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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2jkcFADFlavin-dependent tryptophan halogenase PrnA1.14.19.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2jkcFADFlavin-dependent tryptophan halogenase PrnA1.14.19.91.000
5hy5FADTryptophan 6-halogenase/0.538
2apgFADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.537
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.511
4j6cSTRCytochrome P450 monooxygenase/0.498
1pkfEPDEpothilone C/D epoxidase1.140.495
3tubFPUTyrosine-protein kinase SYK2.7.10.20.495
3lanKBTGag-Pol polyprotein2.7.7.490.492
1l2jETCEstrogen receptor beta/0.491
1rdtL79Retinoic acid receptor RXR-alpha/0.488
3cv9VDXVitamin D3 dihydroxylase/0.487
1culFOKAdenylate cyclase type 2/0.486
1culFOKAdenylate cyclase type 5/0.486
3d4bDZDNAD-dependent protein deacetylase/0.486
3p9tTCLRepressor/0.486
1vruAAPGag-Pol polyprotein2.7.7.490.485
4wa9AXITyrosine-protein kinase ABL12.7.10.20.485
1xlsREARetinoic acid receptor RXR-alpha/0.484
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.484
2bf7HBIPteridine reductase 11.5.1.330.482
2ij7TPFMycocyclosin synthase1.14.21.90.481
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.481
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.480
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.479
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.479
2rqfJH3Hemolymph juvenile hormone binding protein/0.478
3rfmCFFAdenosine receptor A2a/0.478
1fm69CRRetinoic acid receptor RXR-alpha/0.477
1u0hFOKAdenylate cyclase type 2/0.477
1u0hFOKAdenylate cyclase type 5/0.477
1hpzAAPGag-Pol polyprotein2.7.7.490.476
1vj3TABDihydrofolate reductase1.5.1.30.476
2w3vTOPDihydrofolate reductase/0.476
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.475
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.475
2ze2T27Gag-Pol polyprotein2.7.7.490.475
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.474
2punACPMethylthioribose kinase2.7.1.1000.474
1ezfIN0Squalene synthase2.5.1.210.473
3gcq1BUMitogen-activated protein kinase 14/0.473
3up3XCAaceDAF-12/0.473
4e0u0MVCyclic dipeptide N-prenyltransferase/0.473
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
1cjkFOKAdenylate cyclase type 2/0.472
1cjkFOKAdenylate cyclase type 5/0.472
3qlhT27Gag-Pol polyprotein2.7.7.490.472
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.472
3f0aACOSpermidine N(1)-acetyltransferase/0.471
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.470
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.470
4j6bPLOCytochrome P450 monooxygenase/0.470
4j6dTESCytochrome P450 monooxygenase/0.470
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.470
1c1bGCAGag-Pol polyprotein2.7.7.490.469
1yc2NADNAD-dependent protein deacylase 2/0.469
2ewaSB2Mitogen-activated protein kinase 14/0.469
2pmdGNPTranslation initiation factor 2 subunit gamma/0.469
3d74NBBPheromone-binding protein ASP1/0.469
1s7gNADNAD-dependent protein deacylase 2/0.468
4r20AERCytochrome P450 family 17 polypeptide 2/0.468
1revTB9Gag-Pol polyprotein2.7.7.490.467
3a1l2CCCytochrome P450/0.467
3w5tLHPVitamin D3 receptor/0.467
4bb3KKAIsopenicillin N synthase1.21.3.10.467
1hfqMOTDihydrofolate reductase1.5.1.30.466
1tvrTB9Gag-Pol polyprotein2.7.7.490.466
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.466
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.466
3is9AC7Gag-Pol polyprotein2.7.7.490.466
3negPYVAbscisic acid receptor PYL1/0.466
4v12POGMaoC like domain protein/0.466
5ab6CAANonspecific lipid-transfer protein, putative/0.466
1fmjRTLRetinol dehydratase/0.465
1kqwRTLCellular retinol-binding protein type II/0.465
1tl1H18Gag-Pol polyprotein2.7.7.490.465
2yg4FADPutrescine oxidase/0.465
3l71AZOCytochrome b/0.465
3qls55VDihydrofolate reductase1.5.1.30.465
