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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1aqbRTLRetinol-binding protein 4

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
1aqbRTLRetinol-binding protein 4/1.000
1iiuRTLRetinol-binding protein 4/0.756
1kt3RTLRetinol-binding protein 4/0.679
1kt4RTLRetinol-binding protein 4/0.679
1brpRTLRetinol-binding protein 4/0.651
1kt7RTLRetinol-binding protein 4/0.651
1kt6RTLRetinol-binding protein 4/0.640
1felFENRetinol-binding protein 4/0.630
4j6dTESCytochrome P450 monooxygenase/0.526
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.524
4j6cSTRCytochrome P450 monooxygenase/0.518
1osvCHCBile acid receptor/0.515
3mg3ECHOrange carotenoid-binding protein/0.510
4at0FADPossible succinate dehydrogenase/0.509
3fmz2T1Retinol-binding protein 4/0.508
1lriCLRBeta-elicitin cryptogein/0.506
1kt5RTLRetinol-binding protein 4/0.500
4i9i1DYTankyrase-12.4.2.300.500
1n4hREANuclear receptor ROR-beta/0.499
2q9fC3SCholesterol 24-hydroxylase/0.497
3eq6BCOAcyl-coenzyme A synthetase ACSM2A, mitochondrial6.2.1.20.497
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.496
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.496
3iptEQUSteroid Delta-isomerase5.3.3.10.494
4jbtASDCytochrome P450 monooxygenase/0.493
4o7uTHFThymidylate synthase/0.493
3w0hW12Vitamin D3 receptor/0.492
5jtbZMAAdenosine receptor A2a/0.492
3h1jSMACytochrome b/0.490
4xbfFADLysine-specific histone demethylase 1A10.489
2qa2FADPolyketide oxygenase CabE/0.488
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.488
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.488
4nieNBHNuclear receptor ROR-gamma/0.488
5fm7ADPRuvB-like helicase/0.488
2iltNN1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.487
3sh0SAXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.487
4ia7BIVVitamin D3 receptor A/0.487
4j6bPLOCytochrome P450 monooxygenase/0.487
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.485
4bj9UHBTankyrase-22.4.2.300.485
3deiRXBCaspase-33.4.22.560.483
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.483
4do30LAFatty-acid amide hydrolase 13.5.1.990.483
4li81XQTankyrase-12.4.2.300.483
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.482
1hrvSDZGenome polyprotein/0.481
1vbnYSATyrosine--tRNA ligase6.1.1.10.481
1hnjMLC3-oxoacyl-[acyl-carrier-protein] synthase 3/0.480
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4fweFADLysine-specific histone demethylase 1B10.480
4pd6URINucleoside permease/0.480
3angDCCTranscriptional repressor, TetR family/0.479
3kytHC2Nuclear receptor ROR-gamma/0.479
4mt92D6Tankyrase-12.4.2.300.479
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.478
2hkoFADLysine-specific histone demethylase 1A10.478
2xc3RT8Steroid C26-monooxygenase1.14.13.1410.478
3gw9VNILanosterol 14-alpha-demethylase/0.478
3p6oETGCamphor 5-monooxygenase1.14.15.10.478
4g20484Vitamin D3 receptor A/0.478
4r21STRCytochrome P450 family 17 polypeptide 2/0.478
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.477
2z78H86Geranylgeranyl pyrophosphate synthase/0.477
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
1egcCO8Medium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.476
1iyzNDPProbable quinone oxidoreductase/0.476
1re9DSOCamphor 5-monooxygenase1.14.15.10.476
1sqvUHDCytochrome b/0.476
4bfpSWYTankyrase-22.4.2.300.476
4k4eK4ETankyrase-12.4.2.300.476
4ug2NGIAdenosine receptor A2a/0.476
1z69F425,10-methylenetetrahydromethanopterin reductase/0.475
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.475
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.475
1dv2ATPBiotin carboxylase6.3.4.140.474
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.474
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.474
