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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1d4c FAD Fumarate reductase flavoprotein subunit 1.3.5.4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 1.339
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.944
1qo8 FADFumarate reductase flavoprotein subunit / 0.902
3aeb FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.857
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.853
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.823
1knp FADL-aspartate oxidase 1.4.3.16 0.822
1knr FADL-aspartate oxidase 1.4.3.16 0.818
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.809
3sfd FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.805
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.803
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.782
1c0k FADD-amino-acid oxidase 1.4.3.3 0.781
4ech FADPolyamine oxidase FMS1 / 0.779
3f8d FADNADH oxidase/thioredoxin reductase / 0.778
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.774
2eq8 FADDihydrolipoyl dehydrogenase / 0.774
4gut FADLysine-specific histone demethylase 1B 1 0.771
4a5l FADThioredoxin reductase / 0.769
4gdp FADPolyamine oxidase FMS1 / 0.768
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.767
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.766
3ad9 FADSubunit beta of sarcosine oxidase / 0.764
3ish FADThioredoxin reductase 1.8.1.9 0.762
3ae4 FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.759
1h83 FADPolyamine oxidase 1.5.3.14 0.757
1kif FADD-amino-acid oxidase 1.4.3.3 0.757
3r9u FADThioredoxin reductase / 0.757
1ryi FADGlycine oxidase 1.4.3.19 0.752
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.751
4k5r FADOxygenase / 0.751
3bi5 FADPolyamine oxidase FMS1 / 0.749
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.749
3cuk FADD-amino-acid oxidase 1.4.3.3 0.748
3nlc FADUncharacterized protein / 0.747
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.744
1z6l FADPolyamine oxidase FMS1 / 0.743
2yvf FADFerredoxin reductase / 0.743
2qa1 FADPgaE / 0.742
2yg5 FADPutrescine oxidase / 0.741
3bi2 FADPolyamine oxidase FMS1 / 0.740
3rha FDAPutrescine oxidase / 0.740
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.739
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.739
4up3 FADThioredoxin reductase / 0.739
3ada NADSubunit alpha of sarocosine oxidase / 0.738
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.737
2q0l FADThioredoxin reductase 1.8.1.9 0.737
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.736
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.736
4ysh FADGlycine oxidase / 0.736
2gqw FADFerredoxin reductase / 0.735
2yg3 FADPutrescine oxidase / 0.735
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.735
4opi FDAConserved Archaeal protein / 0.735
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.735
4fwf FADLysine-specific histone demethylase 1B 1 0.734
2gr0 FADFerredoxin reductase / 0.733
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.733
4hb9 FADUncharacterized protein / 0.733
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.731
4jq9 FADDihydrolipoyl dehydrogenase / 0.731
4cnk FADL-amino acid oxidase / 0.730
5j60 FADThioredoxin reductase / 0.730
1cf3 FADGlucose oxidase 1.1.3.4 0.729
1ng4 FADGlycine oxidase 1.4.3.19 0.729
1yy5 FADPolyamine oxidase FMS1 / 0.729
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.728
4guu FA9Lysine-specific histone demethylase 1B 1 0.728
4opg FDAConserved Archaeal protein / 0.728
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.727
1h81 FADPolyamine oxidase 1.5.3.14 0.726
4tm4 FDAKtzI / 0.725
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.724
2whd FADThioredoxin reductase / 0.724
3ka7 FADPutative oxidoreductase / 0.723
4cnj FADL-amino acid oxidase / 0.723
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.723
2yg6 FADPutrescine oxidase / 0.722
3znp FADD-amino-acid oxidase 1.4.3.3 0.722
1joa FADNADH peroxidase 1.11.1.1 0.721
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.721
3atq FDAConserved Archaeal protein / 0.720
3v76 FDAUncharacterized protein / 0.720
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.720
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.719
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.718
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.718
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.718
3lov FADProtoporphyrinogen oxidase / 0.718
4c3x FAD3-ketosteroid dehydrogenase / 0.718
4usr FADMonooxygenase / 0.718
3cnd FADPolyamine oxidase FMS1 / 0.717
3cn8 FADPolyamine oxidase FMS1 / 0.716
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.714
3f8r NAPNADH oxidase/thioredoxin reductase / 0.714
3we0 FADLysine 2-monooxygenase / 0.714
4at0 FADPossible succinate dehydrogenase / 0.714
2yg4 FADPutrescine oxidase / 0.713
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.713
3lad FADDihydrolipoyl dehydrogenase / 0.713
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.713
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.712
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.712
1zk7 FADMercuric reductase 1.16.1.1 0.711
2dw4 FADLysine-specific histone demethylase 1A 1 0.711
3ad9 NADSubunit alpha of sarocosine oxidase / 0.711
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.711
