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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.25

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.251.000
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.602
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.577
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.568
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.560
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.554
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.550
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.545
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.543
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.537
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.537
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.533
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.523
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.513
1aq1STUCyclin-dependent kinase 22.7.11.220.511
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.511
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.510
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.509
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.509
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.508
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.508
3zewSTUEphrin type-B receptor 42.7.10.10.508
4jia1K3Tyrosine-protein kinase JAK2/0.505
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.504
1bygSTUTyrosine-protein kinase CSK/0.503
1xjdSTUProtein kinase C theta type2.7.11.130.503
4hvi19STyrosine-protein kinase JAK32.7.10.20.501
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.500
2h96893Mitogen-activated protein kinase 82.7.11.240.498
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.498
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.498
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.498
5e8ySTUTGF-beta receptor type-22.7.11.300.498
4fod0UVALK tyrosine kinase receptor2.7.10.10.497
4jqeANPCasein kinase II subunit alpha2.7.11.10.497
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.496
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.495
3zh8C58Protein kinase C iota type2.7.11.130.495
4hvg19QTyrosine-protein kinase JAK32.7.10.20.495
4hvh19RTyrosine-protein kinase JAK32.7.10.20.495
4wsqKSAAP2-associated protein kinase 12.7.11.10.495
5e8wSTUTGF-beta receptor type-12.7.11.300.495
4gk2L66Ephrin type-A receptor 32.7.10.10.494
5e8xSTUTGF-beta receptor type-12.7.11.300.494
1pmn984Mitogen-activated protein kinase 102.7.11.240.493
2xa4AZ5Tyrosine-protein kinase JAK2/0.493
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.493
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.493
1yvj4STTyrosine-protein kinase JAK32.7.10.20.492
2yn8STUEphrin type-B receptor 42.7.10.10.491
3gxlQIGTGF-beta receptor type-12.7.11.300.490
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.489
4c62XWWTyrosine-protein kinase JAK2/0.489
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.489
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.488
4fob0USALK tyrosine kinase receptor2.7.10.10.488
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.487
3l8p0CEAngiopoietin-1 receptor2.7.10.10.486
4erwSTUCyclin-dependent kinase 22.7.11.220.486
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.486
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.486
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.485
1u54ACPActivated CDC42 kinase 1/0.484
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.484
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.484
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.484
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.483
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.483
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.482
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.482
3ttjJBIMitogen-activated protein kinase 102.7.11.240.482
4e4m0NHTyrosine-protein kinase JAK2/0.482
4i22IREEpidermal growth factor receptor2.7.10.10.482
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.481
1pkdUCNCyclin-dependent kinase 22.7.11.220.481
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.481
4anmWULCasein kinase II subunit alpha2.7.11.10.481
4aqc88ATyrosine-protein kinase JAK2/0.481
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.481
1zrzBI1Protein kinase C iota type2.7.11.130.480
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.480
3i60E86Mitogen-activated protein kinase 12.7.11.240.480
4hge15VTyrosine-protein kinase JAK2/0.480
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.479
2hog710Serine/threonine-protein kinase Chk12.7.11.10.479
2pmoHMDProtein kinase 7/0.479
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.479
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.479
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.478
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.477
2pvnP63Casein kinase II subunit alpha2.7.11.10.477
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.477
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.477
4gmy0X5Tyrosine-protein kinase JAK2/0.477
2j0m4STFocal adhesion kinase 12.7.10.20.476
3w2rW2REpidermal growth factor receptor2.7.10.10.476
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.475
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.475
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
4o0wADNAurora kinase A2.7.11.10.475
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.474
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.473
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.473
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.473
3gubGUBDeath-associated protein kinase 12.7.11.10.473
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.473