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.474
4c77N01Phenylacetone monooxygenase1.14.13.920.474
4ez8DHFThymidylate synthase2.1.1.450.474
4ia2BIVVitamin D3 receptor A/0.474
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.473
2aibERGBeta-elicitin cinnamomin/0.473
2p15EZTEstrogen receptor/0.473
3p6mDSOCamphor 5-monooxygenase1.14.15.10.473
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.473
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.473
4fehFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.473
4g3jVNTLanosterol 14-alpha-demethylase/0.473
4oztP1AEcdysone receptor, putative/0.473
2yjxYJXHeat shock protein HSP 90-alpha/0.472
3zos0LIEpithelial discoidin domain-containing receptor 12.7.10.10.472
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.472
1n83CLRNuclear receptor ROR-alpha/0.471
1ot7CHCBile acid receptor/0.471
2q4wFADCytokinin dehydrogenase 71.5.99.120.471
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.471
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.471
1pp9SMACytochrome b/0.470
1sqi8694-hydroxyphenylpyruvate dioxygenase/0.470
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.470
3qlrNDPDihydrofolate reductase1.5.1.30.470
3tfq07MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
3vt5YI2Vitamin D3 receptor/0.470
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.469
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
1yhjR6CPyridoxal kinase2.7.1.350.469
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.469
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.469
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.469
3nx4NAPPutative oxidoreductase/0.469
3qwbNDPProbable quinone oxidoreductase1.6.5.50.469
3tvuB37Acetyl-CoA carboxylase/0.469
3vt65YIVitamin D3 receptor/0.469
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.469
4ia1BIVVitamin D3 receptor A/0.469
1hvyD16Thymidylate synthase2.1.1.450.468
1xddAAYIntegrin alpha-L/0.468
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.468
2ywlFADThioredoxin reductase related protein/0.468
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.468
4h4o506Gag-Pol polyprotein2.7.7.490.468
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.468
2e48FADD-amino-acid oxidase1.4.3.30.467
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.467
4ia3BIVVitamin D3 receptor A/0.467
4mfb29TGag-Pol polyprotein2.7.7.490.467
4wa9AXITyrosine-protein kinase ABL12.7.10.20.467
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.466
1m52P17Tyrosine-protein kinase ABL12.7.10.20.466
2p4iMR9Angiopoietin-1 receptor2.7.10.10.466
3h86AP5Adenylate kinase/0.466
3p6pA6BCamphor 5-monooxygenase1.14.15.10.466
4c2zMYAGlycylpeptide N-tetradecanoyltransferase 1/0.466
4l9q9TPSerum albumin/0.466
5dozNDPJamJ/0.466
5g53NECAdenosine receptor A2a/0.466
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.465
1tduCB3Thymidylate synthase/0.465
1tlcF89Thymidylate synthase/0.465
2dubCO8Enoyl-CoA hydratase, mitochondrial4.2.1.170.465
2wonZZEGag-Pol polyprotein2.7.7.490.465
3abaFLICytochrome P450/0.465
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.465
3jzdNADMaleylacetate reductase/0.465
3l0lHC3Nuclear receptor ROR-gamma/0.465
3p99LNPLanosterol 14-alpha-demethylase/0.465
4g1z0VPVitamin D3 receptor A/0.465
5ag7MYAGlycylpeptide N-tetradecanoyltransferase/0.465
1ot7IU5Bile acid receptor/0.464
1rf9DBRCamphor 5-monooxygenase1.14.15.10.464
1umlFR4Adenosine deaminase3.5.4.40.464
2bktRPFRenin3.4.23.150.464
2dvlFADAcyl-CoA dehydrogenase/0.464
3bhrTHGThymidylate synthase/0.464
3vtbTKAVitamin D3 receptor/0.464
4fwjFADLysine-specific histone demethylase 1B10.464
4g7gVFVLanosterol 14-alpha-demethylase/0.464
4lb2DM5Serum albumin/0.464
