Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4emj FAD Toluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 1.347
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 1.188
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.950
3fg2 FADPutative rubredoxin reductase / 0.944
2gr0 FADFerredoxin reductase / 0.920
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.886
1d7y FADFerredoxin reductase / 0.869
2gqw FADFerredoxin reductase / 0.863
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.863
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.859
4eqs FADCoenzyme A disulfide reductase / 0.854
2gr3 FADFerredoxin reductase / 0.848
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.848
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.845
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.836
3ict FADCoenzyme A disulfide reductase / 0.836
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.829
4em4 FADCoenzyme A disulfide reductase / 0.829
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.829
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.829
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.828
4eqw FADCoenzyme A disulfide reductase / 0.824
4em3 FADCoenzyme A disulfide reductase / 0.822
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.820
1yqz FADCoenzyme A disulfide reductase / 0.819
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.813
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.803
1f3p FADFerredoxin reductase / 0.802
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.801
4eqr FADCoenzyme A disulfide reductase / 0.801
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.800
1nhr FADNADH peroxidase 1.11.1.1 0.798
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.796
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.795
2q0k FADThioredoxin reductase 1.8.1.9 0.790
3cgb FADCoenzyme A disulfide reductase / 0.789
2zbw FADFerredoxin--NADP reductase / 0.778
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.778
1trb FADThioredoxin reductase 1.8.1.9 0.777
3cgc FADCoenzyme A disulfide reductase / 0.776
1nhq FADNADH peroxidase 1.11.1.1 0.773
4ccq FADThioredoxin reductase / 0.773
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.772
3nlc FADUncharacterized protein / 0.763
3t37 FADPyridoxine 4-oxidase / 0.761
1q1r FADPutidaredoxin reductase 1.18.1.5 0.756
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.755
3icr FADCoenzyme A disulfide reductase / 0.755
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.754
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.753
3fbs FADOxidoreductase / 0.752
4jn9 FADDepH / 0.750
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.748
1tdf FADThioredoxin reductase 1.8.1.9 0.747
4eqx FADCoenzyme A disulfide reductase / 0.747
3cge FADCoenzyme A disulfide reductase / 0.746
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.745
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.745
1npx FADNADH peroxidase 1.11.1.1 0.742
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.742
3rp8 FADFAD-dependent urate hydroxylase / 0.742
2yvj FADFerredoxin reductase / 0.741
4a5l FADThioredoxin reductase / 0.741
1gxf FADTrypanothione reductase 1.8.1.12 0.740
4ntc FADThioredoxin reductase gliT / 0.740
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.740
4nte FADDepH / 0.739
1nhp FADNADH peroxidase 1.11.1.1 0.738
4opg FDAConserved Archaeal protein / 0.738
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.737
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.737
4cnj FADL-amino acid oxidase / 0.737
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.734
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.734
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.733
3cty FADProbable thioredoxin reductase / 0.731
4gcm FADThioredoxin reductase 1.8.1.9 0.731
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.730
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.730
1nhs FADNADH peroxidase 1.11.1.1 0.728
2wp5 FADTrypanothione reductase / 0.728
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
4up3 FADThioredoxin reductase / 0.728
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.727
4yry FADGlutamate synthase, beta subunit / 0.727
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.726
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.726
1b4v FADCholesterol oxidase 1.1.3.6 0.725
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.724
4b1b FADThioredoxin reductase 1.8.1.9 0.724
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.724
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.723
2wow FADTrypanothione reductase / 0.723
3ada NADSubunit alpha of sarocosine oxidase / 0.722
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.722
1fec FADTrypanothione reductase 1.8.1.12 0.721
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.721
3ics FADCoenzyme A disulfide reductase / 0.721
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.720
2gr1 FADFerredoxin reductase / 0.719