3s7a684Dihydrofolate reductase1.5.1.30.465
1x2hLPALipoate-protein ligase A6.3.1.200.464
3dlgGWEGag-Pol polyprotein2.7.7.490.464
3i0rRT3Gag-Pol polyprotein2.7.7.490.464
3vi7CBDHematopoietic prostaglandin D synthase/0.464
3zkyWT4Isopenicillin N synthase1.21.3.10.464
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.464
4ixd1HVIntegrin alpha-L/0.464
1cjcFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.463
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.463
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.463
2zbaZBATrichothecene 3-O-acetyltransferase/0.463
3a4pDFQHepatocyte growth factor receptor2.7.10.10.463
3ibdCPZCytochrome P450 2B61.14.130.463
3oafOAGDihydrofolate reductase1.5.1.30.463
4fnyI3KALK tyrosine kinase receptor2.7.10.10.463
4iw8KN3Estrogen receptor/0.463
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.463
3reyXACAdenosine receptor A2a/0.463
1hnvTBOGag-Pol polyprotein2.7.7.490.462
2ph5NADHomospermidine synthase/0.462
2y30SM8Putative repressor SimReg2/0.462
2z4bDC8Estrogen receptor beta/0.462
3c3xNAPEugenol synthase 11.1.1.3180.462
3ctj320Hepatocyte growth factor receptor2.7.10.10.462
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.462
1hfpMOTDihydrofolate reductase1.5.1.30.461
1ndeMONEstrogen receptor beta/0.461
2ban357Gag-Pol polyprotein2.7.7.490.461
2hasC3OVitamin D3 receptor/0.461
2xvw9NRSerum albumin/0.461
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.461
3t8xT8XT-cell surface glycoprotein CD1b/0.461
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4h4o506Gag-Pol polyprotein2.7.7.490.461
3aosJH2Hemolymph juvenile hormone binding protein/0.460
3dleGFAGag-Pol polyprotein2.7.7.490.460
3tk3CPZCytochrome P450 2B41.14.14.10.460
4dm6TTBRetinoic acid receptor beta/0.460
4g1z0VPVitamin D3 receptor A/0.460
5k2aZMAAdenosine receptor A2a/0.460
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.459
3h4vDVPPteridine reductase 11.5.1.330.459
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.459
4g2gTDHMycocyclosin synthase1.14.21.90.459
4jvmXDIEstrogen sulfotransferase2.8.2.40.459
4z9g1Q5Corticotropin-releasing factor receptor 1/0.459
2dw4FADLysine-specific histone demethylase 1A10.458
2gvcFADThiol-specific monooxygenase1.14.130.458
2rabNADGlutathione amide reductase/0.458
2wpxACOOrf14/0.458
2ydoADNAdenosine receptor A2a/0.458
3hv3R49Mitogen-activated protein kinase 14/0.458
3m8qDJZGag-Pol polyprotein2.7.7.490.458
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
3vrwYS5Vitamin D3 receptor/0.458
4ea13RXDehydrosqualene synthase/0.458
4rupH97Vitamin D3 receptor A/0.458
1qknRALEstrogen receptor beta/0.457
1upw444Oxysterols receptor LXR-beta/0.457
2bxqIMNSerum albumin/0.457
2giuFBREstrogen receptor beta/0.457
2puiADPMethylthioribose kinase2.7.1.1000.457
3h3sH15Collagen type IV alpha-3-binding protein/0.457
3lfcZ86Mitogen-activated protein kinase 14/0.457
4i2q1BTGag-Pol polyprotein2.7.7.490.457
5k2bZMAAdenosine receptor A2a/0.457
1hb3SCVIsopenicillin N synthase1.21.3.10.456
1pd9CO4Dihydrofolate reductase1.5.1.30.456
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.456
2aclREARetinoic acid receptor RXR-alpha/0.456
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.456
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.456
3c15FOKAdenylate cyclase type 2/0.456
3c15FOKAdenylate cyclase type 5/0.456
3g8eIS1Nicotinamide phosphoribosyltransferase2.4.2.120.456
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.456
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3u8hBHPPhospholipase A2, membrane associated/0.456
4b4w9L9Bifunctional protein FolD/0.456
4bfsZVSPantothenate kinase2.7.1.330.456
4elb34RDihydrofolate reductase/0.456
4ifvT27Gag-Pol polyprotein2.7.7.490.456
1crbRTLRetinol-binding protein 1/0.455
1q5dEPBEpothilone C/D epoxidase1.140.455