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.464
1eioGCHGastrotropin/0.463
1s0xC3SNuclear receptor ROR-alpha/0.463
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.463
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.463
2jn3JN3Fatty acid-binding protein, liver/0.463
2nsd4PIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.463
2yneNHWGlycylpeptide N-tetradecanoyltransferase/0.463
3p6nDSOCamphor 5-monooxygenase1.14.15.10.463
3pm9FADPutative oxidoreductase/0.463
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.463
4iaq2GM5-hydroxytryptamine receptor 1B/0.463
4o4eATPKinase/0.463
5ab6CAANonspecific lipid-transfer protein, putative/0.463
2dw4FADLysine-specific histone demethylase 1A10.462
2he5NDPAldo-keto reductase family 1 member C211.1.10.462
2p4yC03Peroxisome proliferator-activated receptor gamma/0.462
2rm2W43Genome polyprotein/0.462
3gkjHC3Niemann-Pick C1 protein/0.462
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
3jqpA2PFerredoxin--NADP reductase, apicoplast/0.462
3lu8IQXSerum albumin/0.462
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.462
3w5p4OAVitamin D3 receptor/0.462
3wixLC3Induced myeloid leukemia cell differentiation protein Mcl-1/0.462
4gevCB3Thymidylate synthase/0.462
4gi2NAPCrotonyl-CoA carboxylase/reductase/0.462
4iarERM5-hydroxytryptamine receptor 1B/0.462
4nb6444Nuclear receptor ROR-gamma/0.462
4tzk641Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
1hb1OCVIsopenicillin N synthase1.21.3.10.461
1suiFRECaffeoyl-CoA O-methyltransferase2.1.1.1040.461
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.461
2hpsCTZCa2+-triggered coelenterazine-binding protein 1/0.461
2rr1W8RGenome polyprotein/0.461
2rs1W84Genome polyprotein/0.461
2uxoTACHTH-type transcriptional regulator TtgR/0.461
3uoyNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
3up4NAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.461
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.461
4d03NAPPhenylacetone monooxygenase1.14.13.920.461
4h380YXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.461
4h4m494Gag-Pol polyprotein2.7.7.490.461
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
4isk1JYThymidylate synthase/0.461
4kaoKAOFocal adhesion kinase 12.7.10.20.461
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
1fwmCB3Thymidylate synthase/0.460
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.460
1qo8FADFumarate reductase flavoprotein subunit/0.460
1xdkREARetinoic acid receptor beta/0.460
1ybgTAVUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.460
2b01TUDPhospholipase A2, major isoenzyme3.1.1.40.460
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.460
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.460
2y60M8FIsopenicillin N synthase1.21.3.10.460
2ylrNAPPhenylacetone monooxygenase1.14.13.920.460
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.460
3bfa9ODOdorant binding protein ASP1/0.460
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
4c3yFAD3-ketosteroid dehydrogenase/0.460
4i3zADPCyclin-dependent kinase 22.7.11.220.460
4jlk1NODeoxycytidine kinase2.7.1.740.460
5k2bZMAAdenosine receptor A2a/0.460
1powFADPyruvate oxidase1.2.3.30.459
1pz1NAPGeneral stress protein 69/0.459
1xiuREARetinoic acid receptor RXR/0.459
2y05NAPProstaglandin reductase 1/0.459
3b6zCO7Enoyl reductase LovC10.459
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.459
3ce31FNHepatocyte growth factor receptor2.7.10.10.459
3dh8B4NUncharacterized protein PA1000/0.459
3gxoSAHMitomycin biosynthesis 6-O-methyltransferase/0.459
3kpkFADSulfide-quinone reductase/0.459
3qm4PN0Cytochrome P450 2D6/0.459
3vryB43Tyrosine-protein kinase HCK2.7.10.20.459
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.459
3w8dNAD3-hydroxybutyrate dehydrogenase/0.459
