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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lz5LDTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3lz5LDTAldose reductase1.1.1.211.000
2pdxZSTAldose reductase1.1.1.210.733
3m64393Aldose reductase1.1.1.210.728
3m4h388Aldose reductase1.1.1.210.725
2fz9ZSTAldose reductase1.1.1.210.707
3lboLDTAldose reductase1.1.1.210.697
2hvoZSTAldose reductase1.1.1.210.691
3lqlLDTAldose reductase1.1.1.210.687
4yu153NAldose reductase1.1.1.210.685
1us0LDTAldose reductase1.1.1.210.666
1z8962PAldose reductase1.1.1.210.666
1t40ID5Aldose reductase1.1.1.210.662
2ikj393Aldose reductase1.1.1.210.654
2dv0ZSTAldose reductase1.1.1.210.653
3mc5393Aldose reductase1.1.1.210.648
1t41ID5Aldose reductase1.1.1.210.642
3m0iZSTAldose reductase1.1.1.210.642
3ghuLDTAldose reductase1.1.1.210.641
2hvnZSTAldose reductase1.1.1.210.639
4gca2X9Aldose reductase1.1.1.210.638
2hv5ZSTAldose reductase1.1.1.210.636
2pdmZSTAldose reductase1.1.1.210.635
2pdfZSTAldose reductase1.1.1.210.627
3ghsLDTAldose reductase1.1.1.210.625
2pdu393Aldose reductase1.1.1.210.624
3mb9ZSTAldose reductase1.1.1.210.622
3lenZSTAldose reductase1.1.1.210.619
2iki388Aldose reductase1.1.1.210.618
2pdp393Aldose reductase1.1.1.210.615
1ieiZESAldose reductase1.1.1.210.613
3ld5LDTAldose reductase1.1.1.210.612
3t423T4Aldose reductase1.1.1.210.612
2pdbZSTAldose reductase1.1.1.210.609
3g5eQ74Aldose reductase1.1.1.210.609
2fz8ZSTAldose reductase1.1.1.210.605
2pdg47DAldose reductase1.1.1.210.605
2pdn47DAldose reductase1.1.1.210.604
2pzn393Aldose reductase1.1.1.210.604
2qxwLDTAldose reductase1.1.1.210.604
2pdq47DAldose reductase1.1.1.210.603
2fzdTOLAldose reductase1.1.1.210.600
2pd5ZSTAldose reductase1.1.1.210.598
3ghrLDTAldose reductase1.1.1.210.597
3ghtLDTAldose reductase1.1.1.210.596
1pwlBFIAldose reductase1.1.1.210.595
2pdh47DAldose reductase1.1.1.210.595
2ikhLITAldose reductase1.1.1.210.589
1el3I84Aldose reductase1.1.1.210.587
1frbZSTAldose reductase-related protein 2/0.581
2pdc393Aldose reductase1.1.1.210.579
1zuaTOLAldo-keto reductase family 1 member B101.1.10.575
2agtFIDAldose reductase1.1.1.210.566
2i17LDTAldose reductase1.1.1.210.565
2pdiZSTAldose reductase1.1.1.210.563
2pdj393Aldose reductase1.1.1.210.562
2duxZSTAldose reductase1.1.1.210.554
1z3n3NAAldose reductase1.1.1.210.548
2duzZSTAldose reductase1.1.1.210.540
2f2kTGGAldose reductase1.1.1.210.533
2pdkSBIAldose reductase1.1.1.210.527
1ah3TOLAldose reductase1.1.1.210.525
2iqdLPAAldose reductase1.1.1.210.515
2i16LDTAldose reductase1.1.1.210.514
2pdlTOLAldose reductase1.1.1.210.514
2fzbTOLAldose reductase1.1.1.210.512
2inzOHPAldose reductase1.1.1.210.511
1ekoI84Aldose reductase1.1.1.210.510
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.507
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.506
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.504
4gabFIDAldo-keto reductase family 1 member B101.1.10.504
1ry0PG2Aldo-keto reductase family 1 member C3/0.502
4fam0SZAldo-keto reductase family 1 member C3/0.501
3v35NTIAldose reductase1.1.1.210.499
2oazI96Methionine aminopeptidase 2/0.498
5liu388Aldo-keto reductase family 1 member B101.1.10.495
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.494
1lkeDOGBilin-binding protein/0.493
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.493
1yw8A75Methionine aminopeptidase 2/0.493
3s3gTLTAldose reductase1.1.1.210.492
3uweVJJAldo-keto reductase family 1 member C3/0.492
5d5aCAUBeta-2 adrenergic receptor/0.492
4ga8SBIAldo-keto reductase family 1 member B101.1.10.491
2aovC2MHistamine N-methyltransferase2.1.1.80.490
4u163C0Muscarinic acetylcholine receptor M3/0.490
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.488
2ga2A19Methionine aminopeptidase 2/0.488
3pn1IVHDNA ligase/0.488
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.488
4wevSUZAldo-keto reductase family 1 member B101.1.10.487
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.486
2cekN8TAcetylcholinesterase3.1.1.70.484
2is72CLAldose reductase1.1.1.210.484
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.484
4bftZVTPantothenate kinase2.7.1.330.483
1umcTDP2-oxoisovalerate dehydrogenase subunit alpha1.2.4.40.482
1umcTDP2-oxoisovalerate dehydrogenase subunit beta1.2.4.40.482
