sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1pzh | NAD | Lactate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1pzh | NAD | Lactate dehydrogenase | / | 1.000 | |
| 1pzg | A3D | Lactate dehydrogenase | / | 0.663 | |
| 1t2d | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.642 | |
| 1sow | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.636 | |
| 1pzf | A3D | Lactate dehydrogenase | / | 0.620 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.601 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.598 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.567 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.567 | |
| 2hjr | APR | Malate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase | / | 0.564 | |
| 4ros | APR | Malate dehydrogenase | / | 0.540 | |
| 4ajo | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.537 | |
| 4ajp | 88N | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.522 | |
| 1ib6 | NAD | Malate dehydrogenase | / | 0.519 | |
| 4mdh | NAD | Malate dehydrogenase, cytoplasmic | 1.1.1.37 | 0.517 | |
| 2yy7 | NAD | L-threonine dehydrogenase | / | 0.513 | |
| 4al4 | W7E | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.510 | |
| 1mg5 | NAI | Alcohol dehydrogenase | 1.1.1.1 | 0.506 | |
| 1ie3 | NAD | Malate dehydrogenase | / | 0.504 | |
| 2aa3 | AP0 | L-lactate dehydrogenase | / | 0.497 | |
| 4ajn | 88V | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.491 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.488 | |
| 3vfq | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.488 | |
| 4b8w | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.488 | |
| 1emd | NAD | Malate dehydrogenase | / | 0.487 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.486 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.484 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.483 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.483 | |
| 2x0i | NAI | Malate dehydrogenase | / | 0.483 | |
| 1kr2 | TAD | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.482 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.482 | |
| 1uxk | NAD | Malate dehydrogenase | / | 0.481 | |
| 1kev | NDP | NADP-dependent isopropanol dehydrogenase | 1.1.1.80 | 0.480 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.480 | |
| 1b16 | NAQ | Alcohol dehydrogenase | 1.1.1.1 | 0.479 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.479 | |
| 4l4s | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.479 | |
| 1uxj | NAD | Malate dehydrogenase | / | 0.477 | |
| 2fze | APR | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.477 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.477 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.477 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.477 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.476 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.475 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.475 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.475 | |
| 3mvm | 39P | Mitogen-activated protein kinase 14 | / | 0.475 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.475 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.474 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.474 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.473 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.472 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.470 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.470 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.470 | |
| 4dl9 | NAD | S-(hydroxymethyl)glutathione dehydrogenase | / | 0.470 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.470 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.469 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3zzn | ADP | L-lactate dehydrogenase | / | 0.469 | |
| 1hyh | NAD | L-2-hydroxyisocaproate dehydrogenase | / | 0.468 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.468 | |
| 3h3j | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.468 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 5a3b | APR | SIR2 family protein | / | 0.468 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 4l4x | NDP | AmphI | / | 0.466 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 3rj5 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.465 | |
| 3ule | C69 | Actin-related protein 3 | / | 0.465 | |
| 4kqr | VPP | Peptidoglycan D,D-transpeptidase FtsI | / | 0.465 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.465 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.464 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1y7l | ASN_LEU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.464 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.464 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.464 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.464 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.463 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.463 | |
| 3jv7 | NAD | Secondary alcohol dehydrogenase | / | 0.463 | |
| 3ksd | NAD | Glyceraldehyde-3-phosphate dehydrogenase 1 | / | 0.463 | |
| 4ajj | 88R | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.463 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.463 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.462 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.462 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.462 | |
| 1a59 | COA | 2-methylcitrate synthase | / | 0.461 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.461 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.461 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.461 | |
| 3h3f | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.461 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.460 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.460 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.460 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.460 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.460 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.460 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.460 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.460 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.459 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.459 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.459 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 4u7w | NDP | MxaA | / | 0.459 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.458 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.458 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.458 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.458 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.458 | |
| 4yvj | SFG | tRNA (guanine-N(1)-)-methyltransferase | 2.1.1.228 | 0.458 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.457 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.457 | |
| 1z7y | AA5 | Cysteine synthase 1 | 2.5.1.47 | 0.457 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.457 | |
| 5a3c | NAD | SIR2 family protein | / | 0.457 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.456 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.456 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.456 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.456 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.455 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.455 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.455 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.454 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.454 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.454 | |
| 2q4b | NAP | Uncharacterized protein At5g02240 | / | 0.454 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 1kvr | NAD | UDP-glucose 4-epimerase | 5.1.3.2 | 0.453 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.453 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.453 | |
| 2znp | K55 | Peroxisome proliferator-activated receptor delta | / | 0.453 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.453 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.453 | |
| 3s55 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.453 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.452 | |
| 1guy | NAD | Malate dehydrogenase | / | 0.452 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.452 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.452 | |
