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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2c43COAL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase2.7.8

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2c43COAL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase2.7.81.000
2cg5COAL-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase2.7.80.556
4mrtCOA4'-phosphopantetheinyl transferase sfp2.7.80.543
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.505
1f3bGBXGlutathione S-transferase A12.5.1.180.499
1f0yCAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.494
4zohFADPutative oxidoreductase FAD-binding subunit/0.488
4qvhCOAPhosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase)/0.485
1z6tADPApoptotic protease-activating factor 1/0.483
4qjkCOAPhosphopantetheinyl transferase PptT (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrier protein]pantetheinephosphotransferase)/0.483
3h06VBPGlutamate receptor 2/0.481
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.480
3up5NAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.480
2rhrEMOPutative ketoacyl reductase1.3.10.478
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.477
3hk1B64Fatty acid-binding protein, adipocyte/0.477
4f9b0SYCell division cycle 7-related protein kinase2.7.11.10.477
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.477
4oaqNDPR-specific carbonyl reductase/0.476
4ztvTA7Anthranilate phosphoribosyltransferase/0.474
3juqAJDPhenazine biosynthesis protein A/B/0.473
2oj9BMIInsulin-like growth factor 1 receptor2.7.10.10.471
4eqrFADCoenzyme A disulfide reductase/0.471
5ej9TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.471
5iqiGNPBifunctional AAC/APH2.3.10.471
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.470
4ntdFADThioredoxin reductase/0.470
1kvtUPGUDP-glucose 4-epimerase5.1.3.20.469
3c15FOKAdenylate cyclase type 2/0.469
3c15FOKAdenylate cyclase type 5/0.469
4dbzNDPPutative ketoacyl reductase1.3.10.469
1culFOKAdenylate cyclase type 2/0.468
1culFOKAdenylate cyclase type 5/0.468
1njfADPDNA polymerase III subunit tau2.7.7.70.468
1jstATPCyclin-dependent kinase 22.7.11.220.467
1qtmTTPDNA polymerase I, thermostable2.7.7.70.467
4dieC5PCytidylate kinase/0.467
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.466
2r8pT6FTransketolase 1/0.466
5iqeGNPBifunctional AAC/APH2.3.10.466
2f3rG5PGuanylate kinase2.7.4.80.465
2q14ADPPhosphohydrolase/0.465
3d72FADVivid PAS protein VVD/0.465
3kjiADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC/0.465
1n2sNAIdTDP-4-dehydrorhamnose reductase1.1.1.1330.464
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.464
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.464
2q6bHR23-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.464
4lb2DM5Serum albumin/0.464
4yfy1YJVioF/0.464
1qvrANPChaperone protein ClpB/0.463
2bfoNDPPteridine reductase 11.5.1.330.463
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.463
3is2FADVivid PAS protein VVD/0.463
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.462
2qqfA1RNAD-dependent protein deacetylase HST23.5.10.462
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.462
5esoTDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.462
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.461
2gyoCOA3-oxoacyl-[acyl-carrier-protein] synthase 3/0.461
2i51FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding/0.461
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3epoMP5Phosphomethylpyrimidine synthase/0.461
4eh60ONMitogen-activated protein kinase 14/0.461
5cyoGDPSeptin-9/0.461
3rfxNADUronate dehydrogenase/0.460
5iqhGNPBifunctional AAC/APH2.3.10.460
1rq1FADEndoplasmic oxidoreductin-11.8.40.459
1uogP1CDeacetoxycephalosporin C synthase1.14.20.10.459
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.459
5bylGCPBifunctional AAC/APH2.3.10.459
5iqgGDPBifunctional AAC/APH2.3.10.459
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.458
3cgfJNFMitogen-activated protein kinase 102.7.11.240.458
3r4pFU7Heat shock protein HSP 90-alpha/0.458
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.458
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.458
2eklNADD-3-phosphoglycerate dehydrogenase/0.457
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3cd57HI3-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.457
4dy4FMNNAD(P)H dehydrogenase (quinone)/0.457
4z69DIFSerum albumin/0.457
1kbjFMNCytochrome b2, mitochondrial1.1.2.30.456
4gukP2GNeuronal calcium sensor 1/0.456
4xnw2IDP2Y purinoceptor 1/0.456
1l8qADPChromosomal replication initiator protein DnaA/0.455
3cgbCOACoenzyme A disulfide reductase/0.455
3icrCOACoenzyme A disulfide reductase/0.455
3l0dNADGlyceraldehyde-3-phosphate dehydrogenase/0.455