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.482
4xo7ASDAldo-keto reductase family 1 member C2/0.482
2wmdZZ0NmrA-like family domain-containing protein 1/0.481
2aot2PMHistamine N-methyltransferase2.1.1.80.480
1pwmFIDAldose reductase1.1.1.210.479
1zq5E04Aldo-keto reductase family 1 member C3/0.479
3af1GDPPantothenate kinase2.7.1.330.479
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.478
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.478
1w6jR71Lanosterol synthase5.4.99.70.478
1yw9A84Methionine aminopeptidase 2/0.478
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.478
4b65NDPL-ornithine N(5)-monooxygenase/0.478
4bfwZVWPantothenate kinase2.7.1.330.478
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.477
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.477
4h7c10HAldo-keto reductase family 1 member C3/0.477
4hmn16JAldo-keto reductase family 1 member C3/0.477
1dgbNDPCatalase1.11.1.60.476
1lnmDTXBilin-binding protein/0.476
2pdyFIDAldose reductase1.1.1.210.476
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.475
1pqc444Oxysterols receptor LXR-beta/0.474
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
5a4wQCTGlutathione S-transferase F22.5.1.180.474
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.473
4jtrIZPAldo-keto reductase family 1 member C2/0.473
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.472
1p0pBCHCholinesterase3.1.1.80.472
2cbqTH2Neocarzinostatin/0.472
2ea4F79Methionine aminopeptidase 2/0.472
2xupTZ5Acetylcholinesterase3.1.1.70.472
3dr7GPDGDP-perosamine synthase/0.472
3ojxFMNNADPH--cytochrome P450 reductase/0.472
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.472
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.472
4psbGA3Cytokinin-specific binding protein/0.472
1r5hAO2Methionine aminopeptidase 2/0.471
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1yw7A41Methionine aminopeptidase 2/0.471
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
2nvcITAAldose reductase1.1.1.210.471
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.471
4dbw511Aldo-keto reductase family 1 member C3/0.471
4jtrIBPAldo-keto reductase family 1 member C2/0.471
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.471
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.471
4stdBFSScytalone dehydratase4.2.1.940.471
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
2xuhTZ4Acetylcholinesterase3.1.1.70.470
3h3r14HCollagen type IV alpha-3-binding protein/0.470
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.469
4phlPILPhosphodiesterase/0.469
1e66HUXAcetylcholinesterase3.1.1.70.468
2aouCQAHistamine N-methyltransferase2.1.1.80.468
2f3815MAldo-keto reductase family 1 member C3/0.468
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.468
3u2cSUZAldose reductase1.1.1.210.468
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.468
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.468
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.468
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
4a1oAMZBifunctional purine biosynthesis protein PurH2.1.2.30.467
4kn2LYAFolate receptor beta/0.467
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.467
1q83TZ5Acetylcholinesterase3.1.1.70.466
1r58AO5Methionine aminopeptidase 2/0.466
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.466
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.466
2xufTZ4Acetylcholinesterase3.1.1.70.466
3p2vDOYAldose reductase1.1.1.210.466
4jq2SUZAldo-keto reductase family 1 member C2/0.466
1ah0SBIAldose reductase1.1.1.210.465
1esmCOAPantothenate kinase2.7.1.330.465
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.465
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.465
4bfxZVXPantothenate kinase2.7.1.330.465
4u140HKMuscarinic acetylcholine receptor M3/0.465
1w4lGL8Acetylcholinesterase3.1.1.70.464
2xegCI9Glutamate carboxypeptidase 23.4.17.210.464
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
4dbuBT9Aldo-keto reductase family 1 member C3/0.464
4j7gTRHPCZA361.3/0.464
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.464
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.463
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.463
