Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
3lz5 | LDT | Aldose reductase | 1.1.1.21 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
3lz5 | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.733 | |
3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.728 | |
3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.725 | |
2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.707 | |
3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.697 | |
2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.691 | |
3lql | LDT | Aldose reductase | 1.1.1.21 | 0.687 | |
4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.685 | |
1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.666 | |
1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.666 | |
1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.662 | |
2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.654 | |
2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.653 | |
3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.648 | |
1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.642 | |
3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.641 | |
2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.639 | |
4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.638 | |
2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.636 | |
2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.635 | |
2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.627 | |
3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.625 | |
2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.624 | |
3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.622 | |
3len | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
2iki | 388 | Aldose reductase | 1.1.1.21 | 0.618 | |
2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.615 | |
1iei | ZES | Aldose reductase | 1.1.1.21 | 0.613 | |
3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.612 | |
3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.612 | |
2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.609 | |
3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.609 | |
2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.605 | |
2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.604 | |
2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.604 | |
2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.604 | |
2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.603 | |
2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.600 | |
2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.598 | |
3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.597 | |
3ght | LDT | Aldose reductase | 1.1.1.21 | 0.596 | |
1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.595 | |
2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.595 | |
2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.589 | |
1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.587 | |
1frb | ZST | Aldose reductase-related protein 2 | / | 0.581 | |
2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.579 | |
1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.575 | |
2agt | FID | Aldose reductase | 1.1.1.21 | 0.566 | |
2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.565 | |
2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.563 | |
2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.562 | |
2dux | ZST | Aldose reductase | 1.1.1.21 | 0.554 | |
1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.548 | |
2duz | ZST | Aldose reductase | 1.1.1.21 | 0.540 | |
2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.533 | |
2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.527 | |
1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.525 | |
2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.515 | |
2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.514 | |
2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.514 | |
2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.512 | |
2inz | OHP | Aldose reductase | 1.1.1.21 | 0.511 | |
1eko | I84 | Aldose reductase | 1.1.1.21 | 0.510 | |
3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.507 | |
3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.506 | |
1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.504 | |
4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.504 | |
1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.502 | |
4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.501 | |
3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.499 | |
2oaz | I96 | Methionine aminopeptidase 2 | / | 0.498 | |
5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.495 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.494 | |
1lke | DOG | Bilin-binding protein | / | 0.493 | |
1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.493 | |
1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.493 | |
3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.492 | |
3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.492 | |
5d5a | CAU | Beta-2 adrenergic receptor | / | 0.492 | |
4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.491 | |
2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.490 | |
4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.490 | |
1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.488 | |
2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.488 | |
3pn1 | IVH | DNA ligase | / | 0.488 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.488 | |
4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.487 | |
4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.486 | |
2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.484 | |
2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.484 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.483 | |
1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.482 | |
1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.482 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.482 | |
4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.482 | |
2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.481 | |
2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.480 | |
1pwm | FID | Aldose reductase | 1.1.1.21 | 0.479 | |
1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.479 | |
3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.479 | |
1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.478 | |
1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.478 | |
1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.478 | |
1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.478 | |
3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.478 | |
4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.478 | |
4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.478 | |
1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.477 | |
3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.477 | |
4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
1dgb | NDP | Catalase | 1.11.1.6 | 0.476 | |
1lnm | DTX | Bilin-binding protein | / | 0.476 | |
2pdy | FID | Aldose reductase | 1.1.1.21 | 0.476 | |
3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.475 | |
1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.474 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
5a4w | QCT | Glutathione S-transferase F2 | 2.5.1.18 | 0.474 | |