4jbqVX6Aurora kinase A2.7.11.10.473
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.473
2qo9ANPEphrin type-A receptor 32.7.10.10.472
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.472
3pxkPXKFocal adhesion kinase 12.7.10.20.472
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.472
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.472
1u4dDBQActivated CDC42 kinase 1/0.471
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.471
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.471
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.471
3a62STURibosomal protein S6 kinase beta-12.7.11.10.470
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.470
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.470
4ji91M3Tyrosine-protein kinase JAK2/0.470
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.469
3rvg17PTyrosine-protein kinase JAK2/0.469
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.469
4c61LMMTyrosine-protein kinase JAK2/0.469
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.469
4fv6E57Mitogen-activated protein kinase 12.7.11.240.469
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.469
5dt3ATPAurora kinase A2.7.11.10.469
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.468
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.468
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.468
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.468
3eljGS7Mitogen-activated protein kinase 82.7.11.240.468
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.468
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.468
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.468
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.468
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.468
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.467
2dwbANPAurora kinase A2.7.11.10.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.467
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.467
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.467
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.467
4dgnLU2Casein kinase II subunit alpha2.7.11.10.467
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.467
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.466
2pvhP19Casein kinase II subunit alpha2.7.11.10.466
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.466
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.466
4gub0Y4Casein kinase II subunit alpha2.7.11.10.466
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.465
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.465
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.465
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.465
3w2sW2REpidermal growth factor receptor2.7.10.10.465
3zep1NXTyrosine-protein kinase JAK32.7.10.20.465
5dr6SKEAurora kinase A2.7.11.10.465
2w05FRTCyclin-dependent kinase 22.7.11.220.464
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.464
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.464
4nka2K7Fibroblast growth factor receptor 1/0.464
2vx07X7Ephrin type-B receptor 42.7.10.10.463
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.463
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.463
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.463
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.463
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.463
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.462
2excJNKMitogen-activated protein kinase 102.7.11.240.462
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.462
3lpbNVBTyrosine-protein kinase JAK2/0.462
3w33W19Epidermal growth factor receptor2.7.10.10.462
4dymIYZActivin receptor type-12.7.11.300.462
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2w1fL0FAurora kinase A2.7.11.10.461
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.461
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.461
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.461
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
4ix6ADPUncharacterized protein/0.461
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.461
1lp4ANPCasein kinase II subunit alpha2.7.11.10.460
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.460
2j0j4STFocal adhesion kinase 12.7.10.20.460
2pvlP55Casein kinase II subunit alpha2.7.11.10.460
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.460
3ttiKBIMitogen-activated protein kinase 102.7.11.240.460
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.460
5drdATPAurora kinase A2.7.11.10.460
1oiyN41Cyclin-dependent kinase 22.7.11.220.459
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.459
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.459
2p33J07Mitogen-activated protein kinase 102.7.11.240.459
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.459
3ggfGVDSerine/threonine-protein kinase 26/0.459
3zmmF9JTyrosine-protein kinase JAK2/0.459
4f081RSTyrosine-protein kinase JAK2/0.459
4f650S9Fibroblast growth factor receptor 1/0.459
4gk3L87Ephrin type-A receptor 32.7.10.10.459
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.459
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.458
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.458
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.458
2vu3LZECyclin-dependent kinase 22.7.11.220.458
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.458
4dgo0JWCasein kinase II subunit alpha2.7.11.10.458
5dr9SKEAurora kinase A2.7.11.10.458
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.457
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.457
3k5uPFQAurora kinase A2.7.11.10.457
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.457
3r9hZ67Cyclin-dependent kinase 22.7.11.220.457
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.457