3axb FADPutative oxidoreductase / 0.710
4z26 FADPutative GMC-type oxidoreductase R135 1 0.710
1f8s FADL-amino-acid oxidase 1.4.3.2 0.709
2iw5 FADLysine-specific histone demethylase 1A 1 0.709
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.709
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.709
3kve FADL-amino-acid oxidase / 0.709
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.709
2y48 FADLysine-specific histone demethylase 1A 1 0.708
3kpf FADPolyamine oxidase 1.5.3.14 0.708
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.708
2q0k FADThioredoxin reductase 1.8.1.9 0.707
4gus FADLysine-specific histone demethylase 1B 1 0.707
4yjd FADD-amino-acid oxidase 1.4.3.3 0.707
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.706
2q7v FADThioredoxin reductase / 0.706
2yg7 FADPutrescine oxidase / 0.706
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.706
4wct FADFructosyl amine:oxygen oxidoreductase / 0.706
1c0l FADD-amino-acid oxidase 1.4.3.3 0.705
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.705
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.705
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.705
1trb FADThioredoxin reductase 1.8.1.9 0.704
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.704
3cnt FADPolyamine oxidase FMS1 / 0.703
4mo2 FDAUDP-galactopyranose mutase / 0.703
2tpr FADTrypanothione reductase 1.8.1.12 0.702
2wow FADTrypanothione reductase / 0.702
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.702
4jnq FDAThioredoxin reductase / 0.702
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.701
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.701
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.701
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.700
2gr1 FADFerredoxin reductase / 0.700
4fwj FADLysine-specific histone demethylase 1B 1 0.700
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.699
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.699
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.699
4mo2 FADUDP-galactopyranose mutase / 0.699
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.699
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.698
2iid FADL-amino-acid oxidase 1.4.3.2 0.698
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.698
2yvj FADFerredoxin reductase / 0.697
3cgc FADCoenzyme A disulfide reductase / 0.697
3kpk FADSulfide-quinone reductase / 0.697
4bjz FADProbable salicylate monooxygenase / 0.696
5buk FADFADH2-dependent halogenase / 0.696
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.695
2gr3 FADFerredoxin reductase / 0.694
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.694
4a65 FADThioredoxin reductase / 0.694
4bk2 FADProbable salicylate monooxygenase / 0.694
4dsg FADUncharacterized protein / 0.694
4mih FADPyranose 2-oxidase 1.1.3.10 0.694
4u2t FADCholesterol oxidase 1.1.3.6 0.694
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.693
3qj4 FADRenalase / 0.693
3vqr FADPutative oxidoreductase / 0.693
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.693
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.691
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.691
4opd FDAConserved Archaeal protein / 0.691
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.690
1ng3 FADGlycine oxidase 1.4.3.19 0.690
2rgh FADAlpha-Glycerophosphate Oxidase / 0.690
2xve FADPutative flavin-containing monooxygenase / 0.690
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.690
1k0j FADp-hydroxybenzoate hydroxylase / 0.689
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.689
4xbf FADLysine-specific histone demethylase 1A 1 0.689
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.688
4ccq FADThioredoxin reductase / 0.688
1rsg FADPolyamine oxidase FMS1 / 0.687
1tde FADThioredoxin reductase 1.8.1.9 0.687
1zx9 FADMercuric reductase 1.16.1.1 0.686
3gsi FADDimethylglycine oxidase 1.5.3.10 0.686
3qvr FADGlucose oxidase 1.1.3.4 0.686
1d7y FADFerredoxin reductase / 0.685
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.685
4cbq FADThioredoxin reductase / 0.685
4jn9 FADDepH / 0.685
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.685
1f3p FADFerredoxin reductase / 0.684
2gqf FADUncharacterized protein HI_0933 / 0.684
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.684
3itj FADThioredoxin reductase 1 1.8.1.9 0.684
3m13 FADMonomeric sarcosine oxidase 1.5.3.1 0.684
3urh FADDihydrolipoyl dehydrogenase / 0.684
1f8r FADL-amino-acid oxidase 1.4.3.2 0.683
2bab FADPutative aminooxidase / 0.683
2vvl FADMonoamine oxidase N 1.4.3.4 0.683
3cge FADCoenzyme A disulfide reductase / 0.683
3qvp FADGlucose oxidase 1.1.3.4 0.683
4fwe FADLysine-specific histone demethylase 1B 1 0.683
4k2x FADPolyketide oxygenase/hydroxylase / 0.683
4tlz FADKtzI / 0.683
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
2eq9 FADDihydrolipoyl dehydrogenase / 0.682
4eqw FADCoenzyme A disulfide reductase / 0.682
4ntd FADThioredoxin reductase / 0.682
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.681
3he3 FADUDP-galactopyranose mutase / 0.681
4b63 FADL-ornithine N(5)-monooxygenase / 0.681
4rek FADCholesterol oxidase 1.1.3.6 0.681
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.680
3d8x FADThioredoxin reductase 1 1.8.1.9 0.680
3lsh FADPyranose 2-oxidase / 0.680
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.680
