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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4equG6ISerine/threonine-protein kinase 102.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4equG6ISerine/threonine-protein kinase 102.7.11.11.000
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.610
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.564
5k2aZMAAdenosine receptor A2a/0.555
2pl0STITyrosine-protein kinase Lck2.7.10.20.549
4tyj0LIFibroblast growth factor receptor 42.7.10.10.534
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.530
5k2cZMAAdenosine receptor A2a/0.527
5jtbZMAAdenosine receptor A2a/0.527
5k2dZMAAdenosine receptor A2a/0.527
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.520
3tubFPUTyrosine-protein kinase SYK2.7.10.20.519
3emlZMAAdenosine receptor A2a/0.519
3dkoIHZEphrin type-A receptor 72.7.10.10.514
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.513
5k2bZMAAdenosine receptor A2a/0.513
3uzcT4EAdenosine receptor A2a/0.512
1pkfEPDEpothilone C/D epoxidase1.140.510
3ctj320Hepatocyte growth factor receptor2.7.10.10.510
1q5dEPBEpothilone C/D epoxidase1.140.509
4j6cSTRCytochrome P450 monooxygenase/0.508
3lfeZ84Mitogen-activated protein kinase 14/0.507
5uviZMAAdenosine receptor A2a/0.507
3reyXACAdenosine receptor A2a/0.506
3p9tTCLRepressor/0.505
5g53NECAdenosine receptor A2a/0.505
4j6bPLOCytochrome P450 monooxygenase/0.503
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.502
5iua6DXAdenosine receptor A2a/0.502
3cth319Hepatocyte growth factor receptor2.7.10.10.501
3gcq1BUMitogen-activated protein kinase 14/0.500
2z2w770Wee1-like protein kinase2.7.10.20.498
3qm4PN0Cytochrome P450 2D6/0.498
4qrc0LIFibroblast growth factor receptor 42.7.10.10.498
3uvvREARetinoic acid receptor RXR-alpha/0.496
3uzaT4GAdenosine receptor A2a/0.496
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.495
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.495
3fzsB96Protein-tyrosine kinase 2-beta2.7.10.20.495
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.494
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.493
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.493
4eiyZMAAdenosine receptor A2a/0.493
4k9yK9YFocal adhesion kinase 12.7.10.20.493
4eevL1XHepatocyte growth factor receptor2.7.10.10.492
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.492
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.490
3t8xT8XT-cell surface glycoprotein CD1b/0.489
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.488
4j6dTESCytochrome P450 monooxygenase/0.488
5iubCLRAdenosine receptor A2a/0.488
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.487
3njoPYVAbscisic acid receptor PYR1/0.487
4jbtASDCytochrome P450 monooxygenase/0.487
3rfmCFFAdenosine receptor A2a/0.486
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.485
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.484
3eta351Insulin receptor2.7.10.10.484
3tdaPN0Cytochrome P450 2D6/0.484
3vg9ZMAAdenosine receptor A2a/0.483
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.482
5iu86DZAdenosine receptor A2a/0.482
3pwhZMAAdenosine receptor A2a/0.482
1x8b824Wee1-like protein kinase2.7.10.20.481
2io6330Wee1-like protein kinase2.7.10.20.481
2ydoADNAdenosine receptor A2a/0.481
2p1u4TNRetinoic acid receptor RXR-alpha/0.480
4kaoKAOFocal adhesion kinase 12.7.10.20.480
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.479
3vf60H6Glucokinase2.7.1.20.479
4r20AERCytochrome P450 family 17 polypeptide 2/0.479
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.478
2owb626Serine/threonine-protein kinase PLK12.7.11.210.478
3d74NBBPheromone-binding protein ASP1/0.478
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.478
4uxq0LIFibroblast growth factor receptor 42.7.10.10.478
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.477
3cv9VDXVitamin D3 dihydroxylase/0.477
3qakUKAAdenosine receptor A2a/0.477
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.476
3l6jZ90Alr2278 protein/0.476
4fnyI3KALK tyrosine kinase receptor2.7.10.10.476
5ckwANPUncharacterized protein/0.476
2rabNADGlutathione amide reductase/0.474
