sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4buw | F33 | Tankyrase-2 | 2.4.2.30 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4buw | F33 | Tankyrase-2 | 2.4.2.30 | 1.000 | |
| 4bue | JQF | Tankyrase-2 | 2.4.2.30 | 0.857 | |
| 4bux | F35 | Tankyrase-2 | 2.4.2.30 | 0.829 | |
| 4l0t | 1V0 | Tankyrase-2 | 2.4.2.30 | 0.813 | |
| 4bs4 | A64 | Tankyrase-2 | 2.4.2.30 | 0.800 | |
| 4bus | 32F | Tankyrase-2 | 2.4.2.30 | 0.781 | |
| 4l2g | 1V4 | Tankyrase-2 | 2.4.2.30 | 0.755 | |
| 4hlh | 20D | Tankyrase-2 | 2.4.2.30 | 0.713 | |
| 4l34 | 1VG | Tankyrase-2 | 2.4.2.30 | 0.713 | |
| 4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.664 | |
| 4l0i | 1UW | Tankyrase-2 | 2.4.2.30 | 0.661 | |
| 4l31 | F08 | Tankyrase-2 | 2.4.2.30 | 0.659 | |
| 4l33 | F70 | Tankyrase-2 | 2.4.2.30 | 0.653 | |
| 4hlf | 15Z | Tankyrase-2 | 2.4.2.30 | 0.651 | |
| 4l0s | 1UZ | Tankyrase-2 | 2.4.2.30 | 0.649 | |
| 3kr8 | XAV | Tankyrase-2 | 2.4.2.30 | 0.648 | |
| 4j22 | AJ7 | Tankyrase-2 | 2.4.2.30 | 0.648 | |
| 4iue | AJ4 | Tankyrase-2 | 2.4.2.30 | 0.644 | |
| 4buf | F36 | Tankyrase-2 | 2.4.2.30 | 0.642 | |
| 4kzl | 20D | Tankyrase-2 | 2.4.2.30 | 0.642 | |
| 4kzu | A73 | Tankyrase-2 | 2.4.2.30 | 0.642 | |
| 4l0v | 1V1 | Tankyrase-2 | 2.4.2.30 | 0.642 | |
| 4l32 | 1VF | Tankyrase-2 | 2.4.2.30 | 0.641 | |
| 4buu | F38 | Tankyrase-2 | 2.4.2.30 | 0.640 | |
| 4bu9 | 08C | Tankyrase-2 | 2.4.2.30 | 0.638 | |
| 4l10 | A63 | Tankyrase-2 | 2.4.2.30 | 0.635 | |
| 3p0p | NNF | Tankyrase-2 | 2.4.2.30 | 0.634 | |
| 4bud | 29F | Tankyrase-2 | 2.4.2.30 | 0.629 | |
| 4hkk | AGI | Tankyrase-2 | 2.4.2.30 | 0.621 | |
| 4hlk | 431 | Tankyrase-2 | 2.4.2.30 | 0.621 | |
| 4hmh | F94 | Tankyrase-2 | 2.4.2.30 | 0.621 | |
| 4l2f | 1V3 | Tankyrase-2 | 2.4.2.30 | 0.616 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.614 | |
| 4j21 | AJ6 | Tankyrase-2 | 2.4.2.30 | 0.614 | |
| 5aku | 29F | Tankyrase-2 | 2.4.2.30 | 0.614 | |
| 4hl5 | 15W | Tankyrase-2 | 2.4.2.30 | 0.612 | |
| 4krs | 1SX | Tankyrase-1 | 2.4.2.30 | 0.605 | |
| 4bui | W2E | Tankyrase-2 | 2.4.2.30 | 0.604 | |
| 4but | 31F | Tankyrase-2 | 2.4.2.30 | 0.601 | |
| 4l09 | 1UR | Tankyrase-2 | 2.4.2.30 | 0.601 | |
| 4l2k | 1V8 | Tankyrase-2 | 2.4.2.30 | 0.600 | |
| 4hlg | 20B | Tankyrase-2 | 2.4.2.30 | 0.597 | |
| 4avw | G18 | Tankyrase-2 | 2.4.2.30 | 0.595 | |
| 4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.591 | |
| 4buv | 16I | Tankyrase-2 | 2.4.2.30 | 0.584 | |
| 4hkn | LU2 | Tankyrase-2 | 2.4.2.30 | 0.573 | |
| 4hki | FLN | Tankyrase-2 | 2.4.2.30 | 0.571 | |
| 4tkg | 09L | Tankyrase-2 | 2.4.2.30 | 0.570 | |
| 4j3l | AJ5 | Tankyrase-2 | 2.4.2.30 | 0.567 | |
| 4j3m | AJ8 | Tankyrase-2 | 2.4.2.30 | 0.563 | |
| 4avu | LDR | Tankyrase-2 | 2.4.2.30 | 0.553 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.542 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.529 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.528 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.506 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.502 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.499 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.499 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.499 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.498 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.493 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.491 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.488 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.488 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.487 | |
| 3tqc | ADP | Pantothenate kinase | / | 0.486 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.486 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.486 | |
| 3eku | CY9 | Actin-5C | / | 0.485 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.484 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.481 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.481 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.480 | |
| 5epo | TUD | 7-alpha-hydroxysteroid deydrogenase | / | 0.480 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.479 | |
| 2wwj | Y28 | Lysine-specific demethylase 4A | / | 0.479 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.479 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.477 | |
| 1t57 | FMN | Conserved protein | / | 0.476 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.474 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.474 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.473 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 4xzj | NAD | Putative NAD(+)--arginine ADP-ribosyltransferase Vis | 2.4.2.31 | 0.472 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.471 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.471 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.470 | |
| 1xk9 | P34 | Exotoxin A | 2.4.2.36 | 0.469 | |
| 3dv1 | AR9 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.467 | |
| 1zdw | FLV | Prenyltransferase | / | 0.467 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.467 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.467 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.467 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.466 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.466 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.466 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.466 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.466 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.465 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.464 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
| 2wat | COA | Fatty acid synthase subunit alpha | 2.3.1.86 | 0.464 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 2rd6 | 78P | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.463 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.463 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.462 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.462 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 3pi5 | 3P5 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.462 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.461 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 4l6s | 1WQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.461 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.461 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.460 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.460 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.460 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.460 | |
| 1cjw | COT | Serotonin N-acetyltransferase | / | 0.459 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2hp2 | KE4 | Glutamate-1-semialdehyde 2,1-aminomutase | 5.4.3.8 | 0.459 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.459 | |
| 3mtw | M3R | Xaa-Pro dipeptidase, putative | / | 0.459 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.459 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.459 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.459 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.458 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.458 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.458 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 2ejz | SAH | Diphthine synthase | / | 0.457 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.457 | |
| 4b1e | 6T6 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.457 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.456 | |
| 1g8j | MGD | Arsenite oxidase subunit AioA | 1.20.9.1 | 0.456 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.456 | |
| 3b6p | TMP | Three-prime repair exonuclease 1 | 3.1.11.2 | 0.456 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.456 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 1hzz | NAP | NAD(P) transhydrogenase subunit beta | 1.6.1.2 | 0.455 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.455 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.455 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.455 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.455 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3s5w | FAD | L-ornithine N(5)-monooxygenase | / | 0.455 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.455 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.454 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.454 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2bfr | ADP | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.454 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.454 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 3qbh | QBH | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.454 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 4lez | 1SY | Cyclic GMP-AMP synthase | / | 0.454 | |