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.719
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.719
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.718
4opi FDAConserved Archaeal protein / 0.718
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.717
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.717
3atq FDAConserved Archaeal protein / 0.717
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.717
1joa FADNADH peroxidase 1.11.1.1 0.714
2tpr FADTrypanothione reductase 1.8.1.12 0.714
3cgd FADCoenzyme A disulfide reductase / 0.714
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.714
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.714
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.714
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.713
3mj4 FADUDP-galactopyranose mutase / 0.711
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.711
1tde FADThioredoxin reductase 1.8.1.9 0.710
3b6d FAECholesterol oxidase 1.1.3.6 0.710
3nix FADFlavoprotein/dehydrogenase / 0.710
4emw FADCoenzyme A disulfide reductase / 0.708
4nev FADTrypanothione reductase / 0.708
1kif FADD-amino-acid oxidase 1.4.3.3 0.706
2vvl FADMonoamine oxidase N 1.4.3.4 0.706
4gut FADLysine-specific histone demethylase 1B 1 0.706
1zk7 FADMercuric reductase 1.16.1.1 0.705
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.705
3cnd FADPolyamine oxidase FMS1 / 0.705
1ges FADGlutathione reductase 1.8.1.7 0.704
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.704
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.704
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.704
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.704
2npx FADNADH peroxidase 1.11.1.1 0.703
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.703
1ger FADGlutathione reductase 1.8.1.7 0.702
2cul FADGidA-related protein / 0.702
2jk6 FADTrypanothione reductase / 0.702
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.702
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
4opt FDAConserved Archaeal protein / 0.702
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.701
3ad9 NADSubunit alpha of sarocosine oxidase / 0.701
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.701
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.701
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.701
1f8w FADNADH peroxidase 1.11.1.1 0.700
2yvf FADFerredoxin reductase / 0.700
3atr FDAConserved Archaeal protein / 0.700
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.700
3ish FADThioredoxin reductase 1.8.1.9 0.699
5buk FADFADH2-dependent halogenase / 0.699
1n4u FAECholesterol oxidase 1.1.3.6 0.697
3zdn FADMonoamine oxidase N 1.4.3.4 0.697
4gus FADLysine-specific histone demethylase 1B 1 0.697
4xwr FADCholesterol oxidase 1.1.3.6 0.697
1cc2 FADCholesterol oxidase 1.1.3.6 0.696
4opl FDAConserved Archaeal protein / 0.696
1d7l RFLp-hydroxybenzoate hydroxylase / 0.695
1n4w FADCholesterol oxidase 1.1.3.6 0.695
1zx9 FADMercuric reductase 1.16.1.1 0.695
3cnj FADCholesterol oxidase 1.1.3.6 0.695
3cox FADCholesterol oxidase 1.1.3.6 0.695
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.695
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.695
1get FADGlutathione reductase 1.8.1.7 0.694
1qo8 FADFumarate reductase flavoprotein subunit / 0.694
3gyi FADCholesterol oxidase 1.1.3.6 0.694
4ccr FADThioredoxin reductase / 0.694
4j57 FADThioredoxin reductase 2 1.8.1.9 0.694
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.693
2x3n FADProbable FAD-dependent monooxygenase / 0.693
3t2y FADSulfide-quinone reductase / 0.693
4rek FADCholesterol oxidase 1.1.3.6 0.693
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.692
2xdo FADTetX family tetracycline inactivation enzyme / 0.692
2hqm FADGlutathione reductase 1.8.1.7 0.691
4jq9 FADDihydrolipoyl dehydrogenase / 0.691
2eq7 FADDihydrolipoyl dehydrogenase / 0.690
4u2t FADCholesterol oxidase 1.1.3.6 0.690
4j31 FADKynurenine 3-monooxygenase / 0.689
4mih FADPyranose 2-oxidase 1.1.3.10 0.689
4opu FDAConserved Archaeal protein / 0.689
1cbo FADCholesterol oxidase 1.1.3.6 0.688
1feb FADTrypanothione reductase 1.8.1.12 0.688
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.688
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.688
2h94 FADLysine-specific histone demethylase 1A 1 0.687
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.687
2v6o FADThioredoxin glutathione reductase / 0.687
3kve FADL-amino-acid oxidase / 0.687
2wba FADTrypanothione reductase 1.8.1.12 0.686
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.685
3f8d FADNADH oxidase/thioredoxin reductase / 0.684
4qi4 FADCellobiose dehydrogenase / 0.684
2vig FADShort-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.1 0.683
4bjz FADProbable salicylate monooxygenase / 0.683
4hb9 FADUncharacterized protein / 0.683
1q1w FADPutidaredoxin reductase 1.18.1.5 0.682
2bab FADPutative aminooxidase / 0.682
3urh FADDihydrolipoyl dehydrogenase / 0.682
4x4j FADPutative oxygenase / 0.682
3qvr FADGlucose oxidase 1.1.3.4 0.681
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.680
