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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2puiADPMethylthioribose kinase2.7.1.100

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2puiADPMethylthioribose kinase2.7.1.1001.000
2pupADPMethylthioribose kinase2.7.1.1000.685
2pulACPMethylthioribose kinase2.7.1.1000.638
2punACPMethylthioribose kinase2.7.1.1000.531
2olcADPMethylthioribose kinase2.7.1.1000.526
1x8b824Wee1-like protein kinase2.7.10.20.518
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.511
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.508
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.502
5iqiGNPBifunctional AAC/APH2.3.10.498
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.497
3qly55VUncharacterized protein/0.497
3iw1ASDSteroid C26-monooxygenase1.14.13.1410.496
4gncASORegucalcin3.1.1.170.495
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.493
2pywADPMethylthioribose kinase2.7.1.1000.491
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.490
2bkkADPAminoglycoside 3'-phosphotransferase2.7.1.950.490
3nksACJProtoporphyrinogen oxidase1.3.3.40.490
4ele31IDihydrofolate reductase/0.489
3qlxQLRUncharacterized protein/0.488
3eej53RUncharacterized protein/0.487
2z2w770Wee1-like protein kinase2.7.10.20.486
3eem53VUncharacterized protein/0.486
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.486
3bi6396Wee1-like protein kinase2.7.10.20.485
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.484
4tx9AMZPhosphoribosyl isomerase A/0.484
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.483
3fl8RARDihydrofolate reductase/0.480
3oroAGSSerine/threonine protein kinase/0.479
3ortAGSSerine/threonine protein kinase/0.479
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.478
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.478
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.478
3wowANPCasein kinase II subunit alpha2.7.11.10.477
1dr5NAPDihydrofolate reductase1.5.1.30.476
5iqaGNPBifunctional AAC/APH2.3.10.476
5iqdGNPBifunctional AAC/APH2.3.10.476
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.475
1qknRALEstrogen receptor beta/0.474
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.474
4yekTHMThymidine phosphorylase/0.474
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.473
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.472
3s7a684Dihydrofolate reductase1.5.1.30.472
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.471
2wufKEM4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.471
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.470
2bxmIMNSerum albumin/0.470
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.469
3p74FMNPentaerythritol tetranitrate reductase/0.469
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.469
3reoEUG(Iso)eugenol O-methyltransferase2.1.1.1460.469
4crsAGSSerine/threonine-protein kinase N22.7.11.130.469
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.468
1kmsLIHDihydrofolate reductase1.5.1.30.468
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.468
3uzcT4EAdenosine receptor A2a/0.468
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.467
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.467
3nmpPYVAbscisic acid receptor PYL2/0.467
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.467
2j0vGDPRac-like GTP-binding protein ARAC7/0.466
2wugHPK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.466
3tkyN7I(Iso)eugenol O-methyltransferase2.1.1.1460.466
3pwhZMAAdenosine receptor A2a/0.466
2pmdGNPTranslation initiation factor 2 subunit gamma/0.465
3datMTXDihydrofolate reductase/0.465
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.465
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.465
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.464
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
4oavACP2-5A-dependent ribonuclease3.1.260.464
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.463
2gjlFMNNitronate monooxygenase1.13.12.160.463
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
1kmvLIIDihydrofolate reductase1.5.1.30.462
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.462
2ejvNADL-threonine 3-dehydrogenase/0.462
2rqfJH3Hemolymph juvenile hormone binding protein/0.462
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.462
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.462
3tm0ANPAminoglycoside 3'-phosphotransferase2.7.1.950.462
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.462
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4bfrJ82Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform2.7.1.1530.462
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4j6dTESCytochrome P450 monooxygenase/0.462
