sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4egi | B2J | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4egi | B2J | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 3r4p | FU7 | Heat shock protein HSP 90-alpha | / | 0.670 | |
| 3vha | VHA | Heat shock protein HSP 90-alpha | / | 0.668 | |
| 4b7p | 9UN | Heat shock protein HSP 90-alpha | / | 0.650 | |
| 3r4o | FU3 | Heat shock protein HSP 90-alpha | / | 0.646 | |
| 2xk2 | ADP | Heat shock protein HSP 90-alpha | / | 0.638 | |
| 3t10 | ACP | Heat shock protein HSP 90-alpha | / | 0.635 | |
| 2qg0 | A94 | Heat shock protein HSP 90-alpha | / | 0.632 | |
| 1u0z | RDC | Endoplasmin | / | 0.619 | |
| 2byh | 2D7 | Heat shock protein HSP 90-alpha | / | 0.616 | |
| 1am1 | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.615 | |
| 1yc3 | 4BC | Heat shock protein HSP 90-alpha | / | 0.615 | |
| 2fxs | RDA | ATP-dependent molecular chaperone HSP82 | / | 0.615 | |
| 2yef | ANP | Heat shock protein HSP 90-alpha | / | 0.609 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.607 | |
| 4ce1 | 7FK | ATP-dependent molecular chaperone HSP82 | / | 0.603 | |
| 4gqt | ADP | Heat shock protein 90 | / | 0.602 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.599 | |
| 1osf | KOS | Heat shock protein HSP 90-alpha | / | 0.598 | |
| 2xx2 | 13C | ATP-dependent molecular chaperone HSP82 | / | 0.596 | |
| 4xcj | ADP | Heat shock cognate 90 kDa protein | / | 0.596 | |
| 3t2s | AGS | Heat shock protein HSP 90-alpha | / | 0.592 | |
| 4bqj | XKL | Heat shock protein HSP 90-alpha | / | 0.591 | |
| 3eko | PYU | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.589 | |
| 4as9 | 4QS | ATP-dependent molecular chaperone HSP82 | / | 0.588 | |
| 1ysz | NEC | Endoplasmin | / | 0.587 | |
| 2iwu | NP5 | ATP-dependent molecular chaperone HSP82 | / | 0.587 | |
| 2byi | 2DD | Heat shock protein HSP 90-alpha | / | 0.585 | |
| 2xab | VHD | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 4xdm | GDM | Heat shock cognate 90 kDa protein | / | 0.583 | |
| 1amw | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.582 | |
| 1qy8 | RDI | Endoplasmin | / | 0.582 | |
| 2wep | ADP | ATP-dependent molecular chaperone HSP82 | / | 0.582 | |
| 3k99 | PFT | Heat shock protein HSP 90-alpha | / | 0.581 | |
| 2bre | KJ2 | ATP-dependent molecular chaperone HSP82 | / | 0.578 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 2fyp | RDE | Endoplasmin | / | 0.575 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.574 | |
| 2cgf | P2N | ATP-dependent molecular chaperone HSP82 | / | 0.572 | |
| 4asf | 62U | ATP-dependent molecular chaperone HSP82 | / | 0.572 | |
| 1bgq | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.567 | |
| 3rlr | 3RR | Heat shock protein HSP 90-alpha | / | 0.564 | |
| 4ce2 | BO5 | ATP-dependent molecular chaperone HSP82 | / | 0.564 | |
| 1u2o | NEC | Endoplasmin | / | 0.563 | |
| 2bt0 | CT5 | Heat shock protein HSP 90-alpha | / | 0.563 | |
| 2o1u | ANP | Endoplasmin | / | 0.563 | |
| 3t1k | ANP | Heat shock protein HSP 90-alpha | / | 0.563 | |
| 2bz5 | AB4 | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 2xht | C0Y | Heat shock protein HSP 90-alpha | / | 0.562 | |
| 3rlq | 3RQ | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 3r4n | FU5 | Heat shock protein HSP 90-alpha | / | 0.558 | |
| 3hyz | 42C | Heat shock protein HSP 90-alpha | / | 0.557 | |
| 1yet | GDM | Heat shock protein HSP 90-alpha | / | 0.556 | |
| 2xd6 | XD6 | ATP-dependent molecular chaperone HSP82 | / | 0.556 | |
| 3ied | AN2 | HSP90 | / | 0.556 | |
| 1y4s | ADP | Chaperone protein HtpG | / | 0.553 | |
| 3k97 | 4CD | Heat shock protein HSP 90-alpha | / | 0.553 | |
| 4xcl | AGS | Heat shock cognate 90 kDa protein | / | 0.553 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.551 | |
| 2brc | CT5 | ATP-dependent molecular chaperone HSP82 | / | 0.551 | |
| 1byq | ADP | Heat shock protein HSP 90-alpha | / | 0.546 | |
| 3t0z | ATP | Heat shock protein HSP 90-alpha | / | 0.545 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 3b28 | B2X | Heat shock protein HSP 90-alpha | / | 0.542 | |
| 2xx4 | 13I | ATP-dependent molecular chaperone HSP82 | / | 0.541 | |
| 4ipe | ANP | TNF receptor-associated protein 1 | / | 0.540 | |
| 2xcm | ADP | Cytosolic heat shock protein 90 | / | 0.538 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.538 | |
| 4ivg | ANP | TNF receptor-associated protein 1 | / | 0.538 | |
| 3rlp | 3RP | Heat shock protein HSP 90-alpha | / | 0.536 | |
| 5f5r | ANP | Heat shock protein 75 kDa, mitochondrial | / | 0.536 | |
| 2wi6 | ZZ6 | Heat shock protein HSP 90-alpha | / | 0.535 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.532 | |
| 1yc1 | 4BC | Heat shock protein HSP 90-alpha | / | 0.531 | |
| 3k98 | 1RC | Heat shock protein HSP 90-alpha | / | 0.530 | |
| 4asg | 814 | ATP-dependent molecular chaperone HSP82 | / | 0.530 | |
| 3wha | WHA | Heat shock protein HSP 90-alpha | / | 0.529 | |
| 2iwx | M1S | ATP-dependent molecular chaperone HSP82 | / | 0.528 | |
| 1u0y | PA7 | Endoplasmin | / | 0.527 | |
| 4ce3 | L4V | ATP-dependent molecular chaperone HSP82 | / | 0.527 | |
| 2exl | GDM | Endoplasmin | / | 0.526 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.525 | |
| 2gqp | PA7 | Endoplasmin | / | 0.524 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.523 | |
| 2ior | ADP | Chaperone protein HtpG | / | 0.523 | |
| 2wer | RDC | ATP-dependent molecular chaperone HSP82 | / | 0.523 | |
| 2qfo | A13 | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.517 | |
| 2vwc | BC2 | ATP-dependent molecular chaperone HSP82 | / | 0.516 | |
| 2xjj | L81 | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.516 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.515 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.514 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.513 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.512 | |