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.463
1mrqSTRAldo-keto reductase family 1 member C1/0.462
1u1jC2F5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 12.1.1.140.462
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
3c1oNAPEugenol synthase/0.462
3q9bB3NAcetylpolyamine amidohydrolase/0.462
4glx0XSDNA ligase6.5.1.20.462
1ogjFADFerredoxin--NADP reductase1.18.1.20.461
1rxjBNIStreptavidin/0.461
1vkgCRIHistone deacetylase 83.5.1.980.461
4i5xFLFAldo-keto reductase family 1 member B101.1.10.461
4lrhFOLFolate receptor alpha/0.461
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.461
1odnAPVIsopenicillin N synthase1.21.3.10.460
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.460
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.460
2jf6S55Strictosidine-O-beta-D-glucosidase3.2.1.1050.460
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
2xuiTZ5Acetylcholinesterase3.1.1.70.460
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.460
3b82NADExotoxin A2.4.2.360.460
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.460
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.460
4bfvZVVPantothenate kinase2.7.1.330.460
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.459
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.459
1zgcA2EAcetylcholinesterase3.1.1.70.459
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2pdwFIDAldose reductase1.1.1.210.459
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.459
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.459
4kn104JFolate receptor beta/0.459
4li61XOTankyrase-12.4.2.300.459
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.459
5dsg0HKMuscarinic acetylcholine receptor M4/0.459
1zgbA1EAcetylcholinesterase3.1.1.70.458
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.458
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.458
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.458
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.458
2iu8UD1UDP-3-O-acylglucosamine N-acyltransferase2.3.10.457
2wzySQXSoluble acetylcholine receptor/0.457
3af2ACPPantothenate kinase2.7.1.330.457
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.457
4yfy0FXVioF/0.457
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.456
1dghNDPCatalase1.11.1.60.456
1gjrFADFerredoxin--NADP reductase1.18.1.20.456
1isgAGSADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 23.2.2.60.456
3af0GDPPantothenate kinase2.7.1.330.456
3r8hZOMAldo-keto reductase family 1 member C3/0.456
3sfh1DIHistone deacetylase 83.5.1.980.456
3ugrIMNAldo-keto reductase family 1 member C3/0.456
3zc3FADFerredoxin--NADP reductase1.18.1.20.456
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.456
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.455
3zkuHCVIsopenicillin N synthase1.21.3.10.455
4e0u0MVCyclic dipeptide N-prenyltransferase/0.455
4ea2RWZDehydrosqualene synthase/0.455
4kniE1ECarbonic anhydrase 24.2.1.10.455
4kw51W6Decaprenylphosphoryl-beta-D-ribose oxidase/0.455
4mlp2CXCryptochrome-2/0.455
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.454
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.454
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.454
3elePLPAminotransferase/0.454
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.454
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.454
4relKMPGlycosyltransferase/0.454
5stdUNNScytalone dehydratase4.2.1.940.454
1gaqFADFerredoxin/0.453
1ihiIU5Aldo-keto reductase family 1 member C2/0.453
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2ipw2CLAldose reductase1.1.1.210.453
2w6cBM4Acetylcholinesterase3.1.1.70.453
2xltNA0Putative flavin-containing monooxygenase/0.453
2zsbADPPantothenate kinase2.7.1.330.453
2zsdCOAPantothenate kinase2.7.1.330.453
3af4GCPPantothenate kinase2.7.1.330.453
3cv7C2UAlcohol dehydrogenase [NADP(+)]1.1.1.20.453
3iu9T07Methionine aminopeptidase 2/0.453
3mjrAC2Deoxycytidine kinase2.7.1.740.453
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.453
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.453
4bb3KKAIsopenicillin N synthase1.21.3.10.453
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.453
5fd8A5APutative carboxypeptidase yocD/0.453
