sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fr0 | SAM | Arsenic methyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4fr0 | SAM | Arsenic methyltransferase | / | 1.000 | |
| 3fri | SAH | 16S rRNA methylase | / | 0.523 | |
| 1ori | SAH | Protein arginine N-methyltransferase 1 | / | 0.509 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.506 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.501 | |
| 3tlj | SAH | Uncharacterized protein | / | 0.501 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.495 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.494 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.491 | |
| 2wsb | NAD | Galactitol dehydrogenase | / | 0.491 | |
| 5je3 | SAH | Methyl transferase | / | 0.491 | |
| 3b89 | 5GP | 16S rRNA methylase | / | 0.486 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.485 | |
| 4gkv | NAD | Alcohol dehydrogenase, propanol-preferring | 1.1.1.1 | 0.484 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 1nw5 | SAM | Modification methylase RsrI | 2.1.1.72 | 0.481 | |
| 1nw6 | SFG | Modification methylase RsrI | 2.1.1.72 | 0.481 | |
| 2ibt | NEA | Modification methylase TaqI | 2.1.1.72 | 0.481 | |
| 3roc | 29A | Mitogen-activated protein kinase 14 | / | 0.481 | |
| 3pt9 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.480 | |
| 5kjc | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.480 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.479 | |
| 3qv2 | SAH | 5-cytosine DNA methyltransferase | / | 0.479 | |
| 3swr | SFG | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.479 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.478 | |
| 2ohx | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.477 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.476 | |
| 3ajr | NAD | NDP-sugar epimerase | / | 0.476 | |
| 3f46 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.476 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.476 | |
| 1c70 | L75 | Protease | / | 0.475 | |
| 2oxt | SAM | Genome polyprotein | / | 0.475 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.475 | |
| 3bc3 | OPT | Cathepsin L1 | 3.4.22.15 | 0.474 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.474 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 4qpp | SAH | Protein arginine N-methyltransferase 6 | / | 0.474 | |
| 1s3z | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.473 | |
| 2dpm | SAM | Modification methylase DpnIIA | 2.1.1.72 | 0.473 | |
| 3s2a | 2NQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.473 | |
| 1h2b | NAJ | NAD-dependent alcohol dehydrogenase | / | 0.472 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.472 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.471 | |
| 4g56 | SAH | Protein arginine N-methyltransferase 5 | / | 0.471 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.470 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.470 | |
| 2q4w | FAD | Cytokinin dehydrogenase 7 | 1.5.99.12 | 0.470 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.470 | |
| 3abi | NAD | Uncharacterized protein | / | 0.469 | |
| 3h8b | NSY | Cathepsin L1 | 3.4.22.15 | 0.469 | |
| 3w0n | ANP | Hygromycin-B 4-O-kinase | 2.7.1.163 | 0.469 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.469 | |
| 2nxe | SAM | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.468 | |
| 2qe6 | SAM | Uncharacterized protein | / | 0.468 | |
| 2vna | NAP | Prostaglandin reductase 2 | 1.3.1.48 | 0.468 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.468 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.468 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.467 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.467 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.466 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.466 | |
| 4nbu | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.466 | |
| 4wxx | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.466 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.465 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.465 | |
| 1qbu | 846 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.465 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.465 | |
| 1axe | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.464 | |
| 1qan | SAH | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.464 | |
| 2x3n | FAD | Probable FAD-dependent monooxygenase | / | 0.464 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 3fz1 | B98 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.464 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 3wmx | NAD | NAD dependent epimerase/dehydratase | / | 0.464 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 5e72 | SAM | N2, N2-dimethylguanosine tRNA methyltransferase | / | 0.464 | |
| 1hdz | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.463 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 2pmo | HMD | Protein kinase 7 | / | 0.463 | |
| 4cql | NAD | Estradiol 17-beta-dehydrogenase 8 | 1.1.1.62 | 0.463 | |
| 4gb9 | 0WR | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.463 | |
| 1c6y | MK1 | Protease | / | 0.462 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.462 | |
| 3o15 | 3NM | Thiamine-phosphate synthase | / | 0.462 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.461 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.461 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.461 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.461 | |
| 3gc8 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.461 | |
| 4gbe | SAH | DNA adenine methylase | 2.1.1.72 | 0.461 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.460 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.460 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.460 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.460 | |