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
1cqp803Integrin alpha-L/0.461
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.461
1dr3TAPDihydrofolate reductase1.5.1.30.461
1rx8NAPDihydrofolate reductase1.5.1.30.461
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
3tk3CPZCytochrome P450 2B41.14.14.10.461
3vrwYS5Vitamin D3 receptor/0.461
4n57ADPAPH(2'')-Id/0.461
5iqhGNPBifunctional AAC/APH2.3.10.461
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2aclREARetinoic acid receptor RXR-alpha/0.460
2fziDH3Dihydrofolate reductase1.5.1.30.460
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
3lu7IPXSerum albumin/0.460
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
4ib4ERM5-hydroxytryptamine receptor 2B/0.460
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
1dr3HBIDihydrofolate reductase1.5.1.30.459
1hfqMOTDihydrofolate reductase1.5.1.30.459
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.459
3junAJDPhenazine biosynthesis protein A/B/0.459
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.459
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.459
4lfiGNPCasein kinase II subunit alpha2.7.11.10.459
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.458
3igoANPCalmodulin-domain protein kinase 1, putative/0.458
3nr4PYVAbscisic acid receptor PYL2/0.458
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4kcfAKMFAD-dependent oxidoreductase/0.458
4nmbFADBifunctional protein PutA/0.458
3uzaT4GAdenosine receptor A2a/0.458
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1yqj6NPMitogen-activated protein kinase 14/0.457
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2in6839Wee1-like protein kinase2.7.10.20.457
2vcmM11Isopenicillin N synthase1.21.3.10.457
3b9lAZZSerum albumin/0.457
3u8hBHPPhospholipase A2, membrane associated/0.457
3zlmANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.457
4elf35IDihydrofolate reductase/0.457
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.457
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
5iqeGNPBifunctional AAC/APH2.3.10.457
5k2aZMAAdenosine receptor A2a/0.457
5jtbZMAAdenosine receptor A2a/0.457
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.456
3cgfJNFMitogen-activated protein kinase 102.7.11.240.456
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.456
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4j6cSTRCytochrome P450 monooxygenase/0.456
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.456
5k2cZMAAdenosine receptor A2a/0.456
2dt5NADRedox-sensing transcriptional repressor Rex/0.455
2ok7FADFerredoxin--NADP reductase, apicoplast/0.455
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.455
3nj0PYVAbscisic acid receptor PYL2/0.455
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.455
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
3emlZMAAdenosine receptor A2a/0.455
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
1cd2FOLDihydrofolate reductase1.5.1.30.454
1j7lADPAminoglycoside 3'-phosphotransferase2.7.1.950.454
1xkdNAPIsocitrate dehydrogenase [NADP]/0.454
2dcnADP2-keto-3-deoxy-gluconate kinase/0.454
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
3cseN22Uncharacterized protein/0.454
4fweFADLysine-specific histone demethylase 1B10.454
4g1z0VPVitamin D3 receptor A/0.454
5ab6CAANonspecific lipid-transfer protein, putative/0.454
1qoqIGPTryptophan synthase alpha chain/0.453
2bakAQZMitogen-activated protein kinase 14/0.453
2hw2RFPRifampin ADP-ribosyl transferase/0.453
2vssACOHydroxycinnamoyl-CoA hydratase-lyase4.1.2.410.453
3bgxMEFThymidylate synthase/0.453
3d84NDPDihydrofolate reductase1.5.1.30.453
3ft8MOJHeat shock protein HSP 90-alpha/0.453
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
3oafOAGDihydrofolate reductase1.5.1.30.453
3oriAGSSerine/threonine protein kinase/0.453
4a9yAQZMitogen-activated protein kinase 14/0.453
4g95OAGDihydrofolate reductase1.5.1.30.453
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.453
5iubCLRAdenosine receptor A2a/0.453
1pkfEPDEpothilone C/D epoxidase1.140.452
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2fzhDH1Dihydrofolate reductase1.5.1.30.452
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.452
2xvw9NRSerum albumin/0.452
3bgxTMPThymidylate synthase/0.452
4elb34SDihydrofolate reductase/0.452
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4gg70J8Hepatocyte growth factor receptor2.7.10.10.452
4h9753SDihydrofolate reductase1.5.1.30.452
4jlm1NNDeoxycytidine kinase2.7.1.740.452
5bylGCPBifunctional AAC/APH2.3.10.452
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
2wo7ASVIsopenicillin N synthase1.21.3.10.451