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.474
2ewaSB2Mitogen-activated protein kinase 14/0.473
2xk85R1Serine/threonine-protein kinase Nek22.7.11.10.473
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.473
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
2zb8IMNProstaglandin reductase 21.3.1.480.472
3c1xCKKHepatocyte growth factor receptor2.7.10.10.472
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.472
3tk3CPZCytochrome P450 2B41.14.14.10.472
4k4j1O8Retinoic acid receptor RXR-alpha/0.472
1zg32HIIsoflavone 4'-O-methyltransferase/0.471
3d78NBBPheromone-binding protein ASP1/0.471
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.471
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.470
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.470
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.470
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
2ydvNECAdenosine receptor A2a/0.469
3cqeP91Wee1-like protein kinase2.7.10.20.469
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.469
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.469
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.469
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.469
4m8e29VRetinoic acid receptor RXR-alpha/0.469
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
1l2jETCEstrogen receptor beta/0.468
1y6bAAXVascular endothelial growth factor receptor 22.7.10.10.468
3oapREARetinoic acid receptor RXR-alpha/0.468
3u8hBHPPhospholipase A2, membrane associated/0.468
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.467
3jwm5WBDihydrofolate reductase/0.467
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
5bp9SAHPutative methyltransferase protein/0.467
5iu4ZMAAdenosine receptor A2a/0.467
1uhlMEIRetinoic acid receptor RXR-beta/0.466
2cl5BIECatechol O-methyltransferase2.1.1.60.466
3biz61EWee1-like protein kinase2.7.10.20.466
3eel53TUncharacterized protein/0.466
4hni16WCasein kinase I isoform epsilon2.7.11.10.466
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.466
1fbyREARetinoic acid receptor RXR-alpha/0.465
1u0hONMAdenylate cyclase type 2/0.465
1u0hONMAdenylate cyclase type 5/0.465
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.465
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.465
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.465
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.465
1h35R01Squalene--hopene cyclase4.2.1.1290.464
1o6rR19Squalene--hopene cyclase4.2.1.1290.464
1rd4L08Integrin alpha-L/0.464
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.464
2dw4FADLysine-specific histone demethylase 1A10.464
4d7eFADPutative lysine-N-oxygenase/0.464
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.464
4xoqF42Coenzyme F420:L-glutamate ligase/0.464
2bakAQZMitogen-activated protein kinase 14/0.463
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
2gvcFADThiol-specific monooxygenase1.14.130.463
4a9yAQZMitogen-activated protein kinase 14/0.463
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.463
4iah1DXAlr2278 protein/0.463
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
1m52P17Tyrosine-protein kinase ABL12.7.10.20.462
1xlsREARetinoic acid receptor RXR-alpha/0.462
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.462
2j0vGDPRac-like GTP-binding protein ARAC7/0.462
3g45988cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
3htjETEbrA repressor/0.462
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.462
1kqwRTLCellular retinol-binding protein type II/0.461
1xddAAYIntegrin alpha-L/0.461
3ar7TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.461
3bi6396Wee1-like protein kinase2.7.10.20.461
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.461
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.461
4dscA8SAbscisic acid receptor PYL3/0.461
4jqh1MFAlr2278 protein/0.461
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2j7t274Serine/threonine-protein kinase 102.7.11.10.460
3jw5TOPDihydrofolate reductase/0.460
3jwcEKBDihydrofolate reductase/0.460
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.460