2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.473 | |
4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.473 | |
1e1f | PSG | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.472 | |
1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.472 | |
2cbq | TH2 | Neocarzinostatin | / | 0.472 | |
2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.472 | |
2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
3dr7 | GPD | GDP-perosamine synthase | / | 0.472 | |
3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.472 | |
3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.472 | |
4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.472 | |
4psb | GA3 | Cytokinin-specific binding protein | / | 0.472 | |
1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.471 | |
1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.471 | |
2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.471 | |
2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.471 | |
3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.471 | |
4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.471 | |
4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.471 | |
4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.471 | |
4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.471 | |
1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.470 | |
3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.470 | |
3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.469 | |
4phl | PIL | Phosphodiesterase | / | 0.469 | |
1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.468 | |
2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.468 | |
2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.468 | |
3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.468 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.468 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
4a1o | AMZ | Bifunctional purine biosynthesis protein PurH | 2.1.2.3 | 0.467 | |
4kn2 | LYA | Folate receptor beta | / | 0.467 | |
4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.467 | |
1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.466 | |
1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.466 | |
1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.466 | |
2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.466 | |
4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
1ah0 | SBI | Aldose reductase | 1.1.1.21 | 0.465 | |
1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.465 | |
1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.465 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.465 | |
4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.465 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.465 | |
1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
2xeg | CI9 | Glutamate carboxypeptidase 2 | 3.4.17.21 | 0.464 | |
3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
4j7g | TRH | PCZA361.3 | / | 0.464 | |
4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.464 | |
1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.463 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
4fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.463 | |
4fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.462 | |
1u1j | C2F | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 1 | 2.1.1.14 | 0.462 | |
1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
3c1o | NAP | Eugenol synthase | / | 0.462 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.462 | |
4glx | 0XS | DNA ligase | 6.5.1.2 | 0.462 | |
1ogj | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.461 | |
1rxj | BNI | Streptavidin | / | 0.461 | |
1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.461 | |
4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.461 | |
4lrh | FOL | Folate receptor alpha | / | 0.461 | |
4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.461 | |
1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.460 | |
2g28 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.460 | |
2jf6 | S55 | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.460 | |
2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.460 | |
3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.460 | |
4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.460 | |
1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.459 | |
1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.459 | |
1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
2pdw | FID | Aldose reductase | 1.1.1.21 | 0.459 | |
3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.459 | |
3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.459 | |
3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.459 | |
4kn1 | 04J | Folate receptor beta | / | 0.459 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.459 | |
4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.459 | |
5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.459 | |
1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.458 | |
2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
2iu8 | UD1 | UDP-3-O-acylglucosamine N-acyltransferase | 2.3.1 | 0.457 | |
2wzy | SQX | Soluble acetylcholine receptor | / | 0.457 | |
3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.457 | |
3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.457 | |
4yfy | 0FX | VioF | / | 0.457 | |
1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.456 | |
1dgh | NDP | Catalase | 1.11.1.6 | 0.456 | |
1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.456 | |
3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.456 | |
3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.456 | |
3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.456 | |
4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.456 | |
1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.455 | |
3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.455 | |
4ea2 | RWZ | Dehydrosqualene synthase | / | 0.455 | |
4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.455 | |
4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.455 | |
4mlp | 2CX | Cryptochrome-2 | / | 0.455 | |
1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
2wnb | C5P | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 | 2.4.99.4 | 0.454 | |
2xje | U5P | Cytosolic purine 5'-nucleotidase | 3.1.3.5 | 0.454 | |
3ele | PLP | Aminotransferase | / | 0.454 | |
3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.454 | |
4rel | KMP | Glycosyltransferase | / | 0.454 | |
5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.454 | |
1gaq | FAD | Ferredoxin | / | 0.453 | |
1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
2ipw | 2CL | Aldose reductase | 1.1.1.21 | 0.453 | |
2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
2xlt | NA0 | Putative flavin-containing monooxygenase | / | 0.453 | |
2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.453 | |
3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.453 | |
3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.453 | |
3iu9 | T07 | Methionine aminopeptidase 2 | / | 0.453 | |
3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.453 | |
3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.453 | |
4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.453 | |
5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.453 | |
2ycz | I32 | Beta-1 adrenergic receptor | / | 0.453 | |