| 2xyn | VX6 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.460 | |
| 2zwv | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.460 | |
| 3tm5 | SFG | Uncharacterized protein | / | 0.460 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.460 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.460 | |
| 4zvm | DM2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.460 | |
| 7mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.460 | |
| 8mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.460 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.459 | |
| 1skm | SAH | Modification methylase HhaI | 2.1.1.37 | 0.459 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 4g9k | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.459 | |
| 1gqt | ACP | Ribokinase | / | 0.458 | |
| 1nfr | NAD | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.458 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3kpk | FAD | Sulfide-quinone reductase | / | 0.458 | |
| 3uxy | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.458 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.458 | |
| 4c05 | SAH | Protein arginine N-methyltransferase 6 | / | 0.458 | |
| 4jvf | 17X | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.458 | |
| 4ng5 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.458 | |
| 5upj | UIN | Gag-Pol polyprotein | / | 0.458 | |
| 9mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.458 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.457 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.457 | |
| 1sh9 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2c7q | SAH | Modification methylase HhaI | 2.1.1.37 | 0.457 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.457 | |
| 4neu | Q1A | Receptor-interacting serine/threonine-protein kinase 1 | 2.7.11.1 | 0.457 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.457 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 2b9w | FAD | Putative aminooxidase | / | 0.456 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.456 | |
| 3ha7 | B32 | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.456 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3tea | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.456 | |
| 5epe | SAH | Uncharacterized protein | / | 0.456 | |
| 5kj6 | PFB | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.456 | |
| 1lld | NAD | L-lactate dehydrogenase 2 | 1.1.1.27 | 0.455 | |
| 1qbs | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3gry | SAM | Probable ribosomal RNA small subunit methyltransferase A | / | 0.455 | |
| 4fi1 | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.455 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.455 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.454 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.454 | |
| 2owu | SAH | Diphthine synthase | / | 0.454 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.454 | |
| 2uzv | SS5 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
| 3f47 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.454 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.454 | |
| 3unj | 0BX | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.454 | |
| 4dsg | FAD | Uncharacterized protein | / | 0.454 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 5eyp | LOC | Tubulin beta chain | / | 0.454 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.453 | |
| 1qaq | SFG | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.453 | |
| 1u3v | NAD | Alcohol dehydrogenase 1B | 1.1.1.1 | 0.453 | |
| 2hw2 | RFP | Rifampin ADP-ribosyl transferase | / | 0.453 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.453 | |
| 3a28 | NAD | L-2,3-butanediol dehydrogenase | 1.1.1.76 | 0.453 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.453 | |
| 3dag | FEG | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.453 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.453 | |
| 3oro | AGS | Serine/threonine protein kinase | / | 0.453 | |
| 3say | OFT | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.453 | |
| 4anw | O92 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.453 | |
| 4nfh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1bl6 | SB6 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 1qao | SAM | rRNA adenine N-6-methyltransferase | 2.1.1.184 | 0.452 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.452 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.452 | |
| 3e8c | G96 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.452 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.452 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.452 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.452 | |
| 1aj8 | COA | Citrate synthase | / | 0.451 | |
| 2cd8 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.451 | |
| 2f1k | NAP | Prephenate dehydrogenase | / | 0.451 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.451 | |
| 2prh | 238 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.451 | |
| 2xvq | 9DS | Serum albumin | / | 0.451 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.451 | |
| 3i6o | GR6 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4d0l | 093 | Phosphatidylinositol 4-kinase beta | 2.7.1.67 | 0.451 | |
| 4e2b | FMN | Dehydrogenase | / | 0.451 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.451 | |
| 4hla | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.451 | |
| 1eag | A70 | Candidapepsin-2 | 3.4.23.24 | 0.450 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.450 | |
| 2xye | CXG | Gag-Pol polyprotein | / | 0.450 | |
| 2zif | SAM | Methyltransferase | / | 0.450 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 5cds | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 5lc1 | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 1b6p | PI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1g38 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.449 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.449 | |