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.457
1xddAAYIntegrin alpha-L/0.456
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.456
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.456
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
3t113T1Gag-Pol polyprotein3.4.23.160.456
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.456
4aotGW8Serine/threonine-protein kinase 102.7.11.10.456
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.456
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.456
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.456
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1m2rMNYCasein kinase II subunit alpha2.7.11.10.455
2bkzSBCCyclin-dependent kinase 22.7.11.220.455
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.455
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.455
2v7a627Tyrosine-protein kinase ABL12.7.10.20.455
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.455
2xvdAS6Ephrin type-B receptor 42.7.10.10.455
3eyhIZATyrosine-protein kinase JAK1/0.455
3hmm855TGF-beta receptor type-12.7.11.300.455
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.455
3oibFDAPutative acyl-CoA dehydrogenase/0.455
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.455
4jajXU1Aurora kinase A2.7.11.10.455
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.455
4qmpDKISerine/threonine-protein kinase 242.7.11.10.455
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.455
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1bxoPP7Penicillopepsin-13.4.23.200.454
1h1s4SPCyclin-dependent kinase 22.7.11.220.454
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.454
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.454
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.454
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.454
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.454
2xneASHAurora kinase A2.7.11.10.454
3uyt0CKCasein kinase I isoform delta2.7.11.10.454
3vryB43Tyrosine-protein kinase HCK2.7.10.20.454
4y93746Tyrosine-protein kinase/0.454
1bwsNDPGDP-L-fucose synthase/0.453
1m2qMNXCasein kinase II subunit alpha2.7.11.10.453
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.453
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.453
2yxuATPPyridoxal kinase2.7.1.350.453
3at3ATKCasein kinase II subunit alpha2.7.11.10.453
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.453
3umw596Serine/threonine-protein kinase pim-12.7.11.10.453
3wmxNADNAD dependent epimerase/dehydratase/0.453
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.453
4nk92K5Fibroblast growth factor receptor 1/0.453
4wkqIREEpidermal growth factor receptor2.7.10.10.453
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.453
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.452
2vwx7X4Ephrin type-B receptor 42.7.10.10.452
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.452
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.452
3w18N13Aurora kinase A2.7.11.10.452
4bgg844Activin receptor type-12.7.11.300.452
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.452
4riyADPEpidermal growth factor receptor2.7.10.10.452
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
2bfyH1NAurora kinase B-A2.7.11.10.451
2c5nCK8Cyclin-dependent kinase 22.7.11.220.451
2x1nX1NCyclin-dependent kinase 22.7.11.220.451
2xb7GUIALK tyrosine kinase receptor2.7.10.10.451
2xyuQ9GEphrin type-A receptor 42.7.10.10.451
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.451
3qaiXNNKetohexokinase/0.451
3vf80JETyrosine-protein kinase SYK2.7.10.20.451
4ccbOFGALK tyrosine kinase receptor2.7.10.10.451
4ewhT77Activated CDC42 kinase 1/0.451
4hjoAQ4Epidermal growth factor receptor2.7.10.10.451
4ocvANPAminoglycoside phosphotransferase/0.451
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.451
1rw8580TGF-beta receptor type-12.7.11.300.450
2eufLQQCyclin-dependent kinase 62.7.11.220.450
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.450
2y6o1N1Ephrin type-A receptor 42.7.10.10.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3eb0DRKUncharacterized protein/0.450
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.450
3upjU03Gag-Pol polyprotein/0.450
4b99R4LMitogen-activated protein kinase 72.7.11.240.450
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.450
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.450
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.450
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.450
4kqwNAPKetol-acid reductoisomerase (NADP(+))/0.450
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.450
1dawANPCasein kinase II subunit alpha2.7.11.10.449
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.449
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.449
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.449
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.449
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.449
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.449
3a60STURibosomal protein S6 kinase beta-12.7.11.10.449
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.449
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.449
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.449
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.449
4g2fC07Ephrin type-A receptor 32.7.10.10.449
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.449
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.448
2itpAEEEpidermal growth factor receptor2.7.10.10.448
2w1eL0EAurora kinase A2.7.11.10.448
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.448
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.448
3dogNNNCyclin-dependent kinase 22.7.11.220.448
3du8553Glycogen synthase kinase-3 beta2.7.11.260.448
3ezrEZRCyclin-dependent kinase 22.7.11.220.448