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.455
4affATPNitrogen regulatory protein P-II/0.455
4m11MXMProstaglandin G/H synthase 21.14.99.10.455
1daaPLPD-alanine aminotransferase2.6.1.210.454
1njfAGSDNA polymerase III subunit tau2.7.7.70.454
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.454
2b4rNADGlyceraldehyde-3-phosphate dehydrogenase/0.454
2bhiSFTCytotoxin 3/0.454
2bu2ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.454
2pd7FADVivid PAS protein VVD/0.454
3gegNADShort-chain dehydrogenase/reductase SDR/0.454
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4r3aRBFBlue-light-activated histidine kinase 22.7.13.30.454
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.454
4xmxBESAminopeptidase N3.4.11.20.454
4zgsNADPutative D-lactate dehydrogenase/0.454
1g9dBABBotulinum neurotoxin type B3.4.24.690.453
1wuuANPGalactokinase2.7.1.60.453
1ywgNADGlyceraldehyde-3-phosphate dehydrogenase/0.453
2hg1N5OEndoplasmin/0.453
2y9qANPMitogen-activated protein kinase 12.7.11.240.453
4a99FADTetX family tetracycline inactivation enzyme/0.453
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.453
4xj43ATCyclic GMP-AMP synthase/0.453
4yagNAIC alpha-dehydrogenase/0.453
1mg5NAIAlcohol dehydrogenase1.1.1.10.452
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.452
2ewnBTXBifunctional ligase/repressor BirA/0.452
2r8oT5XTransketolase 1/0.452
3a7jADPSerine/threonine-protein kinase 242.7.11.10.452
3triNAPPyrroline-5-carboxylate reductase/0.452
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.452
1g4tFTPThiamine-phosphate synthase/0.451
1pq944BOxysterols receptor LXR-beta/0.451
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.451
2udpUPPUDP-glucose 4-epimerase5.1.3.20.451
2ym1FADPhenylacetone monooxygenase1.14.13.920.451
3ag6PAJPantothenate synthetase/0.451
3bv2P38Mitogen-activated protein kinase 14/0.451
3ddw055Glycogen phosphorylase, liver form2.4.1.10.451
3dmhSAMProbable ribosomal RNA small subunit methyltransferase/0.451
3icsCOACoenzyme A disulfide reductase/0.451
3stw2TDMethylketone synthase I/0.451
4avlTMPPolymerase acidic protein/0.451
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.451
1touB1VFatty acid-binding protein, adipocyte/0.450
1towCRZFatty acid-binding protein, adipocyte/0.450
2aa3AP0L-lactate dehydrogenase/0.450
2rghFADAlpha-Glycerophosphate Oxidase/0.450
3jvhHHV2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.450
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.450
4idgNADPutative UDP-glucose 4-epimerase/0.450
4iq71G9Mycocyclosin synthase1.14.21.90.450
4k33ACPFibroblast growth factor receptor 32.7.10.10.450
4kvgGTPRas-related protein Rap-1A/0.450
2od7A1RNAD-dependent protein deacetylase HST23.5.10.449
2yxuATPPyridoxal kinase2.7.1.350.449
3fr5I4AFatty acid-binding protein, adipocyte/0.449
3w10RO9Aurora kinase A2.7.11.10.449
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.449
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.448
1nmkSFMPeptidyl-prolyl cis-trans isomerase A5.2.1.80.448
1r6w164o-succinylbenzoate synthase/0.448
2acxANPG protein-coupled receptor kinase 62.7.11.160.448
2vv9IM9Cyclin-dependent kinase 22.7.11.220.448
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.448
3c4wATPRhodopsin kinase/0.448
3qiyQI1Botulinum neurotoxin type A3.4.24.690.448
3rbvNAPSugar 3-ketoreductase/0.448
4qmySTUSerine/threonine-protein kinase 242.7.11.10.448
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.448
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
1szcCNANAD-dependent protein deacetylase HST23.5.10.447
1um8ADPATP-dependent Clp protease ATP-binding subunit ClpX/0.447
1xelUPGUDP-glucose 4-epimerase5.1.3.20.447
2bfyH1NAurora kinase B-A2.7.11.10.447
2henADPEphrin type-B receptor 22.7.10.10.447
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
3e51N35Genome polyprotein2.7.7.480.447
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.447
3n87N873-dehydroquinate dehydratase4.2.1.100.447
4paoGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.447
5bsgNAPPyrroline-5-carboxylate reductase/0.447
5dp2NAPCurF/0.447
5e92ANPTGF-beta receptor type-22.7.11.300.447
1a5uATPPyruvate kinase PKM2.7.1.400.446
1bwfATFGlycerol kinase/0.446
1d2hSAHGlycine N-methyltransferase2.1.1.200.446
1i3mUD1UDP-glucose 4-epimerase/0.446
1phqFPE2-dehydro-3-deoxyphosphooctonate aldolase2.5.1.550.446
1qssDG3DNA polymerase I, thermostable2.7.7.70.446
1s4eADPGalactokinase/0.446
2gmvPEPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.446
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.446
2oapANPType II secretion system protein (GspE-2)/0.446
2p9cNAID-3-phosphoglycerate dehydrogenase1.1.1.950.446
2panFADGlyoxylate carboligase4.1.1.470.446
2vojNADAlanine dehydrogenase1.4.1.10.446
2yg7FADPutrescine oxidase/0.446
3a7hATPSerine/threonine-protein kinase 242.7.11.10.446
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.446
3t9aANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.446
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.446
4ih71ERGenome polyprotein2.7.7.480.446
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.446
4nmdFDABifunctional protein PutA/0.446
4prxADPDNA gyrase subunit B/0.446
5kgpACOPredicted acetyltransferase/0.446
1drhNAPDihydrofolate reductase1.5.1.30.445
1ia1NDPDihydrofolate reductase1.5.1.30.445
1u71MXADihydrofolate reductase1.5.1.30.445
2ceoT44Thyroxine-binding globulin/0.445
3bv3P39Mitogen-activated protein kinase 14/0.445
3copADPGlycogen synthase2.4.1.210.445
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.445
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
4r1fADPDNA topoisomerase 2-alpha5.99.1.30.445
4u07ATPAdenosine monophosphate-protein transferase FICD2.7.7.n10.445
4z24FADPutative GMC-type oxidoreductase R13510.445
1am1ADPATP-dependent molecular chaperone HSP82/0.444
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.444
1lrlUPGUDP-glucose 4-epimerase5.1.3.20.444
1ykfNAPNADP-dependent isopropanol dehydrogenase1.1.1.800.444
3hwxTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.444
4loi1YCStimulator of interferon genes protein/0.444
4nzoANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.444
4ra3TFXBeta-2-microglobulin/0.444
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
1jscTPPAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.443
1lb9DNQGlutamate receptor 2/0.443
1u4oNDDL-lactate dehydrogenase1.1.1.270.443
2eudGCQRibonucleoside-diphosphate reductase large chain 11.17.4.10.443
2pvjP44Casein kinase II subunit alpha2.7.11.10.443
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.443
3dds26BGlycogen phosphorylase, liver form2.4.1.10.443
3h3jNADL-lactate dehydrogenase 11.1.1.270.443
3mvyBHZNickel-binding periplasmic protein/0.443
3nbvANPKetohexokinase/0.443
3wdlATP4-phosphopantoate--beta-alanine ligase6.3.2.360.443
4bqjXKLHeat shock protein HSP 90-alpha/0.443
4dxhNAJAlcohol dehydrogenase E chain1.1.1.10.443
4egkRDCHeat shock protein HSP 90-alpha/0.443
4wjiNAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase/0.443
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.443
5ej4TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.443
5kf9ACOPredicted acetyltransferase/0.443
1aj22PHDihydropteroate synthase/0.442
1f20FADNitric oxide synthase, brain1.14.13.390.442
1i44ACPInsulin receptor2.7.10.10.442
1i58ADPChemotaxis protein CheA2.7.13.30.442
1tehNADAlcohol dehydrogenase class-31.1.1.10.442
2b7aIZATyrosine-protein kinase JAK2/0.442
2j4kU5PUridylate kinase2.7.4.220.442
2lbaCHOFatty acid binding protein 6/0.442
2pd8FADVivid PAS protein VVD/0.442
3lu6IMXSerum albumin/0.442
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.442
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.442
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.441
1tkaN3TTransketolase 12.2.1.10.441
1x09IPEDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.441
3bw4FMNPutative 2-nitropropane dioxygenase/0.441
3lshFADPyranose 2-oxidase/0.441
3o03NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase)/0.441
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.441
3sjzGNPTranslation initiation factor 2 subunit gamma/0.441
4e03ADPPlasmid partitioning protein ParF/0.441
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.441
4wboANWRhodopsin kinase/0.441
5kwvANPPantothenate synthetase/0.441
1dc6NADGlyceraldehyde-3-phosphate dehydrogenase A/0.440
1m78NDPDihydrofolate reductase1.5.1.30.440
1nq24HYThyroid hormone receptor beta/0.440
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.440
1rj9GCPSignal recognition particle receptor FtsY/0.440
1sxjADPReplication factor C subunit 5/0.440
1ykdCMPAdenylate cyclase/0.440
1zotEMABifunctional hemolysin/adenylate cyclase4.6.1.10.440
2jahNDPClavaldehyde dehydrogenase/0.440
2wqeADPAurora kinase A2.7.11.10.440
2x1eX1EAcyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form2.3.1.1640.440
3e5hGNPRas-related protein Rab-28/0.440
3hyg099A disintegrin and metalloproteinase with thrombospondin motifs 53.4.240.440
3m12FADMonomeric sarcosine oxidase1.5.3.10.440
3o9aK14Pol polyprotein/0.440
3qfcNAPNADPH--cytochrome P450 reductase/0.440
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.440
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.440
4echFADPolyamine oxidase FMS1/0.440
4gk3L87Ephrin type-A receptor 32.7.10.10.440
4x2dATPFic family protein putative filamentation induced by cAMP protein/0.440
5a8aADPRiboflavin biosynthesis protein RibF2.7.1.260.440