| 2rkf | AB1 | Pol protein | / | 0.449 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.449 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.449 | |
| 3ort | AGS | Serine/threonine protein kinase | / | 0.449 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.449 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.449 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.449 | |
| 4ydu | ADP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.449 | |
| 5mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.449 | |
| 1h1s | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.448 | |
| 1xny | 191 | Propionyl-CoA carboxylase complex B subunit | / | 0.448 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2har | OCC | Vitamin D3 receptor | / | 0.448 | |
| 2ohv | NHL | Glutamate racemase | / | 0.448 | |
| 2pau | D5M | 5'-deoxynucleotidase YfbR | / | 0.448 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.448 | |
| 2zdt | 46C | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.448 | |
| 3gcn | TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.448 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.448 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.448 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4kdr | SAH | Ubiquinone biosynthesis O-methyltransferase | / | 0.448 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.448 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.448 | |
| 6upj | NIU | Gag-Pol polyprotein | / | 0.448 | |
| 1ajv | NMB | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.447 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.447 | |
| 1s5k | COA | Aminoglycoside N(6')-acetyltransferase type 1 | / | 0.447 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.447 | |
| 3b3f | SAH | Histone-arginine methyltransferase CARM1 | / | 0.447 | |
| 3g7j | GTX | Glutathione transferase GST1-4 | / | 0.447 | |
| 3vey | 0H5 | Glucokinase | 2.7.1.2 | 0.447 | |
| 3vru | YS3 | Vitamin D3 receptor | / | 0.447 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.447 | |
| 5bp7 | SAH | SAM-dependent methyltransferase | / | 0.447 | |
| 5br4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.447 | |
| 1eby | BEB | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1ppj | ANY | Cytochrome b | / | 0.446 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.446 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.446 | |
| 2gtk | 208 | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 2i4u | DJR | Protease | / | 0.446 | |
| 2qk8 | MTX | Dihydrofolate reductase | / | 0.446 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.446 | |
| 3fl4 | FL4 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3hwr | NDP | 2-dehydropantoate 2-reductase | / | 0.446 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.446 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.446 | |
| 3zuy | TCH | Transporter | / | 0.446 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4iv8 | SAM | Phosphoethanolamine N-methyltransferase,putative | / | 0.446 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1eg2 | MTA | Modification methylase RsrI | 2.1.1.72 | 0.445 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.445 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.445 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.445 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.445 | |
| 1kzk | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1w5v | BE3 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.445 | |
| 2p4y | C03 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2q55 | MU0 | Protease | / | 0.445 | |
| 2rc6 | NAP | Ferredoxin--NADP reductase | / | 0.445 | |
| 2vwp | NDP | Glucose 1-dehydrogenase | / | 0.445 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.445 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.445 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 3cgf | JNF | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 3egv | SAH | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.445 | |
| 3lga | SAH | tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI | 2.1.1.219 | 0.445 | |
| 3mxd | K53 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3p2e | SAH | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.445 | |
| 3wow | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.445 | |
| 4g3p | UD1 | Bifunctional protein GlmU | / | 0.445 | |
| 4gh5 | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.445 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.445 | |
| 4hdp | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4mle | VO1 | Glucokinase | 2.7.1.2 | 0.445 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 4u7t | SAH | DNA (cytosine-5)-methyltransferase 3A | 2.1.1.37 | 0.445 | |
| 1bw9 | NAD | Phenylalanine dehydrogenase | / | 0.444 | |
| 1byg | STU | Tyrosine-protein kinase CSK | / | 0.444 | |
| 1e3w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 1fdt | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.444 | |
| 1hsh | MK1 | Gag-Pol polyprotein | / | 0.444 | |
| 1u8v | FAD | 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase | / | 0.444 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.444 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.444 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.444 | |
| 2wou | ZZF | TGF-beta receptor type-1 | 2.7.11.30 | 0.444 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.444 | |
| 3bus | SAH | Demethylrebeccamycin-D-glucose O-methyltransferase | / | 0.444 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 3cjt | SAH | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.444 | |
| 3gco | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.444 | |
