2 | / | 0.451 | |
| 4ntc | FAD | Thioredoxin reductase gliT | / | 0.451 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.451 | |
| 1klk | PMD | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.450 | |
| 2piw | DHT | Androgen receptor | / | 0.450 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.450 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.450 | |
| 2rtm | IMI | Streptavidin | / | 0.450 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.450 | |
| 3ipu | O40 | Oxysterols receptor LXR-alpha | / | 0.450 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.450 | |
| 1kt5 | RTL | Retinol-binding protein 4 | / | 0.449 | |
| 1kzi | THG | Thymidylate synthase | / | 0.449 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1txi | TX5 | Vitamin D3 receptor | / | 0.449 | |
| 2fto | TMP | Thymidylate synthase | / | 0.449 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.449 | |
| 2g1q | N9H | Kinesin-like protein KIF11 | / | 0.449 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.449 | |
| 3pd4 | A3G | Threonine--tRNA ligase | 6.1.1.3 | 0.449 | |
| 3tm0 | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.449 | |
| 4jhz | 1KV | Beta-glucuronidase | 3.2.1.31 | 0.449 | |
| 4jqe | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.449 | |
| 4ww9 | ADP | EKC/KEOPS complex subunit BUD32 | 3.6 | 0.449 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.449 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.449 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.449 | |
| 1ltz | HBI | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.448 | |
| 1xp9 | AIJ | Estrogen receptor | / | 0.448 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2bik | BI1 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 2q7i | TES | Androgen receptor | / | 0.448 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.448 | |
| 3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.448 | |
| 3djf | BC3 | Purine nucleoside phosphorylase | / | 0.448 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3k3k | A8S | Abscisic acid receptor PYR1 | / | 0.448 | |
| 3nmv | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.448 | |
| 4f7j | 0SU | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.448 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.448 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.448 | |
| 1e2j | THM | Thymidine kinase | / | 0.447 | |
| 1mc0 | PCG | cGMP-dependent 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 1s4m | LUM | Riboflavin biosynthesis protein | / | 0.447 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.447 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2ab2 | SNL | Mineralocorticoid receptor | / | 0.447 | |
| 2az3 | CDP | Nucleoside diphosphate kinase | / | 0.447 | |
| 2b1z | 17M | Estrogen receptor | / | 0.447 | |
| 2e7z | MGD | Acetylene hydratase | / | 0.447 | |
| 2f99 | AKV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.447 | |
| 2o4j | VD4 | Vitamin D3 receptor | / | 0.447 | |
| 2x7d | EGB | Kinesin-like protein KIF11 | / | 0.447 | |
| 3hav | ATP | Aminoglycoside phosphotransferase | / | 0.447 | |
| 4app | N53 | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.447 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.447 | |
| 4kwh | NAP | Reductase homolog | / | 0.447 | |
| 4prx | ADP | DNA gyrase subunit B | / | 0.447 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1m2z | DEX | Glucocorticoid receptor | / | 0.446 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1o2e | ANN | Phospholipase A2 | 3.1.1.4 | 0.446 | |
| 1rjk | VDZ | Vitamin D3 receptor | / | 0.446 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2am9 | TES | Androgen receptor | / | 0.446 | |
| 2blb | CP7 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2ea1 | GPG | Ribonuclease I | 3.1.27.6 | 0.446 | |
| 2piq | DHT | Androgen receptor | / | 0.446 | |
| 2pix | DHT | Androgen receptor | / | 0.446 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.446 | |
| 3cgb | COA | Coenzyme A disulfide reductase | / | 0.446 | |
| 3fsu | C2F | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.446 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.446 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3kdj | A8S | Abscisic acid receptor PYL1 | / | 0.446 | |
| 3ldf | SAH | Uncharacterized protein | / | 0.446 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.446 | |
| 3o0g | 3O0 | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.446 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3r9n | Z68 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.446 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.446 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4ogr | ADN | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.446 | |
| 4zqm | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.446 | |
| 1axw | MTX | Thymidylate synthase | / | 0.445 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.445 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.445 | |
| 1vhn | FMN | tRNA-dihydrouridine synthase | / | 0.445 | |
| 1yi4 | ADN | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 2j2p | SC2 | Ficolin-2 | / | 0.445 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.445 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3i5x | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.445 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.445 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.445 | |
| 3tij | URI | Nucleoside permease | / | 0.445 | |
| 4pda | CTN | Nucleoside permease | / | 0.445 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.445 | |
| 1fin | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.444 | |
| 1q19 | SSC | Carbapenam-3-carboxylate synthase | 6.3.3.6 | 0.444 | |
| 1tdu | DUR | Thymidylate synthase | / | 0.444 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2gm1 | 2AZ | Kinesin-like protein KIF11 | / | 0.444 | |
| 2hb8 | MVD | Vitamin D3 receptor | / | 0.444 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.444 | |
| 2yis | YIS | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3afh | GSU | Glutamate--tRNA ligase 2 | / | 0.444 | |
| 3d90 | NOG | Progesterone receptor | / | 0.444 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.444 | |
| 3sai | 9DR | Dihydrofolate reductase | / | 0.444 | |
