sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.740 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.704 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.697 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.681 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.672 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.669 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.663 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.663 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.659 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.659 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.649 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.649 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.648 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.643 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.642 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.641 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.638 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.638 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.634 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.632 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.628 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.627 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.626 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.625 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.625 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.623 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.623 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.619 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.617 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.612 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.612 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.611 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.610 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.608 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.607 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.602 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.599 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.598 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.597 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.596 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.594 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.587 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.583 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.577 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.569 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.561 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.555 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.554 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.553 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.534 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.527 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.524 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.518 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.517 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.505 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.505 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.505 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.497 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.496 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.496 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.496 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.494 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.492 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.491 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.490 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.490 | |
| 4h7c | 10H | Aldo-keto reductase family 1 member C3 | / | 0.490 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.489 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.489 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.487 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.487 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.486 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.486 | |
| 4fa3 | 0SL | Aldo-keto reductase family 1 member C3 | / | 0.486 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.486 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.485 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.485 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.483 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.483 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.481 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.481 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.481 | |
| 1s36 | CEI | Obelin | / | 0.480 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.480 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.480 | |
| 3r58 | NPS | Aldo-keto reductase family 1 member C3 | / | 0.480 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.480 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.479 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.479 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.479 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.479 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.479 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.478 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.478 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.477 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.477 | |
| 3ugr | IMN | Aldo-keto reductase family 1 member C3 | / | 0.477 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.477 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.476 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.475 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.475 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.474 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.473 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.472 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.472 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.472 | |
| 3gsi | THG | Dimethylglycine oxidase | 1.5.3.10 | 0.472 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.472 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.472 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.472 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.471 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.471 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.471 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.470 | |
| 1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.469 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.469 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.469 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.468 | |
| 3r43 | ID8 | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.468 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.467 | |
| 2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.467 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.467 | |
| 4bjb | P34 | Tankyrase-2 | 2.4.2.30 | 0.467 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.467 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.467 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.466 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.466 | |
| 4b52 | RDF | Bacillolysin | / | 0.466 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3up3 | XCA | aceDAF-12 | / | 0.465 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.464 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.464 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 3pn1 | IVH | DNA ligase | / | 0.464 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.464 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3r94 | FLR | Aldo-keto reductase family 1 member C3 | / | 0.463 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.463 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.462 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.462 | |
| 3r8h | ZOM | Aldo-keto reductase family 1 member C3 | / | 0.462 | |
| 4hcy | 0YN | Transketolase | / | 0.462 | |
| 4mm9 | FVX | Na(+):neurotransmitter symporter (Snf family) | / | 0.462 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.462 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.461 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.461 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.461 | |
| 4kmz | FOL | Folate receptor beta | / | 0.461 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.461 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.460 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.460 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.460 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.460 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.460 | |
| 3b82 | NAD | Exotoxin A | 2.4.2.36 | 0.460 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4lrh | FOL | Folate receptor alpha | / | 0.460 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.460 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.460 | |
| 1dgg | NDP | Catalase | 1.11.1.6 | 0.459 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.459 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2v0m | KLN | Cytochrome P450 3A4 | / | 0.459 | |
| 2ycw | CAU | Beta-1 adrenergic receptor | / | 0.459 | |
| 3b9o | FMN | Alkane monoxygenase | / | 0.459 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.459 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 4xwt | U5P | Ribonuclease J | / | 0.459 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.458 | |
| 4jt9 | 1NS | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.458 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.457 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.457 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.457 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.456 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.456 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.456 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.456 | |
| 4b65 | NDP | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.456 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.455 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.455 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.454 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.454 | |
| 2xnv | VU3 | Soluble acetylcholine receptor | / | 0.454 | |
| 3hgg | CHD | CmeR | / | 0.454 | |
| 3pah | XDE | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.454 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.453 | |
| 3cv7 | C2U | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.453 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 3mj4 | URM | UDP-galactopyranose mutase | / | 0.453 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.453 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.453 | |
| 1gm8 | SOX | Penicillin G acylase | 3.5.1.11 | 0.452 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.452 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.452 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 3lzz | GDP | Uncharacterized protein | / | 0.452 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.452 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4i9i | 1DY | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 4phl | PIL | Phosphodiesterase | / | 0.452 | |
| 5doz | NDP | JamJ | / | 0.452 | |
| 1c7o | PPG | Hemolysin | / | 0.451 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.451 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.451 | |
| 4iwn | GEK | Carboxy-S-adenosyl-L-methionine synthase | / | 0.451 | |
| 4l4v | 1VY | Major histocompatibility complex class I-related gene protein | / | 0.451 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.451 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.451 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.451 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.451 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.450 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.450 | |
| 4dyp | 0MS | Nucleoprotein | / | 0.450 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.449 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.449 | |
| 1rxj | BNI | Streptavidin | / | 0.449 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.449 | |
| 1zis | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.449 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4ajm | 3A6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.449 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.449 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.448 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.448 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.448 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.448 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.448 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 3tfy | MET_LEU_GLY_PRO | N-alpha-acetyltransferase 50 | 2.3.1 | 0.448 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.448 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 3zov | WZV | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4mmd | 29E | Na(+):neurotransmitter symporter (Snf family) | / | 0.448 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.448 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2pdw | FID | Aldose reductase | 1.1.1.21 | 0.447 | |
| 2rcw | AAI | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.447 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.447 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.447 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.447 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.447 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.447 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.447 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.447 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.446 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1z4i | UMP | 5'(3')-deoxyribonucleotidase, mitochondrial | 3.1.3 | 0.446 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.446 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.446 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.446 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.445 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.445 | |
| 1qv0 | CZH | Obelin | / | 0.445 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.445 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.445 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 2fjm | 073 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.445 | |
| 2qjp | ANJ | Cytochrome b | / | 0.445 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.445 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.445 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.445 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.445 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.445 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.445 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.445 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.444 | |
| 1qvu | PRL | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.444 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.444 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.444 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 4b64 | NAP | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.444 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4tvj | 09L | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.444 | |
| 5pah | LDP | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.444 | |
| 2y04 | 68H | Beta-1 adrenergic receptor | / | 0.444 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.443 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.443 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.443 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.443 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.443 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.443 | |
| 3c1o | NAP | Eugenol synthase | / | 0.443 | |
| 3gey | P34 | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.443 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.443 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 4d6q | PD2 | Lysine-specific demethylase 4D | 1.14.11 | 0.443 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.442 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.442 | |
| 1el4 | CTZ | Obelin | / | 0.442 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 1sg0 | STL | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.442 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 2ym1 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.442 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.442 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.442 | |
| 3w2e | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.442 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2hzq | STR | Apolipoprotein D | / | 0.441 | |
| 3e78 | TPP | High affinity transport system protein p37 | / | 0.441 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3inr | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 4jsr | 1NQ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.441 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.441 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.441 | |
| 1kyy | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.440 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1tg2 | H2B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.440 | |
| 1xu9 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 1xuz | MMN | Capsule biosynthesis protein | / | 0.440 | |
| 2ohj | FMN | Type A flavoprotein FprA | 1 | 0.440 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3bmc | FOL | Pteridine reductase | / | 0.440 | |
| 3fap | ARD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.440 | |
| 3fap | ARD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.440 | |
| 3iu7 | FCD | Methionine aminopeptidase 2 | / | 0.440 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.440 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.440 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.440 |