1sd1 | FMC | S-methyl-5'-thioadenosine phosphorylase | / | 0.452 | |
2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.452 | |
2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.452 | |
2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.452 | |
3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.452 | |
4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.452 | |
4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.452 | |
4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.452 | |
4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.452 | |
4xwt | U5P | Ribonuclease J | / | 0.452 | |
1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.451 | |
1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.451 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.451 | |
1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.451 | |
2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.451 | |
2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.451 | |
2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.451 | |
3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.450 | |
2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.450 | |
2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.450 | |
2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.450 | |
3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.450 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
4kn0 | MTX | Folate receptor beta | / | 0.450 | |
5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.450 | |
1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.449 | |
2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.449 | |
3g72 | A6T | Renin | 3.4.23.15 | 0.449 | |
3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
3p0p | NNF | Tankyrase-2 | 2.4.2.30 | 0.449 | |
3t0k | DCQ | Sulfide-quinone reductase | / | 0.449 | |
3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.449 | |
4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.449 | |
4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.449 | |
3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.449 | |
1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.448 | |
1z5u | CMP | Class B acid phosphatase | / | 0.448 | |
2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
3nwl | NDP | Catalase | 1.11.1.6 | 0.448 | |
3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.448 | |
3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.448 | |
4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.448 | |
1d3d | BZT | Prothrombin | 3.4.21.5 | 0.447 | |
1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.447 | |
3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.447 | |
3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.447 | |
3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.447 | |
3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.447 | |
4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.447 | |
4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.447 | |
4hcy | 0YN | Transketolase | / | 0.447 | |
4l8v | NAP | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.447 | |
1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.446 | |
2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.446 | |
2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.446 | |
2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
3irh | DTP | HD domain protein | / | 0.446 | |
3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
3ocx | 2AM | Lipoprotein E | / | 0.446 | |
3v94 | WYQ | Phosphodiesterase | / | 0.446 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
5d6l | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
4gbr | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.445 | |
2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.445 | |
2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.445 | |
2ohj | FMN | Type A flavoprotein FprA | 1 | 0.445 | |
2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
3akl | ADP | Serine/threonine-protein kinase CtkA | 2.7.11.1 | 0.445 | |
3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
3n39 | FMN | Protein NrdI | / | 0.445 | |
3pqb | VGP | Putative oxidoreductase | / | 0.445 | |
3zov | WZV | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
4r81 | FMN | Predicted NADH dehydrogenase | / | 0.445 | |
4xp4 | COC | Sodium-dependent dopamine transporter | / | 0.445 | |
5cc9 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.445 | |
1qzy | TDE | Methionine aminopeptidase 2 | / | 0.444 | |
1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
2uuk | 897 | Prothrombin | 3.4.21.5 | 0.444 | |
2xnv | VU3 | Soluble acetylcholine receptor | / | 0.444 | |
2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.444 | |
3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.444 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.444 | |
4fal | 0T0 | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.444 | |
4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.444 | |
4n1f | CZH | Obelin | / | 0.444 | |
1afs | TES | 3-alpha-hydroxysteroid dehydrogenase | 1.1.1.50 | 0.443 | |
1dtp | APU | Diphtheria toxin | / | 0.443 | |
1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.443 | |
2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.443 | |
3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.443 | |
1kmy | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.442 | |
1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.442 | |
1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.442 | |
1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
1zz1 | SHH | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.442 | |
2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.442 | |
2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.442 | |
2pb1 | NFG | Glucan 1,3-beta-glucosidase | / | 0.442 | |
3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
3szf | DCQ | Sulfide-quinone reductase | / | 0.442 | |
3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.442 | |
4g2w | NI0 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.442 | |
4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.442 | |
4mrx | CZH | Obelin | / | 0.442 | |
4nbi | D3Y | D-tyrosyl-tRNA(Tyr) deacylase | / | 0.442 | |
5doz | NDP | JamJ | / | 0.442 | |
1acj | THA | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.441 | |
1re0 | AFB | ADP-ribosylation factor 1 | / | 0.441 | |
1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.441 | |
1upw | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.441 | |
2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.441 | |
3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.441 | |
3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.441 | |
4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.441 | |
1dgf | NDP | Catalase | 1.11.1.6 | 0.440 | |
1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.440 | |
2std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
2vz0 | D64 | Pteridine reductase | / | 0.440 | |
2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.440 | |
3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.440 | |
3zhv | TDW | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
3zpq | XF5 | Beta-1 adrenergic receptor | / | 0.440 | |
4es5 | MGT | Polymerase basic protein 2 | / | 0.440 | |
4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.440 |