| 2o1v | ADP | Endoplasmin | / | 0.509 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 2xjx | XJX | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.509 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.508 | |
| 1qy5 | NEC | Endoplasmin | / | 0.507 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.506 | |
| 3peh | IBD | Endoplasmin homolog, putative | / | 0.506 | |
| 2gfd | RDA | Endoplasmin | / | 0.505 | |
| 2hg1 | N5O | Endoplasmin | / | 0.505 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2ye4 | 2FY | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.504 | |
| 2esa | GDM | Endoplasmin | / | 0.501 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 3hz1 | 42C | Heat shock protein HSP 90-alpha | / | 0.500 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.499 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 4egk | RDC | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 2yi5 | YI5 | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.497 | |
| 4xc0 | ACP | Heat shock cognate 90 kDa protein | / | 0.497 | |
| 2wi5 | ZZ5 | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.496 | |
| 1i5c | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.495 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.495 | |
| 2zdy | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.493 | |
| 3c11 | GDM | ATP-dependent molecular chaperone HSP82 | / | 0.493 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.492 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.492 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.491 | |
| 2hch | N5A | Endoplasmin | / | 0.490 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 1i58 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.489 | |
| 1gjv | AGS | [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial | 2.7.11.4 | 0.488 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.488 | |
| 2bsm | BSM | Heat shock protein HSP 90-alpha | / | 0.486 | |
| 2bu8 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.485 | |
| 3d2r | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.485 | |
| 1yt0 | ADP | Endoplasmin | / | 0.484 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.482 | |
| 2yec | XQ0 | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.482 | |
| 2wi1 | ZZ2 | Heat shock protein HSP 90-alpha | / | 0.481 | |
| 2zdx | P4A | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.481 | |
| 2e0a | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.480 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.477 | |
| 2vci | 2GJ | Heat shock protein HSP 90-alpha | / | 0.475 | |
| 3u8k | 09P | Acetylcholine-binding protein | / | 0.475 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.475 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.475 | |
| 3pej | BC2 | Endoplasmin homolog, putative | / | 0.474 | |
| 2vcj | 2EQ | Heat shock protein HSP 90-alpha | / | 0.473 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 4egh | 0OY | Heat shock protein HSP 90-alpha | / | 0.471 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.470 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 2uwd | 2GG | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 4dpu | AGS | Mevalonate diphosphate decarboxylase | / | 0.470 | |
| 4fcq | 2N6 | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.469 | |
| 2yjw | YJW | Heat shock protein HSP 90-alpha | / | 0.469 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.468 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.467 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.467 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.466 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 3crl | ANP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.465 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.465 | |
| 4oae | CLM | Uncharacterized protein | / | 0.465 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.464 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.464 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.464 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.463 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 1x8v | ESL | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.462 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.462 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.461 | |
| 2wi2 | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 2zkj | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial | 2.7.11.2 | 0.461 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.461 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 3ft5 | MO8 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.461 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.461 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.461 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.461 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.460 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.460 | |
| 1jm6 | ADP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.459 | |
| 2xx5 | 13N | ATP-dependent molecular chaperone HSP82 | / | 0.459 | |
| 2yi7 | BZ8 | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.459 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.458 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.457 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.457 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.456 | |
| 1yjq | NAP | 2-dehydropantoate 2-reductase | 1.1.1.169 | 0.456 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.456 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.456 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.455 | |
