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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1reo FAD L-amino-acid oxidase 1.4.3.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
1reo FADL-amino-acid oxidase 1.4.3.2 1.471
1tdn FADL-amino-acid oxidase 1.4.3.2 1.429
1tdk FADL-amino-acid oxidase 1.4.3.2 1.414
1tdo FADL-amino-acid oxidase 1.4.3.2 1.394
2iid FADL-amino-acid oxidase 1.4.3.2 1.256
1f8r FADL-amino-acid oxidase 1.4.3.2 1.177
1f8s FADL-amino-acid oxidase 1.4.3.2 1.153
3kve FADL-amino-acid oxidase / 1.004
3ka7 FADPutative oxidoreductase / 0.894
1rsg FADPolyamine oxidase FMS1 / 0.841
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.826
4u8o FDAUDP-galactopyranose mutase / 0.821
2jae FADL-amino acid oxidase / 0.812
2jb1 FADL-amino acid oxidase / 0.812
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.807
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.798
2y48 FADLysine-specific histone demethylase 1A 1 0.790
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.790
4wx1 FDAUDP-galactopyranose mutase / 0.789
2jb2 FADL-amino acid oxidase / 0.787
3bi5 FADPolyamine oxidase FMS1 / 0.785
3ukf FDAUDP-galactopyranose mutase / 0.784
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.782
3uth FDAUDP-galactopyranose mutase / 0.782
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.775
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.774
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.774
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.772
4ysh FADGlycine oxidase / 0.772
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.771
4u8n FDAUDP-galactopyranose mutase / 0.768
5l3d FADLysine-specific histone demethylase 1A 1 0.768
3ad9 FADSubunit beta of sarcosine oxidase / 0.767
4u8l FDAUDP-galactopyranose mutase / 0.765
4u8p FDAUDP-galactopyranose mutase / 0.765
4u8i FDAUDP-galactopyranose mutase / 0.761
2cdu FADNADH oxidase / 0.760
3vqr FADPutative oxidoreductase / 0.759
2r0c FADPutative FAD-monooxygenase / 0.758
4u8j FDAUDP-galactopyranose mutase / 0.758
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.757
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.756
4u8m FDAUDP-galactopyranose mutase / 0.756
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.755
1zx9 FADMercuric reductase 1.16.1.1 0.755
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.755
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.754
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.754
2yg5 FADPutrescine oxidase / 0.754
3dme FADPutative conserved exported protein / 0.754
4gde FDAUDP-galactopyranose mutase / 0.752
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.751
1h81 FADPolyamine oxidase 1.5.3.14 0.749
3utf FDAUDP-galactopyranose mutase / 0.748
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.745
4fwf FADLysine-specific histone demethylase 1B 1 0.745
4ech FADPolyamine oxidase FMS1 / 0.743
4rsl FADFructosyl peptide oxidase / 0.743
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.742
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.740
2yg4 FADPutrescine oxidase / 0.739
3lov FADProtoporphyrinogen oxidase / 0.739
4opg FDAConserved Archaeal protein / 0.739
4opi FDAConserved Archaeal protein / 0.739
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.738
1f8w FADNADH peroxidase 1.11.1.1 0.737
1onf FADGlutathione reductase 1.8.1.7 0.737
3cnd FADPolyamine oxidase FMS1 / 0.737
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.735
4u8k FDAUDP-galactopyranose mutase / 0.735
2e1m FADL-glutamate oxidase / 0.734
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.734
2bab FADPutative aminooxidase / 0.733
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.733
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.733
3cn8 FADPolyamine oxidase FMS1 / 0.732
3kpf FADPolyamine oxidase 1.5.3.14 0.731
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.731
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.730
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.729
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.729
3ukk FDAUDP-galactopyranose mutase / 0.729
4gdp FADPolyamine oxidase FMS1 / 0.728
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.728
1nhp FADNADH peroxidase 1.11.1.1 0.727
3qj4 FADRenalase / 0.727
4hsu FADLysine-specific histone demethylase 1B 1 0.727
4bk3 FADProbable salicylate monooxygenase / 0.725
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.725
2dw4 FADLysine-specific histone demethylase 1A 1 0.724
3utg FDAUDP-galactopyranose mutase / 0.724
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.723
2b9y FADPutative aminooxidase / 0.723
3gsi FADDimethylglycine oxidase 1.5.3.10 0.723
4gur FADLysine-specific histone demethylase 1B 1 0.723
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.722
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.721
3atq FDAConserved Archaeal protein / 0.720
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.719
4guu FA9Lysine-specific histone demethylase 1B 1 0.719
4dsh FDAUncharacterized protein / 0.718
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.716
2rgh FADAlpha-Glycerophosphate Oxidase / 0.715
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.714
2yg6 FADPutrescine oxidase / 0.713
