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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ny3ADPMAP kinase-activated protein kinase 22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ny3ADPMAP kinase-activated protein kinase 22.7.11.11.000
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.550
3c4xATPRhodopsin kinase/0.542
4l9i8PRRhodopsin kinase/0.539
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.532
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.527
3t8oATPRhodopsin kinase/0.526
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.525
3c4wATPRhodopsin kinase/0.525
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.522
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.518
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.513
2w1fL0FAurora kinase A2.7.11.10.511
2ijmATPFocal adhesion kinase 12.7.10.20.509
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.507
4k8aK8AFocal adhesion kinase 12.7.10.20.507
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.501
3i60E86Mitogen-activated protein kinase 12.7.11.240.500
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.500
4ic7ANPMitogen-activated protein kinase 72.7.11.240.500
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.498
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.498
3a62STURibosomal protein S6 kinase beta-12.7.11.10.497
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.497
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.497
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.496
2j0lANPFocal adhesion kinase 12.7.10.20.495
4jajXU1Aurora kinase A2.7.11.10.495
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.494
3igoANPCalmodulin-domain protein kinase 1, putative/0.494
3qc9ADPRhodopsin kinase/0.494
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.493
2uzdC85Cyclin-dependent kinase 22.7.11.220.491
3c4zADPRhodopsin kinase/0.491
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.490
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.489
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.489
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.489
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.488
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.486
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.486
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.485
3sheI85MAP kinase-activated protein kinase 32.7.11.10.485
2hog710Serine/threonine-protein kinase Chk12.7.11.10.484
2uzbC75Cyclin-dependent kinase 22.7.11.220.484
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.483
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.483
3my5RFZCyclin-dependent kinase 22.7.11.220.482
4c3pACPAurora kinase A2.7.11.10.482
4qmlANPSerine/threonine-protein kinase 242.7.11.10.482
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.481
2ojj82AMitogen-activated protein kinase 12.7.11.240.481
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.481
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.481
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.480
2ijmADPFocal adhesion kinase 12.7.10.20.479
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.479
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.479
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.478
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.478
3pxkPXKFocal adhesion kinase 12.7.10.20.477
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.477
4eooATPCyclin-dependent kinase 22.7.11.220.477
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.476
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.476
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.476
4ysjADPCalmodulin-like domain protein kinase/0.476
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.475
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.475
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.475
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
4dt9GMPAPH(2'')-Id/0.475
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.475
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.475
2xvdAS6Ephrin type-B receptor 42.7.10.10.474
4aguD15Cyclin-dependent kinase-like 1/0.473
2j0m4STFocal adhesion kinase 12.7.10.20.472
2x9fX9FEphrin type-B receptor 42.7.10.10.472
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.472
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.471
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.471
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.471
4btjADPTau-tubulin kinase 12.7.11.10.471
4jbpYPHAurora kinase A2.7.11.10.471
1fvv107Cyclin-dependent kinase 22.7.11.220.470
1i44ACPInsulin receptor2.7.10.10.470
3dfcANPDeath-associated protein kinase 12.7.11.10.470
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.470
3zh8C58Protein kinase C iota type2.7.11.130.470
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.470
4o0uADNAurora kinase A2.7.11.10.470
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
2xngA0HAurora kinase A2.7.11.10.468
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.468
4jqeANPCasein kinase II subunit alpha2.7.11.10.468
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.468
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.467
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.467
3c50ADPRhodopsin kinase/0.467
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.467
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.467
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4o0wADNAurora kinase A2.7.11.10.466
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2x1nX1NCyclin-dependent kinase 22.7.11.220.465
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
4jia1K3Tyrosine-protein kinase JAK2/0.465
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.465
2cchATPCyclin-dependent kinase 22.7.11.220.464
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.464
2vv9IM9Cyclin-dependent kinase 22.7.11.220.464
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.464
4fv6E57Mitogen-activated protein kinase 12.7.11.240.464
5auwQUEDeath-associated protein kinase 12.7.11.10.464
3nuyJPZ3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3lltANPProtein serine/threonine kinase-1/0.462
4eor4SPCyclin-dependent kinase 22.7.11.220.462
4gu94GUFocal adhesion kinase 12.7.10.20.462
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.462
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
5dnrATPAurora kinase A2.7.11.10.462
1p4fDRGDeath-associated protein kinase 12.7.11.10.461
2btsU32Cyclin-dependent kinase 22.7.11.220.461
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.461
2zjwREFCasein kinase II subunit alpha2.7.11.10.461
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.461
5av2KMPDeath-associated protein kinase 12.7.11.10.461
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.460
4dtaADNAPH(2'')-Id/0.460
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.460