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.459
4li71XPTankyrase-12.4.2.300.459
5k2cZMAAdenosine receptor A2a/0.459
1trgCB3Thymidylate synthase/0.458
2fhkMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.458
2w4qCBWProstaglandin reductase 21.3.1.480.458
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.458
3anpDCCTranscriptional repressor, TetR family/0.458
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.458
3t8xT8XT-cell surface glycoprotein CD1b/0.458
3w33W19Epidermal growth factor receptor2.7.10.10.458
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.458
4i3vNADAldehyde dehydrogenase (NAD+)/0.458
4qbjNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.458
4qi5FADCellobiose dehydrogenase/0.458
1diuBDMDihydrofolate reductase1.5.1.30.457
1fd0254Retinoic acid receptor gamma/0.457
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.457
1thnADPAnti-sigma F factor/0.457
2wuuNHWGlycylpeptide N-tetradecanoyltransferase/0.457
3ffi3OBGag-Pol polyprotein2.7.7.490.457
3jynNDPQuinone oxidoreductase/0.457
3l70JZVCytochrome b/0.457
3mqgACOLipopolysaccharides biosynthesis acetyltransferase/0.457
3ol5SAWCamphor 5-monooxygenase1.14.15.10.457
3tdaPN0Cytochrome P450 2D6/0.457
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.457
4eevL1XHepatocyte growth factor receptor2.7.10.10.457
4g1d0VKVitamin D3 receptor A/0.457
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
4jqh1MFAlr2278 protein/0.457
4yt5H4MH(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338/0.457
5uviZMAAdenosine receptor A2a/0.457
4uhrNGIAdenosine receptor A2a/0.457
1rx0FADIsobutyryl-CoA dehydrogenase, mitochondrial1.3.990.456
1wuuANPGalactokinase2.7.1.60.456
1z6lFADPolyamine oxidase FMS1/0.456
2wleCOAPolysialic acid O-acetyltransferase/0.456
3cwkREACellular retinoic acid-binding protein 2/0.456
3ijdC2FMethylenetetrahydrofolate reductase/0.456
3slkNDPPolyketide synthase extender module 2/0.456
3tm5SFGUncharacterized protein/0.456
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.456
3w0gW07Vitamin D3 receptor/0.456
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.455
2belCBOCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
2c0cNAPProstaglandin reductase 310.455
2lfoGCHFatty acid-binding protein, liver/0.455
2o4rVD5Vitamin D3 receptor/0.455
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
2zl9VDAVitamin D3 receptor/0.455
3ar4TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.455
3dl9V2HVitamin D 25-hydroxylase/0.455
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.455
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.455
3w2cN15Aurora kinase A2.7.11.10.455
4oviN01Phenylacetone monooxygenase1.14.13.920.455
4qofFMNRibosyldihydronicotinamide dehydrogenase [quinone]/0.455
4rv9SAHD-mycarose 3-C-methyltransferase/0.455
1kijNOVDNA gyrase subunit B/0.454
1xqcAEJEstrogen receptor/0.454
1xuoLA1Integrin alpha-L/0.454
2qjySMACytochrome b/0.454
2uxxFAJLysine-specific histone demethylase 1A10.454
2y03Y01Beta-1 adrenergic receptor/0.454
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.454
3cnjFADCholesterol oxidase1.1.3.60.454
3ha5SFGHydroxymycolate synthase MmaA42.1.10.454
3ipq965Oxysterols receptor LXR-alpha/0.454
3tguWF3Cytochrome b/0.454
3vs1VSATyrosine-protein kinase HCK2.7.10.20.454
4bbhNHWGlycylpeptide N-tetradecanoyltransferase/0.454
4c68NHWGlycylpeptide N-tetradecanoyltransferase/0.454
4hyf1AKTankyrase-22.4.2.300.454
4ucnMYAGlycylpeptide N-tetradecanoyltransferase/0.454
5ag5MYAGlycylpeptide N-tetradecanoyltransferase/0.454
5bt42LOBromodomain-containing protein 4/0.454
1fm99CRRetinoic acid receptor RXR-alpha/0.453
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.453
2r04W71Genome polyprotein/0.453
2trtTACTetracycline repressor protein class D/0.453
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.453
2zb3NDPProstaglandin reductase 21.3.1.480.453
3icrCOACoenzyme A disulfide reductase/0.453
3ox4NADAlcohol dehydrogenase 21.1.1.10.453
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.453
4gdpFADPolyamine oxidase FMS1/0.453
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.453
4rupH97Vitamin D3 receptor A/0.453
5br4NADLactaldehyde reductase1.1.1.770.453
1e1nFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.452
1mr9ACOStreptogramin A acetyltransferase2.3.10.452
1ppjANYCytochrome b/0.452
2b04CHOPhospholipase A2, major isoenzyme3.1.1.40.452
2fhjMFNFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.452
3bgxMEFThymidylate synthase/0.452
3di6PDZGag-Pol polyprotein2.7.7.490.452
3pqbVGPPutative oxidoreductase/0.452
4a95NHWGlycylpeptide N-tetradecanoyltransferase/0.452
4q71FADBifunctional protein PutA/0.452
4trj665Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.452
5a3bAPRSIR2 family protein/0.452
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.452
5dp2NAPCurF/0.452
5iu86DZAdenosine receptor A2a/0.452
3uzcT4EAdenosine receptor A2a/0.452
3reyXACAdenosine receptor A2a/0.452
1f123HCHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.451
1kvoOAPPhospholipase A2, membrane associated/0.451
1rdtL79Retinoic acid receptor RXR-alpha/0.451
1sqpMYXCytochrome b/0.451
2c3qGTXGlutathione S-transferase theta-12.5.1.180.451
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.451
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.451
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.451
2rewREWPeroxisome proliferator-activated receptor alpha/0.451
2wetFADTryptophan 5-halogenase/0.451
3ds6A17Mitogen-activated protein kinase 14/0.451
3tubFPUTyrosine-protein kinase SYK2.7.10.20.451
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.451
4a6dSAMAcetylserotonin O-methyltransferase2.1.1.40.451
4eb4D16Thymidylate synthase2.1.1.450.451
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.451
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.450
1nkzRG1Light-harvesting protein B-800/850 alpha chain/0.450
1nkzRG1Light-harvesting protein B-800/850 beta chain/0.450
1xlsREARetinoic acid receptor RXR-alpha/0.450
2y6fM9FIsopenicillin N synthase1.21.3.10.450
2zb8IMNProstaglandin reductase 21.3.1.480.450
3dxjNE6DNA-directed RNA polymerase subunit beta/0.450
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.450
3nbpJGZGag-Pol polyprotein2.7.7.490.450
3w0iO11Vitamin D3 receptor/0.450
4at5MUJBDNF/NT-3 growth factors receptor2.7.10.10.450
4fnyI3KALK tyrosine kinase receptor2.7.10.10.450
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.450
5g3sFDAFlavin-dependent L-tryptophan oxidase VioA/0.450
1dajMOTDihydrofolate reductase1.5.1.30.449
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.449
1qiqACCIsopenicillin N synthase1.21.3.10.449
1rrmAPRLactaldehyde reductase1.1.1.770.449
2djiFADPyruvate oxidase/0.449
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.449
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.449
2yncYNCGlycylpeptide N-tetradecanoyltransferase/0.449
3cx5SMACytochrome b/0.449
3ey4352Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.449
3h0aD30Peroxisome proliferator-activated receptor gamma/0.449
3lalKRVGag-Pol polyprotein2.7.7.490.449
3mlaJJZProbable nicotinate-nucleotide adenylyltransferase/0.449
3nwlNDPCatalase1.11.1.60.449
3uwlFOZThymidylate synthase/0.449
3w78CBDFMN-dependent NADH-azoreductase/0.449
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4klaCHDFerrochelatase, mitochondrial4.99.1.10.449
5envNADAlcohol dehydrogenase 11.1.1.10.449
1jscFADAcetolactate synthase catalytic subunit, mitochondrial2.2.1.60.448
