Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1l9kSAHGenome polyprotein2.7.7.48

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1l9kSAHGenome polyprotein2.7.7.481.000
2p1dSAHGenome polyprotein2.7.7.480.692
2pxaSAHGenome polyprotein2.7.7.480.597
2p3qSAHGenome polyprotein/0.594
4ctjSAMGenome polyprotein/0.578
1r6aSAHGenome polyprotein2.7.7.480.577
3eluSAMMethyltransferase/0.573
2p41SAHGenome polyprotein/0.560
2xbmSAHGenome polyprotein/0.560
5jjrSAHGenome polyprotein/0.556
3eldSFGMethyltransferase/0.549
3p8zSAHGenome polyprotein2.1.1.560.547
2px2SAHGenome polyprotein2.7.7.480.543
3elySAHMethyltransferase/0.543
4ctkSAMGenome polyprotein/0.536
5cuqNSCGenome polyprotein/0.536
3p97SAMGenome polyprotein2.1.1.560.531
5jjsSAHGenome polyprotein/0.529
4k6mSAHGenome polyprotein/0.528
5dtoSAHGenome polyprotein/0.526
3evcSAHGenome polyprotein2.1.1.560.523
2px5SAHGenome polyprotein2.7.7.480.521
3evbSAHGenome polyprotein2.1.1.560.516
3p8z36AGenome polyprotein2.1.1.560.510
3evaSAHGenome polyprotein2.1.1.560.509
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.496
2he5NDPAldo-keto reductase family 1 member C211.1.10.495
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.489
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.488
2wa2SAMGenome polyprotein/0.481
1hb1OCVIsopenicillin N synthase1.21.3.10.480
1hb3SCVIsopenicillin N synthase1.21.3.10.480
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.479
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.478
2oc4IMHPurine nucleoside phosphorylase2.4.2.10.477
4mv8ACPBiotin carboxylase6.3.4.140.477
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.474
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.474
3bhtMFRCyclin-dependent kinase 22.7.11.220.473
2w9hTOPDihydrofolate reductase1.5.1.30.470
2yx6ADPUncharacterized protein/0.470
3zoiM2WIsopenicillin N synthase1.21.3.10.470
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.469
2vbdV10Isopenicillin N synthase1.21.3.10.469
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.469
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4wa9AXITyrosine-protein kinase ABL12.7.10.20.469
2c31TZDOxalyl-CoA decarboxylase4.1.1.80.468
4ocpADPN-acetylhexosamine 1-kinase2.7.1.1620.468
1s3uTQDDihydrofolate reductase1.5.1.30.466
1ykdCMPAdenylate cyclase/0.466
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
2iviACWIsopenicillin N synthase1.21.3.10.465
2jb4A14Isopenicillin N synthase1.21.3.10.465
3d84NDPDihydrofolate reductase1.5.1.30.465
4xr9NADCalS8/0.465
5eyuNADBetaine-aldehyde dehydrogenase/0.465
1oc1ASVIsopenicillin N synthase1.21.3.10.464
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.464
2wouZZFTGF-beta receptor type-12.7.11.300.464
1a27ESTEstradiol 17-beta-dehydrogenase 11.1.1.620.463
1dhjMTXDihydrofolate reductase1.5.1.30.463
2i7pACOPantothenate kinase 32.7.1.330.463
3drcMTXDihydrofolate reductase1.5.1.30.463
4f700STCyclin-dependent kinase 82.7.11.220.463
1xddAAYIntegrin alpha-L/0.462
2csnCKICasein kinase I homolog 12.7.11.10.462
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.462
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
2v58LZJBiotin carboxylase6.3.4.140.462
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
2ph5NADHomospermidine synthase/0.461
2vn0TDZCytochrome P450 2C8/0.461
2zbaZBATrichothecene 3-O-acetyltransferase/0.461
3mtfA3FActivin receptor type-12.7.11.300.461
2oxtSAMGenome polyprotein/0.460
3gwfNAPCyclohexanone monooxygenase/0.460
3s1dZIRCytokinin dehydrogenase 11.5.99.120.460
4yaoFMNNADPH--cytochrome P450 reductase/0.460
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.459
2on6IMHPurine nucleoside phosphorylase2.4.2.10.459
4f3xNADPutative aldehyde dehydrogenase/0.459
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
1bk0ACVIsopenicillin N synthase1.21.3.10.458
3ha7B32Hydroxymycolate synthase MmaA42.1.10.458
3u9eCOALmo1369 protein/0.458
4ocvANPAminoglycoside phosphotransferase/0.458
1kgjFL8Transthyretin/0.457
2jlaTPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase/0.457
2w6nOA2Biotin carboxylase6.3.4.140.457
2x1nX1NCyclin-dependent kinase 22.7.11.220.457
