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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eqs FAD Coenzyme A disulfide reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4eqs FADCoenzyme A disulfide reductase / 1.444
1yqz FADCoenzyme A disulfide reductase / 1.425
4eqr FADCoenzyme A disulfide reductase / 1.403
4eqw FADCoenzyme A disulfide reductase / 1.399
4em4 FADCoenzyme A disulfide reductase / 1.396
4emw FADCoenzyme A disulfide reductase / 1.323
4em3 FADCoenzyme A disulfide reductase / 1.317
4eqx FADCoenzyme A disulfide reductase / 1.313
3icr FADCoenzyme A disulfide reductase / 1.069
3ics FADCoenzyme A disulfide reductase / 0.973
3fg2 FADPutative rubredoxin reductase / 0.957
3ict FADCoenzyme A disulfide reductase / 0.953
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.946
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.932
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.902
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.894
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.875
1nhr FADNADH peroxidase 1.11.1.1 0.870
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.867
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.863
1nhq FADNADH peroxidase 1.11.1.1 0.857
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.854
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.830
1nhp FADNADH peroxidase 1.11.1.1 0.819
3cgd FADCoenzyme A disulfide reductase / 0.819
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.817
2zbw FADFerredoxin--NADP reductase / 0.817
1joa FADNADH peroxidase 1.11.1.1 0.812
1q1r FADPutidaredoxin reductase 1.18.1.5 0.810
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.806
1f8w FADNADH peroxidase 1.11.1.1 0.804
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.804
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.799
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.790
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.790
1q1w FADPutidaredoxin reductase 1.18.1.5 0.789
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.789
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.788
3cge FADCoenzyme A disulfide reductase / 0.786
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.786
1d7y FADFerredoxin reductase / 0.785
1nhs FADNADH peroxidase 1.11.1.1 0.785
2qa1 FADPgaE / 0.784
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.784
4rsl FADFructosyl peptide oxidase / 0.783
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.777
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.777
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.776
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.772
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.770
3t37 FADPyridoxine 4-oxidase / 0.767
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.761
2yvj FADFerredoxin reductase / 0.761
2rab FADGlutathione amide reductase / 0.760
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.758
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.758
4hb9 FADUncharacterized protein / 0.758
4tm3 FADKtzI / 0.758
1ges FADGlutathione reductase 1.8.1.7 0.753
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.751
1npx FADNADH peroxidase 1.11.1.1 0.751
2eq6 FADDihydrolipoyl dehydrogenase / 0.751
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.751
2r9z FADGlutathione amide reductase / 0.750
3cgb FADCoenzyme A disulfide reductase / 0.750
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.750
2npx FADNADH peroxidase 1.11.1.1 0.749
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.748
1k0j FADp-hydroxybenzoate hydroxylase / 0.746
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.745
2gqf FADUncharacterized protein HI_0933 / 0.744
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.744
4b69 FADL-ornithine N(5)-monooxygenase / 0.744
2yvf FADFerredoxin reductase / 0.743
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.738
3gwf FADCyclohexanone monooxygenase / 0.738
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.735
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.734
5dbj FADFADH2-dependent halogenase PltA / 0.734
1f3p FADFerredoxin reductase / 0.732
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.732
1ng3 FADGlycine oxidase 1.4.3.19 0.732
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.730
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.730
5cku FADL-ornithine N(5)-monooxygenase / 0.730
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.729
3qvr FADGlucose oxidase 1.1.3.4 0.729
4x4j FADPutative oxygenase / 0.729
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.728
2yqu FADDihydrolipoyl dehydrogenase / 0.727
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.727
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.726
4dsh FDAUncharacterized protein / 0.725
2xdo FADTetX family tetracycline inactivation enzyme / 0.724
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.722
5j60 FADThioredoxin reductase / 0.722
1trb FADThioredoxin reductase 1.8.1.9 0.721
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
4j36 FADKynurenine 3-monooxygenase / 0.721
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.720
4dsg FADUncharacterized protein / 0.720
5hxw FADL-amino acid deaminase / 0.720
3dme FADPutative conserved exported protein / 0.719
4gcm FADThioredoxin reductase 1.8.1.9 0.719
3ad9 FADSubunit beta of sarcosine oxidase / 0.717
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.717
1k0l FADp-hydroxybenzoate hydroxylase / 0.716
2x3n FADProbable FAD-dependent monooxygenase / 0.716
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.716
4k5r FADOxygenase / 0.716
4opd FDAConserved Archaeal protein / 0.716
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.714
2w0h FADTrypanothione reductase / 0.713
3atq FDAConserved Archaeal protein / 0.712
3k30 ADPHistamine dehydrogenase / 0.712
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.712
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.711
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.711
4jn9 FADDepH / 0.711
4opc FDAConserved Archaeal protein / 0.711
1ger FADGlutathione reductase 1.8.1.7 0.710
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.710
3c96 FADFlavin-containing monooxygenase / 0.710
3cgc FADCoenzyme A disulfide reductase / 0.710
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.709
4j57 FADThioredoxin reductase 2 1.8.1.9 0.709
3qvp FADGlucose oxidase 1.1.3.4 0.708
3rp8 FADFAD-dependent urate hydroxylase / 0.708
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.707
1pdh FASp-hydroxybenzoate hydroxylase / 0.706
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.705
3ukf FDAUDP-galactopyranose mutase / 0.704
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.704
4icy FADPgaE / 0.704
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.703
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.703
2q7v FADThioredoxin reductase / 0.703
2xve FADPutative flavin-containing monooxygenase / 0.703
5buk FADFADH2-dependent halogenase / 0.703
3ihg FADAklavinone 12-hydroxylase RdmE / 0.702
1ng4 FADGlycine oxidase 1.4.3.19 0.701
2rgh FADAlpha-Glycerophosphate Oxidase / 0.700
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.700
4nzh FADL-ornithine N(5)-monooxygenase / 0.700
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.700
1cf3 FADGlucose oxidase 1.1.3.4 0.699
1h81 FADPolyamine oxidase 1.5.3.14 0.699
3nlc FADUncharacterized protein / 0.699
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.699
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.698
4i58 FADCyclohexylamine Oxidase / 0.698
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.698
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.698
1get FADGlutathione reductase 1.8.1.7 0.697
2yg4 FADPutrescine oxidase / 0.697
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.695
1zk7 FADMercuric reductase 1.16.1.1 0.694
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.694
3nix FADFlavoprotein/dehydrogenase / 0.694
2bac FADPutative aminooxidase / 0.693
2x8g FADThioredoxin glutathione reductase / 0.693
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.693
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.693
4gde FDAUDP-galactopyranose mutase / 0.693
2yg6 FADPutrescine oxidase / 0.692
3lad FADDihydrolipoyl dehydrogenase / 0.692
3r9u FADThioredoxin reductase / 0.692
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.691
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.691
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.691
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.690
3bg7 FADPyranose 2-oxidase / 0.689
2gr3 FADFerredoxin reductase / 0.688
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.688
2q0k FADThioredoxin reductase 1.8.1.9 0.687
3ish FADThioredoxin reductase 1.8.1.9 0.687
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.687
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.686
4tm4 FDAKtzI / 0.686
4z26 FADPutative GMC-type oxidoreductase R135 1 0.686
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.685
4up3 FADThioredoxin reductase / 0.685
4fwf FADLysine-specific histone demethylase 1B 1 0.684
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.683
2cdu FADNADH oxidase / 0.683
2uyh SAHModification methylase HhaI 2.1.1.37 0.683
3syi FADSulfide-quinone reductase / 0.683
4u8k FDAUDP-galactopyranose mutase / 0.683
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.682
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.682
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.681
4u8l FDAUDP-galactopyranose mutase / 0.681
4uir FADOleate hydratase 4.2.1.53 0.681
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.680
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.680
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.680
3cnd FADPolyamine oxidase FMS1 / 0.679
4gut FADLysine-specific histone demethylase 1B 1 0.679
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.678
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.678
2cdu ADPNADH oxidase / 0.678
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.678
1tdf FADThioredoxin reductase 1.8.1.9 0.677
3mht SAHModification methylase HhaI 2.1.1.37 0.677
3sz0 FADSulfide-quinone reductase / 0.677
3urh FADDihydrolipoyl dehydrogenase / 0.677
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.677
4tm0 FADKtzI / 0.677
1fec FADTrypanothione reductase 1.8.1.12 0.676
1gpe FADGlucose oxidase 1.1.3.4 0.676
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.676
2ji6 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.676
4opi FDAConserved Archaeal protein / 0.676
5hsa FASAlcohol oxidase 1 1.1.3.13 0.676
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.675
2jb2 FADL-amino acid oxidase / 0.675
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.675
1tde FADThioredoxin reductase 1.8.1.9 0.674
2gr0 FADFerredoxin reductase / 0.674
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.674
4oa5 SAHO-methyltransferase family protein / 0.674
2e1m FADL-glutamate oxidase / 0.673
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.673
3utg FDAUDP-galactopyranose mutase / 0.673
3uth FDAUDP-galactopyranose mutase / 0.673
4j34 FADKynurenine 3-monooxygenase / 0.673
4opg FDAConserved Archaeal protein / 0.673
4yry FADGlutamate synthase, beta subunit / 0.673
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.672
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.672
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.671
4u8n FDAUDP-galactopyranose mutase / 0.671
3gyj FADCholesterol oxidase 1.1.3.6 0.670
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.669
4k2x FADPolyketide oxygenase/hydroxylase / 0.669
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.669
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.668
3ka7 FADPutative oxidoreductase / 0.668
1feb FADTrypanothione reductase 1.8.1.12 0.667
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.667
2q0l FADThioredoxin reductase 1.8.1.9 0.667
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.667
3he3 FADUDP-galactopyranose mutase / 0.667
4dna FADProbable glutathione reductase / 0.667
4u8o FDAUDP-galactopyranose mutase / 0.667
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.666
2o06 MTASpermidine synthase 2.5.1.16 0.666
2x8h FADThioredoxin glutathione reductase / 0.666
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.666
4ccq FADThioredoxin reductase / 0.666
4ntc FADThioredoxin reductase gliT / 0.666
2xlr FADPutative flavin-containing monooxygenase / 0.665
4mo2 FDAUDP-galactopyranose mutase / 0.665
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.664
4mok FADPyranose 2-oxidase / 0.664
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.663
2eq7 NADDihydrolipoyl dehydrogenase / 0.663
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.663
4j31 FADKynurenine 3-monooxygenase / 0.663
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.662
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.662
2gqw FADFerredoxin reductase / 0.662
3lov FADProtoporphyrinogen oxidase / 0.662
3rha FDAPutrescine oxidase / 0.662
3ukl FADUDP-galactopyranose mutase / 0.662
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.662
4mih FADPyranose 2-oxidase 1.1.3.10 0.662
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.661
3ssm SAHMycinamicin VI 2''-O-methyltransferase / 0.661
3we0 FADLysine 2-monooxygenase / 0.661
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.660
9mht SAHModification methylase HhaI 2.1.1.37 0.660
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.659
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.659
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.659
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.659
2jae FADL-amino acid oxidase / 0.658
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.658
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.658
4nte FADDepH / 0.658
4opt FDAConserved Archaeal protein / 0.658
1phh FADp-hydroxybenzoate hydroxylase / 0.657
2bh2 SAH23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD / 0.657
2yg3 FADPutrescine oxidase / 0.657
4a99 FADTetX family tetracycline inactivation enzyme / 0.657
4bk3 FADProbable salicylate monooxygenase / 0.657
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.657
4opl FDAConserved Archaeal protein / 0.657
1c0k FADD-amino-acid oxidase 1.4.3.3 0.655
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
1gxf FADTrypanothione reductase 1.8.1.12 0.655
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.655
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.655
1bzl FADTrypanothione reductase 1.8.1.12 0.654
2whd FADThioredoxin reductase / 0.654
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.653
3kkj FADRenalase / 0.653
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
2yg7 FADPutrescine oxidase / 0.652
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.652
3v76 FDAUncharacterized protein / 0.652
3vqr FADPutative oxidoreductase / 0.652
2eq7 FADDihydrolipoyl dehydrogenase / 0.651
4a5l FADThioredoxin reductase / 0.651
4c3y FAD3-ketosteroid dehydrogenase / 0.651
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.650
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.650
3t14 FADSulfide-quinone reductase / 0.650
4b1b FADThioredoxin reductase 1.8.1.9 0.650
5br7 FADUDP-galactopyranose mutase / 0.650