sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3qwh | KMP | 17beta-hydroxysteroid dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3qwh | KMP | 17beta-hydroxysteroid dehydrogenase | / | 1.000 | |
| 4fj0 | HHF | 17beta-hydroxysteroid dehydrogenase | / | 0.679 | |
| 3qwi | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.634 | |
| 4fj1 | GEN | 17beta-hydroxysteroid dehydrogenase | / | 0.606 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.602 | |
| 4fj2 | QSO | 17beta-hydroxysteroid dehydrogenase | / | 0.570 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.505 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.498 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.497 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.491 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.491 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.491 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.490 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.489 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.489 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.487 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.487 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.487 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.486 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.484 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.484 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.483 | |
| 3qfr | FAD | NADPH--cytochrome P450 reductase | / | 0.481 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.480 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.478 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.478 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.478 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.477 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.477 | |
| 5d4v | YGP | Uncharacterized protein MJ0489 | / | 0.477 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.476 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.476 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.475 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.474 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.473 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.471 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.470 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.470 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.469 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.469 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.468 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.467 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.467 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.467 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.467 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.466 | |
| 2mm3 | CHO | Gastrotropin | / | 0.466 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.465 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.465 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.465 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.463 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.463 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.463 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.463 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.463 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.462 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.461 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.461 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.461 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.461 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.461 | |
| 1uhh | CZP | Aequorin-2 | / | 0.460 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.460 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.460 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.460 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.460 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.460 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.460 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.460 | |
| 4yfy | 0FX | VioF | / | 0.460 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.459 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.459 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.459 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 3b3m | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 1wkg | POI | [LysW]-aminoadipate semialdehyde transaminase | / | 0.458 | |
| 2oci | TYC | Valacyclovir hydrolase | 3.1 | 0.458 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.458 | |
| 2vrj | NCW | Beta-glucosidase A | 3.2.1.21 | 0.458 | |
| 3c1o | NAP | Eugenol synthase | / | 0.458 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.458 | |
| 3h18 | PMS | Esterase/lipase | / | 0.458 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.458 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.458 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.458 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.458 | |
| 1odn | APV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.457 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.457 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.456 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.456 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.456 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.456 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.456 | |
| 3nhk | VAP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.456 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 3seq | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.456 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.456 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 4kxj | P34 | Nucleoprotein | / | 0.456 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.456 | |
| 1cnf | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.455 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.455 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.455 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.455 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.455 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.454 | |
| 1s36 | CEI | Obelin | / | 0.454 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.454 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.454 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 5agp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.454 | |
| 2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.453 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.453 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.453 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 4e2z | JHZ | Methyltransferase | / | 0.453 | |
| 4lsj | LSJ | Glucocorticoid receptor | / | 0.453 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.453 | |
| 4uy6 | SAH | Histidine N-alpha-methyltransferase | / | 0.453 | |
| 1ja0 | FMN | NADPH--cytochrome P450 reductase | / | 0.452 | |
| 1w87 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.452 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2nmt | MIM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.452 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.452 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.452 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.452 | |
| 4oe4 | NAD | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial | 1.2.1.88 | 0.452 | |
| 1c7o | PPG | Hemolysin | / | 0.451 | |
| 1rp4 | FAD | Endoplasmic oxidoreductin-1 | 1.8.4 | 0.451 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.451 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.451 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.451 | |
| 2v58 | LZJ | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3g5m | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.451 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.451 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.450 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.450 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.450 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.450 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 3x06 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.450 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.450 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.450 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.450 | |
| 4rrl | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.450 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.450 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.449 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.449 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.449 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.449 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.449 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.449 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.449 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4e2x | TYD | Methyltransferase | / | 0.449 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.448 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.448 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.448 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.448 | |
| 2hzq | STR | Apolipoprotein D | / | 0.448 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.448 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.448 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.448 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.448 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.448 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.447 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.447 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2e0i | FAD | DNA photolyase | / | 0.447 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.447 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4epq | 0RR | Poly(ADP-ribose) glycohydrolase | / | 0.447 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.447 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.447 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.446 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2clf | F6F | Tryptophan synthase alpha chain | / | 0.446 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.446 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.446 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.446 | |
| 2ydd | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.446 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.446 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.446 | |
| 4n1g | CEI | Obelin | / | 0.446 | |
| 4qfx | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.446 | |
| 4qnq | 1XJ | Bcl-2-like protein 1 | / | 0.446 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1qv0 | CZH | Obelin | / | 0.445 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 2ay8 | 4TB | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.445 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2r8o | T5X | Transketolase 1 | / | 0.445 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.445 | |
| 3arp | DEQ | Chitinase A | / | 0.445 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 3ox1 | 695 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.445 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.445 | |
| 4da6 | GA2 | Purine nucleoside phosphorylase DeoD-type | 2.4.2.1 | 0.445 | |
| 5cp8 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.445 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.444 | |
| 1ogi | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.444 | |
| 1pwm | FID | Aldose reductase | 1.1.1.21 | 0.444 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.444 | |
| 1wl4 | COA | Acetyl-CoA acetyltransferase, cytosolic | 2.3.1.9 | 0.444 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.444 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.444 | |
| 2r8p | T6F | Transketolase 1 | / | 0.444 | |
| 3gie | ACP | Sensor histidine kinase DesK | 2.7.13.3 | 0.444 | |
| 3of1 | CMP | cAMP-dependent protein kinase regulatory subunit | / | 0.444 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.444 | |
| 4eqs | COA | Coenzyme A disulfide reductase | / | 0.444 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.444 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.444 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.444 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.444 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.443 | |
| 1el4 | CTZ | Obelin | / | 0.443 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.443 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.443 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.443 | |
| 2ejz | SAH | Diphthine synthase | / | 0.443 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2vqb | FAD | Putative flavin-containing monooxygenase | / | 0.443 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 3dla | NXX | Glutamine-dependent NAD(+) synthetase | 6.3.5.1 | 0.443 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.443 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.443 | |
| 3tfn | 2CJ | Dehydrosqualene synthase | / | 0.443 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4kot | CE3 | Uncharacterized protein | / | 0.443 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.443 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.442 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1zvl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 2c92 | TP6 | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.442 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.442 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.442 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.442 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.442 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3jt4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.442 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.442 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 3mj5 | GRM | Replicase polyprotein 1a | 3.4.22 | 0.442 | |
| 3nhj | A2Z | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.442 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4eh4 | IRG | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 4phl | PIL | Phosphodiesterase | / | 0.442 | |
| 4qof | FMN | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 4rr8 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.442 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.441 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.441 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.441 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 2oym | MNI | Endoglycoceramidase II | / | 0.441 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 2xve | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.441 | |
| 3lal | KRV | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.441 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3rl4 | 5GP | Metallophosphoesterase MPPED2 | 3.1 | 0.441 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 4jvl | EST | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4kox | CLS | Uncharacterized protein | / | 0.441 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.440 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1syn | F89 | Thymidylate synthase | / | 0.440 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.440 | |
| 2cl5 | BIE | Catechol O-methyltransferase | 2.1.1.6 | 0.440 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.440 | |
| 2vcx | D26 | Hematopoietic prostaglandin D synthase | / | 0.440 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.440 | |
| 3gwn | FAD | Probable FAD-linked sulfhydryl oxidase R596 | 1.8.3.2 | 0.440 | |
| 3nhl | YTR | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3nhu | M42 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 4bfr | J82 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 2.7.1.153 | 0.440 | |
| 4hki | FLN | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 4l0v | 1V1 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4qoh | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.440 |