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
4g1wG1WMitogen-activated protein kinase 82.7.11.240.457
4hnc0UTMandelate racemase/0.457
4l8u9AZSerum albumin/0.457
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
1m2qMNXCasein kinase II subunit alpha2.7.11.10.456
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.456
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.456
2qblCAMCamphor 5-monooxygenase1.14.15.10.456
2yoj8Y6Genome polyprotein2.7.7.480.456
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.456
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
2hb7O1CVitamin D3 receptor/0.455
3p74FMNPentaerythritol tetranitrate reductase/0.455
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.455
3wv9FEGHmd co-occurring protein HcgE/0.455
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
4jxhHRCCytohesin-2/0.455
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.455
1dhiMTXDihydrofolate reductase1.5.1.30.454
1h51FMNPentaerythritol tetranitrate reductase/0.454
2qimZEAClass 10 plant pathogenesis-related protein/0.454
3a7jADPSerine/threonine-protein kinase 242.7.11.10.454
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.454
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.454
4c9oCAMCytochrome P450/0.454
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
4i9bNADPutative betaine aldehyde dehyrogenase/0.453
1qiqACCIsopenicillin N synthase1.21.3.10.452
2cchATPCyclin-dependent kinase 22.7.11.220.452
2nniMTKCytochrome P450 2C8/0.452
3jzfJZKBiotin carboxylase6.3.4.140.452
4fvrATPTyrosine-protein kinase JAK2/0.452
1bwsNDPGDP-L-fucose synthase/0.451
1cqp803Integrin alpha-L/0.451
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.451
2hasC3OVitamin D3 receptor/0.451
2p5uNADUDP-glucose 4-epimerase/0.451
2v59LZKBiotin carboxylase6.3.4.140.451
3iwkNADAminoaldehyde dehydrogenase/0.451
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
2cy0NAPShikimate dehydrogenase (NADP(+))/0.450
2hl2SSAThreonine--tRNA ligase6.1.1.30.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.450
2ii6C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.450
3evgSAHGenome polyprotein2.1.1.560.450
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.450
3nmnPYVAbscisic acid receptor PYL1/0.450
3tqaNDPDihydrofolate reductase/0.450
4bfvZVVPantothenate kinase2.7.1.330.450
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4iqlFMNEnoyl-(Acyl-carrier-protein) reductase II/0.450
4q73FADBifunctional protein PutA/0.450
4y8wSTRSteroid 21-hydroxylase/0.450
1draMTXDihydrofolate reductase1.5.1.30.449
1v0oINRCell division control protein 2 homolog2.7.11.220.449
1wc6TATAdenylate cyclase/0.449
2z0x5CAUncharacterized protein/0.449
3nmpPYVAbscisic acid receptor PYL2/0.449
4a6cQG9Gag-Pol polyprotein3.4.23.160.449
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4fhj0TZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4xj43ATCyclic GMP-AMP synthase/0.449
1pkdUCNCyclin-dependent kinase 22.7.11.220.448
2w6zL21Biotin carboxylase6.3.4.140.448
3cwkREACellular retinoic acid-binding protein 2/0.448
3dpd41APhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.448
4f09JAKTyrosine-protein kinase JAK2/0.448
4gk3L87Ephrin type-A receptor 32.7.10.10.448
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.448
4h6rFDAProline dehydrogenase/0.448
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.448
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.448
4n57ADPAPH(2'')-Id/0.448
4v12POGMaoC like domain protein/0.448
5a3bAPRSIR2 family protein/0.448
5adhAPRAlcohol dehydrogenase E chain1.1.1.10.448
1drbMTXDihydrofolate reductase1.5.1.30.447
1mvsDTMDihydrofolate reductase1.5.1.30.447
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.447
2qn7HBZGlycogen phosphorylase, muscle form2.4.1.10.447
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.447
3f03FMNPentaerythritol tetranitrate reductase/0.447
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.447
4x5iFOLDihydrofolate reductase1.5.1.30.447
1dr2TAPDihydrofolate reductase1.5.1.30.446
1ie9VDXVitamin D3 receptor/0.446
1m78NDPDihydrofolate reductase1.5.1.30.446
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
2qboCAMCamphor 5-monooxygenase1.14.15.10.446
3bc3OPTCathepsin L13.4.22.150.446
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
3mvm39PMitogen-activated protein kinase 14/0.446
3vjoANPEpidermal growth factor receptor2.7.10.10.446
3zkuHCVIsopenicillin N synthase1.21.3.10.446
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
1h50FMNPentaerythritol tetranitrate reductase/0.445
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.445
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.445
2qbmCAMCamphor 5-monooxygenase1.14.15.10.445
2wihP48Cyclin-dependent kinase 22.7.11.220.445
3a783EVVitamin D3 receptor/0.445
3h3r14HCollagen type IV alpha-3-binding protein/0.445
3jpuTY4Transcriptional activator protein LasR/0.445
3mdmFJZCholesterol 24-hydroxylase/0.445
4bfuZVUPantothenate kinase2.7.1.330.445
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
4g2fC07Ephrin type-A receptor 32.7.10.10.445
4zlaBESCytosol aminopeptidase3.4.11.10.445
2bkzSBCCyclin-dependent kinase 22.7.11.220.444
2bl4NADLactaldehyde reductase1.1.1.770.444
2bxmIMNSerum albumin/0.444
2feuCAMCamphor 5-monooxygenase1.14.15.10.444
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
2vbpVB1Isopenicillin N synthase1.21.3.10.444
2y6fM9FIsopenicillin N synthase1.21.3.10.444
3a6rFMNFMN-binding protein/0.444
3bgrT27Gag-Pol polyprotein2.7.7.490.444
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3p3zP3ZPutative cytochrome P450/0.444
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3uf6CODLmo1369 protein/0.444
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4j95ACPFibroblast growth factor receptor 2/0.444
1ia3TQ5Dihydrofolate reductase1.5.1.30.443
1oi9N20Cyclin-dependent kinase 22.7.11.220.443
2dhfDZFDihydrofolate reductase1.5.1.30.443
2fszOHTEstrogen receptor beta/0.443
2gcgNDPGlyoxylate reductase/hydroxypyruvate reductase1.1.1.790.443
2jfaRALEstrogen receptor/0.443
2vcmM11Isopenicillin N synthase1.21.3.10.443
3eej53RUncharacterized protein/0.443
3fwgCAMCamphor 5-monooxygenase1.14.15.10.443
3ml9ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3oafOAGDihydrofolate reductase1.5.1.30.443
4u7wNDPMxaA/0.443
4wh2ADPN-acetylhexosamine 1-kinase2.7.1.1620.443
4zs2FLUAlpha-ketoglutarate-dependent dioxygenase FTO/0.443
1ai9NDPDihydrofolate reductase1.5.1.30.442
1qvuPRLHTH-type transcriptional regulator QacR/0.442
2fhnBNIAvidin-related protein 4/5/0.442
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
2uzeC95Cyclin-dependent kinase 22.7.11.220.442
2v5aLZLBiotin carboxylase6.3.4.140.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.442
3iwjNADAminoaldehyde dehydrogenase/0.442
3js2VM1Fibroblast growth factor receptor 1/0.442
3jziJZLBiotin carboxylase6.3.4.140.442
3ojiPYVAbscisic acid receptor PYL3/0.442
3t8oATPRhodopsin kinase/0.442
4l6gCNL1,8-cineole 2-endo-monooxygenase1.14.13.1560.442
4qmySTUSerine/threonine-protein kinase 242.7.11.10.442
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.442
1jpaANPEphrin type-B receptor 22.7.10.10.441
1rfvADPPyridoxal kinase2.7.1.350.441
1uyuCAMCamphor 5-monooxygenase1.14.15.10.441
2jf9OHTEstrogen receptor/0.441
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3d7tSTUTyrosine-protein kinase CSK/0.441
3h3sH15Collagen type IV alpha-3-binding protein/0.441
3invC50Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4enhFVXCholesterol 24-hydroxylase/0.441
4qq3XMPInosine-5'-monophosphate dehydrogenase/0.441
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.441
1h63FMNPentaerythritol tetranitrate reductase/0.440
1pd9CO4Dihydrofolate reductase1.5.1.30.440
1t88CAMCamphor 5-monooxygenase1.14.15.10.440
1vsvNADGlyceraldehyde-3-phosphate dehydrogenase/0.440
1w51L01Beta-secretase 13.4.23.460.440
2hydADPPutative multidrug export ATP-binding/permease protein SAV18663.6.30.440
3crlANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial2.7.11.20.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.440
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.440
4i8vBHFCytochrome P450 1A11.14.14.10.440
4ia7BIVVitamin D3 receptor A/0.440
4iteTEYVitamin D3 receptor/0.440
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.440