| 3grr | SAH | Probable ribosomal RNA small subunit methyltransferase A | / | 0.444 | |
| 3h65 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.444 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 3upj | U03 | Gag-Pol polyprotein | / | 0.444 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.444 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.444 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.444 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.444 | |
| 1a71 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.443 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.443 | |
| 1mtr | PI6 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.443 | |
| 2fdd | 385 | Pol protein | / | 0.443 | |
| 2hs2 | 017 | Protease | / | 0.443 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2p33 | J07 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.443 | |
| 2z6u | SAH | Modification methylase HhaI | 2.1.1.37 | 0.443 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.443 | |
| 3o9z | NAD | Lipopolysaccaride biosynthesis protein wbpB | / | 0.443 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3up0 | D7S | aceDAF-12 | / | 0.443 | |
| 3zsh | 469 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4enx | Z20 | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.443 | |
| 4kvz | SAH | PtnL protein | / | 0.443 | |
| 4oti | MI1 | Serine/threonine-protein kinase N1 | / | 0.443 | |
| 5ifi | PRX | Acetyl-coenzyme A synthetase | / | 0.443 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.442 | |
| 1hld | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1mgo | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 1sg9 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.442 | |
| 1w5x | BE5 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.442 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.442 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.442 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.442 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.442 | |
| 2qfx | NDP | Isocitrate dehydrogenase [NADP], mitochondrial | 1.1.1.42 | 0.442 | |
| 2w05 | FRT | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 2xcl | ANP | Phosphoribosylamine--glycine ligase | / | 0.442 | |
| 3cx8 | GSP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.442 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3ete | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.442 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.442 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3p2k | SAM | 16S rRNA (adenine(1408)-N(1))-methyltransferase | 2.1.1.180 | 0.442 | |
| 3syi | FAD | Sulfide-quinone reductase | / | 0.442 | |
| 3vet | ADP | nebramycin 5' synthase | 6.1.2.2 | 0.442 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.442 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.442 | |
| 3w1f | 1O5 | Dual specificity protein kinase TTK | 2.7.12.1 | 0.442 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.442 | |
| 4bco | T6Q | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.442 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 4l8u | 9AZ | Serum albumin | / | 0.442 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.442 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1h74 | AGS | Homoserine kinase | 2.7.1.39 | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.441 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.441 | |
| 2aa0 | MTP | Adenosine kinase | 2.7.1.20 | 0.441 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 2ooy | ATP | 5'-AMP-activated protein kinase subunit gamma | / | 0.441 | |
| 2qa2 | FAD | Polyketide oxygenase CabE | / | 0.441 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.441 | |
| 2ylx | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.441 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3hll | I45 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.441 | |
| 3zlx | 5EZ | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 4dwv | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 4gav | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.441 | |
| 4gdd | NAI | UDP-galactopyranose mutase | / | 0.441 | |
| 4ia2 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4j98 | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.441 | |
| 4q0a | 4OA | Vitamin D3 receptor A | / | 0.441 | |
| 4v12 | POG | MaoC like domain protein | / | 0.441 | |
| 4ylf | FAD | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog | / | 0.441 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.440 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 1pmn | 984 | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.440 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.440 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.440 | |
| 2b03 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2dkn | NAI | 3-alpha-hydroxysteroid dehydrogenase | / | 0.440 | |
| 2jhf | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 2pvh | P19 | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 3l8p | 0CE | Angiopoietin-1 receptor | 2.7.10.1 | 0.440 | |
| 3lu8 | IQX | Serum albumin | / | 0.440 | |
| 3sdi | 3SD | Proteasome subunit beta type-5 | 3.4.25.1 | 0.440 | |
| 3sdi | 3SD | Proteasome subunit beta type-6 | 3.4.25.1 | 0.440 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.440 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 3ua3 | SAH | Protein arginine N-methyltransferase 5 | / | 0.440 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.440 | |
| 3zux | TCH | Transporter | / | 0.440 | |
| 4bid | IE8 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 | |
| 4jlc | SU6 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.440 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 | |
| 4q1x | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.440 | |
| 4y95 | 746 | Tyrosine-protein kinase | / | 0.440 |