sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1nmq | 160 | Caspase-3 | 3.4.22.56 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1nmq | 160 | Caspase-3 | 3.4.22.56 | 1.000 | |
| 4pry | LEU_GLU_THR_ACE_ASA | Caspase-3 | 3.4.22.56 | 0.537 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.505 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.505 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.494 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.487 | |
| 1ex7 | 5GP | Guanylate kinase | 2.7.4.8 | 0.484 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.484 | |
| 1og4 | NAI | T-cell ecto-ADP-ribosyltransferase 2 | / | 0.483 | |
| 2ixk | TDO | dTDP-4-dehydrorhamnose 3,5-epimerase | 5.1.3.13 | 0.483 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.481 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.480 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.480 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.478 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.478 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.477 | |
| 3hl4 | CDC | Choline-phosphate cytidylyltransferase A | / | 0.476 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.475 | |
| 4ikz | AFS | Di-tripeptide ABC transporter (Permease) | / | 0.475 | |
| 2xq0 | BES | Leukotriene A-4 hydrolase homolog | 3.3.2.6 | 0.474 | |
| 4zvr | ASP_GLU_VAL_ACE_ASJ | Caspase-7 | 3.4.22.60 | 0.474 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.473 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.472 | |
| 3ukf | GDU | UDP-galactopyranose mutase | / | 0.472 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 4bek | XK0 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.471 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.470 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.470 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.470 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.470 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.469 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 4brd | ANP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.468 | |
| 4f3x | NAD | Putative aldehyde dehydrogenase | / | 0.468 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.467 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.467 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 4c13 | UML | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase | / | 0.467 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.467 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.466 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.466 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.466 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.465 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.465 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 3cb2 | GDP | Tubulin gamma-1 chain | / | 0.465 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.465 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.465 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 1nup | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.464 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.464 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4j4n | D44 | Peptidylprolyl isomerase | / | 0.464 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.463 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.463 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.462 | |
| 4gdc | NDP | UDP-galactopyranose mutase | / | 0.462 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.461 | |
| 1pz0 | NAP | Protein IolS | 1.1.1 | 0.461 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.461 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 4c49 | HCY | Corticosteroid-binding globulin | / | 0.461 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4ohw | ATP | Protein clpf-1 | / | 0.461 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.460 | |
| 2rd2 | QSI | Glutamine--tRNA ligase | 6.1.1.18 | 0.460 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.460 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3vjk | M51 | Dipeptidyl peptidase 4 | / | 0.459 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.459 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.459 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.459 | |
| 4zgs | NAD | Putative D-lactate dehydrogenase | / | 0.459 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.458 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.458 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.458 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.457 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.457 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.457 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.457 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.456 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.456 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.456 | |
| 3v2u | ATP | Protein GAL3 | / | 0.456 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.456 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.455 | |
| 2jgs | BTN | Avidin | / | 0.455 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.455 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 3qbj | NXZ | Dipeptidyl peptidase 4 | / | 0.455 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.455 | |
| 1pwy | AC2 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.454 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.454 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2z95 | NDP | GDP-mannose 4,6-dehydratase | / | 0.454 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.454 | |
| 3n19 | FNR | Xenobiotic reductase | / | 0.454 | |
| 3o76 | GTB | Glutathione S-transferase P 1 | 2.5.1.18 | 0.454 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4l7g | 1W0 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 5bv3 | M7G | m7GpppX diphosphatase | 3.6.1.59 | 0.454 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.453 | |
| 1pl1 | ABY | Glutathione S-transferase A1 | 2.5.1.18 | 0.453 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.453 | |
| 1xjq | ADP | Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 | 2.7.1.25 | 0.453 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.453 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.453 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.453 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 1je1 | GMP | Purine nucleoside phosphorylase | / | 0.452 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.452 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.452 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.452 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 3opm | LUI | Dipeptidyl peptidase 4 | / | 0.452 | |
| 3vjl | W94 | Dipeptidyl peptidase 4 | / | 0.452 | |
| 4jay | NAP | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.452 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.452 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.452 | |
| 4xr9 | NAD | CalS8 | / | 0.452 | |
| 1hku | NAD | C-terminal-binding protein 1 | 1.1.1 | 0.451 | |