1xpq FADPolyamine oxidase FMS1 / 0.680
2r9z FADGlutathione amide reductase / 0.680
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.680
1cl0 FADThioredoxin reductase 1.8.1.9 0.679
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.679
1n1p FADCholesterol oxidase 1.1.3.6 0.679
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.679
4la1 FADThioredoxin glutathione reductase / 0.678
4qi7 FADCellobiose dehydrogenase / 0.678
4u8k FDAUDP-galactopyranose mutase / 0.678
1b8s FADCholesterol oxidase 1.1.3.6 0.677
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.677
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.676
2eq8 FADDihydrolipoyl dehydrogenase / 0.676
3hdy FADUDP-galactopyranose mutase / 0.676
1ijh FADCholesterol oxidase 1.1.3.6 0.675
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.675
4z24 FADPutative GMC-type oxidoreductase R135 1 0.675
1yy5 FADPolyamine oxidase FMS1 / 0.674
2gew FADCholesterol oxidase 1.1.3.6 0.674
4u2s FDACholesterol oxidase 1.1.3.6 0.674
4xxg FADCholesterol oxidase 1.1.3.6 0.674
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.673
1n4v FADCholesterol oxidase 1.1.3.6 0.673
3fmw FADOxygenase / 0.673
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.672
3gyj FADCholesterol oxidase 1.1.3.6 0.671
3lad FADDihydrolipoyl dehydrogenase / 0.671
4jnq FDAThioredoxin reductase / 0.671
3utg FDAUDP-galactopyranose mutase / 0.670
4cbq FADThioredoxin reductase / 0.670
2yqu FADDihydrolipoyl dehydrogenase / 0.669
3utf FDAUDP-galactopyranose mutase / 0.669
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.669
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.668
2iw5 FADLysine-specific histone demethylase 1A 1 0.668
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.668
4qi5 FADCellobiose dehydrogenase / 0.668
4u8j FDAUDP-galactopyranose mutase / 0.668
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.667
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.667
2jb2 FADL-amino acid oxidase / 0.667
2x8g FADThioredoxin glutathione reductase / 0.667
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.666
2rab FADGlutathione amide reductase / 0.666
3cnt FADPolyamine oxidase FMS1 / 0.666
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.666
4ntd FADThioredoxin reductase / 0.666
4rsl FADFructosyl peptide oxidase / 0.666
1fea FADTrypanothione reductase 1.8.1.12 0.665
1h81 FADPolyamine oxidase 1.5.3.14 0.665
3uth FDAUDP-galactopyranose mutase / 0.665
4j34 FADKynurenine 3-monooxygenase / 0.665
1geu FADGlutathione reductase 1.8.1.7 0.664
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.664
2x8h FADThioredoxin glutathione reductase / 0.664
3cn8 FADPolyamine oxidase FMS1 / 0.664
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.664
4opd FDAConserved Archaeal protein / 0.664
4u8i FDAUDP-galactopyranose mutase / 0.664
2whd FADThioredoxin reductase / 0.663
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.663
4guu FA9Lysine-specific histone demethylase 1B 1 0.663
1f8r FADL-amino-acid oxidase 1.4.3.2 0.662
1tyt FADTrypanothione reductase 1.8.1.12 0.662
2iid FADL-amino-acid oxidase 1.4.3.2 0.662
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.662
4ech FADPolyamine oxidase FMS1 / 0.662
4gdd FADUDP-galactopyranose mutase / 0.662
1k0j FADp-hydroxybenzoate hydroxylase / 0.661
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.661
2eq6 FADDihydrolipoyl dehydrogenase / 0.661
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.661
4j36 FADKynurenine 3-monooxygenase / 0.661
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.660
3lov FADProtoporphyrinogen oxidase / 0.660
2cdu FADNADH oxidase / 0.659
2qa1 FADPgaE / 0.659
4cnk FADL-amino acid oxidase / 0.659
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.658
1mxt FAECholesterol oxidase 1.1.3.6 0.658
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.658
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.658
4u8l FDAUDP-galactopyranose mutase / 0.658
3axb FADPutative oxidoreductase / 0.657
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.657
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.656
2b9w FADPutative aminooxidase / 0.656
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.656
2vqb FADPutative flavin-containing monooxygenase / 0.656
1f8s FADL-amino-acid oxidase 1.4.3.2 0.655
2yg5 FADPutrescine oxidase / 0.655
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.653
5hsa FASAlcohol oxidase 1 1.1.3.13 0.653
2eq9 FADDihydrolipoyl dehydrogenase / 0.652
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.651
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.651
3itj FADThioredoxin reductase 1 1.8.1.9 0.651
4at0 FADPossible succinate dehydrogenase / 0.651
1gal FADGlucose oxidase 1.1.3.4 0.650
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.650
1ojt FADDihydrolipoyl dehydrogenase / 0.650
3gwd FADCyclohexanone monooxygenase / 0.650
3r9u FADThioredoxin reductase / 0.650
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.650
4tlz FADKtzI / 0.650
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.650