1uyfPU1Heat shock protein HSP 90-alpha/0.455
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2bxmIMNSerum albumin/0.455
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.455
2hb8MVDVitamin D3 receptor/0.455
2pupADPMethylthioribose kinase2.7.1.1000.455
3fu83DMLaccase-11.10.3.20.455
3njoPYVAbscisic acid receptor PYR1/0.455
3w5rLOAVitamin D3 receptor/0.455
3zv64HBCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.455
4ele31IDihydrofolate reductase/0.455
4kko1REGag-Pol polyprotein2.7.7.490.455
1hniAAAGag-Pol polyprotein2.7.7.490.454
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.454
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
1wsvTHHAminomethyltransferase, mitochondrial/0.454
2fziDH3Dihydrofolate reductase1.5.1.30.454
2oaxSNLMineralocorticoid receptor/0.454
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3ce31FNHepatocyte growth factor receptor2.7.10.10.454
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
3ix4TX1Transcriptional activator protein LasR/0.454
3nxvD2FDihydrofolate reductase1.5.1.30.454
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.454
3r6pA8SAbscisic acid receptor PYL10/0.454
3sruQ26Dihydrofolate reductase1.5.1.30.454
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
4e5yNDPGDP-L-fucose synthase1.1.1.2710.454
4jbtASDCytochrome P450 monooxygenase/0.454
5bsrCOA4-coumarate--CoA ligase 26.2.1.120.454
1i58ADPChemotaxis protein CheA2.7.13.30.453
1x8b824Wee1-like protein kinase2.7.10.20.453
1x8lOXRRetinol dehydratase/0.453
1y6bAAXVascular endothelial growth factor receptor 22.7.10.10.453
2qg2A91Heat shock protein HSP 90-alpha/0.453
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.453
2y60M8FIsopenicillin N synthase1.21.3.10.453
3cth319Hepatocyte growth factor receptor2.7.10.10.453
3jpuTY4Transcriptional activator protein LasR/0.453
3lfeZ84Mitogen-activated protein kinase 14/0.453
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3zv5BPYCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase1.3.1.560.453
4a9mP9MBromodomain-containing protein 2/0.453
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.453
4g47TZFMycocyclosin synthase1.14.21.90.453
4ia3BIVVitamin D3 receptor A/0.453
3uzcT4EAdenosine receptor A2a/0.453
1pq6965Oxysterols receptor LXR-beta/0.452
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.452
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.452
2bfpH4BPteridine reductase 11.5.1.330.452
3cemAVDGlycogen phosphorylase, liver form2.4.1.10.452
3fnu006HAP protein/0.452
3iaeD7KBenzaldehyde lyase/0.452
3new3NEMitogen-activated protein kinase 14/0.452
3pqbVGPPutative oxidoreductase/0.452
3qlzQLZUncharacterized protein/0.452
3wfgWFGMineralocorticoid receptor/0.452
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.452
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.452
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
1eioGCHGastrotropin/0.451
1mczRMNBenzoylformate decarboxylase4.1.1.70.451
1txiTX5Vitamin D3 receptor/0.451
2pulACPMethylthioribose kinase2.7.1.1000.451
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.451
2zb8IMNProstaglandin reductase 21.3.1.480.451
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.451
3irxUDRGag-Pol polyprotein2.7.7.490.451
3qcmNXWReceptor-type tyrosine-protein phosphatase gamma3.1.3.480.451
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.451
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.451
4hni16WCasein kinase I isoform epsilon2.7.11.10.451
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
4rbs0RVMetallo-beta-lactamase type 2/0.451
1thnADPAnti-sigma F factor/0.450
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.450
3cx5SMACytochrome b/0.450
3fnfJPMEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
3htjETEbrA repressor/0.450
