sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 1.000 | |
| 2p1v | 5TN | Retinoic acid receptor RXR-alpha | / | 0.765 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.614 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.614 | |
| 1k74 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.598 | |
| 1fby | REA | Retinoic acid receptor RXR-alpha | / | 0.596 | |
| 3fc6 | REA | Retinoic acid receptor RXR-alpha | / | 0.595 | |
| 1xiu | REA | Retinoic acid receptor RXR | / | 0.594 | |
| 3uvv | REA | Retinoic acid receptor RXR-alpha | / | 0.592 | |
| 1mzn | BM6 | Retinoic acid receptor RXR-alpha | / | 0.589 | |
| 4m8e | 29V | Retinoic acid receptor RXR-alpha | / | 0.588 | |
| 1fm9 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.585 | |
| 1fm6 | 9CR | Retinoic acid receptor RXR-alpha | / | 0.584 | |
| 4k4j | 1O8 | Retinoic acid receptor RXR-alpha | / | 0.584 | |
| 4k6i | 9RA | Retinoic acid receptor RXR-alpha | / | 0.583 | |
| 4m8h | R4M | Retinoic acid receptor RXR-alpha | / | 0.575 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.574 | |
| 3oap | REA | Retinoic acid receptor RXR-alpha | / | 0.570 | |
| 1xls | REA | Retinoic acid receptor RXR-alpha | / | 0.567 | |
| 1mvc | BM6 | Retinoic acid receptor RXR-alpha | / | 0.564 | |
| 2acl | REA | Retinoic acid receptor RXR-alpha | / | 0.564 | |
| 3fal | REA | Retinoic acid receptor RXR-alpha | / | 0.553 | |
| 2bxq | IMN | Serum albumin | / | 0.512 | |
| 1ppj | ANY | Cytochrome b | / | 0.503 | |
| 2xvv | 9DN | Serum albumin | / | 0.500 | |
| 3p9t | TCL | Repressor | / | 0.496 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.496 | |
| 3cz0 | 9OD | Pheromone-binding protein ASP1 | / | 0.495 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.488 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.486 | |
| 3d78 | NBB | Pheromone-binding protein ASP1 | / | 0.485 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.484 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.483 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.482 | |
| 4iw8 | KN3 | Estrogen receptor | / | 0.481 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.480 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 2p15 | EZT | Estrogen receptor | / | 0.479 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.479 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.479 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.478 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.477 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.476 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2wpw | ACO | Orf14 | / | 0.475 | |
| 3b9l | AZZ | Serum albumin | / | 0.475 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.474 | |
| 3d74 | NBB | Pheromone-binding protein ASP1 | / | 0.474 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.473 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.473 | |
| 3bfa | 9OD | Odorant binding protein ASP1 | / | 0.472 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.472 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.471 | |
| 2xvw | 9NR | Serum albumin | / | 0.471 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.471 | |
| 3h0a | 9RA | Retinoic acid receptor RXR-alpha | / | 0.471 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.470 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.470 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.470 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.470 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.470 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.470 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.468 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.468 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.468 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.468 | |
| 1e7a | PFL | Serum albumin | / | 0.467 | |
| 1s3y | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 2ewp | TXF | Estrogen-related receptor gamma | / | 0.467 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.467 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.467 | |
| 4e6a | 0O9 | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.466 | |
| 3kr6 | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.466 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.465 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.465 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.464 | |
| 2bxm | IMN | Serum albumin | / | 0.464 | |
| 2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.464 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.464 | |
| 3qg2 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.464 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.464 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.464 | |
| 1ai9 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1ykd | CMP | Adenylate cyclase | / | 0.463 | |
| 2acw | UPG | Glycosyltransferase | / | 0.463 | |
| 3up0 | D7S | aceDAF-12 | / | 0.463 | |
| 4gg7 | 0J8 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.463 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.462 | |
| 3d77 | NBB | Pheromone-binding protein ASP1 | / | 0.462 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.462 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.462 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.461 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.461 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.461 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.461 | |
| 3sp9 | IL2 | Peroxisome proliferator-activated receptor delta | / | 0.461 | |
| 4zju | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.461 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.461 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.460 | |
| 4bii | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.460 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.460 | |
| 4zqc | F6F | Tryptophan synthase alpha chain | / | 0.460 | |
| 1osv | CHC | Bile acid receptor | / | 0.459 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.459 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.459 | |
| 3reo | EUG | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.459 | |
| 4apu | A2K | Progesterone receptor | / | 0.459 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2uxi | G50 | HTH-type transcriptional regulator TtgR | / | 0.458 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.458 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.458 | |
| 4h96 | 14Q | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 5akk | 1P8 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.458 | |
| 1fm7 | DFV | Chalcone--flavonone isomerase 1 | 5.5.1.6 | 0.457 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.457 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.457 | |
