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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3ansS38Bifunctional epoxide hydrolase 23.3.2.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3ansS38Bifunctional epoxide hydrolase 23.3.2.101.000
3koo24DBifunctional epoxide hydrolase 23.3.2.100.547
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.544
5ai5BSUBifunctional epoxide hydrolase 23.1.3.760.539
4jnc1LFBifunctional epoxide hydrolase 23.1.3.760.537
3antS82Bifunctional epoxide hydrolase 23.3.2.100.526
3lu8IQXSerum albumin/0.502
4l8u9AZSerum albumin/0.495
1fmjRTLRetinol dehydratase/0.494
4u9zCOAAlpha-tubulin N-acetyltransferase 1/0.493
2izrBRKCasein kinase I isoform gamma-32.7.11.10.492
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.491
2uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.489
2xpwOTCTetracycline repressor protein class D/0.487
2vtdLKMUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.484
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.483
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.482
1zdwFLVPrenyltransferase/0.481
3zoiM2WIsopenicillin N synthase1.21.3.10.480
3nmpPYVAbscisic acid receptor PYL2/0.479
2jb4A14Isopenicillin N synthase1.21.3.10.478
2trtTACTetracycline repressor protein class D/0.478
3zkyWT4Isopenicillin N synthase1.21.3.10.478
4kbyC2EStimulator of interferon genes protein/0.475
4o701QKBromodomain-containing protein 4/0.475
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.474
1prcUQ1Reaction center protein L chain/0.473
1hvyD16Thymidylate synthase2.1.1.450.472
2j9lATPH(+)/Cl(-) exchange transporter 5/0.472
4p68MTXDihydrofolate reductase/0.472
2zb8IMNProstaglandin reductase 21.3.1.480.471
3nr4PYVAbscisic acid receptor PYL2/0.471
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.470
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.470
1dxrMSTReaction center protein L chain/0.469
3gwfNAPCyclohexanone monooxygenase/0.469
1hb3SCVIsopenicillin N synthase1.21.3.10.468
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
2vcmM11Isopenicillin N synthase1.21.3.10.467
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.466
1dhiMTXDihydrofolate reductase1.5.1.30.466
1z6tADPApoptotic protease-activating factor 1/0.466
2vbdV10Isopenicillin N synthase1.21.3.10.466
3sgy06WDihydrofolate reductase1.5.1.30.466
1i58ACPChemotaxis protein CheA2.7.13.30.465
1obnASVIsopenicillin N synthase1.21.3.10.465
1qjfACSIsopenicillin N synthase1.21.3.10.465
1d3dBZTProthrombin3.4.21.50.464
1qiqACCIsopenicillin N synthase1.21.3.10.464
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.464
1l8qADPChromosomal replication initiator protein DnaA/0.463
1m78CLZDihydrofolate reductase1.5.1.30.463
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.463
4bb3KKAIsopenicillin N synthase1.21.3.10.463
1oc1ASVIsopenicillin N synthase1.21.3.10.462
2i5nUQ1Reaction center protein L chain/0.462
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.462
2uxpCLMHTH-type transcriptional regulator TtgR/0.462
3h3r14HCollagen type IV alpha-3-binding protein/0.462
3nj0PYVAbscisic acid receptor PYL2/0.462
4hxyNDPPlm1/0.462
4l4xNDPAmphI/0.462
4q71FADBifunctional protein PutA/0.462
3l0lHC3Nuclear receptor ROR-gamma/0.461
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.460
2p5uNADUDP-glucose 4-epimerase/0.460
4auxXTCTetracycline repressor protein class D/0.460
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2hz44STTyrosine-protein kinase ABL12.7.10.20.459
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.459
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.459
3hz137DHeat shock protein HSP 90-alpha/0.459
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.459