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.450
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3lakKR1Gag-Pol polyprotein2.7.7.490.450
3q0gBCOProbable enoyl-CoA hydratase echA84.2.1.170.450
3q2mCKISpectinomycin phosphotransferase/0.450
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.450
4j26ESTEstrogen receptor beta/0.450
4kfj1R0Dihydrofolate reductase1.5.1.30.450
4lsjLSJGlucocorticoid receptor/0.450
4rh10TTSpore photoproduct lyase/0.450
5cc9DDFDihydrofolate reductase1.5.1.30.450
1e7aPFLSerum albumin/0.449
1errRALEstrogen receptor/0.449
1ikyMSDGag-Pol polyprotein2.7.7.490.449
1rkhVD2Vitamin D3 receptor/0.449
1yye196Estrogen receptor beta/0.449
1zgaHMKIsoflavone 4'-O-methyltransferase/0.449
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
2j0vGDPRac-like GTP-binding protein ARAC7/0.449
3eek53SUncharacterized protein/0.449
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3nmpPYVAbscisic acid receptor PYL2/0.449
3slkNDPPolyketide synthase extender module 2/0.449
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.449
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.449
4e37NDPCatalase1.11.1.60.449
4eevL1XHepatocyte growth factor receptor2.7.10.10.449
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.449
4ia1BIVVitamin D3 receptor A/0.449
4ok1198Androgen receptor/0.449
1dyhDZFDihydrofolate reductase1.5.1.30.448
1ikxPNUGag-Pol polyprotein2.7.7.490.448
1kl2FONSerine hydroxymethyltransferase/0.448
1s9eADBGag-Pol polyprotein2.7.7.490.448
1tkzH16Gag-Pol polyprotein2.7.7.490.448
1u3r338Estrogen receptor beta/0.448
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
2aclL05Oxysterols receptor LXR-alpha/0.448
2c7xNRBCytochrome P450 monooxygenase PikC/0.448
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.448
2on6IMHPurine nucleoside phosphorylase2.4.2.10.448
3abaFLICytochrome P450/0.448
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.448
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3nwlNDPCatalase1.11.1.60.448
3qly55VUncharacterized protein/0.448
3vt3VDXVitamin D3 receptor/0.448
3vt9YI4Vitamin D3 receptor/0.448
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
4fhi0S4Vitamin D3 receptor A/0.448
4j361HRKynurenine 3-monooxygenase/0.448
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.448
3pwhZMAAdenosine receptor A2a/0.448
1f28F89Thymidylate synthase2.1.1.450.447
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.447
1x8vESLLanosterol 14-alpha demethylase1.14.13.700.447
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.447
2bktRPFRenin3.4.23.150.447
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2fszOHTEstrogen receptor beta/0.447
2puhHPK2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.447
2qk8MTXDihydrofolate reductase/0.447
2zsdCOAPantothenate kinase2.7.1.330.447
3d75NBBPheromone-binding protein ASP1/0.447
3dl9V2HVitamin D 25-hydroxylase/0.447
3gwfNAPCyclohexanone monooxygenase/0.447
3k47D09Dihydrofolate reductase1.5.1.30.447
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.447
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.447
4h9814QUncharacterized protein/0.447
4iarERM5-hydroxytryptamine receptor 1B/0.447
4u7wNDPMxaA/0.447
4xwtU5PRibonuclease J/0.447
5uviZMAAdenosine receptor A2a/0.447
3emlZMAAdenosine receptor A2a/0.447
1axwMTXThymidylate synthase/0.446
1blzACVIsopenicillin N synthase1.21.3.10.446
1e92HBIPteridine reductase 11.5.1.330.446
1hquHBYGag-Pol polyprotein2.7.7.490.446
1ia4TQ6Dihydrofolate reductase1.5.1.30.446
1kmsLIHDihydrofolate reductase1.5.1.30.446
1qiqACCIsopenicillin N synthase1.21.3.10.446
2hw2RFPRifampin ADP-ribosyl transferase/0.446
2opqHBQGag-Pol polyprotein2.7.7.490.446
2owb626Serine/threonine-protein kinase PLK12.7.11.210.446
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.446