| 2dw4 | FAD | Lysine-specific histone demethylase 1A | 1 | 0.457 | |
| 2h9i | EAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.457 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 4bmp | FMN | Protein NrdI | / | 0.457 | |
| 4hu1 | V13 | Carbonic anhydrase 13 | 4.2.1.1 | 0.457 | |
| 5ai5 | BSU | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.457 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.457 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3ans | S38 | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.456 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.456 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.456 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.456 | |
| 4g1y | 0VO | Vitamin D3 receptor A | / | 0.456 | |
| 4iah | 1DX | Alr2278 protein | / | 0.456 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.456 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.456 | |
| 1l2j | ETC | Estrogen receptor beta | / | 0.455 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.455 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.455 | |
| 2g2h | P16 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.455 | |
| 2qd5 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.455 | |
| 3pe6 | ZYH | Monoglyceride lipase | / | 0.455 | |
| 3qly | 55V | Uncharacterized protein | / | 0.455 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.455 | |
| 1j3j | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.454 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.454 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.454 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.454 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 4bqp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 4hee | 14R | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.454 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.453 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1tg5 | 645 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.453 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2o4r | VD5 | Vitamin D3 receptor | / | 0.453 | |
| 3dol | GWI | Pol protein | / | 0.453 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.453 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.453 | |
| 5doz | NDP | JamJ | / | 0.453 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.453 | |
| 1fko | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.452 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.452 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.452 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.452 | |
| 3ar7 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.452 | |
| 3q0g | BCO | Probable enoyl-CoA hydratase echA8 | 4.2.1.17 | 0.452 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.452 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.452 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.452 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.451 | |
| 1lso | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.451 | |
| 1rf7 | DHF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2bxo | OPB | Serum albumin | / | 0.451 | |
| 2pnu | ENM | Androgen receptor | / | 0.451 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.451 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.451 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.451 | |
| 4g48 | PZB | Mycocyclosin synthase | 1.14.21.9 | 0.451 | |
| 4xoi | GTP | Transforming protein RhoA | / | 0.451 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.450 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 1zdw | FLV | Prenyltransferase | / | 0.450 | |
| 2ij7 | TPF | Mycocyclosin synthase | 1.14.21.9 | 0.450 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.450 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.450 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.450 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4iae | 1DX | Alr2278 protein | / | 0.450 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.450 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.450 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.449 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.449 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3cse | N22 | Uncharacterized protein | / | 0.449 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4pkl | 1GH | Uncharacterized protein | / | 0.449 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.449 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.448 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.448 | |
| 3a3y | OBN | Sodium/potassium-transporting ATPase subunit alpha | / | 0.448 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 3dok | GWJ | Pol protein | / | 0.448 | |
| 3gbk | 2PQ | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 3lkh | LT6 | Genome polyprotein | 2.7.7.48 | 0.448 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.448 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.448 | |
| 4g47 | TZF | Mycocyclosin synthase | 1.14.21.9 | 0.448 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.448 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 1ppj | SMA | Cytochrome b | / | 0.447 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.447 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.447 | |
| 3qj5 | 022 | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.447 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.447 | |
| 3zze | 6XP | Hepatocyte growth factor receptor | 2.7.10.1 | 0.447 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.447 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.447 | |
| 3uza | T4G | Adenosine receptor A2a | / | 0.447 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.446 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.446 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.446 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2ydo | ADN | Adenosine receptor A2a | / | 0.446 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.446 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.446 | |
| 3w5t | LHP | Vitamin D3 receptor | / | 0.446 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.446 | |
| 4i0s | 1B5 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.446 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.446 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.446 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.445 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.445 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.445 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.445 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.445 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.445 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.445 | |
| 4egn | TWO | Cytochrome P450 | / | 0.445 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.445 | |
| 5d7p | OCZ | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 1eio | GCH | Gastrotropin | / | 0.444 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.444 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.444 | |
| 1l0l | FMX | Cytochrome b | / | 0.444 | |
| 1xdu | SFG | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.444 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2a19 | ANP | Interferon-induced, double-stranded RNA-activated protein kinase | 2.7.11.1 | 0.444 | |
| 2aqi | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.444 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.444 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.444 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.444 | |
| 2xk8 | 5R1 | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.444 | |
| 3exn | ACO | Probable acetyltransferase | / | 0.444 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3qaq | QAQ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.444 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.444 | |
| 4iui | 1GQ | Estrogen receptor | / | 0.444 | |
| 4k4f | K4F | Tankyrase-1 | 2.4.2.30 | 0.444 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.444 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.444 | |
| 4xsr | UPG | Alr3699 protein | / | 0.444 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.444 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.444 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.444 | |
| 1flm | FMN | FMN-binding protein | / | 0.443 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1wrl | TFP | Troponin C, slow skeletal and cardiac muscles | / | 0.443 | |
| 1zc3 | GNP | Ras-related protein Ral-A | / | 0.443 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.443 | |
| 2hko | FAD | Lysine-specific histone demethylase 1A | 1 | 0.443 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.443 | |
| 2npn | SAM | Putative cobalamin synthesis related protein | / | 0.443 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.443 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.443 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.443 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3elm | 24F | Collagenase 3 | 3.4.24 | 0.443 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.443 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.443 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3zv6 | 4HB | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.443 | |
| 4c71 | 7RD | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.443 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 4gue | QCT | Ribosomal protein S6 kinase alpha-3 | 2.7.11.1 | 0.443 | |
| 4h4o | 506 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.443 | |
| 4m2x | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4xym | COA | Acyl-CoA synthetase (NDP forming) | / | 0.443 | |
| 1hvi | A77 | Protease | / | 0.442 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.442 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2fgk | ATP | Alpha-hemolysin translocation ATP-binding protein HlyB | / | 0.442 | |
| 2nv6 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.442 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3cyz | 9OD | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3nx4 | NAP | Putative oxidoreductase | / | 0.442 | |
| 3pld | F90 | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 3pm0 | BHF | Cytochrome P450 1B1 | / | 0.442 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.442 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.442 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.442 | |
| 4a2j | AS0 | Progesterone receptor | / | 0.442 | |
| 4dsc | A8S | Abscisic acid receptor PYL3 | / | 0.442 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.442 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.442 | |
| 5je2 | SAH | Methyl transferase | / | 0.442 | |
| 1a4i | NDP | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.441 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1d3h | A26 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.441 | |
| 1dif | A85 | Gag-Pol polyprotein | / | 0.441 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1ikv | EFZ | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1pp9 | SMA | Cytochrome b | / | 0.441 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 2ji9 | TPW | Oxalyl-CoA decarboxylase | 4.1.1.8 | 0.441 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.441 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 3bgi | SAH | Thiopurine S-methyltransferase | 2.1.1.67 | 0.441 | |
| 3bjh | NBB | Odorant binding protein ASP1 | / | 0.441 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3d4p | NAD | L-lactate dehydrogenase 1 | 1.1.1.27 | 0.441 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.441 | |
| 3l1s | Z92 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.441 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.441 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.441 | |
| 3um6 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.441 | |
| 3v1s | 0LH | Strictosidine synthase | 4.3.3.2 | 0.441 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.440 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.440 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.440 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.440 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.440 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.440 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.440 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.440 | |
| 3nmh | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3nxe | 2NC | Protease | / | 0.440 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.440 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.440 | |
| 3tky | N7I | (Iso)eugenol O-methyltransferase | 2.1.1.146 | 0.440 | |
| 3um5 | CP6 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.440 | |
| 3w5p | 4OA | Vitamin D3 receptor | / | 0.440 | |
| 3zu2 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.440 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.440 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.440 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.440 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.440 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.440 | |
| 4jv6 | 18F | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.440 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.440 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.440 |