4jx1CAHCamphor 5-monooxygenase1.14.15.10.459
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.459
3mnrSD1Heat shock protein HSP 90-alpha/0.458
4em9TCEPeroxisome proliferator-activated receptor gamma/0.458
4erf0R3E3 ubiquitin-protein ligase Mdm26.3.20.458
1dajMOTDihydrofolate reductase1.5.1.30.457
1sbrVIBPutative HMP/thiamine-binding protein YkoF/0.457
2hb8MVDVitamin D3 receptor/0.457
2w4qCBWProstaglandin reductase 21.3.1.480.457
3cgtBCDCyclomaltodextrin glucanotransferase2.4.1.190.457
3h3t16HCollagen type IV alpha-3-binding protein/0.457
3pe2E1BCasein kinase II subunit alpha2.7.11.10.457
4c9oCAMCytochrome P450/0.457
1ek2CDUBifunctional epoxide hydrolase 2/0.456
1uykPUXHeat shock protein HSP 90-alpha/0.456
2wo7ASVIsopenicillin N synthase1.21.3.10.456
3nn6HNK6-hydroxy-L-nicotine oxidase/0.456
3wznBTNStreptavidin/0.456
4qa2SHHHistone deacetylase 83.5.1.980.456
4ubuCOASteroid 3-ketoacyl-CoA thiolase/0.456
1avdBTNAvidin/0.455
1bk0ACVIsopenicillin N synthase1.21.3.10.455
1rx2FOLDihydrofolate reductase1.5.1.30.455
1synF89Thymidylate synthase/0.455
1uy8PU5Heat shock protein HSP 90-alpha/0.455
1x7jGENEstrogen receptor beta/0.455
3ls8AJZPhosphatidylinositol 3-kinase catalytic subunit type 32.7.1.1370.455
3ns2PYVAbscisic acid receptor PYL2/0.455
3p6oETGCamphor 5-monooxygenase1.14.15.10.455
3vt65YIVitamin D3 receptor/0.455
4h3g10QBeta-secretase 13.4.23.460.455
4nieNBHNuclear receptor ROR-gamma/0.455
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
1rf9DBRCamphor 5-monooxygenase1.14.15.10.454
3h18PMSEsterase/lipase/0.454
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.454
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
4ipw1G7Mycocyclosin synthase1.14.21.90.454
3sn6P0GBeta-2 adrenergic receptor/0.454
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.453
1klkPMDDihydrofolate reductase1.5.1.30.453
1ludTRRDihydrofolate reductase1.5.1.30.453
3gwfFADCyclohexanone monooxygenase/0.453
3pm1ETHTH-type transcriptional regulator QacR/0.453
3zvuA8SAbscisic acid receptor PYR1/0.453
4a83DXCMajor pollen allergen Bet v 1-A/0.453
1f4fTP3Thymidylate synthase/0.452
1hb1OCVIsopenicillin N synthase1.21.3.10.452
1w06W05Isopenicillin N synthase1.21.3.10.452
2rabNADGlutathione amide reductase/0.452
2y60M8FIsopenicillin N synthase1.21.3.10.452
3o0iP54Heat shock protein HSP 90-alpha/0.452
3uagUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.452
4h9506UDihydrofolate reductase1.5.1.30.452
4j6cSTRCytochrome P450 monooxygenase/0.452
4l9q9TPSerum albumin/0.452
4ryvZEAProtein LlR18A/0.452
1blzACVIsopenicillin N synthase1.21.3.10.451
1bsvNDPGDP-L-fucose synthase/0.451
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1ohkCOPDihydrofolate reductase1.5.1.30.451
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.451
1sreHABStreptavidin/0.451
2fhnBNIAvidin-related protein 4/5/0.451
2hasC3OVitamin D3 receptor/0.451
2vkeTACTetracycline repressor protein class D/0.451
3cseN22Uncharacterized protein/0.451
4dfrMTXDihydrofolate reductase1.5.1.30.451
4mv1ADPBiotin carboxylase6.3.4.140.451
4rbs0RVMetallo-beta-lactamase type 2/0.451
4uymVOR14-alpha sterol demethylase Cyp51B/0.451
1d2sDHTSex hormone-binding globulin/0.450
1d6w00RProthrombin3.4.21.50.450
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2hcdBIVVitamin D3 receptor A/0.450
2xysSY9Soluble acetylcholine receptor/0.450
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.450
3sqyQ11Dihydrofolate reductase1.5.1.30.450
3vrwYS5Vitamin D3 receptor/0.450
3zkuHCVIsopenicillin N synthase1.21.3.10.450
4h9614QDihydrofolate reductase1.5.1.30.450
4r81FMNPredicted NADH dehydrogenase/0.450
1mvsDTMDihydrofolate reductase1.5.1.30.449