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.711
1nhs FADNADH peroxidase 1.11.1.1 0.711
2b9x FADPutative aminooxidase / 0.711
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.711
5hxw FADL-amino acid deaminase / 0.711
3zdn FADMonoamine oxidase N 1.4.3.4 0.710
4xbf FADLysine-specific histone demethylase 1A 1 0.710
4mo2 FADUDP-galactopyranose mutase / 0.709
1tde FADThioredoxin reductase 1.8.1.9 0.708
2x8h FADThioredoxin glutathione reductase / 0.708
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.708
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.707
1trb FADThioredoxin reductase 1.8.1.9 0.705
2vqb FADPutative flavin-containing monooxygenase / 0.705
4mo2 FDAUDP-galactopyranose mutase / 0.705
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.704
3ish FADThioredoxin reductase 1.8.1.9 0.703
4fwj FADLysine-specific histone demethylase 1B 1 0.703
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.703
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.702
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.702
2vvl FADMonoamine oxidase N 1.4.3.4 0.701
4opc FDAConserved Archaeal protein / 0.701
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.700
3lad FADDihydrolipoyl dehydrogenase / 0.699
4bjz FADProbable salicylate monooxygenase / 0.699
4c3y FAD3-ketosteroid dehydrogenase / 0.699
4x9m FADUncharacterized protein MG039 homolog / 0.699
1f3p FADFerredoxin reductase / 0.698
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.698
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.698
1kif FADD-amino-acid oxidase 1.4.3.3 0.697
1zk7 FADMercuric reductase 1.16.1.1 0.697
2jk6 FADTrypanothione reductase / 0.697
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.696
2gr0 FADFerredoxin reductase / 0.696
3cty FADProbable thioredoxin reductase / 0.696
4b63 FADL-ornithine N(5)-monooxygenase / 0.696
1q1r FADPutidaredoxin reductase 1.18.1.5 0.695
2gr3 FADFerredoxin reductase / 0.695
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.695
2yg7 FADPutrescine oxidase / 0.695
5i39 FADL-amino acid deaminase / 0.695
1h83 FADPolyamine oxidase 1.5.3.14 0.694
3bi2 FADPolyamine oxidase FMS1 / 0.694
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
3we0 FADLysine 2-monooxygenase / 0.694
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.693
3ukl FADUDP-galactopyranose mutase / 0.693
4bk2 FADProbable salicylate monooxygenase / 0.693
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.693
2q7v FADThioredoxin reductase / 0.692
3cnt FADPolyamine oxidase FMS1 / 0.692
4gcm FADThioredoxin reductase 1.8.1.9 0.692
4opt FDAConserved Archaeal protein / 0.692
1nhr FADNADH peroxidase 1.11.1.1 0.691
1wam FADUDP-galactopyranose mutase 5.4.99.9 0.691
2gqw FADFerredoxin reductase / 0.691
2npx FADNADH peroxidase 1.11.1.1 0.691
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.691
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.690
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.690
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.689
1ryi FADGlycine oxidase 1.4.3.19 0.689
2b9w FADPutative aminooxidase / 0.689
3q9t FAYUncharacterized protein / 0.689
4j34 FADKynurenine 3-monooxygenase / 0.689
4tm3 FADKtzI / 0.689
1d7y FADFerredoxin reductase / 0.688
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.688
2qa2 FADPolyketide oxygenase CabE / 0.688
3r9u FADThioredoxin reductase / 0.688
4i58 FADCyclohexylamine Oxidase / 0.688
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.688
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.688
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.687
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.687
1d7l RFLp-hydroxybenzoate hydroxylase / 0.686
2qcu FADAerobic glycerol-3-phosphate dehydrogenase 1.1.5.3 0.686
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.686
1nhq FADNADH peroxidase 1.11.1.1 0.685
1npx FADNADH peroxidase 1.11.1.1 0.685
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.685
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.685
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.685
2qa1 FADPgaE / 0.684
3atr FDAConserved Archaeal protein / 0.684
3cgb FADCoenzyme A disulfide reductase / 0.683
3rha FDAPutrescine oxidase / 0.683
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.683
4opu FDAConserved Archaeal protein / 0.683
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
1ng4 FADGlycine oxidase 1.4.3.19 0.682
4c3x FAD3-ketosteroid dehydrogenase / 0.682
2ba9 FADPutative aminooxidase / 0.681
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.681
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.680
1ng3 FADGlycine oxidase 1.4.3.19 0.680
2du8 FADD-amino-acid oxidase 1.4.3.3 0.680
3cgc FADCoenzyme A disulfide reductase / 0.680
3ict FADCoenzyme A disulfide reductase / 0.680
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.680
4opd FDAConserved Archaeal protein / 0.680
4x4j FADPutative oxygenase / 0.680
4x9n FADUncharacterized protein MG039 homolog / 0.680
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.680
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.679
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.679
4ynt FDAGlucose oxidase, putative / 0.679
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.678