4ix5ANPUncharacterized protein/0.460
4jboWPHAurora kinase A2.7.11.10.460
2pvmP29Casein kinase II subunit alpha2.7.11.10.459
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.459
3zewSTUEphrin type-B receptor 42.7.10.10.459
4fod0UVALK tyrosine kinase receptor2.7.10.10.459
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.458
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.458
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.458
3kvxFMYMitogen-activated protein kinase 102.7.11.240.458
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.458
4k33ACPFibroblast growth factor receptor 32.7.10.10.458
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.457
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.457
2r3iSCFCyclin-dependent kinase 22.7.11.220.457
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.457
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.457
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.457
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.457
5e8ySTUTGF-beta receptor type-22.7.11.300.457
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.456
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.456
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.456
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.456
3ormAGSSerine/threonine protein kinase/0.456
3r1yX76Cyclin-dependent kinase 22.7.11.220.456
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4bcmT7ZCyclin-dependent kinase 22.7.11.220.456
4deeADPAurora kinase A2.7.11.10.456
4j99ACPFibroblast growth factor receptor 2/0.456
1zrzBI1Protein kinase C iota type2.7.11.130.455
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.455
4y95746Tyrosine-protein kinase/0.455
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4ix6ADPUncharacterized protein/0.454
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.454
4y93746Tyrosine-protein kinase/0.454
2pwlACPFibroblast growth factor receptor 2/0.453
3k5uPFQAurora kinase A2.7.11.10.452
4b99R4LMitogen-activated protein kinase 72.7.11.240.452
1h0w207Cyclin-dependent kinase 22.7.11.220.451
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.451
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.451
2c6iDT1Cyclin-dependent kinase 22.7.11.220.451
2c6lDT4Cyclin-dependent kinase 22.7.11.220.451
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.451
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3a8wATPProtein kinase C iota type2.7.11.130.451
3r73X87Cyclin-dependent kinase 22.7.11.220.451
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.451
4lrjANPUncharacterized protein/0.451
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.450
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.450
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.450
2qoqANPEphrin type-A receptor 32.7.10.10.450
2yaaATPDeath-associated protein kinase 2/0.450
3hmm855TGF-beta receptor type-12.7.11.300.450
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.450
5cvcPLPSerine racemase/0.450
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.449
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.449
2v7a627Tyrosine-protein kinase ABL12.7.10.20.449
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.448
1unlRRCCyclin-dependent-like kinase 52.7.11.10.448
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.448
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.448
4fob0USALK tyrosine kinase receptor2.7.10.10.448
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.448
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.448
4fuxE75Mitogen-activated protein kinase 12.7.11.240.448
4gk2L66Ephrin type-A receptor 32.7.10.10.448
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.447
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.447
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
4btjATPTau-tubulin kinase 12.7.11.10.447
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.447
5dosATPAurora kinase A2.7.11.10.447
1g5sI17Cyclin-dependent kinase 22.7.11.220.446
3be9P04Casein kinase II subunit alpha2.7.11.10.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.446
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.446
3s2pPMUCyclin-dependent kinase 22.7.11.220.446
4gk3L87Ephrin type-A receptor 32.7.10.10.446
5dt0SKEAurora kinase A2.7.11.10.446
1o76CAMCamphor 5-monooxygenase1.14.15.10.445
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.445
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.445
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.445
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.445
3orpAGSSerine/threonine protein kinase/0.445
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.445
2nomDUTPoly(A) polymerase, putative/0.444
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.444
3nynSGVG protein-coupled receptor kinase 62.7.11.160.444
3r7yZ04Cyclin-dependent kinase 22.7.11.220.444
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.443
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2w17I19Cyclin-dependent kinase 22.7.11.220.443
2xneASHAurora kinase A2.7.11.10.443
2yn8STUEphrin type-B receptor 42.7.10.10.443
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3efwAK8Aurora kinase A2.7.11.10.443
3iok1P6Tyrosine-protein kinase JAK2/0.443
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.443
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.443
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.443
4fv9E71Mitogen-activated protein kinase 12.7.11.240.443
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.443
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.442
2vd5BI8Myotonin-protein kinase2.7.11.10.442
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.442
3a7hATPSerine/threonine-protein kinase 242.7.11.10.442
3bqr4RBDeath-associated protein kinase 3/0.442
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.442
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.441
2izsBRQCasein kinase I isoform gamma-32.7.11.10.441
2qbnCAMCamphor 5-monooxygenase1.14.15.10.441
2w1gL0GAurora kinase A2.7.11.10.441
2wqeADPAurora kinase A2.7.11.10.441
2xp2VGHALK tyrosine kinase receptor2.7.10.10.441
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.441
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.441
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4dgmAGICasein kinase II subunit alpha2.7.11.10.441
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.441
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.440
2c4g514Cyclin-dependent kinase 22.7.11.220.440
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.440
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.440
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.440
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.440
4m4922YL-lactate dehydrogenase A chain1.1.1.270.440
5ap7SVEDual specificity protein kinase TTK2.7.12.10.440