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2ph5NADHomospermidine synthase/0.449
2x7hPFNProstaglandin reductase 310.449
3csdEMOPutative ketoacyl reductase1.3.10.449
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.449
4cd2FOLDihydrofolate reductase1.5.1.30.449
4haiI23Bifunctional epoxide hydrolase 23.1.3.760.449
4nh82LCHeat shock protein HSP 90-alpha/0.449
4q0a4OAVitamin D3 receptor A/0.449
4rujVDXVitamin D3 receptor A/0.449
6prcCEBReaction center protein L chain/0.449
1dyrTOPDihydrofolate reductase1.5.1.30.448
1ie9VDXVitamin D3 receptor/0.448
1pd9CO4Dihydrofolate reductase1.5.1.30.448
2hamC33Vitamin D3 receptor/0.448
2hb7O1CVitamin D3 receptor/0.448
2iviACWIsopenicillin N synthase1.21.3.10.448
2y6fM9FIsopenicillin N synthase1.21.3.10.448
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.448
3owj1ELCasein kinase II subunit alpha2.7.11.10.448
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.448
4iteTEYVitamin D3 receptor/0.448
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.448
4nx6FOLDihydrofolate reductase1.5.1.30.448
5dn1AMZPhosphoribosyl isomerase A5.3.1.160.448
1dr3HBIDihydrofolate reductase1.5.1.30.447
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.447
2r2nKYNKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
2rbeZMGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
2vbpVB1Isopenicillin N synthase1.21.3.10.447
2z3uCRRCytochrome P450/0.447
3bhrTHGThymidylate synthase/0.447
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.447
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.447
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.447
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3vt8YI3Vitamin D3 receptor/0.447
4b1rITCTetracycline repressor protein class D/0.447
4l9kEHFSerum albumin/0.447
1bwsNDPGDP-L-fucose synthase/0.446
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
1vkgCRIHistone deacetylase 83.5.1.980.446
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.446
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
2yejXQKHeat shock protein HSP 90-alpha/0.446
3h3sH15Collagen type IV alpha-3-binding protein/0.446
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.446
3kpzZNEVitamin D3 receptor/0.446
3vrtYS2Vitamin D3 receptor/0.446
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.446
5k2cZMAAdenosine receptor A2a/0.446
1m79MQ1Dihydrofolate reductase1.5.1.30.445
1tysDHFThymidylate synthase/0.445
2ftoCB3Thymidylate synthase/0.445
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
3d0bSNXHeat shock protein HSP 90-alpha/0.445
3qdd94MHeat shock protein HSP 90-alpha/0.445
3qlrQLRDihydrofolate reductase1.5.1.30.445
3sf6FDAGlutaryl-CoA dehydrogenase/0.445
4cdmFO1Deoxyribodipyrimidine photolyase/0.445
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.445
4ia7BIVVitamin D3 receptor A/0.445
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
4jx1CAMCamphor 5-monooxygenase1.14.15.10.445
4lg5A1OAbscisic acid receptor PYL2/0.445
4qa0SHHHistone deacetylase 83.5.1.980.445
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.445
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.445
5hs1VORLanosterol 14-alpha demethylase/0.445
1s4dSAHUroporphyrinogen-III C-methyltransferase2.1.1.1070.444
1uyePU9Heat shock protein HSP 90-alpha/0.444
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2bu9HFVIsopenicillin N synthase1.21.3.10.444
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.444
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.444
2tohHBITyrosine 3-monooxygenase1.14.16.20.444
2xlsFADPutative flavin-containing monooxygenase/0.444
3pqbVGPPutative oxidoreductase/0.444
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.444