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.678
1z6l FADPolyamine oxidase FMS1 / 0.677
3fg2 FADPutative rubredoxin reductase / 0.677
3k30 ADPHistamine dehydrogenase / 0.677
4k2x FADPolyketide oxygenase/hydroxylase / 0.677
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.676
1yy5 FADPolyamine oxidase FMS1 / 0.676
2iw5 FADLysine-specific histone demethylase 1A 1 0.676
3he3 FADUDP-galactopyranose mutase / 0.676
2yg3 FADPutrescine oxidase / 0.674
3axb FADPutative oxidoreductase / 0.674
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.674
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.674
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.673
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.673
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.673
1gpe FADGlucose oxidase 1.1.3.4 0.672
1tdf FADThioredoxin reductase 1.8.1.9 0.672
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.672
2q0l FADThioredoxin reductase 1.8.1.9 0.672
4b64 FADL-ornithine N(5)-monooxygenase / 0.672
4j33 FADKynurenine 3-monooxygenase / 0.672
4yxd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.672
1get FADGlutathione reductase 1.8.1.7 0.671
2e48 FADD-amino-acid oxidase 1.4.3.3 0.671
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.671
2uxx FAJLysine-specific histone demethylase 1A 1 0.671
2yqu FADDihydrolipoyl dehydrogenase / 0.671
3kkj FADRenalase / 0.671
3rp8 FADFAD-dependent urate hydroxylase / 0.671
4b65 FADL-ornithine N(5)-monooxygenase / 0.671
4gus FADLysine-specific histone demethylase 1B 1 0.671
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.671
4uy6 SAHHistidine N-alpha-methyltransferase / 0.671
2h94 FADLysine-specific histone demethylase 1A 1 0.670
3mj4 FADUDP-galactopyranose mutase / 0.670
4nev FADTrypanothione reductase / 0.670
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.669
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.669
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.669
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.668
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.667
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.667
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.667
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.667
3ics FADCoenzyme A disulfide reductase / 0.667
4jnq FDAThioredoxin reductase / 0.667
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.666
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.666
1k0l FADp-hydroxybenzoate hydroxylase / 0.665
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.665
2xdo FADTetX family tetracycline inactivation enzyme / 0.665
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.665
5cku FADL-ornithine N(5)-monooxygenase / 0.665
1cqx FADFlavohemoprotein / 0.664
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.664
2eq9 FADDihydrolipoyl dehydrogenase / 0.664
2vq7 FADPutative flavin-containing monooxygenase / 0.664
4b69 FADL-ornithine N(5)-monooxygenase / 0.664
2bac FADPutative aminooxidase / 0.663
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
3hdy FADUDP-galactopyranose mutase / 0.662
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.662
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
1q1w FADPutidaredoxin reductase 1.18.1.5 0.661
2v7g NADUrocanate hydratase 4.2.1.49 0.661
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.661
4em3 FADCoenzyme A disulfide reductase / 0.661
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.660
3cge FADCoenzyme A disulfide reductase / 0.660
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.660
4jq9 FADDihydrolipoyl dehydrogenase / 0.660
4yry FADGlutamate synthase, beta subunit / 0.660
2ifa FMNUncharacterized protein / 0.659
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.659
3t37 FADPyridoxine 4-oxidase / 0.659
4k5r FADOxygenase / 0.659
4rpj FADUDP-galactopyranose mutase 5.4.99.9 0.659
4yjd FADD-amino-acid oxidase 1.4.3.3 0.659
1qo8 FADFumarate reductase flavoprotein subunit / 0.658
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.658
2z6d FMNPhototropin-2 2.7.11.1 0.658
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.658
3haz FADBifunctional protein PutA / 0.657
4cnj FADL-amino acid oxidase / 0.657
4opl FDAConserved Archaeal protein / 0.657
1xpq FADPolyamine oxidase FMS1 / 0.656
3ept FDAPutative FAD-monooxygenase / 0.656
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.655
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.655
1k0j FADp-hydroxybenzoate hydroxylase / 0.654
2q0k FADThioredoxin reductase 1.8.1.9 0.654
2xvf FADPutative flavin-containing monooxygenase / 0.654
3sz0 FADSulfide-quinone reductase / 0.654
4uir FADOleate hydratase 4.2.1.53 0.654
3duw SAHO-methyltransferase, putative / 0.653
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.652
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.652
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.652
3cuk FADD-amino-acid oxidase 1.4.3.3 0.652
1ger FADGlutathione reductase 1.8.1.7 0.651
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.651
5br7 FADUDP-galactopyranose mutase / 0.651
2o06 MTASpermidine synthase 2.5.1.16 0.650
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.650
3uka FADUDP-galactopyranose mutase / 0.650