2xlsFADPutative flavin-containing monooxygenase/0.446
2ydvNECAdenosine receptor A2a/0.446
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.446
2zjwREFCasein kinase II subunit alpha2.7.11.10.446
3d78NBBPheromone-binding protein ASP1/0.446
3hz142CHeat shock protein HSP 90-alpha/0.446
3p3zP3ZPutative cytochrome P450/0.446
3p62FMNPentaerythritol tetranitrate reductase/0.446
3ue6FMNAureochrome1/0.446
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.446
4aa0AA0Mitogen-activated protein kinase 14/0.446
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.446
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.446
4g1y0VOVitamin D3 receptor A/0.446
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.446
4klaCHDFerrochelatase, mitochondrial4.99.1.10.446
4k5y1Q5Corticotropin-releasing factor receptor 1/0.446
1fm99CRRetinoic acid receptor RXR-alpha/0.445
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.445
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.445
1vrwNAIEnoyl-ACP reductase/0.445
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2fwyH64Heat shock protein HSP 90-alpha/0.445
2geuCOKPantothenate kinase2.7.1.330.445
2hamC33Vitamin D3 receptor/0.445
2po7CHDFerrochelatase, mitochondrial4.99.1.10.445
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.445
2zd1T27Gag-Pol polyprotein2.7.7.490.445
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
3ed1GA3Gibberellin receptor GID1/0.445
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.445
4jqh1MFAlr2278 protein/0.445
4o701QKBromodomain-containing protein 4/0.445
4o761M3Bromodomain-containing protein 4/0.445
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
5k2cZMAAdenosine receptor A2a/0.445
1ia2TQ4Dihydrofolate reductase1.5.1.30.444
1kb9SMACytochrome b/0.444
1klkPMDDihydrofolate reductase1.5.1.30.444
1lwlDSOCamphor 5-monooxygenase1.14.15.10.444
1nq7ARLNuclear receptor ROR-beta/0.444
1ogxEQUSteroid Delta-isomerase5.3.3.10.444
1ove358Mitogen-activated protein kinase 14/0.444
1sezFADProtoporphyrinogen oxidase, mitochondrial1.3.3.40.444
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2fvdLIACyclin-dependent kinase 22.7.11.220.444
2hk9NAPShikimate dehydrogenase (NADP(+))/0.444
2rhrEMOPutative ketoacyl reductase1.3.10.444
2yeiXQIHeat shock protein HSP 90-alpha/0.444
3imxB84Glucokinase2.7.1.20.444
4a9e3PFBromodomain-containing protein 2/0.444
4dhyS41Glucokinase2.7.1.20.444
4fhf0TTSpore photoproduct lyase/0.444
4g20484Vitamin D3 receptor A/0.444
4g8zTOPDihydrofolate reductase1.5.1.30.444
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
4i7fNVEGag-Pol polyprotein2.7.7.490.444
4iah1DXAlr2278 protein/0.444
4l021V2Sphingosine kinase 12.7.1.910.444
1dnaCB3Thymidylate synthase/0.443
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.443
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1fm4DXCMajor pollen allergen Bet v 1-L/0.443
1fmlRTLRetinol dehydratase/0.443
1kt3RTLRetinol-binding protein 4/0.443
1mp0NADAlcohol dehydrogenase class-31.1.1.10.443
1r2jFADFkbI/0.443
1sjwNGVNogalonic acid methyl ester cyclase/0.443
1xiuREARetinoic acid receptor RXR/0.443
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
2d29FADAcyl-CoA dehydrogenase/0.443
2hcdBIVVitamin D3 receptor A/0.443
2iw5FADLysine-specific histone demethylase 1A10.443
2jb4A14Isopenicillin N synthase1.21.3.10.443
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.443
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.443
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3l8sBFFMitogen-activated protein kinase 14/0.443
3lamKRPGag-Pol polyprotein2.7.7.490.443
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.443
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4bquCLRJapanin/0.443
4dm8REARetinoic acid receptor beta/0.443
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.443