2xvv9DNSerum albumin/0.451
3dds26BGlycogen phosphorylase, liver form2.4.1.10.451
3eel53TUncharacterized protein/0.451
3ix9MTXDihydrofolate reductase1.5.1.30.451
3q2mCKISpectinomycin phosphotransferase/0.451
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.451
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4eevL1XHepatocyte growth factor receptor2.7.10.10.451
4j6bPLOCytochrome P450 monooxygenase/0.451
4k33ACPFibroblast growth factor receptor 32.7.10.10.451
4m2xTMQDihydrofolate reductase1.5.1.30.451
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.451
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2blcCP7Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
2xk3XK3Serine/threonine-protein kinase Nek22.7.11.10.450
2zzaFOLDihydrofolate reductase/0.450
3ansS38Bifunctional epoxide hydrolase 23.3.2.100.450
3gc9B45Mitogen-activated protein kinase 112.7.11.240.450
3lfcZ86Mitogen-activated protein kinase 14/0.450
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.450
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.450
4fryNADPutative signal-transduction protein with CBS domains/0.450
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4ix5ANPUncharacterized protein/0.450
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.450
4orkGDPBifunctional AAC/APH2.3.10.450
1ci7UMPThymidylate synthase2.1.1.450.449
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.449
1u1f183Uridine phosphorylase2.4.2.30.449
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.449
3qftNAPNADPH--cytochrome P450 reductase/0.449
3t3q9PLCytochrome P450 2A61.14.130.449
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4cukNAID-lactate dehydrogenase/0.449
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
5kghACOPredicted acetyltransferase/0.449
1efaNPFLactose operon repressor/0.448
1ewyFADFerredoxin--NADP reductase1.18.1.20.448
1ir3ANPInsulin receptor2.7.10.10.448
1qjfACSIsopenicillin N synthase1.21.3.10.448
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2g78REACellular retinoic acid-binding protein 2/0.448
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
3a783EVVitamin D3 receptor/0.448
3ae4FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.448
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.448
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
3vqvANPPyrrolysine--tRNA ligase/0.448
3vx4ATPPutative ABC transporter, ATP-binding protein ComA/0.448
4dc0NDPPutative ketoacyl reductase1.3.10.448
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
4elg52JDihydrofolate reductase/0.448
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.448
4gg50J3Hepatocyte growth factor receptor2.7.10.10.448
4i6gFADCryptochrome-2/0.448
4lrjANPUncharacterized protein/0.448
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.447
1suoCPZCytochrome P450 2B41.14.14.10.447
1tysTMPThymidylate synthase/0.447
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.447
2hk9NAPShikimate dehydrogenase (NADP(+))/0.447
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.447
2x86ADPADP-L-glycero-D-manno-heptose-6-epimerase/0.447
3a4pDFQHepatocyte growth factor receptor2.7.10.10.447
3eek53SUncharacterized protein/0.447
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3nxxNDPDihydrofolate reductase1.5.1.30.447
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3qlwN22Dihydrofolate reductase1.5.1.30.447
3zoiM2WIsopenicillin N synthase1.21.3.10.447
4a86H35Major pollen allergen Bet v 1-A/0.447
4gyiADPUncharacterized protein/0.447
4ia7BIVVitamin D3 receptor A/0.447
4tyj0LIFibroblast growth factor receptor 42.7.10.10.447
5k2bZMAAdenosine receptor A2a/0.447
1al7HSTPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.446
1ia3TQ5Dihydrofolate reductase1.5.1.30.446
1ia9ANPTransient receptor potential cation channel subfamily M member 72.7.11.10.446
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
1xu9CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2imkGTXAGAP009194-PA/0.446
2nnqT4BFatty acid-binding protein, adipocyte/0.446
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.446
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.446
3hz142CHeat shock protein HSP 90-alpha/0.446
3ictADPCoenzyme A disulfide reductase/0.446
3l0lHC3Nuclear receptor ROR-gamma/0.446
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4ie0PD2Alpha-ketoglutarate-dependent dioxygenase FTO/0.446
4itmATPTetraacyldisaccharide 4'-kinase/0.446
1aoeGW3Dihydrofolate reductase1.5.1.30.445
1f5fDHTSex hormone-binding globulin/0.445
1tduCB3Thymidylate synthase/0.445
1z6lFADPolyamine oxidase FMS1/0.445
2ociTYCValacyclovir hydrolase3.10.445
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.445