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
4iaq2GM5-hydroxytryptamine receptor 1B/0.460
4qx5CMPcGMP-dependent protein kinase 12.7.11.120.460
4uhrNGIAdenosine receptor A2a/0.460
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.459
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
3up3XCAaceDAF-12/0.459
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.459
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.459
1diuBDMDihydrofolate reductase1.5.1.30.458
1rgsCMPcAMP-dependent protein kinase type I-alpha regulatory subunit/0.458
2a4nCOAAac(6')-Ii protein/0.458
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2po7CHDFerrochelatase, mitochondrial4.99.1.10.458
3d75NBBPheromone-binding protein ASP1/0.458
3fy9XCFDihydrofolate reductase1.5.1.30.458
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3nalDBKCalcium-transporting ATPase/0.458
3qlxQLRUncharacterized protein/0.458
3v94WYQPhosphodiesterase/0.458
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
4f1mACPProbable serine/threonine-protein kinase roco42.7.11.10.458
4h9614QDihydrofolate reductase1.5.1.30.458
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
4m8hR4MRetinoic acid receptor RXR-alpha/0.458
1jxzBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.457
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3abaFLICytochrome P450/0.457
3p3zP3ZPutative cytochrome P450/0.457
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
1og5SWFCytochrome P450 2C9/0.456
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
2p1t3TNRetinoic acid receptor RXR-alpha/0.456
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.456
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.456
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4iarERM5-hydroxytryptamine receptor 1B/0.456
5ab7MLCNonspecific lipid-transfer protein, putative/0.456
5dp2NAPCurF/0.456
4ug2NGIAdenosine receptor A2a/0.456
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.455
1rdtL79Retinoic acid receptor RXR-alpha/0.455
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.455
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.455
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
4xe606UDihydrofolate reductase1.5.1.30.455
5dozNDPJamJ/0.455
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2j9lATPH(+)/Cl(-) exchange transporter 5/0.454
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
2oscMUHAngiopoietin-1 receptor2.7.10.10.454
2yac937Serine/threonine-protein kinase PLK12.7.11.210.454
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.454
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3lfcZ86Mitogen-activated protein kinase 14/0.454
4ea13RXDehydrosqualene synthase/0.454
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.454
4fgh0U6Dihydrofolate reductase1.5.1.30.454
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.454
4iae1DXAlr2278 protein/0.454
1blzACVIsopenicillin N synthase1.21.3.10.453
1e79ADPATP synthase subunit alpha, mitochondrial/0.453
1e79ADPATP synthase subunit beta, mitochondrial3.6.3.140.453
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.453
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
2in6839Wee1-like protein kinase2.7.10.20.453
2rjp886A disintegrin and metalloproteinase with thrombospondin motifs 43.4.24.820.453
3k47D09Dihydrofolate reductase1.5.1.30.453
3sgy06WDihydrofolate reductase1.5.1.30.453
4ajwVWNPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform2.7.1.1530.453
1cd2FOLDihydrofolate reductase1.5.1.30.452
1g63FMNEpidermin decarboxylase4.1.10.452
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
2zruFMNIsopentenyl-diphosphate delta-isomerase/0.452
3e5aVX6Aurora kinase A2.7.11.10.452
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.452
3q2mCKISpectinomycin phosphotransferase/0.452
3w0hW12Vitamin D3 receptor/0.452
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4r21STRCytochrome P450 family 17 polypeptide 2/0.452
1h36R88Squalene--hopene cyclase4.2.1.1290.451
1tsdF89Thymidylate synthase/0.451
1upw444Oxysterols receptor LXR-beta/0.451
2g78REACellular retinoic acid-binding protein 2/0.451