4eerFMNPhototropin-22.7.11.10.443
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.443
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4gueQCTRibosomal protein S6 kinase alpha-32.7.11.10.443
4i8vBHFCytochrome P450 1A11.14.14.10.443
4ia7BIVVitamin D3 receptor A/0.443
4ig3T27Gag-Pol polyprotein2.7.7.490.443
4ixgIXGDihydrofolate reductase1.5.1.30.443
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.443
4m8e29VRetinoic acid receptor RXR-alpha/0.443
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.443
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.443
1dr3HBIDihydrofolate reductase1.5.1.30.442
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1sqvUHDCytochrome b/0.442
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2w6oOA3Biotin carboxylase6.3.4.140.442
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.442
3a60STURibosomal protein S6 kinase beta-12.7.11.10.442
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3eej53RUncharacterized protein/0.442
3ipq965Oxysterols receptor LXR-alpha/0.442
3nga3NGCasein kinase II subunit alpha2.7.11.10.442
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.442
3zs5SB2Mitogen-activated protein kinase 14/0.442
4b2gV1NUncharacterized protein/0.442
4id5T27Gag-Pol polyprotein2.7.7.490.442
5djuFMNNPH1-2/0.442
1cd2FOLDihydrofolate reductase1.5.1.30.441
1synF89Thymidylate synthase/0.441
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2g97DGBNicotinamide phosphoribosyltransferase2.4.2.120.441
2j4z626Aurora kinase A2.7.11.10.441
2j7yE3OEstrogen receptor beta/0.441
2p15EZTEstrogen receptor/0.441
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.441
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3drcMTXDihydrofolate reductase1.5.1.30.441
3gc9B45Mitogen-activated protein kinase 112.7.11.240.441
3ghvGHCDihydrofolate reductase1.5.1.30.441
3ghwGHWDihydrofolate reductase1.5.1.30.441
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.441
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3nr4PYVAbscisic acid receptor PYL2/0.441
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
3ov4EQUSteroid Delta-isomerase5.3.3.10.441
3qpvADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.441
3srrQ20Dihydrofolate reductase1.5.1.30.441
3v4aPK1Androgen receptor/0.441
3vhuSNLMineralocorticoid receptor/0.441
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4bfpSWYTankyrase-22.4.2.300.441
4boeCLRJapanin/0.441
4dymIYZActivin receptor type-12.7.11.300.441
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.441
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.441
4xivACPChemotaxis protein CheA2.7.13.30.441
5iu4ZMAAdenosine receptor A2a/0.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
1cjvFOKAdenylate cyclase type 2/0.440
1cjvFOKAdenylate cyclase type 5/0.440
1ia3TQ5Dihydrofolate reductase1.5.1.30.440
1kzjCB3Thymidylate synthase/0.440
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
1z5vGSPTubulin gamma-1 chain/0.440
1z6tADPApoptotic protease-activating factor 1/0.440
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.440
2jizADPATP synthase subunit beta, mitochondrial3.6.3.140.440
2nnqT4BFatty acid-binding protein, adipocyte/0.440
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3fy9XCFDihydrofolate reductase1.5.1.30.440
3gb4D3MDdmC/0.440
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3jwcEKBDihydrofolate reductase/0.440
3jwm5WBDihydrofolate reductase/0.440
3ndcSAHPrecorrin-4 C(11)-methyltransferase2.1.1.1330.440
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.440
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.440
4ips1G4Mycocyclosin synthase1.14.21.90.440
4isf1FXGlucokinase2.7.1.20.440
5ikqJMSProstaglandin G/H synthase 21.14.99.10.440
5iubCLRAdenosine receptor A2a/0.440