| 1uxy | EPU | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.451 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2vut | NAD | Nitrogen metabolite repression protein nmrA | / | 0.451 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.451 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.451 | |
| 4flj | Y08 | Methionine aminopeptidase 1 | / | 0.451 | |
| 4jxx | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.451 | |
| 4l7j | 1W2 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.450 | |
| 1ds7 | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.450 | |
| 1jdv | ADN | Purine nucleoside phosphorylase | / | 0.450 | |
| 1k9s | FM1 | Purine nucleoside phosphorylase DeoD-type | / | 0.450 | |
| 1lpc | CMP | Antiviral protein DAP-30 | 3.2.2.22 | 0.450 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 2e07 | SAH | Diphthine synthase | / | 0.450 | |
| 2nnq | T4B | Fatty acid-binding protein, adipocyte | / | 0.450 | |
| 2o3u | NGD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.450 | |
| 2q96 | A18 | Methionine aminopeptidase | / | 0.450 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.450 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.450 | |
| 4h0x | NAD | Iota toxin component Ia | / | 0.450 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.450 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.449 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.449 | |
| 2wzw | NDP | Nitroreductase NfnB | / | 0.449 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.449 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.449 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.449 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.449 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.449 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.448 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2gg8 | U15 | Methionine aminopeptidase | / | 0.448 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.448 | |
| 2x93 | X93 | Angiotensin-converting enzyme | 3.4.15.1 | 0.448 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 3dz7 | O8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.448 | |
| 4g8j | THM | Uridine phosphorylase | / | 0.448 | |
| 4to5 | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.448 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.448 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.447 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.447 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.447 | |
| 2gg9 | U16 | Methionine aminopeptidase | / | 0.447 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3f8s | PF2 | Dipeptidyl peptidase 4 | / | 0.447 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.447 | |
| 3mes | PT3 | Putative choline kinase | / | 0.447 | |
| 3muo | ZPR | Prolyl endopeptidase | / | 0.447 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.447 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 4yaw | 2AM | NADPH--cytochrome P450 reductase | / | 0.447 | |
| 4zwe | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.447 | |
| 1aka | PLP | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.446 | |
| 1j8q | FMN | Flavodoxin | / | 0.446 | |
| 1m4i | COA | Aminoglycoside 2'-N-acetyltransferase | 2.3.1 | 0.446 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.446 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.446 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.446 | |
| 2eeq | SAH | Diphthine synthase | / | 0.446 | |
| 2evc | FC3 | Methionine aminopeptidase | / | 0.446 | |
| 2idv | M7G | Eukaryotic translation initiation factor 4E-1 | / | 0.446 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.446 | |
| 3fsj | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.446 | |
| 3hdy | GDU | UDP-galactopyranose mutase | / | 0.446 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.446 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.445 | |
| 2d3a | ADP | Glutamine synthetase root isozyme 3 | 6.3.1.2 | 0.445 | |
| 2xwe | AMF | Glucosylceramidase | 3.2.1.45 | 0.445 | |
| 3nt5 | NAI | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.445 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 4j1f | 1HL | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4wlj | IK2 | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.445 | |
| 1gtr | ATP | Glutamine--tRNA ligase | 6.1.1.18 | 0.444 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.444 | |
| 1s64 | 778 | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.444 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.444 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.444 | |
| 2b3v | ACO | Diamine acetyltransferase 1 | / | 0.444 | |
| 2q85 | 973 | UDP-N-acetylenolpyruvoylglucosamine reductase | 1.3.1.98 | 0.444 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.444 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.444 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.443 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1s4o | GDP | Glycolipid 2-alpha-mannosyltransferase | / | 0.443 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.443 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.443 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.443 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.443 | |
| 3g0b | T22 | Dipeptidyl peptidase 4 | / | 0.443 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.443 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4b77 | 54M | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 4e32 | DWN | Methyltransferase | / | 0.443 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.443 | |
| 4f5y | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 4kl1 | PCG | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.443 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1gm9 | SOX | Penicillin G acylase | 3.5.1.11 | 0.442 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2v5u | FMN | Flavodoxin | / | 0.442 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.442 | |
| 3ccc | 7AC | Dipeptidyl peptidase 4 | / | 0.442 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3l67 | FMN | Xenobiotic reductase | / | 0.442 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 1yki | FMN | Oxygen-insensitive NAD(P)H nitroreductase | / | 0.441 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.441 | |
| 2dxi | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.441 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.441 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.441 | |
| 3c1o | NAP | Eugenol synthase | / | 0.441 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.441 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.441 | |
| 4e2y | JHZ | Methyltransferase | / | 0.441 | |
| 4j7h | TRH | PCZA361.3 | / | 0.441 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.440 | |
| 1nhk | CMP | Nucleoside diphosphate kinase | 2.7.4.6 | 0.440 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.440 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.440 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.440 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.440 | |
| 3ojw | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 4b79 | NAD | Probable short-chain dehydrogenase | / | 0.440 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.440 | |
| 4qfy | DCP | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 | |
| 4x9d | U5P | Uncharacterized protein MJ1435 | / | 0.440 |