3a1l2CCCytochrome P450/0.451
3p2oNADBifunctional protein FolD/0.451
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.451
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.451
4rupH97Vitamin D3 receptor A/0.451
1disBDMDihydrofolate reductase1.5.1.30.450
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.450
1k749CRRetinoic acid receptor RXR-alpha/0.450
1yhoTRRDihydrofolate reductase1.5.1.30.450
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.450
2vd0D27Hematopoietic prostaglandin D synthase/0.450
3da24MDCarbonic anhydrase 134.2.1.10.450
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3n0yAPCAdenylate cyclase 2/0.450
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
4rbs0RVMetallo-beta-lactamase type 2/0.450
5kf2COAPredicted acetyltransferase/0.450
1kzjCB3Thymidylate synthase/0.449
1yc2NADNAD-dependent protein deacylase 2/0.449
2a19ANPInterferon-induced, double-stranded RNA-activated protein kinase2.7.11.10.449
2jn3JN3Fatty acid-binding protein, liver/0.449
2p1v5TNRetinoic acid receptor RXR-alpha/0.449
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.449
2punACPMethylthioribose kinase2.7.1.1000.449
2uxhQUEHTH-type transcriptional regulator TtgR/0.449
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.449
3gieACPSensor histidine kinase DesK2.7.13.30.449
3is9AC7Gag-Pol polyprotein2.7.7.490.449
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3nxrD2DDihydrofolate reductase1.5.1.30.449
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3vrwYS5Vitamin D3 receptor/0.449
3vt9YI4Vitamin D3 receptor/0.449
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.448
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2xnmWGZSerine/threonine-protein kinase Nek22.7.11.10.448
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.448
4ap1NAPSteroid monooxygenase/0.448
4ia2BIVVitamin D3 receptor A/0.448
4iw8KN3Estrogen receptor/0.448
1nzyBCA4-chlorobenzoyl coenzyme A dehalogenase3.8.1.70.447
1qknRALEstrogen receptor beta/0.447
2fziDH3Dihydrofolate reductase1.5.1.30.447
2oh4GIGVascular endothelial growth factor receptor 22.7.10.10.447
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
2uxpCLMHTH-type transcriptional regulator TtgR/0.447
3cseN22Uncharacterized protein/0.447
3hl0NADMaleylacetate reductase/0.447
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3l0lHC3Nuclear receptor ROR-gamma/0.447
3oafOAGDihydrofolate reductase1.5.1.30.447
3p99LNPLanosterol 14-alpha-demethylase/0.447
3tfn2CJDehydrosqualene synthase/0.447
4aotGW8Serine/threonine-protein kinase 102.7.11.10.447
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.447
4dm6TTBRetinoic acid receptor beta/0.447
4elf35IDihydrofolate reductase/0.447
4gqkADPActin cross-linking toxin VgrG1/0.447
4grb0XGCasein kinase II subunit alpha2.7.11.10.447
4i8vBHFCytochrome P450 1A11.14.14.10.447
4qa0SHHHistone deacetylase 83.5.1.980.447
1dkfBMSRetinoic acid receptor alpha/0.446
1o6qR17Squalene--hopene cyclase4.2.1.1290.446
1vj3TABDihydrofolate reductase1.5.1.30.446
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
2hasC3OVitamin D3 receptor/0.446
2qjpSMACytochrome b/0.446
2wesFADTryptophan 5-halogenase/0.446
2xtbKRMAdenosine kinase, putative/0.446
2y6fM9FIsopenicillin N synthase1.21.3.10.446
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3eej53RUncharacterized protein/0.446
3eem53VUncharacterized protein/0.446
3fy8XCFDihydrofolate reductase1.5.1.30.446
3fyvXCFDihydrofolate reductase1.5.1.30.446
3ihgVAKAklavinone 12-hydroxylase RdmE/0.446
3negPYVAbscisic acid receptor PYL1/0.446
3nxvD2FDihydrofolate reductase1.5.1.30.446
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4h9814QUncharacterized protein/0.446
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
1exa394Retinoic acid receptor gamma/0.445
1ie4T44Transthyretin/0.445
1p8dCO1Oxysterols receptor LXR-beta/0.445
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
2ibzSMACytochrome b/0.445
2y30SM8Putative repressor SimReg2/0.445
2yiuSMACytochrome b/0.445
3uk6ADPRuvB-like 23.6.4.120.445
4elb34RDihydrofolate reductase/0.445