4hsu FADLysine-specific histone demethylase 1B 1 0.680
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.679
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.679
4b69 FADL-ornithine N(5)-monooxygenase / 0.679
1gal FADGlucose oxidase 1.1.3.4 0.678
1ger FADGlutathione reductase 1.8.1.7 0.678
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.678
3b6d FAECholesterol oxidase 1.1.3.6 0.678
4emw FADCoenzyme A disulfide reductase / 0.678
4tm3 FADKtzI / 0.678
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.677
3cty FADProbable thioredoxin reductase / 0.677
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.677
2uxx FAJLysine-specific histone demethylase 1A 1 0.676
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.676
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.676
4gur FADLysine-specific histone demethylase 1B 1 0.676
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.675
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.675
4ynt FDAGlucose oxidase, putative / 0.675
1b4v FADCholesterol oxidase 1.1.3.6 0.674
3ict FADCoenzyme A disulfide reductase / 0.674
4dsh FDAUncharacterized protein / 0.674
4nte FADDepH / 0.674
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.673
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.673
4opc FDAConserved Archaeal protein / 0.673
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.672
2b9x FADPutative aminooxidase / 0.672
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.672
3awi FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC 1.5 0.672
4mok FADPyranose 2-oxidase / 0.672
1xpq FADPolyamine oxidase FMS1 / 0.671
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.671
1nhs FADNADH peroxidase 1.11.1.1 0.670
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.670
3k4c FADPyranose 2-oxidase / 0.670
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.670
5l3d FADLysine-specific histone demethylase 1A 1 0.670
2xvi FADPutative flavin-containing monooxygenase / 0.669
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.669
4uir FADOleate hydratase 4.2.1.53 0.669
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.668
2jb1 FADL-amino acid oxidase / 0.668
3fbs FADOxidoreductase / 0.668
1cl0 FADThioredoxin reductase 1.8.1.9 0.667
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.667
4gcm FADThioredoxin reductase 1.8.1.9 0.667
2xlp FADPutative flavin-containing monooxygenase / 0.666
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.666
4nzh FADL-ornithine N(5)-monooxygenase / 0.666
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.666
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.666
1tdf FADThioredoxin reductase 1.8.1.9 0.665
2eq7 FADDihydrolipoyl dehydrogenase / 0.665
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.665
2rgo FADAlpha-Glycerophosphate Oxidase / 0.665
3lsi FADPyranose 2-oxidase / 0.665
2hko FADLysine-specific histone demethylase 1A 1 0.664
4i58 FADCyclohexylamine Oxidase / 0.664
4ytn FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.664
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.663
2e1m FADL-glutamate oxidase / 0.662
2jb2 FADL-amino acid oxidase / 0.662
4x9n FADUncharacterized protein MG039 homolog / 0.662
1nhq FADNADH peroxidase 1.11.1.1 0.661
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.661
4bk3 FADProbable salicylate monooxygenase / 0.661
4icy FADPgaE / 0.661
2ywl FADThioredoxin reductase related protein / 0.660
3pl8 FADPyranose 2-oxidase / 0.660
3rp8 FADFAD-dependent urate hydroxylase / 0.660
3ukk FADUDP-galactopyranose mutase / 0.660
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
3if9 FADGlycine oxidase 1.4.3.19 0.659
3zdn FADMonoamine oxidase N 1.4.3.4 0.659
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.659
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.658
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.658
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.658
2x8h FADThioredoxin glutathione reductase / 0.658
4opt FDAConserved Archaeal protein / 0.658
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.658
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.657
4hia FMNLOV protein / 0.657
5i39 FADL-amino acid deaminase / 0.657
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.656
2jae FADL-amino acid oxidase / 0.656
3gwd FADCyclohexanone monooxygenase / 0.656
1nhr FADNADH peroxidase 1.11.1.1 0.655
1sez FADProtoporphyrinogen oxidase, mitochondrial 1.3.3.4 0.655
2eq7 NADDihydrolipoyl dehydrogenase / 0.655
3atr FDAConserved Archaeal protein / 0.655
3t2k FADSulfide-quinone reductase / 0.654
4ccr FADThioredoxin reductase / 0.654
2npx FADNADH peroxidase 1.11.1.1 0.653
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.652
2igo FADPyranose 2-oxidase / 0.652
2xls FADPutative flavin-containing monooxygenase / 0.652
3jsk AHZThiamine thiazole synthase / 0.652
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.652
4rsl FADFructosyl peptide oxidase / 0.652
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.651
3k30 ADPHistamine dehydrogenase / 0.651
1cc2 FADCholesterol oxidase 1.1.3.6 0.650
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.650
2eq6 FADDihydrolipoyl dehydrogenase / 0.650
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.650
4eqs FADCoenzyme A disulfide reductase / 0.650