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.448
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.448
1uzwCDHIsopenicillin N synthase1.21.3.10.448
2hcdBIVVitamin D3 receptor A/0.448
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.448
2lbdREARetinoic acid receptor gamma/0.448
2qfxNDPIsocitrate dehydrogenase [NADP], mitochondrial1.1.1.420.448
2ykjYKJHeat shock protein HSP 90-alpha/0.448
3nalDBKCalcium-transporting ATPase/0.448
3ntgD72Prostaglandin G/H synthase 21.14.99.10.448
3vt3VDXVitamin D3 receptor/0.448
3vt8YI3Vitamin D3 receptor/0.448
4a2zMYAGlycylpeptide N-tetradecanoyltransferase/0.448
4b14NHWGlycylpeptide N-tetradecanoyltransferase/0.448
4bvaT3Ketimine reductase mu-crystallin1.5.1.250.448
4dbs0HVAldo-keto reductase family 1 member C3/0.448
4klnAGSTransitional endoplasmic reticulum ATPase3.6.4.60.448
4tzt468Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.448
1dkfBMSRetinoic acid receptor alpha/0.447
1h2bNAJNAD-dependent alcohol dehydrogenase/0.447
1kb9SMACytochrome b/0.447
1ndzFR5Adenosine deaminase3.5.4.40.447
1obnASVIsopenicillin N synthase1.21.3.10.447
1p8dCO1Oxysterols receptor LXR-beta/0.447
1tw4CHDFatty acid-binding protein, liver/0.447
1yb5NAPQuinone oxidoreductase1.6.5.50.447
2b9wFADPutative aminooxidase/0.447
2y00Y01Beta-1 adrenergic receptor/0.447
2yiuSMACytochrome b/0.447
3w8wFADPutative FAD-dependent oxygenase EncM/0.447
4a30MYAGlycylpeptide N-tetradecanoyltransferase/0.447
4b4vL34Bifunctional protein FolD/0.447
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.447
4cavMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.447
4gapNADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.447
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.447
4iah1DXAlr2278 protein/0.447
4ruoBIVVitamin D3 receptor A/0.447
4ysjADPCalmodulin-like domain protein kinase/0.447
5l3dFADLysine-specific histone demethylase 1A10.447
5k2aZMAAdenosine receptor A2a/0.447
3sn6P0GBeta-2 adrenergic receptor/0.447
1amoFADNADPH--cytochrome P450 reductase/0.446
1an5CB3Thymidylate synthase/0.446
1ci7CB3Thymidylate synthase2.1.1.450.446
1cjwCOTSerotonin N-acetyltransferase/0.446
1fmjRTLRetinol dehydratase/0.446
1fmlRTLRetinol dehydratase/0.446
1nq7ARLNuclear receptor ROR-beta/0.446
1o5rFR9Adenosine deaminase3.5.4.40.446
1o8cNDPProbable acrylyl-CoA reductase AcuI1.3.1.840.446
1qxlFR8Adenosine deaminase3.5.4.40.446
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.446
1yc2NADNAD-dependent protein deacylase 2/0.446
2aazCB3Thymidylate synthase2.1.1.450.446
2bu9HFVIsopenicillin N synthase1.21.3.10.446
2wsaMYAGlycylpeptide N-tetradecanoyltransferase/0.446
2z3uCRRCytochrome P450/0.446
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.446
3bi5FADPolyamine oxidase FMS1/0.446
3czr3CZCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3t2zFADSulfide-quinone reductase/0.446
3wmxNADNAD dependent epimerase/dehydratase/0.446
3zbrNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.446
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4dm6TTBRetinoic acid receptor beta/0.446
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.446
4ma628EAra h 8 allergen/0.446
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.446
4ytnFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.446
1db1VDXVitamin D3 receptor/0.445
1disBDMDihydrofolate reductase1.5.1.30.445
1k749CRRetinoic acid receptor RXR-alpha/0.445
1qinGIPLactoylglutathione lyase4.4.1.50.445
1tysDHFThymidylate synthase/0.445
1ztq033Collagenase 33.4.240.445
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
2ardFDAFlavin-dependent tryptophan halogenase PrnA1.14.19.90.445
2ol4JPNEnoyl-ACP reductase/0.445
2p1u4TNRetinoic acid receptor RXR-alpha/0.445