4jv41ORcAMP-dependent protein kinase type I-alpha regulatory subunit/0.445
4rh10TTSpore photoproduct lyase/0.445
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.445
1iyzNDPProbable quinone oxidoreductase/0.444
1ndeMONEstrogen receptor beta/0.444
1ohkCOPDihydrofolate reductase1.5.1.30.444
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.444
2qk8MTXDihydrofolate reductase/0.444
2uxuNARHTH-type transcriptional regulator TtgR/0.444
3fl8RARDihydrofolate reductase/0.444
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3tdkUPGUDP-glucose 6-dehydrogenase1.1.1.220.444
4gmy0X5Tyrosine-protein kinase JAK2/0.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.443
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.443
1uzwCDHIsopenicillin N synthase1.21.3.10.443
1xuoLA1Integrin alpha-L/0.443
2chw039Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
2vcmM11Isopenicillin N synthase1.21.3.10.443
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
3gb4D3MDdmC/0.443
3hucG97Mitogen-activated protein kinase 14/0.443
3hx3RETRetinaldehyde-binding protein 1/0.443
3hywDCQSulfide-quinone reductase/0.443
3qly55VUncharacterized protein/0.443
3sh25DRDihydrofolate reductase1.5.1.30.443
3vt65YIVitamin D3 receptor/0.443
3vt7VDXVitamin D3 receptor/0.443
4iv41GSEstrogen receptor/0.443
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.443
4l8u9AZSerum albumin/0.443
5ab6CAANonspecific lipid-transfer protein, putative/0.443
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.443
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.442
1hfqMOTDihydrofolate reductase1.5.1.30.442
1ia3TQ5Dihydrofolate reductase1.5.1.30.442
1xngDNDNH(3)-dependent NAD(+) synthetase6.3.1.50.442
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.442
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.442
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.442
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3ce31FNHepatocyte growth factor receptor2.7.10.10.442
3d4bDZDNAD-dependent protein deacetylase/0.442
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3ua506XCytochrome P450 2B61.14.130.442
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.442
4f1sF1SPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4g95OAGDihydrofolate reductase1.5.1.30.442
4if5ACOAlpha-tubulin N-acetyltransferase 1/0.442
4klaCHDFerrochelatase, mitochondrial4.99.1.10.442
4nc3ERM5-hydroxytryptamine receptor 2B/0.442
5bt42LOBromodomain-containing protein 4/0.442
1fd0254Retinoic acid receptor gamma/0.441
1synF89Thymidylate synthase/0.441
1xdkREARetinoic acid receptor beta/0.441
2bktRPFRenin3.4.23.150.441
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.441
3clbTMQBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3cx5SMACytochrome b/0.441
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3dl9V2HVitamin D 25-hydroxylase/0.441
3fkoFKOMitogen-activated protein kinase 14/0.441
3gkjHC3Niemann-Pick C1 protein/0.441
3hv3R49Mitogen-activated protein kinase 14/0.441
3s41S41Glucokinase2.7.1.20.441
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3vruYS3Vitamin D3 receptor/0.441
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.441
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.441
4bubADPUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase/0.441
4dm8REARetinoic acid receptor beta/0.441
4fhf0TTSpore photoproduct lyase/0.441
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.441
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.441
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.440
1ly3COGDihydrofolate reductase1.5.1.30.440
1mczRMNBenzoylformate decarboxylase4.1.1.70.440
1x2hLPALipoate-protein ligase A6.3.1.200.440
2a9z26AAdenosine kinase2.7.1.200.440
2fs4PZ1Renin3.4.23.150.440
2zbaZBATrichothecene 3-O-acetyltransferase/0.440
3d5wADPSerine/threonine-protein kinase PLK/0.440
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3png8CXNitric oxide synthase, brain1.14.13.390.440
3qlhT27Gag-Pol polyprotein2.7.7.490.440
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4kfj1R0Dihydrofolate reductase1.5.1.30.440
4v12POGMaoC like domain protein/0.440