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.448
3le62BZCyclin-dependent kinase 22.7.11.220.448
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.448
3nxe2NCProtease/0.448
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.448
1hdrNADDihydropteridine reductase1.5.1.340.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.447
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.447
3d7tSTUTyrosine-protein kinase CSK/0.447
3so9017Pol protein/0.447
4dgmAGICasein kinase II subunit alpha2.7.11.10.447
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.447
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.447
4jr7GNPCasein kinase II subunit alpha2.7.11.10.447
5dn3ATPAurora kinase A2.7.11.10.447
1e9hINRCyclin-dependent kinase 22.7.11.220.446
1hshMK1Gag-Pol polyprotein/0.446
1om1IQACasein kinase II subunit alpha2.7.11.10.446
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.446
1vjy460TGF-beta receptor type-12.7.11.300.446
2fxdDR7Pol polyprotein/0.446
2q59240Peroxisome proliferator-activated receptor gamma/0.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
2vwy7X5Ephrin type-B receptor 42.7.10.10.446
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.446
3iok1P6Tyrosine-protein kinase JAK2/0.446
3t8oATPRhodopsin kinase/0.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.446
4foc0UUALK tyrosine kinase receptor2.7.10.10.446
4lrjANPUncharacterized protein/0.446
5aaaVGHALK tyrosine kinase receptor2.7.10.10.446
5cvhADPCasein kinase II subunit alpha2.7.11.10.446
1gqtACPRibokinase/0.445
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.445
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.445
2q9fC3SCholesterol 24-hydroxylase/0.445
2x2mX2MProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.445
3ddpRC8Cyclin-dependent kinase 22.7.11.220.445
3emg685Tyrosine-protein kinase SYK2.7.10.20.445
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.445
4bcnT9NCyclin-dependent kinase 22.7.11.220.445
4btkDTQTau-tubulin kinase 12.7.11.10.445
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.445
4fv7E94Mitogen-activated protein kinase 12.7.11.240.445
1dhrNADDihydropteridine reductase1.5.1.340.444
1eh4IC1Casein kinase I homolog 12.7.11.10.444
1hosPHPGag-Pol polyprotein/0.444
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.444
2vx17X8Ephrin type-B receptor 42.7.10.10.444
3ixj586Beta-secretase 13.4.23.460.444
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.444
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.444
4e6d0NUTyrosine-protein kinase JAK2/0.444
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.444
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.444
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4ux9ANPMitogen-activated protein kinase 82.7.11.240.444
4yryFADGlutamate synthase, beta subunit/0.444
1egeFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.443
1sguMK1Gag-Pol polyprotein3.4.23.160.443
1wvxBD4Death-associated protein kinase 12.7.11.10.443
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.443
2cig1DGDihydrofolate reductase1.5.1.30.443
2ckeIQUDeath-associated protein kinase 2/0.443
2vd5BI8Myotonin-protein kinase2.7.11.10.443
2zdt46CMitogen-activated protein kinase 102.7.11.240.443
3at4CCKCasein kinase II subunit alpha2.7.11.10.443
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.443
3hx4ANPCalmodulin-domain protein kinase 1/0.443
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.443
4i0r1B4Tyrosine-protein kinase SYK2.7.10.20.443
4jq8KJ8Epidermal growth factor receptor2.7.10.10.443
1u3cFADCryptochrome-1/0.442
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.442
2of4979Tyrosine-protein kinase Lck2.7.10.20.442
2vwz7X6Ephrin type-B receptor 42.7.10.10.442
2yfxVGHALK tyrosine kinase receptor2.7.10.10.442
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.442
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.442
3aidARQGag-Pol polyprotein3.4.23.160.442
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.442
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3pe6ZYHMonoglyceride lipase/0.442
3t2zFADSulfide-quinone reductase/0.442
3uo50BXAurora kinase A2.7.11.10.442
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.442
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.442
4jbpYPHAurora kinase A2.7.11.10.442
4nbwNADShort-chain dehydrogenase/reductase SDR/0.442
4utdACPAurora kinase A2.7.11.10.442
4v2gITCTetracycline repressor protein class D/0.442
5aabVGHALK tyrosine kinase receptor2.7.10.10.442
5cshATPCasein kinase II subunit alpha2.7.11.10.442
1dayGNPCasein kinase II subunit alpha2.7.11.10.441
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.441
2wecPP5Penicillopepsin-13.4.23.200.441
3w32W32Epidermal growth factor receptor2.7.10.10.441
4bb432WEphrin type-B receptor 42.7.10.10.441
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4gk4L90Ephrin type-A receptor 32.7.10.10.441
4q73FADBifunctional protein PutA/0.441
1csnATPCasein kinase I homolog 12.7.11.10.440
1m2pHNACasein kinase II subunit alpha2.7.11.10.440
1oguST8Cyclin-dependent kinase 22.7.11.220.440
2om9AJAPeroxisome proliferator-activated receptor gamma/0.440
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.440
2pvmP29Casein kinase II subunit alpha2.7.11.10.440
3gggNADPrephenate dehydrogenase/0.440
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.440
3rk507ZCyclin-dependent kinase 22.7.11.220.440
3rkb12ZCyclin-dependent kinase 22.7.11.220.440
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.440
4anqVGHALK tyrosine kinase receptor2.7.10.10.440
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4j97ACPFibroblast growth factor receptor 2/0.440
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.440
5dnrATPAurora kinase A2.7.11.10.440
5dosATPAurora kinase A2.7.11.10.440