4g1z0VPVitamin D3 receptor A/0.444
4g210VPVitamin D3 receptor A/0.444
4ia3BIVVitamin D3 receptor A/0.444
4j6bPLOCytochrome P450 monooxygenase/0.444
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.444
4kwhNAPReductase homolog/0.444
4qa1B3NHistone deacetylase 83.5.1.980.444
4u7wNDPMxaA/0.444
1nceCB3Thymidylate synthase/0.443
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2harOCCVitamin D3 receptor/0.443
2w71L23Biotin carboxylase6.3.4.140.443
3h4vDVPPteridine reductase 11.5.1.330.443
3il1B5DGlutamate receptor 2/0.443
3inxJZCHeat shock protein HSP 90-alpha/0.443
3ixp834Ecdysone receptor/0.443
3nmnPYVAbscisic acid receptor PYL1/0.443
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.442
1dduCB3Thymidylate synthase/0.442
1h36R88Squalene--hopene cyclase4.2.1.1290.442
1ia3TQ5Dihydrofolate reductase1.5.1.30.442
1uyfPU1Heat shock protein HSP 90-alpha/0.442
2ejvNADL-threonine 3-dehydrogenase/0.442
2jfgUMAUDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.442
2nq8ZIDEnoyl-ACP reductase/0.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.442
3bxxQUEDihydroflavonol 4-reductase1.1.1.2190.442
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.442
3dg8RJ6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
3ft8MOJHeat shock protein HSP 90-alpha/0.442
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.442
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.442
3njoPYVAbscisic acid receptor PYR1/0.442
3sai9DRDihydrofolate reductase/0.442
3zeiAWHO-acetylserine sulfhydrylase/0.442
4a9iP9IBromodomain-containing protein 2/0.442
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.442
4gh5NADShort-chain dehydrogenase/reductase SDR/0.442
4iarERM5-hydroxytryptamine receptor 1B/0.442
4jlj1NMDeoxycytidine kinase2.7.1.740.442
1a8t061Metallo-beta-lactamase type 2/0.441
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.441
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
1qxlFR8Adenosine deaminase3.5.4.40.441
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1uydPU8Heat shock protein HSP 90-alpha/0.441
2qg2A91Heat shock protein HSP 90-alpha/0.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
2vn1FK5Peptidylprolyl isomerase/0.441
3bac3B9DNA ligase/0.441
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.441
3vtcTK3Vitamin D3 receptor/0.441
3vtdTKDVitamin D3 receptor/0.441
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.441
4j6dTESCytochrome P450 monooxygenase/0.441
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.441
5uviZMAAdenosine receptor A2a/0.441
5iua6DXAdenosine receptor A2a/0.441
3emlZMAAdenosine receptor A2a/0.441
1cf3FADGlucose oxidase1.1.3.40.440
1dhrNADDihydropteridine reductase1.5.1.340.440
1kruIPTGalactoside O-acetyltransferase2.3.1.180.440
1lhwESMSex hormone-binding globulin/0.440
1uy7PU4Heat shock protein HSP 90-alpha/0.440
1uzwCDHIsopenicillin N synthase1.21.3.10.440
1zgaHMKIsoflavone 4'-O-methyltransferase/0.440
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2vteIK4UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.440
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.440
3w0hW12Vitamin D3 receptor/0.440
3w78CBDFMN-dependent NADH-azoreductase/0.440
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.440
4d7mTDCTetracycline repressor protein class D/0.440
4g2h0VQVitamin D3 receptor A/0.440
4gxs0YSGlutamate receptor 2/0.440
4h4uNDPBiphenyl dioxygenase ferredoxin reductase subunit/0.440
4hgs15GCasein kinase I isoform gamma-32.7.11.10.440
4ia1BIVVitamin D3 receptor A/0.440
4lva20MNicotinamide phosphoribosyltransferase2.4.2.120.440
4ruoBIVVitamin D3 receptor A/0.440
5a3cNADSIR2 family protein/0.440