2v1aFMNNPH1-1/0.445
4b8uIBK3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.445
4o1mNADEnoyl-acyl carrier reductase/0.445
4yau2AMNADPH--cytochrome P450 reductase/0.445
5iqbGNPBifunctional AAC/APH2.3.10.445
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
1wpgADPSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2bl9CP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.444
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
3m9vTYDFAD-dependent oxidoreductase/0.444
3opdHIEHeat shock protein 83/0.444
3qlsNDPDihydrofolate reductase1.5.1.30.444
3rr3FLRProstaglandin G/H synthase 21.14.99.10.444
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.444
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.444
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.444
4h1e10JBeta-secretase 13.4.23.460.444
4jpe1M7Beta-secretase 13.4.23.460.444
4ku2MYA3-oxoacyl-[ACP] synthase III/0.444
4l9q9TPSerum albumin/0.444
4r20AERCytochrome P450 family 17 polypeptide 2/0.444
5eccNAPDehydrofolate reductase type I/0.444
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.443
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
2pauD5M5'-deoxynucleotidase YfbR/0.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.443
3d5wADPSerine/threonine-protein kinase PLK/0.443
3hziATPSerine/threonine-protein kinase toxin HipA/0.443
3koo24DBifunctional epoxide hydrolase 23.3.2.100.443
3pdtADPMyosin heavy chain kinase A2.7.11.70.443
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.443
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.443
3w5rLOAVitamin D3 receptor/0.443
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.443
4b0532DBeta-secretase 13.4.23.460.443
4djw0KPBeta-secretase 13.4.23.460.443
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.443
4zmeADNMyosin heavy chain kinase A2.7.11.70.443
5hi6MTXDihydrofolate reductase/0.443
1fm4DXCMajor pollen allergen Bet v 1-L/0.442
1h8hADPATP synthase subunit alpha, mitochondrial/0.442
1h8hADPATP synthase subunit beta, mitochondrial3.6.3.140.442
1nzdUPGDNA beta-glucosyltransferase/0.442
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.442
1tdrMTXDihydrofolate reductase1.5.1.30.442
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.442
2yee2ECHeat shock protein HSP 90-alpha/0.442
3um61CYBifunctional dihydrofolate reductase-thymidylate synthase/0.442
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.442
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4qmlANPSerine/threonine-protein kinase 242.7.11.10.442
4rnvFMNNADPH dehydrogenase 11.6.99.10.442
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.442
5bn4ANPV-type ATP synthase alpha chain/0.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1jioDEB6-deoxyerythronolide B hydroxylase/0.441
1kquBR4Phospholipase A2, membrane associated/0.441
1lp4ANPCasein kinase II subunit alpha2.7.11.10.441
1n4hREANuclear receptor ROR-beta/0.441
1nytNAPShikimate dehydrogenase (NADP(+))/0.441
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.441
2bxqIMNSerum albumin/0.441
2gvcFADThiol-specific monooxygenase1.14.130.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
2jblSMAReaction center protein L chain/0.441
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.441
2pujHPZ2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase3.7.1.80.441
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.441
2ykeYKEHeat shock protein HSP 90-alpha/0.441
3h4vDVPPteridine reductase 11.5.1.330.441
3hz137DHeat shock protein HSP 90-alpha/0.441
3kjsDQ1Bifunctional dihydrofolate reductase-thymidylate synthase/0.441
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4equG6ISerine/threonine-protein kinase 102.7.11.10.441
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.441
4yaf2AMNADPH--cytochrome P450 reductase/0.441
5uviZMAAdenosine receptor A2a/0.441
1pd9CO4Dihydrofolate reductase1.5.1.30.440
1w06W05Isopenicillin N synthase1.21.3.10.440
1zydATPeIF-2-alpha kinase GCN2/0.440
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2gr1FADFerredoxin reductase/0.440
2xh9J01Uncharacterized protein/0.440
2yg4FADPutrescine oxidase/0.440
2z6iFMN2-nitropropane dioxygenase/0.440
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3jwm5WBDihydrofolate reductase/0.440
3lkiATPFructokinase/0.440
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
4btjADPTau-tubulin kinase 12.7.11.10.440
4cdmFO1Deoxyribodipyrimidine photolyase/0.440
4jbtASDCytochrome P450 monooxygenase/0.440
4jlj1NMDeoxycytidine kinase2.7.1.740.440
4jrnANPRhoptry kinase family protein/0.440
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.440
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.440