| 2vww | 7X2 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.455 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.454 | |
| 2mwg | FMN | Blue-light photoreceptor | / | 0.454 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.454 | |
| 3cgc | COA | Coenzyme A disulfide reductase | / | 0.454 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.454 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 3cgd | COA | Coenzyme A disulfide reductase | / | 0.453 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.453 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 4r1f | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.453 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.452 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.452 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 2eau | CZA | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 2xhx | T5M | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.452 | |
| 4u8i | FDA | UDP-galactopyranose mutase | / | 0.452 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.452 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.451 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.451 | |
| 4xiv | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.451 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.450 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.450 | |
| 2bu2 | ATP | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial | 2.7.11.2 | 0.450 | |
| 2xh9 | J01 | Uncharacterized protein | / | 0.450 | |
| 1bif | AGS | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 | 2.7.1.105 | 0.449 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.449 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.449 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.449 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 2bxm | IMN | Serum albumin | / | 0.448 | |
| 3eyh | IZA | Tyrosine-protein kinase JAK1 | / | 0.448 | |
| 3hx4 | ANP | Calmodulin-domain protein kinase 1 | / | 0.448 | |
| 3iw1 | ASD | Steroid C26-monooxygenase | 1.14.13.141 | 0.448 | |
| 4hj6 | FMN | LOV protein | / | 0.448 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.448 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1xny | 191 | Propionyl-CoA carboxylase complex B subunit | / | 0.447 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.447 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.447 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4gll | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.447 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.447 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.447 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.446 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.446 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.446 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.446 | |
| 2c3l | IDZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.446 | |
| 4ku2 | MYA | 3-oxoacyl-[ACP] synthase III | / | 0.446 | |
| 1h7u | AGS | Mismatch repair endonuclease PMS2 | 3.1 | 0.445 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.445 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.444 | |
| 3abi | NAD | Uncharacterized protein | / | 0.444 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.444 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.444 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.444 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.444 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.444 | |
| 1mwm | ADP | Plasmid segregation protein ParM | / | 0.443 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 3cge | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.443 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.443 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 4ok1 | 198 | Androgen receptor | / | 0.443 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.442 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.442 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.442 | |
| 4b4o | NDP | Epimerase family protein SDR39U1 | / | 0.442 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.442 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.442 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.442 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.442 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.442 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 1a8p | FAD | Ferredoxin--NADP reductase | / | 0.441 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.441 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.441 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.441 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.441 | |
| 3dmg | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.441 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3w1q | YRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.441 | |
| 4fv8 | E63 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1c1d | NAI | Phenylalanine dehydrogenase | / | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.440 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.440 | |
| 1o94 | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.440 | |
| 1vsv | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.440 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.440 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.440 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.440 | |
| 3sc1 | 3S1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 3uib | SB2 | Putative mitogen-activated protein kinase | / | 0.440 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.440 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.440 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |