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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2q92B23Methionine aminopeptidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2q92B23Methionine aminopeptidase/1.000
2q94A04Methionine aminopeptidase/0.804
2evmFC2Methionine aminopeptidase/0.782
2evcFC3Methionine aminopeptidase/0.734
2p99YE6Methionine aminopeptidase/0.696
2q93B21Methionine aminopeptidase/0.692
2q96A18Methionine aminopeptidase/0.681
2p98YE7Methionine aminopeptidase/0.680
1xnzFCDMethionine aminopeptidase/0.663
3iu7FCDMethionine aminopeptidase 2/0.646
2ggbU17Methionine aminopeptidase/0.625
2gg0U11Methionine aminopeptidase/0.616
3iu8T03Methionine aminopeptidase 2/0.616
2gg3U13Methionine aminopeptidase/0.607
2gg2U12Methionine aminopeptidase/0.599
2gg8U15Methionine aminopeptidase/0.594
2g6pHM2Methionine aminopeptidase 1/0.590
2gg9U16Methionine aminopeptidase/0.574
3pkeY10Methionine aminopeptidase 2/0.573
4iksTFDMethionine aminopeptidase 1/0.568
3d27W29Methionine aminopeptidase/0.567
4fliY16Methionine aminopeptidase 1/0.559
3pkbY16Methionine aminopeptidase 2/0.556
4ikuSHXMethionine aminopeptidase 1/0.548
2nq7HM5Methionine aminopeptidase 1/0.540
3pkdY10Methionine aminopeptidase 2/0.540
1c23MPHMethionine aminopeptidase/0.539
4iktTFVMethionine aminopeptidase 1/0.535
4fllYZ6Methionine aminopeptidase 1/0.532
3pkcY08Methionine aminopeptidase 2/0.531
4flkY10Methionine aminopeptidase 1/0.524
4hxx1AYMethionine aminopeptidase 1/0.523
4fljY08Methionine aminopeptidase 1/0.522
3pkaY02Methionine aminopeptidase 2/0.521
1r5gAO1Methionine aminopeptidase 2/0.520
4ikrPVPMethionine aminopeptidase 1/0.516
1r58AO5Methionine aminopeptidase 2/0.507
4gd40WSLysine-specific demethylase 4A1.14.110.499
2ea4F79Methionine aminopeptidase 2/0.497
2oazI96Methionine aminopeptidase 2/0.497
2ea2F77Methionine aminopeptidase 2/0.496
1eveE20Acetylcholinesterase3.1.1.70.494
2ga2A19Methionine aminopeptidase 2/0.489
1qzyTDEMethionine aminopeptidase 2/0.484
1odcA8BAcetylcholinesterase3.1.1.70.482
1tllFMNNitric oxide synthase, brain1.14.13.390.481
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.480
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.480
2w6cBM4Acetylcholinesterase3.1.1.70.479
1r5hAO2Methionine aminopeptidase 2/0.478
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.478
4q7f3D1Uncharacterized protein/0.478
2qimZEAClass 10 plant pathogenesis-related protein/0.477
4b7zQ4QAcetylcholinesterase3.1.1.70.477
4ey7E20Acetylcholinesterase3.1.1.70.477
5c1mCLRMu-type opioid receptor/0.477
2j3qTFLAcetylcholinesterase3.1.1.70.476
1w4lGL8Acetylcholinesterase3.1.1.70.475
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.475
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.475
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.475
1yw7A41Methionine aminopeptidase 2/0.473
1zgcA2EAcetylcholinesterase3.1.1.70.472
2xupTZ5Acetylcholinesterase3.1.1.70.472
2wzySQXSoluble acetylcholine receptor/0.471
2xuhTZ4Acetylcholinesterase3.1.1.70.471
1amoFMNNADPH--cytochrome P450 reductase/0.470
1yw8A75Methionine aminopeptidase 2/0.470
5ah5LSSLeucine--tRNA ligase/0.470
1h22E10Acetylcholinesterase3.1.1.70.469
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.469
3h3qH13Collagen type IV alpha-3-binding protein/0.469
2xukTZ5Acetylcholinesterase3.1.1.70.468
3s8pSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.468
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.468
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.468
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.468
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.468
3jusBCDLanosterol 14-alpha demethylase1.14.13.700.467
3ziuLSSLeucyl-tRNA synthetase/0.467
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.466
4to5DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.466
2oz57XYUncharacterized protein/0.465
2xufTZ4Acetylcholinesterase3.1.1.70.465
4arbC57Acetylcholinesterase3.1.1.70.465
1q84TZ4Acetylcholinesterase3.1.1.70.464
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.464
3iu9T07Methionine aminopeptidase 2/0.464
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.464
4m0f1YKAcetylcholinesterase3.1.1.70.464
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.464
1ja1FMNNADPH--cytochrome P450 reductase/0.463
1jwtBLIProthrombin3.4.21.50.463
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.463
1zgbA1EAcetylcholinesterase3.1.1.70.463
2vd7PD2Lysine-specific demethylase 4A1.14.110.463
4d6qPD2Lysine-specific demethylase 4D1.14.110.463
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.462
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
2v57PRLTetR family transcriptional regulator/0.460
1i9c5ADGlutamate mutase epsilon subunit/0.459
2ha6SCKAcetylcholinesterase3.1.1.70.458
1qtiGNTAcetylcholinesterase3.1.1.70.457
2cekN8TAcetylcholinesterase3.1.1.70.457
2ckmAA7Acetylcholinesterase3.1.1.70.457
2gywOBIAcetylcholinesterase3.1.1.70.457
2jf0HBPAcetylcholinesterase3.1.1.70.457
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.457
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
1u65CP0Acetylcholinesterase3.1.1.70.455
2bf4FMNNADPH--cytochrome P450 reductase/0.455
3wqmB29Diterpene synthase3.1.7.80.455
2ixkTDOdTDP-4-dehydrorhamnose 3,5-epimerase5.1.3.130.454
2xuqTZ4Acetylcholinesterase3.1.1.70.454
3af1GDPPantothenate kinase2.7.1.330.454
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
4j4nD44Peptidylprolyl isomerase/0.454
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.454
4zwpM44Xaa-Pro dipeptidase3.4.13.90.454
1yw9A84Methionine aminopeptidase 2/0.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.453
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.453
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4ey6GNTAcetylcholinesterase3.1.1.70.453
1by5GLY_GLY_GLY_AHO_AHO_AHO_FEFerrichrome-iron receptor/0.452
1dx6GNTAcetylcholinesterase3.1.1.70.452
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.452
2g1r3IGRenin3.4.23.150.452
2pb1NFGGlucan 1,3-beta-glucosidase/0.452
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.451
3pdqKC6Lysine-specific demethylase 4A1.14.110.451
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.451
1ex75GPGuanylate kinase2.7.4.80.450
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.450
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.450
4bf9FMNtRNA-dihydrouridine(16) synthase/0.450
4rxrDCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.450
1c7oPPGHemolysin/0.449
1gpnHUBAcetylcholinesterase3.1.1.70.449
1icqOPD12-oxophytodienoate reductase 11.3.1.420.449
1z71L17Prothrombin3.4.21.50.449
2g247IGRenin3.4.23.150.449
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.449
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.449
4araC56Acetylcholinesterase3.1.1.70.449
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.449
4ts7ADPPurine phosphoribosyltransferase (GpT-1)/0.449
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.448
2xujTZ5Acetylcholinesterase3.1.1.70.448
3intFDAUDP-galactopyranose mutase5.4.99.90.448
3zv7NHGAcetylcholinesterase3.1.1.70.448
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.448
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4drm0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.447
1e66HUXAcetylcholinesterase3.1.1.70.446
1nm6L86Prothrombin3.4.21.50.446
1vkgCRIHistone deacetylase 83.5.1.980.446
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.446
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.446
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.445
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3pm1ETHTH-type transcriptional regulator QacR/0.445
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.445
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4kl1PCGPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4/0.445
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.444
3rvhHQ2Lysine-specific demethylase 4A1.14.110.444
3vilSA0Beta-glucosidase/0.444
1gj4132Prothrombin3.4.21.50.443
1ja0FMNNADPH--cytochrome P450 reductase/0.443
2aouCQAHistamine N-methyltransferase2.1.1.80.443
2il2LIXRenin3.4.23.150.443
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.443
2whqHI6Acetylcholinesterase3.1.1.70.443
2wwjY28Lysine-specific demethylase 4A/0.443
2xuiTZ5Acetylcholinesterase3.1.1.70.443
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.443
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.443
3qeoLLTDeoxycytidine kinase2.7.1.740.443
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
4qg1DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.443
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.442
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
2aot2PMHistamine N-methyltransferase2.1.1.80.442
2po3T4K4-dehydrase/0.442
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.442
3ojxFMNNADPH--cytochrome P450 reductase/0.442
5kwvANPPantothenate synthetase/0.442
1wamFADUDP-galactopyranose mutase5.4.99.90.441
2futH1SHeparin and heparin-sulfate lyase/0.441
2x91LPRAngiotensin-converting enzyme3.4.15.10.441
3h7rNAPAldo-keto reductase family 4 member C8/0.441
4b63FADL-ornithine N(5)-monooxygenase/0.441
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.441
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.441
4lxlPD2Lysine-specific demethylase 4B1.14.110.441
5hvnNAD3-dehydroquinate synthase/0.441
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2vn1FK5Peptidylprolyl isomerase/0.440
3f90FMNFlavodoxin/0.440
4xczT3QQdtf/0.440