2yczI32Beta-1 adrenergic receptor/0.453
1sd1FMCS-methyl-5'-thioadenosine phosphorylase/0.452
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.452
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.452
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.452
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3f3y4OABile salt sulfotransferase2.8.2.140.452
4bfuZVUPantothenate kinase2.7.1.330.452
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.452
4jtqFLPAldo-keto reductase family 1 member C2/0.452
4mv1ADPBiotin carboxylase6.3.4.140.452
4xwtU5PRibonuclease J/0.452
1al7HSTPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.451
1h42FADFerredoxin--NADP reductase1.18.1.20.451
1odcA8BAcetylcholinesterase3.1.1.70.451
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.451
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.451
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.451
2qimZEAClass 10 plant pathogenesis-related protein/0.451
2vqqTFGHistone deacetylase 43.5.1.980.451
2w3mFOLDihydrofolate reductase1.5.1.30.451
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.451
3r43ID8Aldo-keto reductase family 1 member C3/0.451
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.451
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
1ry8RUTAldo-keto reductase family 1 member C3/0.450
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.450
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.450
2rqfJH3Hemolymph juvenile hormone binding protein/0.450
2vt4P32Beta-1 adrenergic receptor/0.450
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3ghvGHCDihydrofolate reductase1.5.1.30.450
3v0p4GWHisto-blood group ABO system transferase/0.450
3zkyWT4Isopenicillin N synthase1.21.3.10.450
4kn0MTXFolate receptor beta/0.450
5irnADPNucleotide binding oligomerization domain containing 2/0.450
1hfqMOTDihydrofolate reductase1.5.1.30.449
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.449
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2aclL05Oxysterols receptor LXR-alpha/0.449
3g72A6TRenin3.4.23.150.449
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3p0pNNFTankyrase-22.4.2.300.449
3t0kDCQSulfide-quinone reductase/0.449
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.449
4b67NAPL-ornithine N(5)-monooxygenase/0.449
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.449
5cxv0HKMuscarinic acetylcholine receptor M1/0.449
3uonQNBMuscarinic acetylcholine receptor M2/0.449
1pq944BOxysterols receptor LXR-beta/0.448
1z5uCMPClass B acid phosphatase/0.448
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3nwlNDPCatalase1.11.1.60.448
3vo2FADFerredoxin--NADP reductase/0.448
3zoiM2WIsopenicillin N synthase1.21.3.10.448
4jq4IMNAldo-keto reductase family 1 member C2/0.448
4jqaID8Aldo-keto reductase family 1 member C2/0.448
4n9qFMNFMN-dependent NADH-azoreductase 1/0.448
1d3dBZTProthrombin3.4.21.50.447
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2d06ESTSulfotransferase 1A12.8.2.10.447
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.447
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.447
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.447
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3hbfMYCFlavonoid 3-O-glucosyltransferase2.4.10.447
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.447
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.447
4hcy0YNTransketolase/0.447
4l8vNAPInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.447
1jqdSAHHistamine N-methyltransferase2.1.1.80.446
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.446
2ea2F77Methionine aminopeptidase 2/0.446
2j3qTFLAcetylcholinesterase3.1.1.70.446
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3irhDTPHD domain protein/0.446
3lxeTORCarbonic anhydrase 14.2.1.10.446
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
3ocx2AMLipoprotein E/0.446
3v94WYQPhosphodiesterase/0.446
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.446
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4dbs0HVAldo-keto reductase family 1 member C3/0.446
4fa30SLAldo-keto reductase family 1 member C3/0.446
5d6lCAUBeta-2 adrenergic receptor/0.446
4gbrCAUBeta-2 adrenergic receptor/0.446