| 1c7o | PPG | Hemolysin | / | 0.453 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.453 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 2jgs | BTN | Avidin | / | 0.453 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.453 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.453 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.453 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1j36 | LPR | Angiotensin-converting enzyme | 3.4.15.1 | 0.452 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.452 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.452 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.452 | |
| 4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.452 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 4phl | PIL | Phosphodiesterase | / | 0.452 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.451 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.451 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.451 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.451 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 3lpg | Z78 | Beta-glucuronidase | 3.2.1.31 | 0.451 | |
| 3r3d | 4CO | 4-hydroxybenzoyl-CoA thioesterase | 3.1.2.23 | 0.451 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.451 | |
| 1yun | ATP | Probable nicotinate-nucleotide adenylyltransferase | 2.7.7.18 | 0.450 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.450 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.450 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.450 | |
| 3lpf | Z77 | Beta-glucuronidase | 3.2.1.31 | 0.450 | |
| 3udj | 092 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4mlp | 2CX | Cryptochrome-2 | / | 0.450 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.450 | |
| 1dg8 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.449 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2vcx | D26 | Hematopoietic prostaglandin D synthase | / | 0.449 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 2zw5 | COA | Bleomycin acetyltransferase | / | 0.449 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 4r5w | XAV | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.449 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2g94 | ZPQ | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3vvp | BNU | Uncharacterized protein | / | 0.448 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.448 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 1vbm | YSA | Tyrosine--tRNA ligase | 6.1.1.1 | 0.447 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.447 | |
| 2ivf | MGD | Alpha-subunit of ethylbenzene dehydrogenase | / | 0.447 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.447 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 3iaa | TYD | CalG2 | / | 0.447 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.447 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.447 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.447 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 2r8o | T5X | Transketolase 1 | / | 0.446 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.446 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.446 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.446 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 1gqy | ACP | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.445 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.445 | |
| 1osv | CHC | Bile acid receptor | / | 0.445 | |
| 1q6n | P90 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.445 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.445 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.445 | |
| 3arv | SAU | Chitinase A | / | 0.445 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.445 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.445 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.445 | |
| 3i28 | 34N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.445 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.445 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.445 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.445 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.444 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.444 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.444 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.444 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.444 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2r8p | T6F | Transketolase 1 | / | 0.444 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4b1h | AR6 | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.444 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.444 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.444 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.443 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.443 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.443 | |
| 2bsx | NOS | Purine nucleoside phosphorylase | / | 0.443 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2h21 | SAM | Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic | 2.1.1.127 | 0.443 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.443 | |
| 3axb | FAD | Putative oxidoreductase | / | 0.443 | |
| 3b7d | CNI | Glutamate receptor 2 | / | 0.443 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.443 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.443 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.443 | |
| 4bgb | ADP | Predicted molecular chaperone distantly related to HSP70-fold metalloproteases | / | 0.443 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.443 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.443 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.443 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.443 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 1axw | MTX | Thymidylate synthase | / | 0.442 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.442 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ri4 | SAM | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.442 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.442 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.442 | |
| 2fto | CB3 | Thymidylate synthase | / | 0.442 | |
| 2hve | ADP | Nucleoside diphosphate kinase A | 2.7.4.6 | 0.442 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.442 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3p8z | 36A | Genome polyprotein | 2.1.1.56 | 0.442 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.442 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.442 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.442 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.442 | |
| 4rhe | FMN | Flavin prenyltransferase UbiX | / | 0.442 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.441 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.441 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.441 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.441 | |
| 4b1i | A8P | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.441 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4e2x | TYD | Methyltransferase | / | 0.441 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.441 | |
| 3ny9 | JSZ | Beta-2 adrenergic receptor | / | 0.441 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.440 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.440 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.440 | |
| 2ivp | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.440 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3hky | IX6 | Genome polyprotein | 2.7.7.48 | 0.440 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.440 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 |