2xw7NDPDihydrofolate reductase/0.445
2yk2YJXHeat shock protein HSP 90-alpha/0.445
2zevB71Geranylgeranyl pyrophosphate synthase/0.445
2zlaVDBVitamin D3 receptor/0.445
2zlcVDXVitamin D3 receptor/0.445
2zynBCDPeriplasmic binding protein/0.445
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.445
3fl8RARDihydrofolate reductase/0.445
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.445
3h0sB38Acetyl-CoA carboxylase/0.445
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
3sfeFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.445
3sfi3SFHTH-type transcriptional regulator EthR/0.445
3uozNAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.445
4bb3KKAIsopenicillin N synthase1.21.3.10.445
4cgpMYAGlycylpeptide N-tetradecanoyltransferase/0.445
4h6rFDAProline dehydrogenase/0.445
4ku5DCC3-oxoacyl-[ACP] synthase III/0.445
4nc3ERM5-hydroxytryptamine receptor 2B/0.445
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.445
5fknTDCTetracycline repressor protein class D/0.445
1jolFFODihydrofolate reductase1.5.1.30.444
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.444
1lquFADNADPH-ferredoxin reductase FprA1.18.1.20.444
1oc1ASVIsopenicillin N synthase1.21.3.10.444
1poxFADPyruvate oxidase1.2.3.30.444
1ygkRRCPyridoxal kinase2.7.1.350.444
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.444
2c7xNRBCytochrome P450 monooxygenase PikC/0.444
2hbhXE4Vitamin D3 receptor A/0.444
2i0ePDSProtein kinase C beta type2.7.11.130.444
2jb4A14Isopenicillin N synthase1.21.3.10.444
2q4bNAPUncharacterized protein At5g02240/0.444
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2y01Y01Beta-1 adrenergic receptor/0.444
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.444
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.444
3icsCOACoenzyme A disulfide reductase/0.444
3ix9MTXDihydrofolate reductase1.5.1.30.444
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.444
3tfp03LDehydrosqualene synthase/0.444
3w8zHTKPutative FAD-dependent oxygenase EncM/0.444
3zkyWT4Isopenicillin N synthase1.21.3.10.444
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.444
4ele31IDihydrofolate reductase/0.444
4irnFADAnaB/0.444
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.444
4q0a4OAVitamin D3 receptor A/0.444
4qe6JN3Bile acid receptor/0.444
5cmsAPRO-acetyl-ADP-ribose deacetylase/0.444
5l7dCLRSmoothened homolog/0.444
5k2dZMAAdenosine receptor A2a/0.444
1hb3SCVIsopenicillin N synthase1.21.3.10.443
1mznBM6Retinoic acid receptor RXR-alpha/0.443
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.443
2o7pNAPRiboflavin biosynthesis protein RibD/0.443
2xlrFADPutative flavin-containing monooxygenase/0.443
3bhlTHGThymidylate synthase/0.443
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3iw8HIZMitogen-activated protein kinase 14/0.443
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.443
3o96IQORAC-alpha serine/threonine-protein kinase2.7.11.10.443
3oqfS51Renin3.4.23.150.443
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.10.443
3up3XCAaceDAF-12/0.443
3up5NAP2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.443
3vvh4BMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.443
3vzcUULSphingosine kinase 12.7.1.910.443
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4d04FADPhenylacetone monooxygenase1.14.13.920.443
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.443
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.443
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.443
4usqFADPyridine nucleotide-disulfide oxidoreductase/0.443
4uxq0LIFibroblast growth factor receptor 42.7.10.10.443
5a28MYAGlycylpeptide N-tetradecanoyltransferase/0.443
5bp9SAHPutative methyltransferase protein/0.443
5cp8TCUEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