1dlrMXADihydrofolate reductase1.5.1.30.445
1hb1OCVIsopenicillin N synthase1.21.3.10.445
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.445
2aotSAHHistamine N-methyltransferase2.1.1.80.445
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.445
2ohjFMNType A flavoprotein FprA10.445
2r6jNDPEugenol synthase 11.1.1.3180.445
3aklADPSerine/threonine-protein kinase CtkA2.7.11.10.445
3c3xNAPEugenol synthase 11.1.1.3180.445
3n39FMNProtein NrdI/0.445
3pqbVGPPutative oxidoreductase/0.445
3zovWZVBeta-secretase 13.4.23.460.445
4araC56Acetylcholinesterase3.1.1.70.445
4r81FMNPredicted NADH dehydrogenase/0.445
4xp4COCSodium-dependent dopamine transporter/0.445
5cc9DDFDihydrofolate reductase1.5.1.30.445
4mqt2CUMuscarinic acetylcholine receptor M2/0.445
1qzyTDEMethionine aminopeptidase 2/0.444
1s2cFLFAldo-keto reductase family 1 member C3/0.444
2cmfF11Acetylcholinesterase3.1.1.70.444
2uuk897Prothrombin3.4.21.50.444
2xnvVU3Soluble acetylcholine receptor/0.444
2y60M8FIsopenicillin N synthase1.21.3.10.444
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
3h3t16HCollagen type IV alpha-3-binding protein/0.444
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.444
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.444
4fal0T0Aldo-keto reductase family 1 member C3/0.444
4j3mAJ8Tankyrase-22.4.2.300.444
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.444
4n1fCZHObelin/0.444
1afsTES3-alpha-hydroxysteroid dehydrogenase1.1.1.500.443
1dtpAPUDiphtheria toxin/0.443
1obnASVIsopenicillin N synthase1.21.3.10.443
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.443
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.443
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
3h3qH13Collagen type IV alpha-3-binding protein/0.443
3r6iJMSAldo-keto reductase family 1 member C3/0.443
4kebFOLDihydrofolate reductase1.5.1.30.443
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4pnrG18Tankyrase-22.4.2.300.443
1kmyBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.442
1pj6FOLDimethylglycine oxidase1.5.3.100.442
1queFADFerredoxin--NADP reductase1.18.1.20.442
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.442
1rvvINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1zz1SHHHistone deacetylase-like amidohydrolase3.5.10.442
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2geuCOKPantothenate kinase2.7.1.330.442
2gevCOKPantothenate kinase2.7.1.330.442
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.442
2pb1NFGGlucan 1,3-beta-glucosidase/0.442
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3r8gIZPAldo-keto reductase family 1 member C3/0.442
3szfDCQSulfide-quinone reductase/0.442
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4b68NAPL-ornithine N(5)-monooxygenase/0.442
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.442
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.442
4mrxCZHObelin/0.442
4nbiD3YD-tyrosyl-tRNA(Tyr) deacylase/0.442
5dozNDPJamJ/0.442
1acjTHAAcetylcholinesterase3.1.1.70.441
1h35R01Squalene--hopene cyclase4.2.1.1290.441
1re0AFBADP-ribosylation factor 1/0.441
1re0AFBARF guanine-nucleotide exchange factor 1/0.441
1upw444Oxysterols receptor LXR-beta/0.441
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.441
2wu4HBPAcetylcholinesterase3.1.1.70.441
2xlpNAPPutative flavin-containing monooxygenase/0.441
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.441
3djlFADPutative acyl-CoA dehydrogenase AidB1.3.990.441
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.441
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
4k4eK4ETankyrase-12.4.2.300.441
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.441
1dgfNDPCatalase1.11.1.60.440
1t47NTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.440
2stdCRPScytalone dehydratase4.2.1.940.440
2vz0D64Pteridine reductase/0.440
2xuoTZ4Acetylcholinesterase3.1.1.70.440
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.440
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.440
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.440
3zhvTDWMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
3zpqXF5Beta-1 adrenergic receptor/0.440
4es5MGTPolymerase basic protein 2/0.440
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.440