| 1u8f | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.452 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.452 | |
| 3cif | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.452 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.452 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.452 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.452 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.452 | |
| 1eq2 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.451 | |
| 1hf3 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.451 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.451 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.451 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.451 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.451 | |
| 3cmc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.451 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.451 | |
| 4a61 | ANP | Plasmid segregation protein ParM | / | 0.451 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.451 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.451 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.451 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.451 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.450 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.450 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.450 | |
| 3ieu | GDP | GTPase Era | / | 0.450 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.450 | |
| 4ej0 | NAP | ADP-L-glycero-D-manno-heptose-6-epimerase | / | 0.450 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.449 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.449 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.449 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.449 | |
| 3i59 | N6R | CRP-like cAMP-activated global transcriptional regulator | / | 0.449 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.449 | |
| 4dxa | GSP | Ras-related protein Rap-1b | / | 0.449 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.449 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.449 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.449 | |
| 1b15 | NAE | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.448 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.448 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.448 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.448 | |
| 3rj9 | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.448 | |
| 5dp2 | NAP | CurF | / | 0.448 | |
| 1ez4 | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.447 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.447 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.447 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.447 | |
| 1sui | FRE | Caffeoyl-CoA O-methyltransferase | 2.1.1.104 | 0.447 | |
| 2fjd | SFD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.447 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.447 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.447 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.447 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.447 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.447 | |
| 4hmv | WUB | Phenazine biosynthesis protein PhzG | 1.4 | 0.447 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.447 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 1rkx | NAD | CDP-D-glucose-4,6-dehydratase | / | 0.446 | |
| 1wn3 | HXC | Phenylacetic acid degradation protein PaaI | / | 0.446 | |
| 2cnt | COA | Ribosomal-protein-alanine acetyltransferase | / | 0.446 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.446 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2gsd | NAD | Formate dehydrogenase | / | 0.446 | |
| 2q29 | ACO | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.446 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.446 | |
| 4o0l | NDP | NADPH-dependent 3-quinuclidinone reductase | / | 0.446 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.445 | |
| 1y9d | TPP | Pyruvate oxidase | 1.2.3.3 | 0.445 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.445 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.445 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3ivm | ZPR | Prolyl endopeptidase | / | 0.445 | |
| 4ceq | QCH | Integrase | / | 0.445 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 4e2b | FMN | Dehydrogenase | / | 0.445 | |
| 4iay | ADP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.445 | |
| 4k9o | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.445 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1ea0 | FMN | Glutamate synthase [NADPH] large chain | 1.4.1.13 | 0.444 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.444 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.444 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.444 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.444 | |
| 2tps | TPS | Thiamine-phosphate synthase | / | 0.444 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 2xaa | NAD | Secondary alcohol dehydrogenase | / | 0.444 | |
| 3gob | HXX | DdmC | / | 0.444 | |
| 3gts | D3M | DdmC | / | 0.444 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.444 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.444 | |
| 1heu | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1kqo | DND | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.443 | |
| 1kt8 | ILP | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.443 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.443 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.443 | |
| 2b56 | UTP | RNA editing complex protein MP57 | / | 0.443 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.443 | |
| 2pk3 | GDD | GDP-6-deoxy-D-mannose reductase | / | 0.443 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.443 | |
| 3eku | CY9 | Actin-5C | / | 0.443 | |
| 3q71 | AR6 | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4cer | VL4 | Integrase | / | 0.443 | |
| 4rvg | TYD | D-mycarose 3-C-methyltransferase | / | 0.443 | |
| 5koi | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.443 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.442 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.442 | |
| 1r37 | NAD | NAD-dependent alcohol dehydrogenase | 1.1.1.1 | 0.442 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.442 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.442 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.442 | |
| 3fpj | SAM | Uncharacterized protein | / | 0.442 | |
| 3wv7 | ADP | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4e2d | FMN | Dehydrogenase | / | 0.442 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 4m9a | FDA | Acyl-CoA dehydrogenase | / | 0.442 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.441 | |
| 1npt | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.441 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.441 | |
| 1sny | NAP | LD36273p | / | 0.441 | |
| 1u2d | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.441 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.441 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.441 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.441 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.441 | |
| 3h6v | NS6 | Glutamate receptor 2 | / | 0.441 | |
| 3ic9 | FAD | Putative dihydrolipoamide dehydrogenase | / | 0.441 | |
| 3ijr | NAD | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.441 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.441 | |
| 3pvc | FAD | tRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC | / | 0.441 | |
| 3r5y | F42 | Uncharacterized protein | / | 0.441 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.441 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.441 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.440 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.440 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.440 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.440 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 2r5n | TPP | Transketolase 1 | / | 0.440 | |
| 2rr1 | W8R | Genome polyprotein | / | 0.440 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.440 | |
| 4cr8 | NAD | N-acylmannosamine 1-dehydrogenase | 1.1.1.233 | 0.440 | |
| 4er7 | AW3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.440 | |
| 5eow | FAD | 6-hydroxynicotinate 3-monooxygenase | 1.14.13.114 | 0.440 |