4k5y1Q5Corticotropin-releasing factor receptor 1/0.443
3emlZMAAdenosine receptor A2a/0.443
1ek2CDUBifunctional epoxide hydrolase 2/0.442
1i5bANPChemotaxis protein CheA2.7.13.30.442
1pt9TAPNAD(P) transhydrogenase, mitochondrial1.6.1.20.442
1qorNDPQuinone oxidoreductase 1/0.442
1sg6NADPentafunctional AROM polypeptide/0.442
1zhzERGOxysterol-binding protein homolog 4/0.442
2cduFADNADH oxidase/0.442
2fgkATPAlpha-hemolysin translocation ATP-binding protein HlyB/0.442
2uxwTH3Very long-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.90.442
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.442
3hub469Mitogen-activated protein kinase 14/0.442
3is9AC7Gag-Pol polyprotein2.7.7.490.442
3p4tFAOPutative acyl-CoA dehydrogenase/0.442
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3s1sSAHRestriction endonuclease BpuSI/0.442
3tqhNDPQuinone oxidoreductase/0.442
3vt45YIVitamin D3 receptor/0.442
4a6eASEAcetylserotonin O-methyltransferase2.1.1.40.442
4elf35IDihydrofolate reductase/0.442
4eoi1ROCyclin-dependent kinase 22.7.11.220.442
4fdpFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.442
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.442
4iae1DXAlr2278 protein/0.442
4jkt04AGlutaminase kidney isoform, mitochondrial3.5.1.20.442
4jtz1NWGenome polyprotein2.7.7.480.442
4xxvNAD3-isopropylmalate dehydrogenase/0.442
4y8wSTRSteroid 21-hydroxylase/0.442
1blzACVIsopenicillin N synthase1.21.3.10.441
1ey3DAKEnoyl-CoA hydratase, mitochondrial4.2.1.170.441
1f4fTP3Thymidylate synthase/0.441
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.441
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.441
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.441
1upw444Oxysterols receptor LXR-beta/0.441
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.441
2bx8AZQSerum albumin/0.441
2bxoOPBSerum albumin/0.441
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.441
2npfMOUElongation factor 2/0.441
2xir00JVascular endothelial growth factor receptor 22.7.10.10.441
2xszATPRuvB-like 23.6.4.120.441
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.441
3crzFADFerredoxin--NADP+ reductase/0.441
3da1FADGlycerol-3-phosphate dehydrogenase/0.441
3p8zSAHGenome polyprotein2.1.1.560.441
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.441
3tm4SAMUncharacterized protein/0.441
4a33MYAGlycylpeptide N-tetradecanoyltransferase/0.441
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.441
4knzCB3Thymidylate synthase/0.441
4yshFADGlycine oxidase/0.441
4z44FADFlavin-dependent tryptophan halogenase PrnA1.14.19.90.441
5a3cNADSIR2 family protein/0.441
1fcx184Retinoic acid receptor gamma/0.440
1kqgHQOFormate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit/0.440
1rsgFADPolyamine oxidase FMS1/0.440
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.440
2e98B29Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.440
2ftoCB3Thymidylate synthase/0.440
2g78REACellular retinoic acid-binding protein 2/0.440
2wbdRO5Fructose-1,6-bisphosphatase 13.1.3.110.440
2ym1NAPPhenylacetone monooxygenase1.14.13.920.440
2yphQQY2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
3ekuCY9Actin-5C/0.440
3g5hYTTMycocyclosin synthase1.14.21.90.440
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.440
3ihgFADAklavinone 12-hydroxylase RdmE/0.440
3ipuO40Oxysterols receptor LXR-alpha/0.440
3p9tTCLRepressor/0.440
3rpnGTXGlutathione S-transferase kappa 12.5.1.180.440
3v0tATRPerakine reductase1.1.1.3170.440
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.440
4i7fNVEGag-Pol polyprotein2.7.7.490.440
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.440
4mfpCOAUncharacterized protein/0.440
4msg2C6Tankyrase-12.4.2.300.440
4yafFADNADPH--cytochrome P450 reductase/0.440