| 4eor | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4i9q | XG4 | DNA-directed DNA polymerase | / | 0.444 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.444 | |
| 4kxl | 6C6 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | / | 0.444 | |
| 5cb3 | APR | O-acetyl-ADP-ribose deacetylase | / | 0.444 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.444 | |
| 1f20 | FAD | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.443 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.443 | |
| 1ne6 | SP1 | cAMP-dependent protein kinase type I-alpha regulatory subunit | / | 0.443 | |
| 1rk3 | VDX | Vitamin D3 receptor | / | 0.443 | |
| 1tkx | GWB | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1x7r | GEN | Estrogen receptor | / | 0.443 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.443 | |
| 2v34 | CTN | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.443 | |
| 3fy8 | XCF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3koo | 24D | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.443 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.443 | |
| 3qf9 | NM8 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 3zqt | TES | Androgen receptor | / | 0.443 | |
| 4a39 | GEM | Uncharacterized protein | / | 0.443 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 4jhi | EMU | Nodulin-13 | / | 0.443 | |
| 4jju | 1MB | Genome polyprotein | 2.7.7.48 | 0.443 | |
| 4lb9 | EVP | Serum albumin | / | 0.443 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.443 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.443 | |
| 1avd | BTN | Avidin | / | 0.442 | |
| 1dd6 | MCI | Metallo-beta-lactamase type 2 | / | 0.442 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1ikg | REX | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.442 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.442 | |
| 1lhu | EST | Sex hormone-binding globulin | / | 0.442 | |
| 1phk | ATP | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform | 2.7.11.19 | 0.442 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.442 | |
| 1snu | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.442 | |
| 1xpc | AIT | Estrogen receptor | / | 0.442 | |
| 1yob | FMN | Flavodoxin 2 | / | 0.442 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2c4i | BTN | Avidin | / | 0.442 | |
| 2fai | 459 | Estrogen receptor | / | 0.442 | |
| 2qfv | NAP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.442 | |
| 2zsh | GA3 | Gibberellin receptor GID1A | 3 | 0.442 | |
| 2zv2 | 609 | Calcium/calmodulin-dependent protein kinase kinase 2 | 2.7.11.17 | 0.442 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3clb | TMQ | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.442 | |
| 3csd | EMO | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.442 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.442 | |
| 3neg | PYV | Abscisic acid receptor PYL1 | / | 0.442 | |
| 3nfr | EWQ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 4cuk | NAI | D-lactate dehydrogenase | / | 0.442 | |
| 4gae | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.442 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 4k0b | SAM | S-adenosylmethionine synthase | / | 0.442 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4ubv | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.442 | |
| 1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.441 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.441 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.441 | |
| 1jut | LYD | Thymidylate synthase | / | 0.441 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 1q65 | BHB | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.441 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.441 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 1xp1 | AIH | Estrogen receptor | / | 0.441 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2ban | 357 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 2g44 | T3O | Estrogen receptor | / | 0.441 | |
| 2i0y | 5CN | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.441 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2w3w | VG9 | Dihydrofolate reductase | / | 0.441 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.441 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.441 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 3n4k | SAH | tRNA (cytidine(34)-2'-O)-methyltransferase | / | 0.441 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.441 | |
| 4bdo | KAI | Glutamate receptor ionotropic, kainate 2 | / | 0.441 | |
| 4grb | 0XG | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 4h0y | NAD | Iota toxin component Ia | / | 0.441 | |
| 4nmb | FAD | Bifunctional protein PutA | / | 0.441 | |
| 4rra | A3T | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.441 | |
| 4rrq | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 4rup | H97 | Vitamin D3 receptor A | / | 0.441 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.441 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.441 | |
| 1h9z | RWF | Serum albumin | / | 0.440 | |
| 1lho | AOM | Sex hormone-binding globulin | / | 0.440 | |
| 1til | ATP | Anti-sigma F factor | / | 0.440 | |
| 1v1k | 3FP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1v3q | 2DI | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 2gv8 | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.440 | |
| 2ieh | MOY | Kinesin-like protein KIF11 | / | 0.440 | |
| 3a8t | ATP | Adenylate isopentenyltransferase | / | 0.440 | |
| 3ed1 | GA3 | Gibberellin receptor GID1 | / | 0.440 | |
| 3fgo | ACP | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.440 | |
| 3gg2 | UGA | Sugar dehydrogenase, UDP-glucose/GDP-mannose dehydrogenase family | / | 0.440 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3oe4 | 610 | Catechol O-methyltransferase | 2.1.1.6 | 0.440 | |
| 3qbw | ADP | Anhydro-N-acetylmuramic acid kinase | / | 0.440 | |
| 3qzy | FAD | FAD-linked sulfhydryl oxidase | / | 0.440 | |
| 4a5y | G7X | Kinesin-like protein KIF11 | / | 0.440 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.440 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.440 | |
| 4dxl | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 4oez | DHT | Androgen receptor | / | 0.440 | |
| 4u3j | GTP | Tubulin beta chain | / | 0.440 | |
| 5hid | B1E | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 |